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1. Full Text Structures and mechanisms of CRISPR RNA-guided effector nucleases
by Nishimasu, Hiroshi and Nureki, Osamu
Current opinion in structural biology, ISSN 0959-440X, 04/2017, Volume 43, pp. 68 - 78
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Ribonucleases - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats | RNA - genetics | RNA - metabolism | RNA | Nucleases | DNA binding proteins | Index Medicus
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2. Full Text Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel
by Kasuya, Go and Yamaura, Toshiaki and Ma, Xiao-Bo and Nakamura, Ryoki and Takemoto, Mizuki and Nagumo, Hiromitsu and Tanaka, Eiichi and Dohmae, Naoshi and Nakane, Takanori and Yu, Ye and Ishitani, Ryuichiro and Matsuzaki, Osamu and Hattori, Motoyuki and Nureki, Osamu
Nature communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 876 - 10
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Hypertension | Competition | Electrophysiology | Arthritis | Channels | Receptors | Computation | Rheumatoid arthritis | Computer applications | Cations | Inhibition | Mutation | ATP | Crystal structure | Conformation | Structure-function relationships | Index Medicus
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3. Full Text Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
by Konermann, Silvana and Brigham, Mark D and Trevino, Alexandro E and Joung, Julia and Abudayyeh, Omar O and Barcena, Clea and Hsu, Patrick D and Habib, Naomi and Gootenberg, Jonathan S and Nishimasu, Hiroshi and Nureki, Osamu and Zhang, Feng
Nature (London), ISSN 0028-0836, 01/2015, Volume 517, Issue 7536, pp. 583 - 588
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Transcriptional Activation - genetics | Genetic Testing | RNA, Untranslated - metabolism | Humans | DNA, Complementary - genetics | Genetic Loci - genetics | RNA, Untranslated - genetics | Melanoma - genetics | DNA, Complementary - biosynthesis | Indoles - pharmacology | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Gene Expression Regulation, Neoplastic - genetics | Genetic Engineering - methods | Reproducibility of Results | Gene Library | CRISPR-Associated Proteins - genetics | Up-Regulation - genetics | Sulfonamides - pharmacology | CRISPR-Cas Systems - genetics | Genome, Human - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | RNA, Untranslated - biosynthesis | CRISPR-Associated Proteins - metabolism | Melanoma - drug therapy | Cell Line, Tumor | Drug Resistance, Neoplasm - drug effects | Enzymes | Nucleotide sequence | Genetic research | Genomes | Genetic aspects | Genetic engineering | Genetic transcription | Research | Proteins | Transcription factors | Genomics | Melanoma | Epigenetics | Drug resistance | Gene expression | Crystal structure | Index Medicus
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4. Full Text Engineered CRISPR-Cas9 nuclease with expanded targeting space
by Nishimasu, Hiroshi and Shi, Xi and Ishiguro, Soh and Gao, Linyi and Hirano, Seiichi and Okazaki, Sae and Noda, Taichi and Abudayyeh, Omar O and Gootenberg, Jonathan S and Mori, Hideto and Oura, Seiya and Holmes, Benjamin and Tanaka, Mamoru and Seki, Motoaki and Hirano, Hisato and Aburatani, Hiroyuki and Ishitani, Ryuichiro and Ikawa, Masahito and Yachie, Nozomu and Zhang, Feng and Nureki, Osamu
Science (American Association for the Advancement of Science), ISSN 0036-8075, 09/2018, Volume 361, Issue 6408, pp. 1259 - 1262
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Endonucleases - genetics | Humans | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | CRISPR-Cas Systems | HEK293 Cells | Protein Engineering | Crystallography, X-Ray | CRISPR-Associated Protein 9 | Gene Editing | Endonucleases - chemistry | Enzymes | Nucleases | RNA | Structure | Cells | Crystals | Genetic research | CRISPR | Target recognition | Streptococcus | Nucleotide sequence | Activation-induced cytidine deaminase | Genomes | Nuclease | Endonuclease | Ribonucleic acid--RNA | Deoxyribonucleic acid--DNA | Crystal structure | Index Medicus
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5. Full Text Crystal Structure of a Claudin Provides Insight into the Architecture of Tight Junctions
by Hiroshi Suzuki and Tomohiro Nishizawa and Kazutoshi Tani and Yuji Yamazaki and Atsushi Tamura and Ryuichiro Ishitani and Naoshi Dohmae and Sachiko Tsukita and Osamu Nureki and Yoshinori Fujiyoshi
Science (American Association for the Advancement of Science), ISSN 0036-8075, 4/2014, Volume 344, Issue 6181, pp. 304 - 307
Proteins | Tight junctions | Epithelial cells | REPORTS | Gastroenterology | Ions | Cell membranes | Electrical potential | Extracellular space | Protein subunits | Crystal structure | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protein Structure, Tertiary | Amino Acid Sequence | Protein Structure, Secondary | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Static Electricity | Protein Folding | Amino Acid Motifs | Tight Junctions - chemistry | Tight Junctions - physiology | Animals | Claudins - chemistry | Protein Conformation | Mice | Protein Subunits - chemistry | Junctional complexes (Epithelium) | Cell research | Cell adhesion | Crystals | Cell junctions | Physiological aspects | Research | Structure | Homeowners | Cells | Cell adhesion & migration | Index Medicus
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6. Full Text Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation
by Shihoya, Wataru and Izume, Tamaki and Inoue, Asuka and Yamashita, Keitaro and Kadji, Francois Marie Ngako and Hirata, Kunio and Aoki, Junken and Nishizawa, Tomohiro and Nureki, Osamu
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 11
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neuroprotection | Drug delivery systems | Endothelin | Endothelin 3 | Activation | Functional analysis | Drug delivery | Drug development | Hydrogen bonding | Vasodilation | Proteins | Coupling (molecular) | Receptors | Vasoactive agents | Endothelin receptors | Blood pressure | Disruption | Receptor mechanisms | Crystal structure | Tumors | Index Medicus
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7. Full Text Structural insights into tetraspanin CD9 function
by Umeda, Rie and Satouh, Yuhkoh and Takemoto, Mizuki and Nakada-Nakura, Yoshiko and Liu, Kehong and Yokoyama, Takeshi and Shirouzu, Mikako and Iwata, So and Nomura, Norimichi and Sato, Ken and Ikawa, Masahito and Nishizawa, Tomohiro and Nureki, Osamu
Nature communications, ISSN 2041-1723, 03/2020, Volume 11, Issue 1, pp. 1606 - 1606
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Membranes | CD9 antigen | Fertilization | Molecular interactions | Viruses | Lipids | Infections | Cell fusion | Adhesion | Cell adhesion & migration | Membrane proteins | Domains | Proteins | Functionals | Cell adhesion | Physiology | Localization | Curvature | Cellular structure | Crystal structure | Index Medicus
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8. Full Text Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas9
by Hirano, Seiichi and Nishimasu, Hiroshi and Ishitani, Ryuichiro and Nureki, Osamu
Molecular cell, ISSN 1097-2765, 03/2016, Volume 61, Issue 6, pp. 886 - 894
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Endonucleases - genetics | RNA, Guide - genetics | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Substrate Specificity | Crystallography, X-Ray | DNA, Intergenic - genetics | Endonucleases - chemistry | DNA - genetics | DNA - chemistry | Genetic Engineering | RNA, Guide - chemistry | CRISPR-Cas Systems | Mutation | Nucleases | RNA | Analysis | Genomics | DNA | Crystals | Nucleotides | Structure | Index Medicus
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9. Full Text Is zucchini a phosphodiesterase or a ribonuclease?
by Nureki, Osamu
Biomedical Journal, ISSN 2319-4170, 11/2014, Volume 37, Issue 6, pp. 369 - 374
X-ray crystallography | biogenesis | phospholipase D superfamily | non-coding RNA | Crystallography, X-Ray - methods | Drosophila melanogaster - metabolism | Endoribonucleases - chemistry | Animals | Endoribonucleases - metabolism | Ribonucleases - chemistry | Humans | Drosophila Proteins - chemistry | Drosophila Proteins - metabolism | Ribonucleases - metabolism | Phosphoric Diester Hydrolases - chemistry | Proteins | Enzymes | Mitochondria | Insects | Biosynthesis | Genomes | Gene expression | Localization | Crystal structure | Index Medicus
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10. Full Text Light-induced structural changes and the site of O=O bond formation in PSII caught by XFEL
by Suga, Michihiro and Akita, Fusamichi and Sugahara, Michihiro and Kubo, Minoru and Nakajima, Yoshiki and Nakane, Takanori and Yamashita, Keitaro and Umena, Yasufumi and Nakabayashi, Makoto and Yamane, Takahiro and Nakano, Takamitsu and Suzuki, Mamoru and Masuda, Tetsuya and Inoue, Shigeyuki and Kimura, Tetsunari and Nomura, Takashi and Yonekura, Shinichiro and Yu, Long-Jiang and Sakamoto, Tomohiro and Motomura, Taiki and Chen, Jing-Hua and Kato, Yuki and Noguchi, Takumi and Tono, Kensuke and Joti, Yasumasa and Kameshima, Takashi and Hatsui, Takaki and Nango, Eriko and Tanaka, Rie and Naitow, Hisashi and Matsuura, Yoshinori and Yamashita, Ayumi and Yamamoto, Masaki and Nureki, Osamu and Yabashi, Makina and Ishikawa, Tetsuya and Iwata, So and Shen, Jian-Ren
Nature (London), ISSN 0028-0836, 03/2017, Volume 543, Issue 7643, pp. 131 - 135
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protons | Temperature | Nonheme Iron Proteins - metabolism | Electron Transport - radiation effects | Cyanobacteria - chemistry | Crystallography - methods | Oxygen - metabolism | Fourier Analysis | Time Factors | Lasers | Light | Oxygen - chemistry | Water - chemistry | Nonheme Iron Proteins - chemistry | Biocatalysis - radiation effects | Water - metabolism | Models, Molecular | Nonheme Iron Proteins - radiation effects | Manganese - chemistry | Photosystem II Protein Complex - metabolism | Manganese - metabolism | Photosystem II Protein Complex - radiation effects | Photosystem II Protein Complex - chemistry | Oxygen - radiation effects | Electrons | Chemical bonds | Physiological aspects | Photosystem II | Structure | Photosynthesis research | Membrane proteins | Datasets | Ligands | Fourier transforms | Binding sites | Index Medicus
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