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1. Full Text Fifty years of B lymphocytes: Alexander D. Gitlin and Michel C. Nussenzweig reflect on the discovery of two lineages of adaptive immune cells, and how it influenced vaccination, cancer therapy and the development of a class of antibody-based drugs
by Gitlin, Alexander D and Nussenzweig, Michel C
Nature (London), ISSN 0028-0836, 01/2015, Volume 517, Issue 7533, p. 139
Cell research | Product development | B cells | Research | Biopharmaceutics
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2. Full Text Role of genomic instability and p53 in AID-induced c-myc – Igh translocations
by McBride, Kevin M and Eisenreich, Thomas R and Ramiro, Almudena R and Nussenzweig, Andre and Lowe, Scott W and Nussenzweig, Michel C and Jankovic, Mila and Callen, Elsa and Chen, Hua-Tang and Chen, Junjie and Dickins, Ross A and Difilippantonio, Simone
Nature, ISSN 0028-0836, 03/2006, Volume 440, Issue 7080, pp. 105 - 109
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Line | Gene Expression | Cytidine Deaminase - genetics | Tumor Suppressor Protein p53 - metabolism | Mutation - genetics | Tumor Suppressor Protein p53 - genetics | Animals | Cytidine Deaminase - metabolism | Genes, myc - genetics | DNA Damage - genetics | Genes, Immunoglobulin Heavy Chain - genetics | Mice | Models, Genetic | Immunoglobulin Class Switching - genetics | B-Lymphocytes - metabolism | Genomic Instability - genetics | Translocation, Genetic - genetics | Enzymes | Acquired immune deficiency syndrome | Genomics | AIDS | Chromosomes | Cells | Tumors | Cancer | Index Medicus
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3. Full Text Clonal selection in the germinal centre by regulated proliferation and hypermutation
by Gitlin, Alexander D and Shulman, Ziv and Nussenzweig, Michel C
Nature (London), ISSN 0028-0836, 2014, Volume 509, Issue 7502, pp. 637 - 640
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Clone Cells - cytology | B-Lymphocytes - cytology | Cell Proliferation | Germinal Center - immunology | Antibody Affinity - immunology | Genes, Reporter - genetics | Male | Antigen Presentation - immunology | Clone Cells - metabolism | Clonal Selection, Antigen-Mediated - immunology | Animals | B-Lymphocytes - immunology | Time Factors | T-Lymphocytes, Helper-Inducer - immunology | S Phase | Clone Cells - immunology | T-Lymphocytes, Helper-Inducer - cytology | Antigens - immunology | Mice | Germinal Center - cytology | Somatic Hypermutation, Immunoglobulin - genetics | B-Lymphocytes - metabolism | Cell Movement | Physiological aspects | Research | T cells | Reproduction, Asexual | Health aspects | Proliferating cell nuclear antigen | Antigens | Mutation | Cellular biology | Rodents | Immune system | Index Medicus
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4. Full Text Origin and development of dendritic cells
by Liu, Kang and Nussenzweig, Michel C
Immunological reviews, ISSN 0105-2896, 03/2010, Volume 234, Issue 1, pp. 45 - 54
monocytes | development | dendritic cells | Dendritic cells | Development | Monocytes | Life Sciences & Biomedicine | Immunology | Science & Technology | Antigens, CD - immunology | Dendritic Cells - immunology | Humans | Homeostasis | Hematopoietic Stem Cells - metabolism | Lymphoid Tissue - immunology | Cell Differentiation - immunology | Lymphoid Tissue - cytology | Hematopoietic Stem Cells - immunology | Animals | Bone Marrow Cells - immunology | Integrin alpha Chains - immunology | Membrane Proteins - metabolism | Dendritic Cells - metabolism | Cell Lineage - immunology | Cell Movement | Index Medicus
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5. Full Text AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations
by Robbiani, Davide F and Bothmer, Anne and Callen, Elsa and Reina-San-Martin, Bernardo and Dorsett, Yair and Difilippantonio, Simone and Bolland, Daniel J and Chen, Hua Tang and Corcoran, Anne E and Nussenzweig, André and Nussenzweig, Michel C
Cell (Cambridge), ISSN 0092-8674, 2008, Volume 135, Issue 6, pp. 1028 - 1038
CELLBIO | MOLIMMUNO | HUMDISEASE | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Translocation, Genetic | Humans | Mice, Inbred C57BL | Plasmacytoma - genetics | Burkitt Lymphoma - metabolism | Genes, myc | DNA Breaks, Double-Stranded | Plasmacytoma - metabolism | Genes, Immunoglobulin Heavy Chain | Animals | Cytidine Deaminase - metabolism | Burkitt Lymphoma - genetics | Integrases - metabolism | Mice | Embryonic Stem Cells | B-Lymphocytes - metabolism | Chromatin | Immunoglobulins | Lymphomas | Gene expression | Lymphocytes | DNA | Index Medicus
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6. Full Text Towards HIV-1 remission: Potential roles for broadly neutralizing antibodies
by Halper-Stromberg, Ariel and Nussenzweig, Michel C
The Journal of clinical investigation, ISSN 0021-9738, 02/2016, Volume 126, Issue 2, pp. 415 - 423
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV-1 - immunology | Animals | HIV Antibodies - immunology | Antibodies, Neutralizing - therapeutic use | Humans | HIV Antibodies - therapeutic use | HIV Infections - drug therapy | Remission Induction | Medicine, Experimental | Medical research | Care and treatment | Immune response | Observations | HIV infection | Studies | Immunoglobulins | Infections | Human immunodeficiency virus--HIV | Binding sites | Index Medicus | Abridged Index Medicus
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7. Full Text Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic
by Caskey, Marina and Klein, Florian and Nussenzweig, Michel C
Nature medicine, ISSN 1078-8956, 04/2019, Volume 25, Issue 4, pp. 547 - 553
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | HIV Infections - immunology | HIV Infections - prevention & control | HIV-1 - immunology | Animals | Antibodies, Neutralizing - therapeutic use | Humans | Antibodies, Monoclonal - therapeutic use | HIV Antibodies - therapeutic use | HIV Infections - drug therapy | Clinical Trials as Topic | Prevention | Host-bacteria relationships | Care and treatment | Usage | Analysis | Immunotherapy | Monoclonal antibodies | HIV infection | Risk factors | Virus diseases | Infection | Antiviral agents | Medical research | Medicine, Experimental | HIV (Viruses) | Health aspects | Viremia | Human immunodeficiency virus--HIV | Proviruses | Viruses | Infections | Immunity | Antiretroviral therapy | Antigen-antibody complexes | Index Medicus
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8. Full Text The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry
by Dominguez-Sola, David and Victora, Gabriel D and Ying, Carol Y and Phan, Ryan T and Saito, Masumichi and Nussenzweig, Michel C and Dalla-Favera, Riccardo
Nature immunology, ISSN 1529-2908, 11/2012, Volume 13, Issue 11, pp. 1083 - 1091
Life Sciences & Biomedicine | Immunology | Science & Technology | Antigens, CD - immunology | Cell Cycle - genetics | Green Fluorescent Proteins | Cell Proliferation | Germinal Center - immunology | Antigens, CD - genetics | Lymphoma - metabolism | T-Lymphocytes - metabolism | Cell Transformation, Neoplastic - genetics | Cell Cycle - immunology | Lymphoma - pathology | B-Lymphocytes - pathology | T-Lymphocytes - pathology | B-Lymphocytes - metabolism | Genes, Reporter | Signal Transduction | Genes, myc - immunology | Gene Expression Regulation | Lymphoma - genetics | Mice, Transgenic | Germinal Center - pathology | Receptors, Antigen, B-Cell - immunology | Proto-Oncogene Proteins c-bcl-6 - genetics | Cell Transformation, Neoplastic - immunology | Animals | B-Lymphocytes - immunology | Germinal Center - metabolism | Receptors, Antigen, B-Cell - genetics | T-Lymphocytes - immunology | Mice | Proto-Oncogene Proteins c-bcl-6 - immunology | Cell Movement | Physiological aspects | Research | B cells | Analysis | Proto-oncogenes | Index Medicus
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