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Lancet Oncology, The, ISSN 1470-2045, 2016, Volume 17, Issue 5, pp. 651 - 662
Journal Article
Cancer Research, ISSN 0008-5472, 12/2016, Volume 76, Issue 24 Supplement, pp. B58 - B58
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2016, Volume 22, Issue 8, pp. 851 - 860
Single-agent immunotherapy has achieved limited clinical benefit to date in patients with pancreatic ductal adenocarcinoma (PDAC). This may be a result of the... 
MEDICINE, RESEARCH & EXPERIMENTAL | SKIN WOUND REPAIR | DUCTAL ADENOCARCINOMA | DECREASES GROWTH | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-INFILTRATING MACROPHAGES | 2 KNOCKOUT MICE | ACTIN CYTOSKELETAL REARRANGEMENT | TISSUE STIFFNESS | CELL BIOLOGY | FAK | ANTIGEN RECEPTOR | T-CELLS | Immunohistochemistry | Pancreatic Neoplasms - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Tumor Microenvironment | Deoxycytidine - pharmacology | Immunoblotting | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Immunotherapy | Antimetabolites, Antineoplastic - pharmacology | Carcinoma, Pancreatic Ductal - immunology | Disease Models, Animal | Tumor Escape - immunology | Immunotherapy, Adoptive - methods | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Pancreatic Neoplasms - pathology | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Pancreatic Ductal - pathology | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Disease Progression | Animals | Aminopyridines - pharmacology | Pancreatic Neoplasms - immunology | Fibrosis | Cell Proliferation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | Deoxycytidine - analogs & derivatives | Molecular targeted therapy | Care and treatment | Pancreatic cancer | Patient outcomes | Innovations | Genetic aspects | Properties | Phosphotransferases | Methods | Kinases | Cell adhesion & migration | pancreatic cancer | PDAC | CXCL12 | VS-4718 | immunotherapy | fibrosis | tumor microenvironment | PD-1
Journal Article
Cancer Research, ISSN 0008-5472, 07/2014, Volume 74, Issue 18, pp. 5057 - 5069
Cancer immunotherapy generally offers limited clinical benefit without coordinated strategies to mitigate the immunosuppressive nature of the tumor... 
ACTIVATION | INHIBITION | MICROENVIRONMENT | ONCOLOGY | ADENOCARCINOMA | INFLAMMATION | KINASE | CSF | POLARIZATION | IPILIMUMAB | PROGRESSION | Receptor, Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Immunotherapy - methods | Receptor, Macrophage Colony-Stimulating Factor - immunology | Adenocarcinoma - pathology | Macrophage Colony-Stimulating Factor - biosynthesis | Mannose-Binding Lectins - biosynthesis | Tissue Array Analysis | Humans | Lectins, C-Type - immunology | Tumor Microenvironment | Deoxycytidine - pharmacology | Lectins, C-Type - biosynthesis | Female | Receptors, Cell Surface - biosynthesis | Carcinoma, Pancreatic Ductal - immunology | Macrophages - immunology | Signal Transduction | Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Adenocarcinoma - immunology | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - therapy | Random Allocation | Carcinoma, Pancreatic Ductal - pathology | Receptors, Cell Surface - immunology | Macrophage Colony-Stimulating Factor - immunology | Animals | Mannose-Binding Lectins - immunology | Pancreatic Neoplasms - immunology | T-Lymphocytes - immunology | Mice | Deoxycytidine - analogs & derivatives | Cohort Studies | Pancreatic Neoplasms - therapy | macrophage | chemoresistance | pancreatic cancer | cytokines | innate immunity | immune checkpoint
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1250 - 19
Journal Article
Gut, ISSN 0017-5749, 06/2018, Volume 67, Issue 6, pp. 1112 - 1123
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 5640 - 5640
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 01/2015, Volume 33, Issue 3_suppl, pp. 299 - 299
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2017, Volume 35, Issue 4_suppl, pp. 605 - 605
Journal Article
Cancer Research, ISSN 0008-5472, 12/2016, Volume 76, Issue 24 Supplement, pp. A70 - A70
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 01/2015, Volume 33, Issue 3_suppl, pp. 298 - 298
Journal Article
Cancer Research, ISSN 0008-5472, 07/2015, Volume 75, Issue 13 Supplement, pp. B60 - B60
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2015, Volume 33, Issue 15_suppl, pp. e15217 - e15217
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 01/2015, Volume 33, Issue 3_suppl, pp. 624 - 624
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 4150 - 4150
Introduction: Pancreatic cancer (PC) is characterized by a dense tumor stroma with a heavy leukocytic infiltrate, comprised predominately of immunosuppressive... 
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 01/2015, Volume 33, Issue 3_suppl, pp. 295 - 295
Journal Article
OncoImmunology, ISSN 2162-4011, 09/2018, Volume 7, Issue 9, p. e1470729
The tumor microenvironment (TME) represents a significant barrier to creating effective therapies for metastatic colorectal cancer (mCRC). In several... 
CCL2 | tumor microenvironment | inflammatory monocyte | immunotherapy | SURVIVAL | CELLS | ONCOLOGY | IMMUNOLOGY | BLOCKADE | CHEMOTHERAPY | PROGRESSION
Journal Article
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