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Science (American Association for the Advancement of Science), ISSN 1095-9203, 2011, Volume 333, Issue 6049, pp. 1593 - 1602
Antibody VRC01 is a human immunoglobulin that neutralizes about 90% of HIV-1 isolates. To understand how such broadly neutralizing antibodies develop, we used... 
Germ cells | Neutralizing antibodies | B lymphocytes | RESEARCH ARTICLES | Genomics | Alleles | Antibodies | Phylogenetics | Epitopes | HIV 1 | High throughput nucleotide sequencing | DESIGN | DOMAIN | EPITOPE | MULTIDISCIPLINARY SCIENCES | BROAD | DIVERSITY | GLYCOPROTEIN | GP120 | MONOCLONAL-ANTIBODIES | SELECTION | BREADTH | Antibody Specificity | Complementarity Determining Regions - genetics | Humans | Immunoglobulin Heavy Chains - chemistry | Molecular Sequence Data | Crystallography, X-Ray | HIV Antibodies - isolation & purification | HIV Envelope Protein gp120 - metabolism | Genes, Immunoglobulin Heavy Chain | HIV Envelope Protein gp120 - immunology | Immunoglobulin Light Chains - chemistry | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - immunology | HIV-1 - chemistry | Immunoglobulin J-Chains - genetics | Base Sequence | HIV Envelope Protein gp120 - chemistry | Binding Sites | Immunoglobulin Heavy Chains - immunology | Immunoglobulin Light Chains - immunology | Amino Acid Sequence | Models, Molecular | Antibody Affinity | Antibodies, Neutralizing - genetics | HIV Antibodies - chemistry | Sequence Analysis, DNA | Antibodies, Neutralizing - isolation & purification | HIV-1 - immunology | Antibodies, Neutralizing - chemistry | Immunoglobulin Fab Fragments - chemistry | AIDS Vaccines | High-Throughput Nucleotide Sequencing | HIV Antibodies - genetics | Immunoglobulin Fab Fragments - immunology | Mutation | Binding Sites, Antibody | CD4 Antigens - metabolism | Evolution, Molecular | Viral antibodies | X-ray crystallography | Immunoglobulins | Physiological aspects | Genetic aspects | HIV (Viruses) | Health aspects | Methods | ANTIBODIES | IMMUNITY | BASIC BIOLOGICAL SCIENCES | GENETICS | IMMUNOGLOBULINS | CRYSTAL STRUCTURE | CRYSTALLOGRAPHY | CHAINS | 60 APPLIED LIFE SCIENCES | FUNCTIONALS
Journal Article
Nature (London), ISSN 1476-4687, 2011, Volume 480, Issue 7377, pp. 336 - 343
Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1) gp120 envelope glycoprotein are critical for viral evasion of antibody... 
CRYSTALLIZATION | POTENT NEUTRALIZATION | DEXTRAN SULFATE | EPITOPE | ENVELOPE GLYCOPROTEINS | MULTIDISCIPLINARY SCIENCES | ARCHITECTURE | BINDING | IMMUNODEFICIENCY | SOFTWARE | REGION | AIDS Vaccines - immunology | Glycopeptides - chemistry | Molecular Sequence Data | Antibody Affinity - immunology | Crystallography, X-Ray | Epitopes - immunology | HIV Envelope Protein gp120 - immunology | Antibodies, Neutralizing - immunology | Glycopeptides - immunology | Antibody Specificity - immunology | HIV Antibodies - immunology | HIV-1 - chemistry | Protein Structure, Quaternary | Conserved Sequence | Polysaccharides - chemistry | HIV Envelope Protein gp120 - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Binding Sites, Antibody - immunology | Models, Molecular | Glycosylation | Polysaccharides - immunology | HIV Antibodies - chemistry | AIDS Vaccines - chemistry | Amino Acid Motifs | HIV-1 - immunology | Immune Evasion | Hydrogen Bonding | Antigen-Antibody Complex - chemistry | Antibodies, Neutralizing - chemistry | Epitopes - chemistry | Antigen-Antibody Complex - immunology | Viral envelopes | Genetic aspects | Research | HIV (Viruses) | Structure | Binding sites (Biochemistry) | Proteins | Crystals | Vaccines | ANTIBODIES | AIDS VIRUS | BASIC BIOLOGICAL SCIENCES | AFFINITY | BIOLOGY | GLYCOPROTEINS | VULNERABILITY | ANTIGENS | IMMUNOLOGY | 60 APPLIED LIFE SCIENCES
Journal Article
Nature (London), ISSN 1476-4687, 2014, Volume 509, Issue 7498, pp. 55 - 62
Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the HIV-1 envelope, but the mechanism of their elicitation has been... 
B-CELLS | MAXIMUM-LIKELIHOOD | STRUCTURAL BASIS | HIV-1-NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | VACCINE EFFICACY | INFECTION | BROAD | HUMAN MONOCLONAL-ANTIBODIES | ENVELOPE TRIMER | Complementarity Determining Regions - genetics | Epitope Mapping | Epitopes, B-Lymphocyte - chemistry | Humans | AIDS Vaccines - immunology | Molecular Sequence Data | Antibody Affinity - immunology | Neutralization Tests | Epitopes, B-Lymphocyte - immunology | HIV Antibodies - isolation & purification | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - immunology | HIV Envelope Protein gp160 - chemistry | Complementarity Determining Regions - chemistry | HIV-1 - chemistry | Binding Sites - immunology | B-Lymphocytes - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | CD4 Antigens - immunology | B-Lymphocytes - cytology | Models, Molecular | Antibody Affinity - genetics | Antibodies, Neutralizing - genetics | HIV Antibodies - chemistry | AIDS Vaccines - chemistry | Antibodies, Neutralizing - isolation & purification | Cell Lineage | HIV-1 - immunology | B-Lymphocytes - immunology | Antibodies, Neutralizing - chemistry | Complementarity Determining Regions - immunology | HIV Envelope Protein gp160 - immunology | HIV Antibodies - genetics | Somatic Hypermutation, Immunoglobulin - genetics | CD4 Antigens - metabolism | Evolution, Molecular | Viral antibodies | Antigen-antibody reactions | AIDS vaccines | AIDS (Disease) | Antibodies | Physiological aspects | Research | AIDS research | Cell culture | Genes | Human immunodeficiency virus--HIV | Phylogenetics | Amino acids | Infections | Genomes | Mutation
Journal Article
PLoS pathogens, ISSN 1553-7374, 2015, Volume 11, Issue 5, p. e1004932
Journal Article
Nature Communications, ISSN 2041-1723, 10/2015, Volume 6, Issue 1, p. 8447
Journal Article
Immunity, ISSN 1074-7613, 04/2016, Volume 44, Issue 4, pp. 939 - 950
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 329, Issue 5993, pp. 856 - 861
Cross-reactive neutralizing antibodies (NAbs) are found in the sera of many HIV-1-infected individuals, but the virologie basis of their neutralization remains... 
Proteins | Reactivity | Infectious diseases | B lymphocytes | Enzyme linked immunosorbent assay | REPORTS | Antibodies | Research facilities | Viruses | Amino acids | HIV 1 | INDIVIDUALS | PANEL | IMMUNOGENICITY | VIRUS | SPECIFICITIES | MULTIDISCIPLINARY SCIENCES | HIGH-AFFINITY | GP120 | GLYCOPROTEIN | TYPE-1 INFECTION | BREADTH | Antibody Specificity | Humans | Molecular Sequence Data | Neutralization Tests | HIV Antibodies - isolation & purification | HIV Envelope Protein gp120 - metabolism | Epitopes - immunology | Genes, Immunoglobulin Heavy Chain | HIV Envelope Protein gp120 - immunology | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - immunology | Drug Design | Protein Engineering | HIV Envelope Protein gp120 - chemistry | Antibodies, Monoclonal - immunology | Recombinant Proteins - metabolism | CD4 Antigens - immunology | Enzyme-Linked Immunosorbent Assay | Genes, Immunoglobulin Light Chain | HIV Infections - virology | Recombinant Proteins - chemistry | Antibodies, Monoclonal - isolation & purification | HIV-1 - genetics | Antibodies, Neutralizing - isolation & purification | Cross Reactions | HIV-1 - immunology | B-Lymphocytes - immunology | Recombinant Proteins - immunology | AIDS Vaccines | Binding Sites, Antibody | CD4 Antigens - metabolism | Monoclonal antibodies | Immunoglobulins | Research | HIV (Viruses) | Glycoproteins | Immunology | Human immunodeficiency virus--HIV
Journal Article
Science, ISSN 0036-8075, 10/2017, Volume 358, Issue 6359, pp. 85 - 90
Journal Article