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1. Full Text Plasma deposition of collagen for cell‐culture applications
by O'sullivan, Denis and McArdle, Hazel and O'Reilly, Julie‐Ann and O'Kennedy, Richard J and Forster, Robert and O'Neill, Liam
Plasma Processes and Polymers, ISSN 1612-8850, 12/2019
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2. Full Text A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications
by Byrne, Hannah and Conroy, Paul J and Whisstock, James C and O’Kennedy, Richard J
Trends in Biotechnology, ISSN 0167-7799, 2013, Volume 31, Issue 11, pp. 621 - 632
Highlights • Recombinant DNA technologies are leading the rapid expansion of bispecific antibody formats. • The therapeutic potential of bispecific antibodies... 
Internal Medicine | AUTOLOGOUS T-CELLS | GROWTH-FACTOR RECEPTOR | B-CELL LYMPHOMA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CD19 X CD3 | VARIABLE-DOMAIN IMMUNOGLOBULIN | SINGLE-CHAIN ANTIBODY | CHRONIC LYMPHOCYTIC-LEUKEMIA | EXPRESSING TUMOR-CELLS | ANTITUMOR-ACTIVITY | ACUTE RESPIRATORY SYNDROME | Recombinant Proteins - therapeutic use | Antibodies, Bispecific - isolation & purification | Point-of-Care Systems - trends | Protein Engineering - methods | Antibodies, Monoclonal - therapeutic use | Technology, Pharmaceutical - methods | Recombinant Proteins - genetics | Antibodies, Monoclonal - isolation & purification | Antibodies, Bispecific - genetics | Protein Engineering - trends | Recombinant Proteins - isolation & purification | Technology, Pharmaceutical - trends | Antibodies, Bispecific - therapeutic use | Antibodies, Monoclonal - genetics | Biotechnology - methods | Biotechnology - trends | Single-Chain Antibodies - genetics | Single-Chain Antibodies - isolation & purification | Single-Chain Antibodies - therapeutic use | Viral antibodies | Antibodies | Health aspects | Proteins | Technological change | Melanoma | Cytotoxicity | T cell receptors | Binding sites | Deoxyribonucleic acid--DNA | Regulatory approval | Molecular weight | Immune system | Apoptosis
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3. Full Text Antibodies and antibody-derived analytical biosensors
by Sharma, Shikha and Byrne, Hannah and O'Kennedy, Richard J
Essays in Biochemistry, ISSN 0071-1365, 06/2016, Volume 60, Issue 1, pp. 9 - 18
The rapid diagnosis of many diseases and timely initiation of appropriate treatment are critical determinants that promote optimal clinical outcomes and... 
FRAGMENTS | ELECTROCHEMICAL DETECTION | PROTEIN | POLYPYRROLE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SINGLE-CHAIN ANTIBODY | RECOMBINANT ANTIBODIES | IMPEDIMETRIC IMMUNOSENSOR | MONOCLONAL-ANTIBODIES | SENSORS | BINDING | Antibodies, Immobilized - chemistry | Biosensing Techniques - methods | Antibodies, Immobilized - immunology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | antibodies | biosensor | recombinant antibodies | monoclonal antibodies
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4. Full Text Antibody production, design and use for biosensor-based applications
by Conroy, Paul J and Hearty, Stephen and Leonard, Paul and O’Kennedy, Richard J
Seminars in Cell and Developmental Biology, ISSN 1084-9521, 2009, Volume 20, Issue 1, pp. 10 - 26
Currently, the reliable detection and quantification of a multitude of different analytes is crucial in many applications and settings. Biosensors have... 
Phage display | Transduction | Recombinant antibodies | Biosensor | Ribosome display | GUIDE LIGHTMODE SPECTROSCOPY | HIGH-AFFINITY ANTIBODIES | DEVELOPMENTAL BIOLOGY | BACILLUS-ANTHRACIS SPORES | CHICKEN MONOCLONAL-ANTIBODY | ALKALINE PHOSPHATASE CONJUGATE | CELL BIOLOGY | SINGLE-CHAIN FV | REAL-TIME BIOSENSOR | SURFACE-PLASMON RESONANCE | MESSENGER-RNA DISPLAY | PHAGE-DISPLAY LIBRARIES | Recombinant Proteins - metabolism | Animals | Antibodies - metabolism | Electrochemical Techniques | Recombinant Proteins - immunology | Humans | Antibodies - immunology | Antibodies - genetics | Biosensing Techniques - methods | Recombinant Proteins - genetics | Databases, Factual | Phosphates | Usage | Reverse transcriptase | Biological products | Phosphatases | Food contamination | Antibodies | Fluorescence | Serum albumin | Glycine | Viral antibodies | Technology application | Messenger RNA | Detectors | Quartz crystals
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5. Full Text Aberrant PSA glycosylation - A sweet predictor of prostate cancer
by Gilgunn, Sarah and Conroy, Paul J and Saldova, Radka and Rudd, Pauline M and O'Kennedy, Richard J
Nature Reviews Urology, ISSN 1759-4812, 2013, Volume 10, Issue 2, pp. 99 - 107
Prostate cancer the most commonly diagnosed cancer in men worldwide can have a substantial effect on quality of life, regardless of the route the cancer takes.... 
MULTICENTER | ANTIGEN PSA | SERUM N-GLYCANS | SEMINAL PLASMA | UROLOGY & NEPHROLOGY | ANTIBODY | MOLECULAR-CLONING | SERINE-PROTEASE | PRECURSOR FORM | FUCOSYLATION | IDENTIFICATION | Prostate-Specific Antigen - genetics | Amino Acid Sequence | Predictive Value of Tests | Early Detection of Cancer - standards | Early Detection of Cancer - methods | Humans | Molecular Sequence Data | Male | Glycosylation | Prostatic Neoplasms - diagnosis | Prostate-Specific Antigen - blood | Biomarkers, Tumor - blood | Animals | Prostatic Neoplasms - genetics | Prostatic Neoplasms - blood | Biomarkers, Tumor - genetics | Care and treatment | Usage | Research | Diagnosis | Prostate cancer | Immune system | Testing
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6. The need for effective pancreatic cancer detection and management: A biomarker-based strategy
by Crawley, Aoife S and Okennedy, Richard J
Expert Review of Molecular Diagnostics, ISSN 1473-7159, 10/2015, Volume 15, Issue 10, pp. 1339 - 1353
Pancreatic cancer (Pa) is generally a very aggressive disease, with few effective approaches available for early diagnosis or therapy. These factors, combined... 
diagnostics | pancreatic cancer | therapeutics | CA19-9 | biomarkers | tumor | SURVIVAL | DIAGNOSIS | STEM-CELLS | DNA METHYLATION | ADENOCARCINOMA | MARKERS | PATHOLOGY | CIRCULATING TUMOR-CELLS | CLINICAL UTILITY | PROGNOSTIC BIOMARKERS | MICRORNA BIOMARKERS | Pancreatic Neoplasms - metabolism | Prognosis | Pancreatic Neoplasms - diagnosis | Humans | Carcinoma, Pancreatic Ductal - metabolism | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - therapy | Sequence Analysis, DNA | Carcinoma, Pancreatic Ductal - genetics | Biomarkers, Tumor - metabolism | Carcinoma, Pancreatic Ductal - diagnosis | Disease Management | High-Throughput Nucleotide Sequencing | Pancreatic Neoplasms - therapy
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7. Full Text Detection of the cyanobacterial toxin, microcystin-LR, using a novel recombinant antibody-based optical-planar waveguide platform
by Murphy, Caroline and Stack, Edwina and Krivelo, Svetlana and McPartlin, Daniel A and Byrne, Barry and Greef, Charles and Lochhead, Michael J and Husar, Greg and Devlin, Shauna and Elliott, Christopher T and O’Kennedy, Richard J
Biosensors and Bioelectronics, ISSN 0956-5663, 05/2015, Volume 67, pp. 708 - 714
Microcystins are a major group of cyanobacterial heptapeptide toxins found in freshwater and brackish environments. There is currently an urgent requirement... 
Microcystin | Immunoassay | Recombinant Antibody | Cyanobacteria | Fluorescent planar wave-guide | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | QUANTIFICATION | PHAGE DISPLAY | NANOSCIENCE & NANOTECHNOLOGY | CHROMATOGRAPHY | FRESH-WATER | FRAGMENTS | BIOPHYSICS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENERATION | BIOSENSOR | SAMPLES | Surface Plasmon Resonance | Immunoglobulin Fragments - chemistry | Immunoglobulin Fragments - immunology | Recombinant Proteins - immunology | Microcystins - chemistry | Cyanobacteria - chemistry | Biosensing Techniques | Microcystins - isolation & purification | Recombinant Proteins - chemistry | Fresh Water - analysis | Viral antibodies | Phenylalanine | Marine toxins | Detectors | Tryptophan | Waveguides | Antibodies | Antigen-antibody reactions | Amino acids | Format | Cartridges | Toxins | Biosensors | Assaying | Recombinant | Fragmentation
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8. Full Text Comprehensive N-glycan profiling of avian immunoglobulin Y
by Gilgunn, Sarah and Martín, Silvia Millán and Wormald, Mark R and Zapatero-Rodríguez, Julia and Conroy, Paul J and O'Kennedy, Richard J and Rudd, Pauline M and Saldova, Radka
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, p. e0159859
Recent exploitation of the avian immune system has highlighted its suitability for the generation of high-quality, high-affinity antibodies to a wide range of... 
ANTIBODY | INFECTIONS | IGY | GLYCOSYLATION | MULTIDISCIPLINARY SCIENCES | REVEALS | Immunoglobulins - metabolism | Avian Proteins - metabolism | Animals | Avian Proteins - blood | Chickens | Immunoglobulins - blood | Female | Glycosylation | Protein Processing, Post-Translational | N-Acetylneuraminic Acid - metabolism | Polysaccharides - metabolism | Polysaccharides | Immunoglobulins | Liquid chromatography | Chemical properties | Health aspects | Analysis | Biological properties | Cell culture | Biotechnology | Poultry | Antibodies | Infections | Biochemistry | Mannose | Reptiles & amphibians | Flexibility | Exploitation | Proteins | Immunoglobulin Y | Sensors | Immune system | Carbohydrates | Antigens | Medical treatment | Knowledge management | Chromatography | Glycan | Infectious diseases | Acids | Immunogenicity | Molecular biology | Fucose
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9. Point-of-care diagnostics, a major opportunity for change in traditional diagnostic approaches: Potential and limitations
by McPartlin, Daniel A and O'Kennedy, Richard J
Expert Review of Molecular Diagnostics, ISSN 1473-7159, 11/2014, Volume 14, Issue 8, pp. 979 - 998
'Point-of-care' (POC) diagnostics are a powerful emerging healthcare approach. They can rapidly provide statistically significant results, are simple to use,... 
cardiovascular disease | prostate cancer | antibody | biosensor | HIV | POC | mHealth | acute myocardial infarction | C-REACTIVE PROTEIN | CLINICAL-PERFORMANCE | PROSTATE-SPECIFIC ANTIGEN | ACUTE HIV-INFECTION | CHEST-PAIN | ACUTE CORONARY SYNDROMES | PATHOLOGY | ISCHEMIA-MODIFIED ALBUMIN | MYCOBACTERIUM-TUBERCULOSIS INFECTION | ACID-BINDING PROTEIN | SKELETAL-RELATED EVENTS | Diagnostic Techniques and Procedures | Point-of-Care Systems - standards | HIV Infections - diagnosis | Humans | Biosensing Techniques - instrumentation | Biosensing Techniques - methods | Neoplasms - diagnosis | Biosensing Techniques - standards | Tuberculosis - diagnosis | Cardiovascular Diseases - diagnosis
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10. Full Text Biosensors for the monitoring of harmful algal blooms
by McPartlin, Daniel A and Loftus, Jonathan H and Crawley, Aoife S and Silke, Joe and Murphy, Caroline S and O’Kennedy, Richard J
Current Opinion in Biotechnology, ISSN 0958-1669, 2017, Volume 45, pp. 164 - 169
Graphical abstract 
Internal Medicine | ALEXANDRIUM-MINUTUM | INTERANNUAL VARIABILITY | TOXIC ALGAE | MICROARRAY | SAMPLE PROCESSOR ESP | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | FORECAST SYSTEM | BIOCHEMICAL RESEARCH METHODS | SENSITIVITY | HYBRIDIZATION | SHELLFISH TOXICITY | PROBES | Biosensing Techniques - methods | Environmental Monitoring | Harmful Algal Bloom | Phytoplankton - growth & development | Phytoplankton - classification | Medical equipment | Physiological apparatus | Detectors | Water bloom | Biosensors | Analysis
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11. Full Text Use of biosensors for the detection of marine toxins
by McPartlin, Daniel A and Lochhead, Michael J and Connell, Laurie B and Doucette, Gregory J and O'Kennedy, Richard J
Essays in Biochemistry, ISSN 0071-1365, 06/2016, Volume 60, Issue 1, pp. 49 - 58
Increasing occurrences of harmful algal blooms (HABs) in the ocean are a major concern for countries around the globe, and with strong links between HABs and... 
LABORATORY VALIDATION | HIGH-PERFORMANCE | PARALYTIC SHELLFISH TOXINS | HARMFUL ALGAL BLOOMS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNOASSAY | FLOW CYTOMETRY SYSTEM | EXTRACTS | OKADAIC ACID | DOMOIC ACID | RECEPTOR-BINDING ASSAY | Marine Toxins - analysis | Biosensing Techniques - methods | Harmful Algal Bloom | shellfish poisoning | biosensors | marine monitoring | harmful algal blooms | marine biotoxins
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12. Full Text Reconciling the structural attributes of avian antibodies
by Conroy, Paul J and Law, Ruby H. P and Gilgunn, Sarah and Hearty, Stephen and Caradoc-Davies, Tom T and Lloyd, Gordon and O'Kennedy, Richard J and Whisstock, James C
Journal of Biological Chemistry, ISSN 0021-9258, 05/2014, Volume 289, Issue 22, pp. 15384 - 15392
Background: Antibodies from alternative immune hosts provide insights into novel mechanisms of antibody diversity in restricted germ-line repertoires. Results:... 
Cardiovascular Disease | REPERTOIRE | Antibody Engineering | PROTEIN | X-ray Crystallography | Cardiac Troponin I | BIOCHEMISTRY & MOLECULAR BIOLOGY | Recombinant Protein Expression | RECOMBINANT ANTIBODIES | Prostate-specific Antigen | FRAGMENTS | Surface Plasmon Resonance (SPR) | GENE | REGIONS | DISEASE | Prostate Cancer | Chicken | GENERATION | Recombinant Antibody | REVEALS | Protein Structure, Tertiary | Amino Acid Sequence | Antibodies - chemistry | Humans | Crystallization | Molecular Sequence Data | Crystallography, X-Ray | Structure-Activity Relationship | Chickens - immunology | Single-Domain Antibodies - immunology | Animals | Single-Domain Antibodies - chemistry | Antibodies - immunology | Antibodies - genetics | Chickens - genetics | Kinetics | Single-Domain Antibodies - genetics | Antigen-Antibody Reactions - immunology | Protein Structure and Folding
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13. Full Text Integrating biomarkers across omic platforms: an approach to improve stratification of patients with indolent and aggressive prostate cancer
by Murphy, Keefe and Murphy, Brendan T and Boyce, Susie and Flynn, Louise and Gilgunn, Sarah and O'Rourke, Colm J and Rooney, Cathy and Stöckmann, Henning and Walsh, Anna L and Finn, Stephen and O'Kennedy, Richard J and O'Leary, John and Pennington, Stephen R and Perry, Antoinette S and Rudd, Pauline M and Saldova, Radka and Sheils, Orla and Shields, Denis C and Watson, R. William
Molecular Oncology, ISSN 1574-7891, 09/2018, Volume 12, Issue 9, pp. 1513 - 1525
Classifying indolent prostate cancer represents a significant clinical challenge. We investigated whether integrating data from different omic platforms could... 
integration | prostate cancer | indolent | omics | biomarkers | LASSO | ASSAY | RISK STRATIFICATION | N-GLYCANS | VALIDATION | DISCOVERY | PREDICTION | HETEROGENEITY | ONCOLOGY | EXPRESSION SIGNATURE
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