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1. Full Text Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study
by Treasure, Tom, Prof and Lang-Lazdunski, Loic, MD and Waller, David, FRCS [CTh] and Bliss, Judith M, Prof and Tan, Carol, FRCS [CTh] and Entwisle, James, FRCR and Snee, Michael, DM and O'Brien, Mary, MD and Thomas, Gill, FRCR and Senan, Suresh, Prof and O'Byrne, Ken, Prof and Kilburn, Lucy S, MSc and Spicer, James, MRCP and Landau, David, FRCR and Edwards, John, FRCS [CTh] and Coombes, Gill, RGN and Darlison, Liz, RGN and Peto, Julian, Prof and for the MARS trialists and MARS Trialists and MARS trialists
The lancet oncology, ISSN 1470-2045, 2011, Volume 12, Issue 8, pp. 763 - 772
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | Humans | Middle Aged | Pleural Neoplasms - surgery | Male | Treatment Outcome | Combined Modality Therapy | Pneumonectomy | Feasibility Studies | Disease-Free Survival | Mesothelioma - radiotherapy | Mesothelioma - surgery | Pleural Neoplasms - radiotherapy | Adult | Female | Aged | Care and treatment | Management science | Patient outcomes | Oncology, Experimental | Clinical trials | Mesothelioma | Research | Cancer | Index Medicus
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2. Full Text First-Line Afatinib versus Chemotherapy in Patients with Non–Small Cell Lung Cancer and Common Epidermal Growth Factor Receptor Gene Mutations and Brain Metastases
by Schuler, Martin and Wu, Yi-Long and Hirsh, Vera and O’Byrne, Kenneth and Yamamoto, Nobuyuki and Mok, Tony and Popat, Sanjay and Sequist, Lecia V and Massey, Dan and Zazulina, Victoria and Yang, James C.-H
Journal of thoracic oncology, ISSN 1556-0864, 03/2016, Volume 11, Issue 3, pp. 380 - 390
Brain metastases | Afatinib | NSCLC | Epidermal growth factor receptor | Respiratory System | Oncology | Life Sciences & Biomedicine | Science & Technology | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Brain Neoplasms - secondary | Neoplasm Metastasis | Organoplatinum Compounds - administration & dosage | Aged, 80 and over | Adult | Female | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Brain Neoplasms - enzymology | Lung Neoplasms - enzymology | Carcinoma, Non-Small-Cell Lung - genetics | Brain Neoplasms - genetics | Treatment Outcome | Brain Neoplasms - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Quinazolines - therapeutic use | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Mutation
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3. Full Text Symptom Control and Quality of Life in LUX-Lung 3: A Phase III Study of Afatinib or Cisplatin/Pemetrexed in Patients With Advanced Lung Adenocarcinoma With EGFR Mutations
by James Chih-Hsin Yang and Vera Hirsh and Martin Schuler and Nobuyuki Yamamoto and Kenneth J. O'Byrne and Tony S.K. Mok and Victoria Zazulina and Mehdi Shahidi and Juliane Lungershausen and Dan Massey and Michael Palmer and Lecia V. Sequist
Journal of clinical oncology, ISSN 0732-183X, 09/2013, Volume 31, Issue 27, pp. 3342 - 3350
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the respiratory system and mediastinum | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Tumors | Pneumology | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Glutamates - adverse effects | Guanine - analogs & derivatives | Humans | ErbB Receptors - genetics | Lung Neoplasms - pathology | Cisplatin - administration & dosage | Adenocarcinoma - genetics | Guanine - adverse effects | Lung Neoplasms - genetics | Lung Neoplasms - enzymology | Adenocarcinoma - enzymology | Treatment Outcome | Adenocarcinoma - drug therapy | Pemetrexed | Afatinib | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Quinazolines - therapeutic use | Quinazolines - adverse effects | Cisplatin - adverse effects | Glutamates - administration & dosage | Quality of Life | Mutation | Neoplasm Staging | Guanine - administration & dosage | Index Medicus
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4. Full Text Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials
by Yang, James Chih-Hsin, Prof and Wu, Yi-Long, Prof and Schuler, Martin, Prof and Sebastian, Martin, MD and Popat, Sanjay, FRCP and Yamamoto, Nobuyuki, Prof and Zhou, Caicun, Prof and Hu, Cheng-Ping, Prof and O'Byrne, Kenneth, Prof and Feng, Jifeng, Prof and Lu, Shun, Prof and Huang, Yunchao, Prof and Geater, Sarayut L, MD and Lee, Kye Young, Prof and Tsai, Chun-Ming, Prof and Gorbunova, Vera, Prof and Hirsh, Vera, Prof and Bennouna, Jaafar, Prof and Orlov, Sergey, Prof and Mok, Tony, Prof and Boyer, Michael, Prof and Su, Wu-Chou, Prof and Lee, Ki Hyeong, Prof and Kato, Terufumi, MD and Massey, Dan, MSc and Shahidi, Mehdi, MD and Zazulina, Victoria, MD and Sequist, Lecia V, MD
The lancet oncology, ISSN 1470-2045, 2015, Volume 16, Issue 2, pp. 141 - 151
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Adenocarcinoma - pathology | Prognosis | Follow-Up Studies | Guanine - analogs & derivatives | Lung Neoplasms - mortality | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Cisplatin - administration & dosage | Aged, 80 and over | Adult | Female | Adenocarcinoma - genetics | Lung Neoplasms - genetics | Deoxycytidine - administration & dosage | Survival Rate | Mutation - genetics | Adenocarcinoma - drug therapy | Pemetrexed | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Quinazolines - therapeutic use | Glutamates - administration & dosage | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Neoplasm Staging | Deoxycytidine - analogs & derivatives | Adenocarcinoma - mortality | Guanine - administration & dosage | Adenocarcinoma | Antimitotic agents | Chemotherapy | Lung cancer | Analysis | Genetic aspects | Antineoplastic agents | Cancer | Index Medicus
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5. Full Text Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-Lung 7): a phase 2B, open-label, randomised controlled trial
by Park, Keunchil, Prof and Tan, Eng-Huat, MD and O'Byrne, Ken, Prof and Zhang, Li, Prof and Boyer, Michael, Prof and Mok, Tony, Prof and Hirsh, Vera, Prof and Yang, James Chih-Hsin, Prof and Lee, Ki Hyeong, MD and Lu, Shun, Prof and Shi, Yuankai, MD and Kim, Sang-We, MD and Laskin, Janessa, MD and Kim, Dong-Wan, Prof and Arvis, Catherine Dubos, MD and Kölbeck, Karl, MD and Laurie, Scott A, MD and Tsai, Chun-Ming, Prof and Shahidi, Mehdi, MD and Kim, Miyoung, MD and Massey, Dan, PhD and Zazulina, Victoria, MD and Paz-Ares, Luis, MD
The lancet oncology, ISSN 1470-2045, 2016, Volume 17, Issue 5, pp. 577 - 589
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | Carcinoma, Non-Small-Cell Lung - pathology | Receptor, Epidermal Growth Factor - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Protein Kinase Inhibitors - adverse effects | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Drug-Related Side Effects and Adverse Reactions - genetics | Quinazolines - adverse effects | Aged, 80 and over | Adult | Female | Quinazolines - administration & dosage | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Drug-Related Side Effects and Adverse Reactions - physiopathology | Drug-Related Side Effects and Adverse Reactions - classification | Tyrosine | Clinical trials | Medical colleges | Care and treatment | Lung cancer, Non-small cell | Gefitinib | Analysis | Index Medicus | Medicin och hälsovetenskap
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6. Full Text High Rate of Recurrent De Novo Mutations in Developmental and Epileptic Encephalopathies
by Hamdan, Fadi F and Myers, Candace T and Cossette, Patrick and Lemay, Philippe and Spiegelman, Dan and Laporte, Alexandre Dionne and Nassif, Christina and Diallo, Ousmane and Monlong, Jean and Cadieux-Dion, Maxime and Dobrzeniecka, Sylvia and Meloche, Caroline and Retterer, Kyle and Cho, Megan T and Rosenfeld, Jill A and Bi, Weimin and Massicotte, Christine and Miguet, Marguerite and Brunga, Ledia and Regan, Brigid M and Mo, Kelly and Tam, Cory and Schneider, Amy and Hollingsworth, Georgie and FitzPatrick, David R and Donaldson, Alan and Canham, Natalie and Blair, Edward and Kerr, Bronwyn and Fry, Andrew E and Thomas, Rhys H and Shelagh, Joss and Hurst, Jane A and Brittain, Helen and Blyth, Moira and Lebel, Robert Roger and Gerkes, Erica H and Davis-Keppen, Laura and Stein, Quinn and Chung, Wendy K and Dorison, Sara J and Benke, Paul J and Fassi, Emily and Corsten-Janssen, Nicole and Kamsteeg, Erik-Jan and Mau-Them, Frederic T and Bruel, Ange-Line and Verloes, Alain and Õunap, Katrin and Wojcik, Monica H and Albert, Dara V.F and Venkateswaran, Sunita and Ware, Tyson and Jones, Dean and Liu, Yu-Chi and Mohammad, Shekeeb S and Bizargity, Peyman and Bacino, Carlos A and Leuzzi, Vincenzo and Martinelli, Simone and Dallapiccola, Bruno and Tartaglia, Marco and Blumkin, Lubov and Wierenga, Klaas J and Purcarin, Gabriela and O’Byrne, James J and Stockler, Sylvia and Lehman, Anna and Keren, Boris and Nougues, Marie-Christine and Mignot, Cyril and Auvin, Stéphane and Nava, Caroline and Hiatt, Susan M and Bebin, Martina and Shao, Yunru and Scaglia, Fernando and Lalani, Seema R and Frye, Richard E and Jarjour, Imad T and Jacques, Stéphanie and Boucher, Renee-Myriam and Riou, Emilie and Srour, Myriam and Carmant, Lionel and Lortie, Anne and Major, Philippe and Diadori, Paola and Dubeau, François and D’Anjou, Guy and Bourque, Guillaume and Berkovic, Samuel F and Sadleir, Lynette G and Campeau, Philippe M and Kibar, Zoha and Lafrenière, Ronald G and Girard, Simon L and Mercimek-Mahmutoglu, Saadet and Boelman, Cyrus and Rouleau, Guy A and ... and Deciphering Developmental Disorders Study and Deciphering Dev Disorders Study
American journal of human genetics, ISSN 0002-9297, 11/2017, Volume 101, Issue 5, pp. 664 - 685
NTRK2 | GABRB2 | GABBR2 | NUS1 | RAB11 | SNAP25 | CLTC | epileptic encephalopathy | DHDDS | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Recurrence | Seizures - genetics | Humans | Brain Diseases - genetics | Child, Preschool | Male | Mutation - genetics | Genome, Human - genetics | Intellectual Disability - genetics | Epilepsy - genetics | Female | Genome-Wide Association Study - methods | Child | Index Medicus | Life Sciences | Human health and pathology
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7. Full Text Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma With EGFR Mutations
by Lecia V. Sequist and James Chih-Hsin Yang and Nobuyuki Yamamoto and Kenneth O'Byrne and Vera Hirsh and Tony Mok and Sarayut Lucien Geater and Sergey Orlov and Chun-Ming Tsai and Michael Boyer and Wu-Chou Su and Jaafar Bennouna and Terufumi Kato and Vera Gorbunova and Ki Hyeong Lee and Riyaz Shah and Dan Massey and Victoria Zazulina and Mehdi Shahidi and Martin Schuler
Journal of clinical oncology, ISSN 0732-183X, 09/2013, Volume 31, Issue 27, pp. 3327 - 3334
Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Cisplatin - pharmacokinetics | Glutamates - adverse effects | Guanine - analogs & derivatives | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | ErbB Receptors - genetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Quinazolines - pharmacokinetics | Lung Neoplasms - pathology | Male | Cisplatin - administration & dosage | Neoplasm Metastasis | Aged, 80 and over | Adult | Female | Adenocarcinoma - genetics | Guanine - adverse effects | Lung Neoplasms - genetics | Lung Neoplasms - enzymology | Guanine - pharmacokinetics | Adenocarcinoma - enzymology | Glutamates - pharmacokinetics | Adenocarcinoma - drug therapy | Pemetrexed | Afatinib | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Quinazolines - therapeutic use | Quinazolines - adverse effects | Cisplatin - adverse effects | Glutamates - administration & dosage | Aged | Mutation | Guanine - administration & dosage | Index Medicus
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8. Full Text Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia
by Smith, Steven G., PhD and Chen, Ruchong, MD and Kjarsgaard, Melanie, RRT and Huang, Chynna, RRT and Oliveria, John-Paul, BSc and O'Byrne, Paul M., MD and Gauvreau, Gail M., PhD and Boulet, Louis-Philippe, MD and Lemiere, Catherine, MD and Martin, James, MD, DSc and Nair, Parameswaran, MD, PhD and Sehmi, Roma, PhD
Journal of allergy and clinical immunology, ISSN 0091-6749, 2015, Volume 137, Issue 1, pp. 75 - 86.e8
Allergy and Immunology | severe asthma | eosinophilic bronchitis | Group 2 innate lymphoid cells | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Sputum - cytology | Humans | Middle Aged | Male | Immunity, Innate | Interleukin-5 - blood | Young Adult | Lymphocytes - immunology | Asthma - blood | Asthma - immunology | Adult | Female | Interleukin-13 - blood | Pulmonary Eosinophilia - blood | Pulmonary Eosinophilia - immunology | Corticosteroids | Eosinophilia | Statistics | Analysis | Asthma | Studies | Airway management | Inflammation | Disease | Cytokines | Index Medicus | Abridged Index Medicus
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