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Lancet, The, ISSN 0140-6736, 2014, Volume 384, Issue 9940, pp. 309 - 318
Journal Article
Gut, ISSN 0017-5749, 08/2013, Volume 62, Issue 8, pp. 1122 - 1130
Objective Etrolizumab (rhuMAb β7, anti-β7, PRO145223) is a humanised monoclonal antibody targeting the β7 subunit of the heterodimeric integrins α4β7 and αEβ7,... 
IBD basic research | IBD clinical | Etrolizumab | apoptosis | IBD | MONOCLONAL-ANTIBODY | antibody targeted therapy | HUMANIZED ANTIBODY | CELL-ADHESION MOLECULE-1 | integrins | dendritic cells | genetics | safety | rhuMAb 7 | pharmacokinetics | inflammatory bowel disorders | LAMINA PROPRIA LYMPHOCYTES | ulcerative colitis | cytokines | immunology | T-CELLS | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | CROHNS-DISEASE | cell cycle | signal transduction | IBD models | drug development | Crohn's disease | E-CADHERIN | IBD-genetics | autoimmune disease | INFLAMMATORY-BOWEL-DISEASE | arthritis | CD103(+) DENDRITIC CELLS | GASTROENTEROLOGY & HEPATOLOGY | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Gastrointestinal Agents - administration & dosage | Antibodies, Monoclonal - therapeutic use | Male | Antibodies, Monoclonal - blood | Dose-Response Relationship, Drug | Young Adult | Antibodies, Monoclonal, Humanized | Injections, Subcutaneous | Adult | Female | Colitis, Ulcerative - drug therapy | Severity of Illness Index | Double-Blind Method | Treatment Outcome | Colitis, Ulcerative - blood | Antibodies, Monoclonal - administration & dosage | Adolescent | Gastrointestinal Agents - therapeutic use | Aged | Gastrointestinal Agents - adverse effects | Gastrointestinal Agents - blood | Infusions, Intravenous | Headache | Immunoglobulins | Intravenous administration | Wound healing | Dendritic cells | Migration | Inflammation | Injection | Retention | Crohns disease | Cell adhesion & migration | Inflammatory bowel disease | Studies | Lymphocytes | Monoclonal antibodies | Remission | Pharmacokinetics | Chronic illnesses | Ulcerative colitis | Integrins | Index Medicus | Abridged Index Medicus | rhuMAb β7 | Inflammatory Bowel Disease | IBD–genetics | 1506
Journal Article
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 03/2018, Volume 58, Issue 3, pp. 386 - 398
Etrolizumab, a humanized monoclonal antibody, specifically binds to the β7 subunit of the heterodimeric integrins α4β7 and αEβ7. Pharmacokinetic (PK) and... 
pharmacokinetics | etrolizumab | β7 receptors | QSS TMDD model | pharmacodynamics | Lymphocytes T | Pharmacology | Patients | Steady state | CD4 antigen | Inflammatory bowel disease | Homing | Receptors | Intestine | Lymphocytes | Monoclonal antibodies | Kinetics | Steady state models | Cell migration | Ulcerative colitis | Integrins | Modeling and Simulation
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, p. e100816
The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4... 
STEM-CELLS | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTORS | RESISTANCE | CHEMORESISTANCE | DIFFERENTIATION | NF-KAPPA-B | TUMOR-GROWTH | EXPRESSION | CARCINOMA | BREAST | Immunohistochemistry | RNA, Small Interfering - genetics | Paclitaxel - pharmacology | Prognosis | Neoplastic Stem Cells - drug effects | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | MicroRNAs - metabolism | Cystadenocarcinoma, Serous - genetics | Ovarian Neoplasms - mortality | Cystadenocarcinoma, Serous - drug therapy | Ovarian Neoplasms - genetics | Neoplasms, Glandular and Epithelial - genetics | Neoplasms, Glandular and Epithelial - mortality | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Female | Neoplasms, Glandular and Epithelial - diagnosis | Toll-Like Receptor 4 - antagonists & inhibitors | Ovarian Neoplasms - drug therapy | Signal Transduction | Ovarian Neoplasms - diagnosis | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Genotype | Toll-Like Receptor 4 - metabolism | Drug Resistance, Neoplasm - genetics | Phenotype | Neoplasms, Glandular and Epithelial - drug therapy | Survival Analysis | Carcinoma, Ovarian Epithelial | Cell Line, Tumor | Cystadenocarcinoma, Serous - mortality | Aged | MicroRNAs - genetics | Cystadenocarcinoma, Serous - diagnosis | Antineoplastic Agents, Phytogenic - pharmacology | Myeloid Differentiation Factor 88 - metabolism | RNA, Small Interfering - metabolism | MicroRNA | Analysis | Genetic aspects | Cell differentiation | Ovarian cancer | Health sciences | Transcription factors | Carcinoma | Ovarian carcinoma | Chemoresistance | Paraffin | Tissues | Cancer therapies | Proteins | Histopathology | Quality | Toll-like receptors | Tumor necrosis factor-TNF | Immune system | Mortality | Gynecology | MiRNA | Breast cancer | Functional analysis | TLR4 protein | Gene expression | Epithelium | Ribonucleic acid--RNA | Survival | Obstetrics | Pathology | Gene amplification | Chemotherapy | Hospitals | Womens health | MicroRNAs | Stem cells | MyD88 protein | Cancer | Tumors | RNA | Ribonucleic acid
Journal Article
Journal Article