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1. Full Text Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study
by Moreno, Gerard and Rodríguez, Alejandro and Reyes, Luis F and Gomez, Josep and Sole-Violan, Jordi and Díaz, Emili and Bodí, María and Trefler, Sandra and Guardiola, Juan and Yébenes, Juan C and Soriano, Alex and Garnacho-Montero, José and Socias, Lorenzo and del Valle Ortíz, María and Correig, Eudald and Marín-Corral, Judith and Vallverdú-Vidal, Montserrat and Restrepo, Marcos I and Torres, Antoni and Martín-Loeches, Ignacio and GETGAG Study Grp and GETGAG Study Group and on behalf of the GETGAG Study Group
Intensive Care Medicine, ISSN 0342-4642, 9/2018, Volume 44, Issue 9, pp. 1470 - 1482
To determine clinical predictors associated with corticosteroid administration and its association with ICU mortality in critically ill patients with severe... 
Pediatrics | Pain Medicine | Pneumonia | Emergency Medicine | Pneumology/Respiratory System | Corticosteroids | Medicine & Public Health | Influenza | Mortality | Intensive / Critical Care Medicine | ICU | Anesthesiology | MANAGEMENT | GUIDELINES | III PATIENTS | ADULTS | IMPACT | NEURAMINIDASE INHIBITORS | THERAPY | VIRAL PNEUMONIA | INFECTIOUS-DISEASES-SOCIETY | CRITICAL CARE MEDICINE | Complications and side effects | Bacterial pneumonia | Dosage and administration | Drug therapy | Corticoids | Therapy | Hematology | Lung diseases | Medical services | Septic shock | Methylprednisolone | Patients | Asthma | Matching | Obstructive lung disease | Ventilation | Chronic obstructive pulmonary disease | Secondary analysis | Hazard assessment
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2. Full Text Personalized therapies in the cancer "omics" era
by Ocaña, Alberto and Pandiella, Atanasio
Molecular Cancer, ISSN 1476-4598, 07/2010, Volume 9, Issue 1, pp. 202 - 202
A molecular hallmark of cancer is the presence of genetic alterations in the tumoral DNA. Understanding how these alterations translate into the malignant... 
HISTONE DEACETYLASE INHIBITOR | ONCOLOGY | SUBEROYLANILIDE HYDROXAMIC ACID | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ORAL MEK INHIBITOR | DEPENDENT KINASE INHIBITOR | AZD6244 ARRY-142886 | PHASE-I | TRASTUZUMAB RESISTANCE | MESENCHYMAL STEM-CELLS | MYELODYSPLASTIC SYNDROMES | Neoplasms - therapy | Neoplasms - genetics | Humans | Precision Medicine | Care and treatment | Usage | Proteomics | Genetic aspects | Research | Nucleotide sequencing | Cancer
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3. Full Text Toxicity of Adjuvant Endocrine Therapy in Postmenopausal Breast Cancer Patients: A Systematic Review and Meta-analysis
by Amir, Eitan and Seruga, Bostjan and Niraula, Saroj and Carlsson, Lindsay and Ocaña, Alberto
Journal of the National Cancer Institute, ISSN 0027-8874, 2011, Volume 103, Issue 17, pp. 1299 - 1309
Background Aromatase inhibitors are associated with consistent improvements in disease-free survival but not in overall survival. We conducted a... 
STROKE | WOMEN | MORBIDITY | ONCOLOGY | TAMOXIFEN | CLINICAL-TRIALS | LETROZOLE | RANDOMIZED-TRIAL | AROMATASE INHIBITORS | CARDIOVASCULAR RISK-FACTORS | ANASTROZOLE | Venous Thrombosis - chemically induced | Thromboembolism - chemically induced | Humans | Middle Aged | Endometrial Neoplasms - chemically induced | Tamoxifen - administration & dosage | Antineoplastic Agents, Hormonal - adverse effects | Aromatase Inhibitors - adverse effects | Neoplasms, Second Primary - chemically induced | Postmenopause | Female | Chemotherapy, Adjuvant | Odds Ratio | Aromatase Inhibitors - administration & dosage | Cerebrovascular Disorders - chemically induced | Antineoplastic Agents, Hormonal - administration & dosage | Breast Neoplasms - drug therapy | Randomized Controlled Trials as Topic | Disease-Free Survival | Confounding Factors (Epidemiology) | Breast Neoplasms - pathology | Neoplasms, Hormone-Dependent - pathology | Survival Analysis | Breast Neoplasms - mortality | Aged | Cardiovascular Diseases - chemically induced | Hypercholesterolemia - chemically induced | Neoplasms, Hormone-Dependent - drug therapy | Tamoxifen - adverse effects | Fractures, Bone - chemically induced | Adjuvant treatment | Breast cancer | Postmenopausal women | Research | Drug therapy | Health aspects | Cancer | Index Medicus
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4. Full Text When are positive clinical trials in oncology truly positive?
by Ocana, Alberto and Tannock, Ian F
Journal of the National Cancer Institute, ISSN 0027-8874, 01/2011, Volume 103, Issue 1, pp. 16 - 20
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5. Full Text Targeting oncogenic vulnerabilities in triple negative breast cancer: Biological bases and ongoing clinical studies
by Ocana, Alberto and Pandiella, Atanasio
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 13, pp. 22218 - 22234
Triple negative breast cancer (TNBC) is still an incurable disease despite the great scientific effort performed during the last years. The huge heterogeneity... 
Breast cancer | Kinases | Novel therapies | Triple negative breast cancer | INITIATING CELLS | ANDROGEN RECEPTOR | KINASE | breast cancer | BET INHIBITORS | ANTITUMOR-ACTIVITY | CHECKPOINT BLOCKADE | CELL BIOLOGY | TUMOR-INFILTRATING LYMPHOCYTES | kinases | BROMODOMAIN INHIBITOR OTX015 | RANDOMIZED PHASE-II | RESISTANCE | triple negative breast cancer | novel therapies | Carcinogenesis - drug effects | Animals | Humans | Clinical Studies as Topic - statistics & numerical data | Oncogenes - drug effects | Female | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Triple Negative Breast Neoplasms - drug therapy
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6. Targeting HER receptors in cancer
by Ocaña, Alberto and Pandiella, Atanasio
Current Pharmaceutical Design, ISSN 1381-6128, 2013, Volume 19, Issue 5, pp. 808 - 817
Receptor tyrosine kinases play important roles in animal development and their deregulation has been linked to several pathologies, including cancer or... 
Targeted therapies | HER receptors | Kinase inhibitors | EGF ligands | CLINICAL-TRIALS GROUP | targeted therapies | HUMAN-BREAST-CANCER | MONOCLONAL-ANTIBODY | METASTATIC COLORECTAL-CANCER | CELL LUNG-CANCER | TUMOR-NECROSIS-FACTOR | kinase inhibitors | ALPHA-CONVERTING ENZYME | EPIDERMAL-GROWTH-FACTOR | ERBB SIGNALING NETWORK | PHARMACOLOGY & PHARMACY | Receptor, ErbB-3 - metabolism | ErbB Receptors - metabolism | Humans | Receptor, ErbB-2 - metabolism | Drug Resistance, Neoplasm | Molecular Targeted Therapy | Neoplasms - drug therapy | Animals | Drug Design | Antineoplastic Agents - pharmacology | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Receptor, ErbB-4
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7. Full Text Functional transcriptomic annotation and protein–protein interaction network analysis identify NEK2, BIRC5, and TOP2A as potential targets in obese patients with luminal A breast cancer
by Nuncia-Cantarero, Miriam and Martinez-Canales, Sandra and Andrés-Pretel, Fernando and Santpere, Gabriel and Ocaña, Alberto and Galan-Moya, Eva Maria
Breast Cancer Research and Treatment, ISSN 0167-6806, 4/2018, Volume 168, Issue 3, pp. 613 - 623
Although obesity is a risk factor for breast cancer, little effort has been made in the identification of druggable molecular alterations in obese–breast... 
Clinical outcome | Medicine & Public Health | Targeted therapy | Novel druggable targets | Oncology | Breast cancer | Transcriptomic analysis | Protein–protein interaction | Protein- Protein interaction | MITOTIC KINASES | CELLS | Protein-protein interaction | SURVIVIN | CHEMOTHERAPY | ONCOLOGY | KINESINS | EXPRESSION | Body Mass Index | Breast Neoplasms - classification | Oligonucleotide Array Sequence Analysis | Obesity - complications | Humans | Poly-ADP-Ribose Binding Proteins - genetics | Transcriptome - genetics | Obesity - genetics | Obesity - pathology | Breast Neoplasms - complications | Breast Neoplasms - genetics | Ethnic Groups - genetics | Protein Interaction Maps - genetics | Breast Neoplasms - pathology | Progression-Free Survival | NIMA-Related Kinases - genetics | Survivin - genetics | DNA Topoisomerases, Type II - genetics | Female | Neoplasm Staging | Gene Expression Regulation, Neoplastic - genetics | Adipose tissues | Obesity | Body mass index | Cancer patients | Genes | Development and progression | Comparative analysis | Gene expression | Cell differentiation | Health aspects | Protein-protein interactions | Preclinical Study
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8. Full Text Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: A systematic review and meta-analysis
by Templeton, Arnoud J and McNamara, Mairéad G and Šeruga, Boštjan and Vera-Badillo, Francisco E and Aneja, Priya and Ocaña, Alberto and Leibowitz-Amit, Raya and Sonpavde, Guru and Knox, Jennifer J and Tran, Ben and Tannock, Ian F and Amir, Eitan
Journal of the National Cancer Institute, ISSN 0027-8874, 06/2014, Volume 106, Issue 6, p. dju124
Background Inflammation may play an important role in cancer progression, and a high neutrophil-to-lymphocyte ratio (NLR) has been reported to be a poor... 
C-REACTIVE PROTEIN | DISEASE-SPECIFIC SURVIVAL | HEPATOCELLULAR-CARCINOMA | COLORECTAL-CANCER PATIENTS | ONCOLOGY | ACTIVATED HUMAN-NEUTROPHILS | PRETREATMENT NEUTROPHIL | CELL CARCINOMA PATIENTS | PREDICTS POOR SURVIVAL | INFLAMMATORY RESPONSE | PREOPERATIVE NEUTROPHIL/LYMPHOCYTE RATIO | Predictive Value of Tests | Prognosis | Humans | Neoplasms - mortality | Survival Rate | Treatment Outcome | Disease-Free Survival | Lymphocytes - pathology | Sensitivity and Specificity | Lymphocyte Count | Neoplasms - pathology | Odds Ratio | Neutrophils - pathology | Physiological aspects | Development and progression | Research | Lymphocytes | Neutrophils | Tumors
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9. Full Text Drug resistance in metastatic castration-resistant prostate cancer
by Tannock, Ian F and Seruga, Bostjan and Ocana, Alberto
Nature Reviews Clinical Oncology, ISSN 1759-4774, 01/2011, Volume 8, Issue 1, pp. 12 - 23
Docetaxel in combination with prednisone is the standard of care in men with symptomatic castration-resistant prostate cancer (CRPC). However, a substantial... 
BETA-TUBULIN | ANDROGEN RECEPTOR | MITOXANTRONE PLUS PREDNISONE | STEM-CELLS | IN-VITRO | ONCOLOGY | RANDOMIZED PHASE-II | BONE METASTASES | ANTISENSE OLIGONUCLEOTIDE | ABIRATERONE ACETATE | DOCETAXEL | Neoplasms, Hormone-Dependent - surgery | Prostatic Neoplasms - pathology | Prostatic Neoplasms - surgery | Antineoplastic Agents - adverse effects | Humans | Neoplasms, Hormone-Dependent - secondary | Drug Resistance, Neoplasm | Male | Clinical Trials as Topic | Neoplasms, Hormone-Dependent - drug therapy | Prostatic Neoplasms - drug therapy | Orchiectomy | Chemotherapy | Development and progression | Research | Drug resistance | Drug therapy | Health aspects | Prostate cancer | Cancer
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10. Full Text Preclinical development of molecular-targeted agents for cancer
by Ocana, Alberto and Siu, Lillian L and Tannock, Ian F and Pandiella, Atanasio
Nature Reviews Clinical Oncology, ISSN 1759-4774, 04/2011, Volume 8, Issue 4, pp. 200 - 209
Molecular-targeted agents are increasingly used for the treatment of cancer. However, the attrition rate for drugs that enter early clinical trials is higher... 
GROWTH-FACTOR RECEPTOR | STEM-CELLS | IMATINIB-RESISTANT | MAMMARY-TUMORS | ONCOLOGY | POTENT ANTIMYELOMA ACTIVITY | IN-VIVO | ACQUIRED-RESISTANCE | TYROSINE KINASE INHIBITOR | SYNTHETIC LETHALITY | ANTITUMOR-ACTIVITY | Antimitotic agents | Usage | Animal models in research | Development and progression | Genetic aspects | Research | Antineoplastic agents | Drug therapy | Health aspects | Cancer
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11. Novel synthetic lethality approaches for drug combinations and early drug development
by Ocana, Alberto and Pandiella, Atanasio
Current Cancer Drug Targets, ISSN 1568-0096, 2017, Volume 17, Issue 1, pp. 48 - 52
Preclinical evaluation of drug combinations is challenging. In this mini-review we discuss the concept of synthetic lethality and how this can impact on the... 
Therapeutic index | Drug combinations | Synthetic lethality | Immunotherapy | Cancer | Immunologic agents | CELLS | immunologic agents | INHIBITION | THERAPY | ONCOLOGY | therapeutic index | immunotherapy | cancer | drug combinations
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