Acta neuropathologica, ISSN 0001-6322, 2017, Volume 133, Issue 4, pp. 535 - 545
Phosphorylated alpha-synuclein (p-alpha-syn) deposits, one of the neuropathological hallmarks of Parkinson's disease (PD), have recently been detected in...
LEWY-BODY DISEASE | Parkinson's disease | REM sleep behaviour disorder | Skin biopsy | FP-CIT-SPECT | MDS RESEARCH CRITERIA | PATHOLOGY | NEUROSCIENCES | Alpha-synuclein | CLINICAL NEUROLOGY | Dopamine Plasma Membrane Transport Proteins - metabolism | Brain - diagnostic imaging | Phosphorylation | Prospective Studies | Skin - metabolism | Humans | Middle Aged | Tomography, Emission-Computed, Single-Photon | Male | Prodromal Symptoms | Case-Control Studies | Brain - metabolism | Female | Parkinson Disease - metabolism | Radiopharmaceuticals | REM Sleep Behavior Disorder - metabolism | Skin - pathology | Biomarkers - metabolism | Parkinson Disease - pathology | REM Sleep Behavior Disorder - pathology | Smell | Leg - innervation | Tropanes | Leg - pathology | Biopsy | Fluorescent Antibody Technique | Parkinson Disease - diagnosis | Skin - innervation | Aged | alpha-Synuclein - metabolism | REM Sleep Behavior Disorder - diagnosis | Medicine, Experimental | Medical research | SPECT imaging | Sleep | Comparative analysis | Mental illness
LEWY-BODY DISEASE | Parkinson's disease | REM sleep behaviour disorder | Skin biopsy | FP-CIT-SPECT | MDS RESEARCH CRITERIA | PATHOLOGY | NEUROSCIENCES | Alpha-synuclein | CLINICAL NEUROLOGY | Dopamine Plasma Membrane Transport Proteins - metabolism | Brain - diagnostic imaging | Phosphorylation | Prospective Studies | Skin - metabolism | Humans | Middle Aged | Tomography, Emission-Computed, Single-Photon | Male | Prodromal Symptoms | Case-Control Studies | Brain - metabolism | Female | Parkinson Disease - metabolism | Radiopharmaceuticals | REM Sleep Behavior Disorder - metabolism | Skin - pathology | Biomarkers - metabolism | Parkinson Disease - pathology | REM Sleep Behavior Disorder - pathology | Smell | Leg - innervation | Tropanes | Leg - pathology | Biopsy | Fluorescent Antibody Technique | Parkinson Disease - diagnosis | Skin - innervation | Aged | alpha-Synuclein - metabolism | REM Sleep Behavior Disorder - diagnosis | Medicine, Experimental | Medical research | SPECT imaging | Sleep | Comparative analysis | Mental illness
Journal Article
1999, ISBN 9781853173790, xi, 260
Book
F1000Research, ISSN 2046-1402, 2017, Volume 6, p. 260
This article summarizes (1) the recent achievements to further improve symptomatic therapy of motor Parkinson's disease (PD) symptoms, (2) the still-few...
Neuronal Signaling Mechanisms | Neuropharmacology & Psychopharmacology | Movement Disorders | Neurobiology of Disease & Regeneration | Non-motor symptoms | Parkinson's disease | Disease modifying treatment | Prodromal stage | Motor symptoms
Neuronal Signaling Mechanisms | Neuropharmacology & Psychopharmacology | Movement Disorders | Neurobiology of Disease & Regeneration | Non-motor symptoms | Parkinson's disease | Disease modifying treatment | Prodromal stage | Motor symptoms
Journal Article
Drugs & Aging, ISSN 1170-229X, 2005, Volume 22, Issue 1, pp. 93 - 94
Journal Article
Journal of Neural Transmission, ISSN 0300-9564, 4/2019, Volume 126, Issue 4, pp. 377 - 396
Neurodegeneration of the nigrostriatal dopaminergic system and concurrent dopamine (DA) deficiency in the basal ganglia represent core features of Parkinson’s...
Dopaminergic systems | Neurology | l - dopa | Neurosciences | Dopamine | Medicine & Public Health | Dopaminergic therapy | Parkinson disease | Psychiatry | Motor symptoms | l-dopa
Dopaminergic systems | Neurology | l - dopa | Neurosciences | Dopamine | Medicine & Public Health | Dopaminergic therapy | Parkinson disease | Psychiatry | Motor symptoms | l-dopa
Journal Article
Movement Disorders, ISSN 0885-3185, 10/2019, Volume 34, Issue 10, pp. 1423 - 1429
Journal Article
Parkinsonism and Related Disorders, ISSN 1353-8020, 03/2019, Volume 60, pp. 43 - 45
Parkinson's disease (PD) is an etiologically heterogeneous disorder. Experimental, clinical and epidemiological data suggest that intestinal inflammation...
Inflammatory bowel disease | Parkinson's disease | Intestinal inflammation | Calprotectin | Crohn's disease | NOD2 | Short chain fatty acids | MICROBIOTA | CLINICAL NEUROLOGY | BOWEL-DISEASE | CHAIN FATTY-ACIDS | VAGOTOMY | DYSFUNCTION | Microbiota (Symbiotic organisms) | Gastrointestinal diseases | Environmental aspects | Disease susceptibility | Inflammation | Fatty acids | Epidemiology
Inflammatory bowel disease | Parkinson's disease | Intestinal inflammation | Calprotectin | Crohn's disease | NOD2 | Short chain fatty acids | MICROBIOTA | CLINICAL NEUROLOGY | BOWEL-DISEASE | CHAIN FATTY-ACIDS | VAGOTOMY | DYSFUNCTION | Microbiota (Symbiotic organisms) | Gastrointestinal diseases | Environmental aspects | Disease susceptibility | Inflammation | Fatty acids | Epidemiology
Journal Article
Journal of Neurology, ISSN 0340-5354, 06/2011, Volume 258, Issue 6, pp. 982 - 990
Ghrelin, an orexigenic peptide, has multiple functions, which include promoting gastrointestinal motility and influencing higher brain functions. Experimental...
Vagal innervation, biomarker | Parkinson's disease | Ghrelin | REM sleep behaviour disorder (RBD) | MEAL | RECEPTOR | PATHOLOGY | CLINICAL NEUROLOGY | DELAYED EMERGENCE | PATHOGENESIS | NORMAL-WEIGHT | MEN | NEURONS | MOTILITY | Severity of Illness Index | Antiparkinson Agents - pharmacology | Fasting | Area Under Curve | Humans | Middle Aged | Male | Parkinson Disease - drug therapy | Biomarkers - blood | Postprandial Period - physiology | Antiparkinson Agents - therapeutic use | Blood Glucose - drug effects | Ghrelin - blood | REM Sleep Behavior Disorder - blood | Analysis of Variance | Time Factors | Female | Aged | Postprandial Period - drug effects | Parkinson Disease - blood | Blood Glucose - metabolism | Physiological aspects | Diagnosis | Research | REM sleep
Vagal innervation, biomarker | Parkinson's disease | Ghrelin | REM sleep behaviour disorder (RBD) | MEAL | RECEPTOR | PATHOLOGY | CLINICAL NEUROLOGY | DELAYED EMERGENCE | PATHOGENESIS | NORMAL-WEIGHT | MEN | NEURONS | MOTILITY | Severity of Illness Index | Antiparkinson Agents - pharmacology | Fasting | Area Under Curve | Humans | Middle Aged | Male | Parkinson Disease - drug therapy | Biomarkers - blood | Postprandial Period - physiology | Antiparkinson Agents - therapeutic use | Blood Glucose - drug effects | Ghrelin - blood | REM Sleep Behavior Disorder - blood | Analysis of Variance | Time Factors | Female | Aged | Postprandial Period - drug effects | Parkinson Disease - blood | Blood Glucose - metabolism | Physiological aspects | Diagnosis | Research | REM sleep
Journal Article
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, ISSN 1436-9990, 4/2016, Volume 59, Issue 4, pp. 420 - 429
Das Kompetenznetz Parkinson (KNP) stellt eine Forschungsinfrastruktur für krankheitsorientierte und klinische Forschung auf dem Gebiet der Parkinson-Syndrome...
Prodromale Parkinson-Krankheit | Public Health | Pharmakoökonomie | Medicine & Public Health | Deep brain stimulation | Kompetenznetz Parkinson | Tiefenhirnstimulation | Prodromal Parkinson’s disease | General Practice / Family Medicine | Competence Network Parkinson | Pharmacoeconomy | German Parkinson Study Group
Prodromale Parkinson-Krankheit | Public Health | Pharmakoökonomie | Medicine & Public Health | Deep brain stimulation | Kompetenznetz Parkinson | Tiefenhirnstimulation | Prodromal Parkinson’s disease | General Practice / Family Medicine | Competence Network Parkinson | Pharmacoeconomy | German Parkinson Study Group
Journal Article
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, ISSN 1436-9990, 04/2016, Volume 59, Issue 4, p. 420
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00103-016-2312-0 Das...
SPECT imaging
SPECT imaging
Journal Article
Pain, ISSN 0304-3959, 01/2014, Volume 155, Issue 1, pp. 200 - 201
Journal Article
NERVENHEILKUNDE, ISSN 0722-1541, 2006, Volume 25, Issue 1-2, pp. 90 - 91
Journal Article
BUNDESGESUNDHEITSBLATT-GESUNDHEITSFORSCHUNG-GESUNDHEITSSCHUTZ, ISSN 1436-9990, 04/2016, Volume 59, Issue 4, pp. 420 - 429
The Competence Network Parkinson (CNP) is a research infrastructure for disease-oriented translational and clinical research in the field of Parkinson...
DIAGNOSIS | EFFICACY | Deep brain stimulation | SAFETY | Competence Network Parkinson | MODEL | SLEEP BEHAVIOR DISORDER | COST | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | Prodromal Parkinson's disease | DISEASE | MOTOR | Pharmacoeconomy | German Parkinson Study Group | TOLCAPONE | BURDEN | Parkinson Disease - therapy | Clinical Competence | Quality Assurance, Health Care - organization & administration | Schizophrenia - therapy | Humans | Models, Organizational | Biomedical Research - organization & administration | Schizophrenia - diagnosis | Parkinson Disease - diagnosis | Interinstitutional Relations | Government Programs - organization & administration | Germany | Clinical Trials as Topic - organization & administration
DIAGNOSIS | EFFICACY | Deep brain stimulation | SAFETY | Competence Network Parkinson | MODEL | SLEEP BEHAVIOR DISORDER | COST | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | Prodromal Parkinson's disease | DISEASE | MOTOR | Pharmacoeconomy | German Parkinson Study Group | TOLCAPONE | BURDEN | Parkinson Disease - therapy | Clinical Competence | Quality Assurance, Health Care - organization & administration | Schizophrenia - therapy | Humans | Models, Organizational | Biomedical Research - organization & administration | Schizophrenia - diagnosis | Parkinson Disease - diagnosis | Interinstitutional Relations | Government Programs - organization & administration | Germany | Clinical Trials as Topic - organization & administration
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2015, Volume 112, Issue 31, p. E4336
Journal Article
Journal of Comparative Neurology, ISSN 0021-9967, 07/2014, Volume 522, Issue 10, pp. 2336 - 2348
Journal Article
Clinical Neuropharmacology, ISSN 0362-5664, 01/2014, Volume 37, Issue 1, pp. 1 - 5
Objectives: The aim of this observational study was to investigate the safety and efficacy of tolcapone under practice conditions. Methods: This 12-month...
Parkinson disease | liver monitoring | transaminase | tolcapone | hepatotoxicity | MULTICENTER | CONTROLLED TRIAL | HEPATITIS | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | IMPROVES MOTOR FUNCTION | CLINICAL NEUROLOGY | Severity of Illness Index | Benzophenones - therapeutic use | Antiparkinson Agents - pharmacology | Humans | International Cooperation | Parkinson Disease - drug therapy | Parkinson Disease - psychology | Compliance - drug effects | Time Factors | Drug-Related Side Effects and Adverse Reactions | Nitrophenols - therapeutic use | Observation | Retrospective Studies | Longitudinal Studies
Parkinson disease | liver monitoring | transaminase | tolcapone | hepatotoxicity | MULTICENTER | CONTROLLED TRIAL | HEPATITIS | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | IMPROVES MOTOR FUNCTION | CLINICAL NEUROLOGY | Severity of Illness Index | Benzophenones - therapeutic use | Antiparkinson Agents - pharmacology | Humans | International Cooperation | Parkinson Disease - drug therapy | Parkinson Disease - psychology | Compliance - drug effects | Time Factors | Drug-Related Side Effects and Adverse Reactions | Nitrophenols - therapeutic use | Observation | Retrospective Studies | Longitudinal Studies
Journal Article
Movement Disorders, ISSN 0885-3185, 09/2003, Volume 18, Issue 9, pp. 977 - 984
Journal Article
DNP - Der Neurologe und Psychiater, ISSN 1616-2455, 09/2014, Volume 15, Issue 9, pp. 3 - 4
Journal Article
Lancet Neurology, The, ISSN 1474-4422, 2007, Volume 6, Issue 6, pp. 513 - 520
Summary Background Continuous dopaminergic drug delivery is an unmet medical need in advanced Parkinson's disease. The aim of this trial—Clinical Efficacy of...
Neurology | MOTOR FLUCTUATIONS | MULTICENTER | PARALLEL-GROUP | CABERGOLINE | ADJUNCT | FOLLOW-UP | ROPINIROLE | PLACEBO-CONTROLLED TRIAL | RASAGILINE | CLINICAL NEUROLOGY | LEVODOPA | Severity of Illness Index | Double-Blind Method | Humans | Middle Aged | Male | Treatment Outcome | Parkinson Disease - drug therapy | Thiophenes - administration & dosage | Administration, Cutaneous | Antiparkinson Agents - therapeutic use | Tetrahydronaphthalenes - administration & dosage | Dopamine Agonists - administration & dosage | Placebos | Female | Aged | Benzothiazoles - therapeutic use | Clinical trials | Transdermal medication | Parkinson's disease
Neurology | MOTOR FLUCTUATIONS | MULTICENTER | PARALLEL-GROUP | CABERGOLINE | ADJUNCT | FOLLOW-UP | ROPINIROLE | PLACEBO-CONTROLLED TRIAL | RASAGILINE | CLINICAL NEUROLOGY | LEVODOPA | Severity of Illness Index | Double-Blind Method | Humans | Middle Aged | Male | Treatment Outcome | Parkinson Disease - drug therapy | Thiophenes - administration & dosage | Administration, Cutaneous | Antiparkinson Agents - therapeutic use | Tetrahydronaphthalenes - administration & dosage | Dopamine Agonists - administration & dosage | Placebos | Female | Aged | Benzothiazoles - therapeutic use | Clinical trials | Transdermal medication | Parkinson's disease
Journal Article
European Journal of Neurology, ISSN 1351-5101, 01/2012, Volume 19, Issue 1, pp. 4 - 5
Journal Article
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