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Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 05/2019, Volume 42, Issue 5, pp. 792 - 800
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, pp. e0170709 - e0170709
Bendamustine (BENDA), which bears the bis(2-chloroethyl) amino moiety, is an alkylating agent that stops the growth of cancer cells by binding to DNA and... 
MULTIPLE-MYELOMA | TRANSCRIPTION FACTORS | ACTIVATION | INDUCED APOPTOSIS | RITUXIMAB | MULTIDISCIPLINARY SCIENCES | NON-HODGKINS-LYMPHOMA | SIGNAL TRANSDUCERS | CHEMOTHERAPEUTIC DRUGS | CELL-LINES | CANCER | Peptides - antagonists & inhibitors | Humans | Alanine - chemistry | Antineoplastic Agents, Alkylating - pharmacology | Structure-Activity Relationship | Phosphotyrosine - metabolism | Peptides - chemical synthesis | Peptides - metabolism | Cysteine - metabolism | Antineoplastic Agents, Alkylating - chemistry | Binding Sites | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Gene Expression | Alanine - metabolism | Cysteine - chemistry | Phosphotyrosine - chemistry | Bendamustine Hydrochloride - analogs & derivatives | src Homology Domains | Bendamustine Hydrochloride - metabolism | Point Mutation | Bendamustine Hydrochloride - pharmacology | Cell Line, Tumor | Protein Binding | STAT3 Transcription Factor - antagonists & inhibitors | Antineoplastic Agents, Alkylating - metabolism | Drug Screening Assays, Antitumor | Complications and side effects | Transcription factors | Bendamustine | Gene mutations | Physiological aspects | Dosage and administration | Genetic aspects | Research | Transcription | Phosphotyrosine | Multiple myeloma | Homology | Kinases | Alkylation | Covalent bonds | Anticancer properties | Proteins | Rodents | Cell cycle | Bonding strength | Inhibition | Growth factors | Pharmaceutical sciences | Deoxyribonucleic acid--DNA | Recombinant | Binding | Cytokines | Stat3 protein | Breast cancer | Point mutation | Cancer | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2019, Volume 42, Issue 5, pp. 792 - 800
Signal transducer and activator of transcription 3 (STAT3) is a latent transcription factor that contributes to tumor cell growth and survival and is often... 
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, pp. e0156643 - e0156643
Forkhead box protein p3 (Foxp3) is crucial to the development and suppressor function of regulatory T cells (Tregs) that have a significant role in... 
EFFECTOR FUNCTIONS | ACTIVATION | NUCLEAR-FACTOR | IMMUNOTHERAPY | ANALOGS | MULTIDISCIPLINARY SCIENCES | DOXORUBICIN | FACTOR-KAPPA-B | ANTITUMOR-ACTIVITY | CARCINOMA | INSIGHTS | Drug Screening Assays, Antitumor - methods | Luciferases - metabolism | Humans | Cells, Cultured | Epirubicin - isolation & purification | Down-Regulation - drug effects | Luciferases - genetics | T-Lymphocytes, Regulatory - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Antineoplastic Agents - isolation & purification | Lymphocyte Activation - drug effects | HEK293 Cells | Female | Antineoplastic Agents - pharmacology | Mice | Mice, Inbred BALB C | Forkhead Transcription Factors - antagonists & inhibitors | Genes, Reporter | Epirubicin - pharmacology | Complications and side effects | Chemotherapy | Luciferase | Physiological aspects | Genetic aspects | Dosage and administration | Research | Epirubicin | T cells | Cancer | Transcription factors | Immunoprecipitation | Toxicity | Cytotoxicity | Lymphocytes T | Kinases | Assaying | Cancer therapies | Immunity | Proteins | Lymphocytes | Immunotherapy | Foxp3 protein | Forkhead protein | Inhibition | Pharmaceutical sciences | NF-κB protein | Immunoglobulins | Immunoregulation | Medical screening | Immune systems | Inhibitors | γ-Interferon | Lymphomas | Interferon | Viability | Tumors | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, pp. e71646 - e71646
Some of the signal transducer and activator of transcription (STAT) family members are constitutively activated in a wide variety of human tumors. The activity... 
TRANSFORMATION | ACTIVATION | FLUORESCENCE POLARIZATION | HIGH-THROUGHPUT SCREEN | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | SIGNAL TRANSDUCERS | KINASE INHIBITOR | IDENTIFICATION | CANCER | SMALL-MOLECULE INHIBITOR | Recombinant Proteins - metabolism | Amino Acid Sequence | Peptides - chemistry | Humans | Molecular Sequence Data | STAT5 Transcription Factor - chemistry | Biological Assay - methods | STAT3 Transcription Factor - chemistry | Structure-Activity Relationship | Protein Transport | src Homology Domains | Digoxigenin - metabolism | STAT5 Transcription Factor - metabolism | Cell Nucleus - metabolism | Peptides - metabolism | STAT5 Transcription Factor - antagonists & inhibitors | Protein Binding | HeLa Cells | STAT3 Transcription Factor - antagonists & inhibitors | STAT3 Transcription Factor - metabolism | Proteins | Tyrosine | Biotin | Multiplexing | Phosphorylation | Transcription factors | Transcription | Peptides | Leukemia | Phosphotyrosine | Homology | Antagonists | Identification | Selectivity | Kinases | Assaying | Cell growth | Clonal deletion | Rodents | Deletion | Inhibition | Growth factors | Pharmaceutical sciences | Recombinant | Binding | Translocation | Cytokines | Stat3 protein | Feasibility studies | Lead compounds | Sodium chloride | Gene expression | Nuclear transport | Mutants | Sodium | Spacer | Reaction time | Ligands | Beads | Prostate cancer | Tumors | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 03/2016, Volume 6, Issue 1, pp. 23372 - 23372
Journal Article
Journal of Experimental Botany, ISSN 0022-0957, 06/2019, Volume 70, Issue 12, pp. 3329 - 3342
To identify the upstream signaling of aluminum-induced malate secretion through aluminum-activated malate transporter 1 (AtALMT1), a pharmacological assay... 
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 08/2015, Volume 2015, Issue 22, pp. 4907 - 4912
Three new ureido‐pyridazinone derivatives, which are structurally related to the known STAT3 inhibitor AVS‐0288 , were designed by taking into account the... 
Conformation analysis | Proteins | Signal transduction | Medicinal chemistry | Inhibitors | Cancer | MOLECULAR TARGETS | CHEMISTRY, ORGANIC | Diffraction
Journal Article
Cancer Research, ISSN 0008-5472, 04/2010, Volume 70, Issue 8 Supplement, pp. 4427 - 4427
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 09/2015, Volume 6, Issue 9, pp. 1004 - 1009
Kinesin spindle protein (KSP), known as Hs Eg5, a member of the kinesin-5 family, plays an important role in the formation and maintenance of the bipolar... 
HCT-116 xenograft model | Kinesin spindle protein | molecular modeling | L-cysteine derivative | differential scanning fluorimetry | TARGET | CHEMISTRY, MEDICINAL | MICROTUBULES | molecular modeling differential scanning fluorimetry | VIVO ANTITUMOR-ACTIVITY | CANCER | MODELS | TRITYL-L-CYSTEINE | EG5 INHIBITORS | AGENTS
Journal Article