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Journal Article
European Urology, ISSN 0302-2838, 11/2012, Volume 62, Issue 5, p. 834
[beta]-Adrenoceptor agonists are effective in animal models of bladder dysfunction, and the human bladder primarily expresses the [beta]3 receptor subtype. 
Analysis | Clinical trials
Journal Article
Drug Discovery Today: Therapeutic Strategies, ISSN 1740-6773, 2012, Volume 9, Issue 1, pp. e1 - e3
Journal Article
Pharmacological reviews, ISSN 0031-6997, 2015, Volume 67, Issue 1, pp. 214 - 258
Journal Article
Drug Discovery Today: Therapeutic Strategies, 03/2012, Volume 9, Issue 1, pp. e1 - e3
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 03/2002, Volume 105, Issue 12, pp. 1497 - 1502
Background-Recent evidence from cultured endothelial cell studies suggests that phosphorylation of endothelial nitric oxide synthase (eNOS) through the... 
Signal transduction | Reperfusion | Nitric oxide | Apoptosis | CELLS | nitric oxide | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCYTES | signal transduction | FLUID SHEAR-STRESS | INDUCED APOPTOSIS | PROTEIN-KINASE AKT | INJURY | apoptosis | CARDIOMYOCYTES | INHIBITION | PERIPHERAL VASCULAR DISEASE | POTASSIUM | HEMATOLOGY | reperfusion | Myocardial Ischemia - metabolism | Apoptosis - drug effects | Protein-Serine-Threonine Kinases | Nitric Oxide Synthase - antagonists & inhibitors | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Myocardium - metabolism | Phosphorylation - drug effects | Reperfusion Injury - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Proto-Oncogene Proteins - metabolism | Insulin - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Nitric Oxide Synthase Type III | Rats | Glucose - pharmacology | Enzyme Activation - drug effects | Potassium - pharmacology | Myocardial Ischemia - drug therapy | Rats, Sprague-Dawley | Myocardial Ischemia - pathology | Myocardium - cytology | Proto-Oncogene Proteins c-akt | Animals | Reperfusion Injury - prevention & control | Androstadienes - pharmacology | Signal Transduction - drug effects | Wortmannin | Nitric Oxide Synthase - metabolism | Nitric Oxide - metabolism
Journal Article
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 2011, Volume JUL, p. 125
Journal Article
Circulation, ISSN 0009-7322, 12/2003, Volume 108, Issue 22, pp. 2805 - 2811
Background-Peroxisome proliferator-activated receptor (PPAR) signaling pathways have been reported to exert anti-inflammatory effects and attenuate... 
Inflammation | Hypercholesterolemia | Atherosclerosis | Endothelium | atherosclerosis | endothelium | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOTHELIAL DYSFUNCTION | NITRIC-OXIDE SYNTHASE | DEPENDENT PROTEIN-KINASE | CELL-GROWTH | hypercholesterolemia | VASODILATOR-STIMULATED PHOSPHOPROTEIN | NAD(P)H OXIDASE | inflammation | MYOCARDIAL ISCHEMIA-REPERFUSION | PPAR-GAMMA | NITROGLYCERIN TREATMENT | PERIPHERAL VASCULAR DISEASE | SUPEROXIDE PRODUCTION | HEMATOLOGY | Carotid Arteries - drug effects | Carotid Arteries - metabolism | Blood Vessels - metabolism | Blood Vessels - pathology | Nitrites - metabolism | Male | Cyclic GMP-Dependent Protein Kinases - metabolism | Hypercholesterolemia - drug therapy | Tyrosine - analogs & derivatives | Thiazolidinediones - therapeutic use | Hypercholesterolemia - pathology | Lipids - blood | Thiazolidinediones - pharmacology | Disease Models, Animal | Rabbits | Receptors, Cytoplasmic and Nuclear - agonists | Antioxidants - pharmacology | Nitrates - metabolism | Antioxidants - therapeutic use | Tyrosine - metabolism | Animals | Cyclic GMP - metabolism | Signal Transduction - drug effects | Blood Vessels - drug effects | Carotid Arteries - pathology | Hypercholesterolemia - physiopathology | Transcription Factors - agonists | Vasodilation - drug effects | In Vitro Techniques | Nitric Oxide - metabolism
Journal Article
Stroke, ISSN 0039-2499, 1998, Volume 29, Issue 5, pp. 1020 - 1030
Background and Purpose-Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade the extracellular matrix and are implicated in... 
Antibody inhibition | Endothelium, vascular | Blood-brain barrier | Neutrophils | Leukocytes | Metalloproteinases | Stroke, ischemic | blood-brain barrier | DEGRADING PROTEINASES | NEUTROPHIL | antibody inhibition | TISSUE | VOLUME | metalloproteinases | CLINICAL NEUROLOGY | STROKE | endothelium, vascular | stroke, ischemic | GELATINASE | ENDOTHELIAL-CELLS | leukocytes | PERIPHERAL VASCULAR DISEASE | BRAIN INJURY | SECRETION | neutrophils | Endothelium, Vascular - cytology | Immunohistochemistry | Neutrophils - cytology | Tissue Extracts - chemistry | Brain Injuries - drug therapy | Male | Metalloendopeptidases - metabolism | Collagenases - analysis | Endothelium, Vascular - enzymology | Protease Inhibitors - immunology | Cerebral Infarction - enzymology | Brain Ischemia - enzymology | Gelatinases - analysis | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Time Factors | Tissue Inhibitor of Metalloproteinase-1 - analysis | Tissue Inhibitor of Metalloproteinases - administration & dosage | Tissue Inhibitor of Metalloproteinases - immunology | Gelatinases - metabolism | Protease Inhibitors - administration & dosage | Arterial Occlusive Diseases - physiopathology | Antibodies, Monoclonal - immunology | Cerebral Infarction - pathology | Metalloendopeptidases - analysis | Rats, Inbred SHR | Collagenases - biosynthesis | Neutrophils - enzymology | Electrophoresis, Polyacrylamide Gel | Matrix Metalloproteinase 2 | Brain Injuries - enzymology | Matrix Metalloproteinase 1 | Enzyme Induction | Rats | Cerebral Arteries - physiopathology | Macrophages - cytology | Arterial Occlusive Diseases - enzymology | Sodium Dodecyl Sulfate | Macrophages - enzymology | Matrix Metalloproteinase 3 - biosynthesis | Metalloendopeptidases - biosynthesis | Animals | Cerebral Arteries - pathology | Matrix Metalloproteinase Inhibitors | Collagenases - metabolism | Matrix Metalloproteinase 9
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 05/2008, Volume 325, Issue 2, pp. 466 - 474
Peroxisome proliferator-activated receptor ( PPAR)-delta is a transcription factor that belongs to the PPAR family. PPAR-delta is abundantly expressed in the... 
TRANSLOCATION | GW0742 reduced serum levels of cardiac troponin-I and infarct | peroxisome proliferator-activated receptor ( PPAR)-delta is a transcription | thiazolyl] methyl | MYOCARDIAL PROTECTION | ALPHA | and its role in the heart is | of PPAR-delta protects the heart from ischemia/reperfusion | size by 63% ( p < 0.01) and 32% ( p < 0.01) | respectively | ACID OXIDATION | and dyslipidemia. A highly selective PPAR-delta agonist | once a day). Ischemic injury was | 4-( trifluoromethyl) phenyl | was administered | produced by occlusion of the left anterior descending artery for 30 | 4-[[[ 2-[ 3fluoro | and | PPAR-DELTA | PHARMACOLOGY & PHARMACY | ( I/R) injury in male Zucker fatty rats | methyl | largely unknown. We tested whether pharmacological activation | a rodent model of obesity | for 7 days at 10 mg/ kg/ day (p.o | methylphenoxy] acetic acid ( GW0742) | OXIDATIVE STRESS | min followed by reperfusion for up to 24 h. Treatment with | improved left ventricular function. Treatment with GW0742 up-regulated | thio | gene expression involved in cardiac fatty acid oxidation | factor that belongs to the PPAR family. PPAR-delta is | GLUCOSE-METABOLISM | abundantly expressed in the heart | BAX | REGULATES BCL-XL | EXPRESSION | Heart - physiopathology | Rats | Male | Thiazoles - therapeutic use | RNA, Messenger - metabolism | Myocardial Reperfusion Injury - physiopathology | PPAR delta - physiology | Troponin I - blood | Cardiotonic Agents - therapeutic use | Rats, Zucker | Metabolic Syndrome - blood | Animals | PPAR delta - agonists | Metabolic Syndrome - physiopathology | Blood Pressure - drug effects | Fatty Acids - blood | Proto-Oncogene Proteins c-akt - metabolism | Cytokines - genetics | Fatty Acids - metabolism | Ketones - metabolism | Myocardial Reperfusion Injury - blood | Myocardial Reperfusion Injury - prevention & control | Disease Models, Animal
Journal Article
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2006, Volume 316, pp. 1 - 11
Gene identification followed by determination of the expression of genes in a given disease and understanding of the function of the gene products is central... 
Biotechnology | Pharmacogenetics | Drug Industry | Genomics | Humans | Drug Design | Proteomics | Genome, Human
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 12/2000, Volume 131, Issue 7, pp. 1262 - 1274
Urotensin‐II (U‐II) and its G‐protein‐coupled receptor, GPR14, are expressed within mammalian cardiac and peripheral vascular tissue and, as such, may regulate... 
SENR | spasmogen | endothelium | Urotensin‐II | GPR14 | somatostatin | vascular reactivity | coronary artery | vasoconstriction | endothelin‐1 | Vascular reactivity | Coronary artery | Endothelin-1 | Vasoconstriction | Urotensin-II | Somatostatin | Spasmogen | Endothelium | ENDOGENOUS LIGAND | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-COUPLED RECEPTORS | ORPHAN RECEPTOR | EURYHALINE FLOUNDER | PLATICHTHYS-FLESUS | CONTRACTION | NEUROPEPTIDE | PHARMACOLOGY & PHARMACY | endothelin-1 | POTENT VASOCONSTRICTOR | urotensin-II | Carotid Arteries - drug effects | Pulmonary Veins - drug effects | Urotensins - pharmacology | Humans | Macaca fascicularis | Trachea - drug effects | Aorta, Abdominal - drug effects | Dose-Response Relationship, Drug | Arteries - physiology | Swine | Aorta, Thoracic - physiology | Pulmonary Veins - physiology | Trachea - physiology | Aorta, Thoracic - drug effects | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | Vasoconstrictor Agents - pharmacology | Coronary Vessels - drug effects | Callithrix | Coronary Vessels - physiology | Rats | Arteries - drug effects | Aorta, Abdominal - physiology | Pulmonary Artery - drug effects | Femoral Artery - drug effects | Vasoconstriction - drug effects | Pulmonary Artery - physiology | Veins - drug effects | Animals | Blood Vessels - drug effects | Carotid Arteries - physiology | Dogs | Femoral Artery - physiology | Mice | Veins - physiology | Blood Vessels - physiology | In Vitro Techniques | Papers
Journal Article