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British Journal of Pharmacology, ISSN 0007-1188, 10/2019, Volume 176, Issue 20, pp. 4065 - 4078
Background and Purpose The pharmacology of polyphenol metabolites on beta‐cell function is largely undetermined. We sought to identify polyphenol metabolites... 
Calcium channels | Channel opening | Calcium (intracellular) | Calcium | Secretion | Calcium channels (voltage-gated) | Electrophysiology | Activation | Pharmacology | Glucose | Insulin | Calcium influx | Depolarization | Molecular modelling | Metabolites | Modelling | Islets of Langerhans | Intracellular | Pancreas | Monitoring | Calcium ions
Journal Article
British journal of pharmacology, ISSN 0007-1188, 08/2019
The pharmacology of polyphenol metabolites on β-cell function is largely undetermined. We sought to identify polyphenol metabolites that enhance the... 
Life Sciences
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e78788
Chicoric acid (CA) is a caffeoyl derivative previously described as having potential anti-diabetic properties. As similarities in cellular mechanism... 
RESVERATROL | ACTIVATED PROTEIN-KINASE | CAFFEIC ACID | FREE FATTY-ACIDS | INSULIN-RESISTANCE | PGC-1-ALPHA | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIAL DYSFUNCTION | C. ELEGANS | GLUCOSE-PRODUCTION | STRESS RESISTANCE | Citrate (si)-Synthase - biosynthesis | Gene Expression Regulation, Enzymologic - drug effects | Caenorhabditis elegans - genetics | Longevity - drug effects | Oxidoreductases - genetics | Caffeic Acids - pharmacology | Transcription Factors - biosynthesis | Antioxidants - pharmacology | Transcription Factors - genetics | Animals | Gene Expression Regulation, Enzymologic - genetics | Adenylate Kinase - metabolism | Citrate (si)-Synthase - genetics | Adenylate Kinase - genetics | Caenorhabditis elegans Proteins - genetics | Longevity - physiology | Succinates - pharmacology | Caenorhabditis elegans - enzymology | Caenorhabditis elegans Proteins - biosynthesis | Muscle Fibers, Skeletal - enzymology | Oxidoreductases - biosynthesis | Antioxidants | Enzymes | Caenorhabditis elegans | RNA | Polyphenols | Biosynthesis | Superoxide | Hypoglycemic agents | TOR protein | Oxidative stress | Reactive oxygen species | Phosphorylation | AKT protein | Superoxide dismutase | Glucose | Kinases | Proteins | Stimulators | Mitochondria | Rodents | Aging | Peroxidase | Glutathione peroxidase | Obesity | Myotubes | AMP | Diabetes mellitus | Gene expression | Insulin | Analogies | Life span | Acids | Insects | Quercetin | Nematodes | Diabetes | Electron transport | Metabolic disorders | Life Sciences | Animal biology | Agricultural sciences
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 06/2006, Volume 148, Issue 3, pp. 350 - 365
1 The growth hormone secretagogue receptor la (GHSR-1a) is a G-protein coupled receptor, involved in the biological actions of ghrelin by triggering inositol... 
SELECTIVE-INHIBITION | PROTEIN-KINASE-C | MAP-KINASE | PKC | ANTERIOR-PITUITARY-CELLS | BETA-ARRESTIN | Elk1 | GH SECRETAGOGUE | ghrelin | SIGNALING PATHWAY | DES-OCTANOYL GHRELIN | COUPLED RECEPTORS | PHARMACOLOGY & PHARMACY | NATURAL GHRELIN | hGHSR-1a | ERK
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 10/2010, Volume 161, Issue 4, pp. 799 - 814
BACKGROUND AND PURPOSE Quercetin lowers plasma glucose, normalizes glucose tolerance tests and preserves pancreatic [beta]-cell integrity in diabetic rats.... 
pancreatic β-cells | ERK1/2 | cell viability | quercetin | insulin secretion | diabetes | oxidative stress
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2019, Volume 62, Issue 2, pp. 965 - 973
The ghrelin receptor or growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor that controls growth hormone and insulin secretion, food... 
CHEMISTRY, MEDICINAL | LIGANDS | DELTA CELLS | CONSTITUTIVE ACTIVITY | ALPHA | HORMONE SECRETAGOGUE RECEPTOR | BETA | Medicinal Chemistry | Chemical Sciences
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 10/2010, Volume 161, Issue 4, pp. 799 - 814
Journal Article