Journal of Gastroenterology, ISSN 0944-1174, 2015, Volume 50, Issue 3, pp. 350 - 360
The number of hepatocellular carcinoma (HCC) patients with non-viral etiologies is increasing in Japan. We conducted a nation-wide survey to examine the...
Hepatocellular carcinoma | Retrospective study | Non-alcoholic fatty liver disease | Non-alcoholic steatohepatitis | Alcoholic liver disease | LIVER-CANCER | CHRONIC HEPATITIS-B | CIRRHOSIS | JAPAN | RISK | INFECTION | GASTROENTEROLOGY & HEPATOLOGY | Japan - epidemiology | Carcinoma, Hepatocellular - epidemiology | Prognosis | Humans | Middle Aged | Male | Liver Neoplasms - therapy | Hepatitis, Viral, Human - epidemiology | Liver Neoplasms - etiology | Non-alcoholic Fatty Liver Disease - complications | Liver Cirrhosis, Biliary - epidemiology | Liver Neoplasms - epidemiology | Female | Hepatitis, Autoimmune - epidemiology | Hepatitis, Viral, Human - complications | Carcinoma, Hepatocellular - etiology | Retrospective Studies | Body Mass Index | Liver Diseases, Alcoholic - epidemiology | Carcinoma, Hepatocellular - diagnosis | Risk Factors | Hepatitis, Autoimmune - complications | Liver Neoplasms - diagnosis | Survival Analysis | Liver Diseases, Alcoholic - complications | Aged | Carcinoma, Hepatocellular - therapy | Liver Cirrhosis, Biliary - complications | Non-alcoholic Fatty Liver Disease - epidemiology | Cohort Studies | Alcoholics | Development and progression | Hepatoma | Liver cirrhosis | Original —Liver, Pancreas, and Biliary Tract
Hepatocellular carcinoma | Retrospective study | Non-alcoholic fatty liver disease | Non-alcoholic steatohepatitis | Alcoholic liver disease | LIVER-CANCER | CHRONIC HEPATITIS-B | CIRRHOSIS | JAPAN | RISK | INFECTION | GASTROENTEROLOGY & HEPATOLOGY | Japan - epidemiology | Carcinoma, Hepatocellular - epidemiology | Prognosis | Humans | Middle Aged | Male | Liver Neoplasms - therapy | Hepatitis, Viral, Human - epidemiology | Liver Neoplasms - etiology | Non-alcoholic Fatty Liver Disease - complications | Liver Cirrhosis, Biliary - epidemiology | Liver Neoplasms - epidemiology | Female | Hepatitis, Autoimmune - epidemiology | Hepatitis, Viral, Human - complications | Carcinoma, Hepatocellular - etiology | Retrospective Studies | Body Mass Index | Liver Diseases, Alcoholic - epidemiology | Carcinoma, Hepatocellular - diagnosis | Risk Factors | Hepatitis, Autoimmune - complications | Liver Neoplasms - diagnosis | Survival Analysis | Liver Diseases, Alcoholic - complications | Aged | Carcinoma, Hepatocellular - therapy | Liver Cirrhosis, Biliary - complications | Non-alcoholic Fatty Liver Disease - epidemiology | Cohort Studies | Alcoholics | Development and progression | Hepatoma | Liver cirrhosis | Original —Liver, Pancreas, and Biliary Tract
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, p. e38322
Background: Nonalcoholic fatty liver disease (NAFLD) includes a broad range of liver pathologies from simple steatosis to cirrhosis and fibrosis, in which a...
STEATOHEPATITIS | I148M | VARIANT | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | Medical research | Fatty liver | Analysis | Genes | Genomics | Genetic research | Medicine, Experimental | Genetic aspects | Hyaluronic acid | Liver cirrhosis | Genetic polymorphisms | Haplotypes | Liver | Genomes | Iron | Single-nucleotide polymorphism | Metabolic syndrome | Epidemiology | Subgroups | Liver cancer | Rodents | Hepatology | Gastroenterology | Population | Degeneration | Genetic factors | Bioinformatics | Drug dosages | Chromosomes | Deoxyribonucleic acid--DNA | University graduates | Liver diseases | Internal medicine | Principal components analysis | Patients | Steatosis | Disease prevention | Medicine | Studies | Cirrhosis | Hospitals | Rheumatoid arthritis | Fibrosis | Biomarkers | Chromosome 22 | Genetic testing | Deoxyribonucleic acid | DNA
STEATOHEPATITIS | I148M | VARIANT | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | Medical research | Fatty liver | Analysis | Genes | Genomics | Genetic research | Medicine, Experimental | Genetic aspects | Hyaluronic acid | Liver cirrhosis | Genetic polymorphisms | Haplotypes | Liver | Genomes | Iron | Single-nucleotide polymorphism | Metabolic syndrome | Epidemiology | Subgroups | Liver cancer | Rodents | Hepatology | Gastroenterology | Population | Degeneration | Genetic factors | Bioinformatics | Drug dosages | Chromosomes | Deoxyribonucleic acid--DNA | University graduates | Liver diseases | Internal medicine | Principal components analysis | Patients | Steatosis | Disease prevention | Medicine | Studies | Cirrhosis | Hospitals | Rheumatoid arthritis | Fibrosis | Biomarkers | Chromosome 22 | Genetic testing | Deoxyribonucleic acid | DNA
Journal Article
Oncology, ISSN 0030-2414, 12/2007, Volume 72, Issue 1, pp. 2 - 15
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death not only in Japan but worldwide. Clinical Practice Guidelines for HCC were...
Paper | Consensus-based clinical practice manual | Evidence-based clinical practice guideline | Clinical practice guidelines, manual | Hepatocellular carcinoma, staging, surveillance, diagnostic algorithm, treatment algorithm | diagnostic algorithm | consensus-based clinical practice manual | HEPATIC ARTERIOGRAPHY | ADENOMATOUS HYPERPLASIA | PRACTICE GUIDELINES | JIS SCORE | manual | NATURAL-HISTORY | PROGNOSTIC STAGING SYSTEM | DYSPLASTIC NODULES | treatment algorithm | Clinical practice guidelines | evidence-based clinical practice guideline | ONCOLOGY | CIRRHOTIC LIVERS | surveillance | CLIP SCORE | staging | PATHOLOGICAL CORRELATION | hepatocellular carcinoma | Liver Transplantation | Age Factors | Humans | Middle Aged | Palliative Care | Liver Neoplasms - therapy | Antineoplastic Agents - administration & dosage | Embolization, Therapeutic | Hepatectomy | Societies, Medical | Carcinoma, Hepatocellular - blood supply | Liver Neoplasms - pathology | Liver Neoplasms - virology | Diagnosis, Differential | Carcinoma, Hepatocellular - diagnosis | Japan | Hepatic Artery | Carcinoma, Hepatocellular - virology | Evidence-Based Medicine | Consensus | Algorithms | Liver Neoplasms - diagnosis | Liver Neoplasms - blood supply | Carcinoma, Hepatocellular - pathology | Aged | Carcinoma, Hepatocellular - therapy | Decision Trees | Neoplasm Staging | Population Surveillance | Infusions, Intra-Arterial | Practice Guidelines as Topic | Medical diagnosis | Evidence-based medicine | Liver | Medical treatment | Cancer | Guidelines
Paper | Consensus-based clinical practice manual | Evidence-based clinical practice guideline | Clinical practice guidelines, manual | Hepatocellular carcinoma, staging, surveillance, diagnostic algorithm, treatment algorithm | diagnostic algorithm | consensus-based clinical practice manual | HEPATIC ARTERIOGRAPHY | ADENOMATOUS HYPERPLASIA | PRACTICE GUIDELINES | JIS SCORE | manual | NATURAL-HISTORY | PROGNOSTIC STAGING SYSTEM | DYSPLASTIC NODULES | treatment algorithm | Clinical practice guidelines | evidence-based clinical practice guideline | ONCOLOGY | CIRRHOTIC LIVERS | surveillance | CLIP SCORE | staging | PATHOLOGICAL CORRELATION | hepatocellular carcinoma | Liver Transplantation | Age Factors | Humans | Middle Aged | Palliative Care | Liver Neoplasms - therapy | Antineoplastic Agents - administration & dosage | Embolization, Therapeutic | Hepatectomy | Societies, Medical | Carcinoma, Hepatocellular - blood supply | Liver Neoplasms - pathology | Liver Neoplasms - virology | Diagnosis, Differential | Carcinoma, Hepatocellular - diagnosis | Japan | Hepatic Artery | Carcinoma, Hepatocellular - virology | Evidence-Based Medicine | Consensus | Algorithms | Liver Neoplasms - diagnosis | Liver Neoplasms - blood supply | Carcinoma, Hepatocellular - pathology | Aged | Carcinoma, Hepatocellular - therapy | Decision Trees | Neoplasm Staging | Population Surveillance | Infusions, Intra-Arterial | Practice Guidelines as Topic | Medical diagnosis | Evidence-based medicine | Liver | Medical treatment | Cancer | Guidelines
Journal Article
Journal of Gastroenterology, ISSN 0944-1174, 5/2014, Volume 49, Issue 5, pp. 941 - 953
Efficacy of available therapies for patients with HCV who have previously failed treatment is limited. Two Phase III, open-label trials in Japan investigated...
Simeprevir | Chronic hepatitis C | Medicine & Public Health | Colorectal Surgery | Treatment-experienced | Hepatology | Gastroenterology | Abdominal Surgery | Surgical Oncology | Sustained virologic response | TMC435 | TELAPREVIR | CHRONIC HEPATITIS-C | SUSTAINED VIROLOGICAL RESPONSE | PROTEASE INHIBITOR | INTERFERON-ALPHA-2B PLUS RIBAVIRIN | PEGYLATED INTERFERON | RESISTANCE | BOCEPREVIR | RETREATMENT | GASTROENTEROLOGY & HEPATOLOGY | EPIDEMIOLOGY | Recombinant Proteins - therapeutic use | Recurrence | Humans | Middle Aged | Hepacivirus - genetics | Polyethylene Glycols - adverse effects | Male | Recombinant Proteins - adverse effects | Polyethylene Glycols - therapeutic use | Young Adult | Ribavirin - administration & dosage | Adult | Female | Drug Therapy, Combination | Hepacivirus - isolation & purification | Drug Administration Schedule | Antiviral Agents - therapeutic use | Japan | Ribavirin - therapeutic use | Interferon-alpha - therapeutic use | Genotype | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Polyethylene Glycols - administration & dosage | Recombinant Proteins - administration & dosage | Interferon-alpha - administration & dosage | Sulfonamides - therapeutic use | Ribavirin - adverse effects | Antiviral Agents - adverse effects | Heterocyclic Compounds, 3-Ring - administration & dosage | Heterocyclic Compounds, 3-Ring - adverse effects | Heterocyclic Compounds, 3-Ring - therapeutic use | Sulfonamides - adverse effects | Aged | Interferon-alpha - adverse effects | Sulfonamides - administration & dosage | Medical research | Care and treatment | Medicine, Experimental | Genetic aspects | Interferon | Hepatitis C | Hepatitis C virus
Simeprevir | Chronic hepatitis C | Medicine & Public Health | Colorectal Surgery | Treatment-experienced | Hepatology | Gastroenterology | Abdominal Surgery | Surgical Oncology | Sustained virologic response | TMC435 | TELAPREVIR | CHRONIC HEPATITIS-C | SUSTAINED VIROLOGICAL RESPONSE | PROTEASE INHIBITOR | INTERFERON-ALPHA-2B PLUS RIBAVIRIN | PEGYLATED INTERFERON | RESISTANCE | BOCEPREVIR | RETREATMENT | GASTROENTEROLOGY & HEPATOLOGY | EPIDEMIOLOGY | Recombinant Proteins - therapeutic use | Recurrence | Humans | Middle Aged | Hepacivirus - genetics | Polyethylene Glycols - adverse effects | Male | Recombinant Proteins - adverse effects | Polyethylene Glycols - therapeutic use | Young Adult | Ribavirin - administration & dosage | Adult | Female | Drug Therapy, Combination | Hepacivirus - isolation & purification | Drug Administration Schedule | Antiviral Agents - therapeutic use | Japan | Ribavirin - therapeutic use | Interferon-alpha - therapeutic use | Genotype | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Polyethylene Glycols - administration & dosage | Recombinant Proteins - administration & dosage | Interferon-alpha - administration & dosage | Sulfonamides - therapeutic use | Ribavirin - adverse effects | Antiviral Agents - adverse effects | Heterocyclic Compounds, 3-Ring - administration & dosage | Heterocyclic Compounds, 3-Ring - adverse effects | Heterocyclic Compounds, 3-Ring - therapeutic use | Sulfonamides - adverse effects | Aged | Interferon-alpha - adverse effects | Sulfonamides - administration & dosage | Medical research | Care and treatment | Medicine, Experimental | Genetic aspects | Interferon | Hepatitis C | Hepatitis C virus
Journal Article
Cancer Letters, ISSN 0304-3835, 2011, Volume 310, Issue 2, pp. 140 - 147
Highlights â–º P300 is highly expressed in 47% of surgically resected HCC specimens by immunohistochemistry. â–º High expression of p300 in HCCs is a predictor of...
Hematology, Oncology and Palliative Medicine | HCC | Overall survival | E-cadherin | P300 | Tumor invasion | FACTOR-I HIF-1 | TRANSCRIPTIONAL COACTIVATOR P300 | BINDING-PROTEIN | BREAST-CANCER | INVASION | ONCOLOGY | GROWTH | HUMAN HEPATOCELLULAR-CARCINOMA | CANCER PROGRESSION | FREQUENT LOSS | E1A-Associated p300 Protein - biosynthesis | Immunohistochemistry | RNA, Small Interfering - genetics | Humans | Middle Aged | E1A-Associated p300 Protein - genetics | Immunoblotting | Male | Cadherins - biosynthesis | Carcinoma, Hepatocellular - genetics | Epithelial-Mesenchymal Transition | Female | Liver Neoplasms - pathology | Cadherins - genetics | Cell Dedifferentiation - physiology | Liver Neoplasms - genetics | Down-Regulation | Carcinoma, Hepatocellular - surgery | Liver Neoplasms - surgery | Cyclin D1 - biosynthesis | Cyclin D1 - genetics | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Survival Analysis | Cell Line, Tumor | Aged | Biomarkers, Tumor - genetics | Apoptosis - physiology | Neoplasm Staging | RNA, Small Interfering - administration & dosage | Biomarkers, Tumor - biosynthesis | Carcinoma, Hepatocellular - metabolism | Prognosis | Tumor proteins | Patient outcomes | Stem cells | Liver cancer | Hepatitis | Angiogenesis | Medical prognosis | Hypoxia | Gene expression | Tumors
Hematology, Oncology and Palliative Medicine | HCC | Overall survival | E-cadherin | P300 | Tumor invasion | FACTOR-I HIF-1 | TRANSCRIPTIONAL COACTIVATOR P300 | BINDING-PROTEIN | BREAST-CANCER | INVASION | ONCOLOGY | GROWTH | HUMAN HEPATOCELLULAR-CARCINOMA | CANCER PROGRESSION | FREQUENT LOSS | E1A-Associated p300 Protein - biosynthesis | Immunohistochemistry | RNA, Small Interfering - genetics | Humans | Middle Aged | E1A-Associated p300 Protein - genetics | Immunoblotting | Male | Cadherins - biosynthesis | Carcinoma, Hepatocellular - genetics | Epithelial-Mesenchymal Transition | Female | Liver Neoplasms - pathology | Cadherins - genetics | Cell Dedifferentiation - physiology | Liver Neoplasms - genetics | Down-Regulation | Carcinoma, Hepatocellular - surgery | Liver Neoplasms - surgery | Cyclin D1 - biosynthesis | Cyclin D1 - genetics | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Survival Analysis | Cell Line, Tumor | Aged | Biomarkers, Tumor - genetics | Apoptosis - physiology | Neoplasm Staging | RNA, Small Interfering - administration & dosage | Biomarkers, Tumor - biosynthesis | Carcinoma, Hepatocellular - metabolism | Prognosis | Tumor proteins | Patient outcomes | Stem cells | Liver cancer | Hepatitis | Angiogenesis | Medical prognosis | Hypoxia | Gene expression | Tumors
Journal Article
6.
Full Text
Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease
Journal of Gastroenterology, ISSN 0944-1174, 1/2011, Volume 46, Issue 1, pp. 101 - 107
Hyperlipidemia, insulin resistance, and oxidative stress can heavily contribute to the initiation and progression of nonalcoholic fatty liver disease (NAFLD)....
NAFLD | Medicine & Public Health | Fatty acid metabolism | Colorectal Surgery | Hepatology | Gastroenterology | Ezetimibe | Internal Medicine | Oncology | Insulin resistance | Lipid metabolism | Surgical Oncology | CONTROLLED-TRIAL | METFORMIN | VITAMIN-E | CLINICAL-TRIAL | ACIDS | OPEN-LABEL | VLDL1 | DIET | INSULIN-RESISTANCE | STEATOHEPATITIS | GASTROENTEROLOGY & HEPATOLOGY | Liver - pathology | Drug Administration Schedule | Fatty Liver - blood | Fatty Liver - pathology | Humans | Middle Aged | Male | Treatment Outcome | Biomarkers - blood | Fatty Liver - drug therapy | Anticholesteremic Agents - therapeutic use | Azetidines - administration & dosage | Azetidines - therapeutic use | Biopsy | Anticholesteremic Agents - administration & dosage | Liver Cirrhosis - classification | Non-alcoholic Fatty Liver Disease | Liver Cirrhosis - pathology | Adult | Female | Care and treatment | Low density lipoproteins | Anticholesteremic agents | Development and progression | Triglycerides | Insulin | Fatty acids | Cholesterol | Fatty liver | Leptin | Collagen | Universities and colleges
NAFLD | Medicine & Public Health | Fatty acid metabolism | Colorectal Surgery | Hepatology | Gastroenterology | Ezetimibe | Internal Medicine | Oncology | Insulin resistance | Lipid metabolism | Surgical Oncology | CONTROLLED-TRIAL | METFORMIN | VITAMIN-E | CLINICAL-TRIAL | ACIDS | OPEN-LABEL | VLDL1 | DIET | INSULIN-RESISTANCE | STEATOHEPATITIS | GASTROENTEROLOGY & HEPATOLOGY | Liver - pathology | Drug Administration Schedule | Fatty Liver - blood | Fatty Liver - pathology | Humans | Middle Aged | Male | Treatment Outcome | Biomarkers - blood | Fatty Liver - drug therapy | Anticholesteremic Agents - therapeutic use | Azetidines - administration & dosage | Azetidines - therapeutic use | Biopsy | Anticholesteremic Agents - administration & dosage | Liver Cirrhosis - classification | Non-alcoholic Fatty Liver Disease | Liver Cirrhosis - pathology | Adult | Female | Care and treatment | Low density lipoproteins | Anticholesteremic agents | Development and progression | Triglycerides | Insulin | Fatty acids | Cholesterol | Fatty liver | Leptin | Collagen | Universities and colleges
Journal Article
Laboratory Investigation, ISSN 0023-6837, 08/2010, Volume 90, Issue 8, pp. 1169 - 1178
Inflammatory processes have an important role in the development of hepatic steatosis and progression to nonalcoholic steatohepatitis (NASH). Interleukin-6...
MCD diet | NASH | SREBP-1 | IL-6 | STAT3 | MEDICINE, RESEARCH & EXPERIMENTAL | METABOLIC SYNDROME | ACTIVATED PROTEIN-KINASE | REGENERATION | MOUSE | NONALCOHOLIC STEATOHEPATITIS | PATHOLOGY | INSULIN-RESISTANCE | IN-VIVO | RECEPTOR ANTIBODY | DISEASE | ADIPOSE-TISSUE | Choline - metabolism | PPAR alpha - adverse effects | Diet - adverse effects | Genes | Choline Deficiency - complications | Male | Alanine Transaminase - blood | Methionine - adverse effects | Fatty Liver - chemically induced | Choline - adverse effects | Choline Deficiency - metabolism | Interleukin-6 - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Methionine - deficiency | Fatty Liver - metabolism | Signal Transduction | Methionine - metabolism | Liver - metabolism | Mice, Inbred C57BL | Fatty Liver - prevention & control | Interleukin-6 - adverse effects | Animals | Mice | Alanine Transaminase - metabolism | PPAR alpha - metabolism | Lipid Peroxidation | Receptors, Interleukin-6 - metabolism
MCD diet | NASH | SREBP-1 | IL-6 | STAT3 | MEDICINE, RESEARCH & EXPERIMENTAL | METABOLIC SYNDROME | ACTIVATED PROTEIN-KINASE | REGENERATION | MOUSE | NONALCOHOLIC STEATOHEPATITIS | PATHOLOGY | INSULIN-RESISTANCE | IN-VIVO | RECEPTOR ANTIBODY | DISEASE | ADIPOSE-TISSUE | Choline - metabolism | PPAR alpha - adverse effects | Diet - adverse effects | Genes | Choline Deficiency - complications | Male | Alanine Transaminase - blood | Methionine - adverse effects | Fatty Liver - chemically induced | Choline - adverse effects | Choline Deficiency - metabolism | Interleukin-6 - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Methionine - deficiency | Fatty Liver - metabolism | Signal Transduction | Methionine - metabolism | Liver - metabolism | Mice, Inbred C57BL | Fatty Liver - prevention & control | Interleukin-6 - adverse effects | Animals | Mice | Alanine Transaminase - metabolism | PPAR alpha - metabolism | Lipid Peroxidation | Receptors, Interleukin-6 - metabolism
Journal Article
Journal of Gastroenterology, ISSN 0944-1174, 1/2018, Volume 53, Issue 1, pp. 129 - 139
Recently we reported novel noninvasive scoring systems for diagnosing nonalcoholic steatohepatitis (NASH) and related fibrosis, namely FM-NASH index and...
Noninvasive diagnosis | Biomarker | Nonalcoholic steatohepatitis | Medicine & Public Health | Colorectal Surgery | Hepatology | Gastroenterology | Abdominal Surgery | Liver fibrosis | Surgical Oncology | BARD SCORE | DOMAIN | FATTY LIVER-DISEASE | BIOPSY | VALIDATION | MARKERS | AREA | NAFLD FIBROSIS | FERRITIN | GASTROENTEROLOGY & HEPATOLOGY | EPIDEMIOLOGY | Collagen Type IV - blood | Predictive Value of Tests | Liver Cirrhosis - diagnosis | Humans | Middle Aged | Logistic Models | Male | Biomarkers - blood | Aspartate Aminotransferases - blood | Non-alcoholic Fatty Liver Disease - diagnosis | Liver Cirrhosis - pathology | Adult | Female | ROC Curve | Aged | Aspartate | Diagnosis | Collagen | Analysis | Liver | Fibrosis | Liver diseases | Fatty liver | Collagen (type IV) | Aspartate aminotransferase | Medical diagnosis
Noninvasive diagnosis | Biomarker | Nonalcoholic steatohepatitis | Medicine & Public Health | Colorectal Surgery | Hepatology | Gastroenterology | Abdominal Surgery | Liver fibrosis | Surgical Oncology | BARD SCORE | DOMAIN | FATTY LIVER-DISEASE | BIOPSY | VALIDATION | MARKERS | AREA | NAFLD FIBROSIS | FERRITIN | GASTROENTEROLOGY & HEPATOLOGY | EPIDEMIOLOGY | Collagen Type IV - blood | Predictive Value of Tests | Liver Cirrhosis - diagnosis | Humans | Middle Aged | Logistic Models | Male | Biomarkers - blood | Aspartate Aminotransferases - blood | Non-alcoholic Fatty Liver Disease - diagnosis | Liver Cirrhosis - pathology | Adult | Female | ROC Curve | Aged | Aspartate | Diagnosis | Collagen | Analysis | Liver | Fibrosis | Liver diseases | Fatty liver | Collagen (type IV) | Aspartate aminotransferase | Medical diagnosis
Journal Article
Laboratory Investigation, ISSN 0023-6837, 04/2011, Volume 91, Issue 4, pp. 609 - 618
Our previous study revealed that blockade of interleukin-6 (IL-6)-STAT3 signaling ameliorated liver injury, although hepatic STAT3(-/-) or GP130(-/-) mice have...
IL-6 receptor | MCD diet | NASH | db/db mice | IL-6 | STAT3 | MEDICINE, RESEARCH & EXPERIMENTAL | HEPATOCYTES | REGENERATION | NONALCOHOLIC STEATOHEPATITIS | PATHOLOGY | INTERLEUKIN-6 | INSULIN-RESISTANCE | RECEPTOR ANTIBODY | IN-VIVO | DISEASE | LEPTIN RECEPTOR | HEPATIC STEATOSIS | Antibodies, Neutralizing - administration & dosage | Liver - pathology | Interleukin-6 - antagonists & inhibitors | Fatty Liver - pathology | Leptin - metabolism | Hepatocytes - pathology | Male | Choline Deficiency | DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics | Receptors, Interleukin-6 - immunology | Methionine - deficiency | Gene Expression | Signal Transduction | Fatty Liver - physiopathology | Mice, Inbred C57BL | Injections, Intraperitoneal | Rats | Animals | Diet | Fibrosis | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | DNA-(Apurinic or Apyrimidinic Site) Lyase - antagonists & inhibitors | Mice | STAT3 Transcription Factor - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis
IL-6 receptor | MCD diet | NASH | db/db mice | IL-6 | STAT3 | MEDICINE, RESEARCH & EXPERIMENTAL | HEPATOCYTES | REGENERATION | NONALCOHOLIC STEATOHEPATITIS | PATHOLOGY | INTERLEUKIN-6 | INSULIN-RESISTANCE | RECEPTOR ANTIBODY | IN-VIVO | DISEASE | LEPTIN RECEPTOR | HEPATIC STEATOSIS | Antibodies, Neutralizing - administration & dosage | Liver - pathology | Interleukin-6 - antagonists & inhibitors | Fatty Liver - pathology | Leptin - metabolism | Hepatocytes - pathology | Male | Choline Deficiency | DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics | Receptors, Interleukin-6 - immunology | Methionine - deficiency | Gene Expression | Signal Transduction | Fatty Liver - physiopathology | Mice, Inbred C57BL | Injections, Intraperitoneal | Rats | Animals | Diet | Fibrosis | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | DNA-(Apurinic or Apyrimidinic Site) Lyase - antagonists & inhibitors | Mice | STAT3 Transcription Factor - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis
Journal Article
Journal of Gastroenterology, ISSN 0944-1174, 4/2017, Volume 52, Issue 4, pp. 520 - 533
Elbasvir (EBR) in combination with grazoprevir (GZR) has demonstrated efficacy in patients with hepatitis C virus (HCV) infections in trials primarily...
Therapy | Medicine & Public Health | Colorectal Surgery | Hepatology | Gastroenterology | Abdominal Surgery | Clinical trial | Genotype | Efficacy | Surgical Oncology | Sustained virologic response | MK-8742 | MK-5172 | OPEN-LABEL | RIBAVIRIN | TRIAL | TREATMENT-NAIVE | HEPATITIS-C VIRUS | CIRRHOSIS | GENOTYPE 1 INFECTION | INHIBITOR | GASTROENTEROLOGY & HEPATOLOGY | Quinoxalines - adverse effects | Humans | Middle Aged | Drug Resistance, Viral | Hepacivirus - genetics | Hepatitis C, Chronic - virology | Imidazoles - administration & dosage | Benzofurans - administration & dosage | Male | RNA, Viral - blood | Benzofurans - blood | Hepatitis C, Chronic - complications | Quinoxalines - blood | Young Adult | Aged, 80 and over | Adult | Female | Imidazoles - therapeutic use | Drug Therapy, Combination | Quinoxalines - therapeutic use | Hepacivirus - drug effects | Hepacivirus - isolation & purification | Liver Cirrhosis - drug therapy | Benzofurans - therapeutic use | Double-Blind Method | Drug Administration Schedule | Quinoxalines - administration & dosage | Administration, Oral | Antiviral Agents - blood | Antiviral Agents - therapeutic use | Imidazoles - adverse effects | Treatment Outcome | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Benzofurans - adverse effects | Hepatitis C, Chronic - blood | Imidazoles - blood | Liver Cirrhosis - virology | Antiviral Agents - adverse effects | Aged | Sustained Virologic Response | Medicine, Experimental | Clinical trials | Medical research | Hepatitis C virus | Health aspects | Original —Liver, Pancreas, and Biliary Tract
Therapy | Medicine & Public Health | Colorectal Surgery | Hepatology | Gastroenterology | Abdominal Surgery | Clinical trial | Genotype | Efficacy | Surgical Oncology | Sustained virologic response | MK-8742 | MK-5172 | OPEN-LABEL | RIBAVIRIN | TRIAL | TREATMENT-NAIVE | HEPATITIS-C VIRUS | CIRRHOSIS | GENOTYPE 1 INFECTION | INHIBITOR | GASTROENTEROLOGY & HEPATOLOGY | Quinoxalines - adverse effects | Humans | Middle Aged | Drug Resistance, Viral | Hepacivirus - genetics | Hepatitis C, Chronic - virology | Imidazoles - administration & dosage | Benzofurans - administration & dosage | Male | RNA, Viral - blood | Benzofurans - blood | Hepatitis C, Chronic - complications | Quinoxalines - blood | Young Adult | Aged, 80 and over | Adult | Female | Imidazoles - therapeutic use | Drug Therapy, Combination | Quinoxalines - therapeutic use | Hepacivirus - drug effects | Hepacivirus - isolation & purification | Liver Cirrhosis - drug therapy | Benzofurans - therapeutic use | Double-Blind Method | Drug Administration Schedule | Quinoxalines - administration & dosage | Administration, Oral | Antiviral Agents - blood | Antiviral Agents - therapeutic use | Imidazoles - adverse effects | Treatment Outcome | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Benzofurans - adverse effects | Hepatitis C, Chronic - blood | Imidazoles - blood | Liver Cirrhosis - virology | Antiviral Agents - adverse effects | Aged | Sustained Virologic Response | Medicine, Experimental | Clinical trials | Medical research | Hepatitis C virus | Health aspects | Original —Liver, Pancreas, and Biliary Tract
Journal Article
11.
Full Text
Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population
BMC Gastroenterology, ISSN 1471-230X, 01/2012, Volume 12, Issue 1, pp. 2 - 2
Background: A reliable and inexpensive noninvasive marker of hepatic fibrosis is required in patients with nonalcoholic fatty liver disease (NAFLD). FIB4 index...
NAFLD | SIMPLE NONINVASIVE INDEX | CLINICAL SCORING SYSTEM | PREDICT | MARKER | SIGNIFICANT FIBROSIS | CIRRHOSIS | STEATOHEPATITIS | GASTROENTEROLOGY & HEPATOLOGY | IV COLLAGEN 7S | HYALURONIC-ACID | Liver Cirrhosis - ethnology | Predictive Value of Tests | Liver - pathology | Age Factors | Humans | Middle Aged | Male | Alanine Transaminase - blood | Fatty Liver - ethnology | Non-alcoholic Fatty Liver Disease | Adult | Female | Retrospective Studies | Severity of Illness Index | Liver Cirrhosis - diagnosis | Fatty Liver - blood | Japan | Liver Cirrhosis - blood | Fatty Liver - diagnosis | Platelet Count | Aspartate Aminotransferases - blood | Biopsy | Biomarkers | ROC Curve | Aged | Cohort Studies | Fatty liver | Research | Biological markers | Comparative analysis | Testing | Science | Hepatitis | Liver cirrhosis | Colleges & universities
NAFLD | SIMPLE NONINVASIVE INDEX | CLINICAL SCORING SYSTEM | PREDICT | MARKER | SIGNIFICANT FIBROSIS | CIRRHOSIS | STEATOHEPATITIS | GASTROENTEROLOGY & HEPATOLOGY | IV COLLAGEN 7S | HYALURONIC-ACID | Liver Cirrhosis - ethnology | Predictive Value of Tests | Liver - pathology | Age Factors | Humans | Middle Aged | Male | Alanine Transaminase - blood | Fatty Liver - ethnology | Non-alcoholic Fatty Liver Disease | Adult | Female | Retrospective Studies | Severity of Illness Index | Liver Cirrhosis - diagnosis | Fatty Liver - blood | Japan | Liver Cirrhosis - blood | Fatty Liver - diagnosis | Platelet Count | Aspartate Aminotransferases - blood | Biopsy | Biomarkers | ROC Curve | Aged | Cohort Studies | Fatty liver | Research | Biological markers | Comparative analysis | Testing | Science | Hepatitis | Liver cirrhosis | Colleges & universities
Journal Article
Journal of Gastroenterology, ISSN 0944-1174, 5/2019, Volume 54, Issue 5, pp. 474 - 475
Journal Article