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1. HDR: A statistical two-step approach successfully identifies disease genes in autosomal recessive families
by Imai, Atsuko and Kohda, Masakazu and Nakaya, Akihiro and Sakata, Yasushi and Murayama, Kei and Ohtake, Akira and Lathrop, Mark and Okazaki, Yasushi and Ott, Jurg
Journal of Human Genetics, ISSN 1434-5161, 11/2016, Volume 61, Issue 11, pp. 959 - 963
In the search for sequence variants underlying disease, commonly applied filtering steps usually result in a number of candidate variants that cannot further... 
GENOMEWIDE SCANS | HOMOZYGOSITY | DNA | LENGTH | GENETICS & HEREDITY | HAMMING DISTANCE | TRUE | MUTATIONS | SEQUENCING DATA | FALSE-POSITIVE PEAKS | CHILDREN | Computational Biology - methods | Genetic Predisposition to Disease | Pedigree | Humans | Genetic Association Studies - methods | Genotype | Software | Genes, Recessive | Case-Control Studies | Genetic Linkage
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2. Full Text HDR‐del: A tool based on Hamming distance for prioritizing pathogenic chromosomal deletions in exome sequencing
by Imai‐Okazaki, Atsuko and Kohda, Masakazu and Kobayashi, Kaori and Hirata, Tomoko and Sakata, Yasushi and Murayama, Kei and Ohtake, Akira and Okazaki, Yasushi and Nakaya, Akihiro and Ott, Jurg
Human Mutation, ISSN 1059-7794, 12/2017, Volume 38, Issue 12, pp. 1796 - 1800
High‐density oligonucleotide arrays have widely been used to detect pathogenic chromosomal deletions. In addition to high‐density oligonucleotide arrays,... 
exome sequencing | chromosomal deletion | Hamming distance | copy‐number variations | runs of homozygosity | mitochondrial disease | copy-number variations | GENETICS & HEREDITY | COPY-NUMBER VARIATION | Chromosome Deletion | Mitochondrial Diseases - genetics | Homozygote | Exome - genetics | Datasets as Topic | Oligonucleotide Array Sequence Analysis | Humans | Statistics as Topic | Child | Whole Exome Sequencing - methods | Chromosomes, Human, Pair 17 - genetics | DNA Copy Number Variations | Medicine, Experimental | Medical research | Depth perception | Mitochondria | Chromosome deletion | DNA microarrays | Clonal deletion | Gene deletion | Index Medicus
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3. Maboroshi no Rōran Karahoto
by Inoue, Yasushi, 1907-1991 and Okazaki, Takashi, 1923-1990 and NHK Shuzaihan
1980, Shiruku Rōdo, Volume dai 3-kan, 235 p., [32] leaves of plates
Xinjiang Uygur Zizhiqu (China) Antiquities | China Antiquities | Xinjiang Uygur Zizhiqu (China) Description and travel | Silk Road
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4. Full Text Relationship Between Bacteremia and Hemorrhagic Stroke in Patients With Continuous-Flow Left Ventricular Assist Device
by Yoshioka, Daisuke and Sakaniwa, Ryoto and Toda, Koichi and Samura, Takaaki and Saito, Shunsuke and Kashiyama, Noriyuki and Okazaki, Shuhei and Domae, Keitaro and Yoshikawa, Yasushi and Miyagawa, Shigeru and Iso, Hiroyasu and Sakata, Yasushi and Sawa, Yoshiki
Circulation Journal, ISSN 1346-9843, 2018, Volume 82, Issue 2, pp. 448 - 456
Background:Blood stream infection is thought to increase the risk of hemorrhagic stroke, a major adverse event with devastating outcome, in patients with... 
Hemorrhagic stroke | Bacteremia | Left ventricular assist device (LVAD) | MORTALITY | SUPPORT | CARDIAC & CARDIOVASCULAR SYSTEMS | BLOOD-STREAM INFECTION | RISK-FACTORS | COMPLICATIONS | VALVE | ENDOCARDITIS | INTRACRANIAL HEMORRHAGE | Stroke - microbiology | Intracranial Hemorrhages - microbiology | Humans | Middle Aged | Risk Factors | Bacteremia - complications | Male | Time Factors | Adult | Female | Chronic Disease | Heart-Assist Devices | Heart Ventricles - pathology | Index Medicus
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5. Full Text Zui Tō teikoku godaishi
by Okazaki, Fumio, 1888 and Kawai, Yasushi, 1958 and Akizuki, Kan'ei, 1922
1995, Shohan., Tōyō bunko, ISBN 9784582805871, Volume 587
Tang Dynasty (China) | 581-979 | China History | China
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6. Full Text Reply to the “Letter to the Editor” from Dr. J Finsterer and colleagues
by Hisatomi, Yuichiro and Murayama, Kei and Ohtake, Akira and Okazaki, Yasushi
neurogenetics, ISSN 1364-6745, 3/2019, Volume 20, Issue 1, pp. 55 - 56
Human Genetics | Neurosciences | Molecular Medicine | Biomedicine
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7. Full Text Tysnd1 Deficiency in Mice Interferes with the Peroxisomal Localization of PTS2 Enzymes, Causing Lipid Metabolic Abnormalities and Male Infertility
by Mizuno, Yumi and Ninomiya, Yuichi and Nakachi, Yutaka and Iseki, Mioko and Iwasa, Hiroyasu and Akita, Masumi and Tsukui, Tohru and Shimozawa, Nobuyuki and Ito, Chizuru and Toshimori, Kiyotaka and Nishimukai, Megumi and Hara, Hiroshi and Maeba, Ryouta and Okazaki, Tomoki and Alodaib, Ali Nasser Ali and Amoudi, Mohammed Al and Jacob, Minnie and Alkuraya, Fowzan S and Horai, Yasushi and Watanabe, Mitsuhiro and Motegi, Hiromi and Wakana, Shigeharu and Noda, Tetsuo and Kurochkin, Igor V and Mizuno, Yosuke and Schönbach, Christian and Okazaki, Yasushi
PLoS Genetics, ISSN 1553-7390, 02/2013, Volume 9, Issue 2, pp. e1003286 - e1003286
Peroxisomes are subcellular organelles involved in lipid metabolic processes, including those of very-long-chain fatty acids and branched-chain fatty acids,... 
ALKYL-DIHYDROXYACETONEPHOSPHATE-SYNTHASE | ACID BETA-OXIDATION | BIOGENESIS DISORDERS | ALZHEIMERS-DISEASE | GENETICS & HEREDITY | TARGETING SIGNAL TYPE-2 | ZELLWEGER SYNDROME | FATTY-ACIDS | MULTIFUNCTIONAL PROTEIN-2 | RHIZOMELIC CHONDRODYSPLASIA PUNCTATA | PHYTANIC ACID | Serine Proteases - genetics | Serine Proteases - metabolism | Amino Acid Sequence | Oxidation-Reduction | Peroxisomal Targeting Signal 2 Receptor | Humans | Male | Receptors, Cytoplasmic and Nuclear - genetics | Peroxisomes - metabolism | Animals | Infertility, Male - genetics | Biological Transport | Protein Sorting Signals - genetics | Cysteine Endopeptidases - genetics | Infertility, Male - metabolism | Lipid Metabolism - genetics | Mice | Receptors, Cytoplasmic and Nuclear - metabolism | Peroxisomes | Infertility, Male | Physiological aspects | Metabolic diseases | Genetic aspects | Lipid metabolism | Health aspects | Proteins | Enzymes | Scholarships & fellowships | Infertility | Biosynthesis | Metabolism | Polyamines | Fatty acids | Index Medicus
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8. Full Text Deficiency of Starch Synthase IIIa and IVb Alters Starch Granule Morphology from Polyhedral to Spherical in Rice Endosperm
by Yoshiko Toyosawa and Yasushi Kawagoe and Ryo Matsushima and Naoko Crofts and Masahiro Ogawa and Masako Fukuda and Toshihiro Kumamaru and Yozo Okazaki and Miyako Kusano and Kazuki Saito and Kiminori Toyooka and Mayuko Sato and Yongfeng Ai and Jay-Lin Jane and Yasunori Nakamura and Naoko Fujita
Plant Physiology, ISSN 0032-0889, 3/2016, Volume 170, Issue 3, pp. 1255 - 1270
Starch granule morphology differs markedly among plant species. However, the mechanisms controlling starch granule morphology have not been elucidated. Rice (... 
BIOCHEMISTRY AND METABOLISM | Recombinant Proteins - metabolism | Endosperm - metabolism | Microscopy, Electron, Transmission | Microscopy, Electron, Scanning | Oryza - metabolism | Starch - metabolism | Lipid Metabolism | Recombinant Proteins - genetics | Phylogeny | Starch - ultrastructure | Plant Proteins - genetics | Starch - chemistry | Oryza - genetics | Endosperm - ultrastructure | Plastids - ultrastructure | Starch Synthase - genetics | Plants, Genetically Modified | Plastids - metabolism | Plant Proteins - metabolism | Mutation | Starch Synthase - deficiency | DNA, Plant - genetics | Physiological aspects | Enzymes | Starch | Rice | Index Medicus
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9. Full Text A Comprehensive Genomic Analysis Reveals the Genetic Landscape of Mitochondrial Respiratory Chain Complex Deficiencies
by Kohda, Masakazu and Tokuzawa, Yoshimi and Kishita, Yoshihito and Nyuzuki, Hiromi and Moriyama, Yohsuke and Mizuno, Yosuke and Hirata, Tomoko and Yatsuka, Yukiko and Yamashita-Sugahara, Yzumi and Nakachi, Yutaka and Kato, Hidemasa and Okuda, Akihiko and Tamaru, Shunsuke and Borna, Nurun Nahar and Banshoya, Kengo and Aigaki, Toshiro and Sato-Miyata, Yukiko and Ohnuma, Kohei and Suzuki, Tsutomu and Nagao, Asuteka and Maehata, Hazuki and Matsuda, Fumihiko and Higasa, Koichiro and Nagasaki, Masao and Yasuda, Jun and Yamamoto, Masayuki and Fushimi, Takuya and Shimura, Masaru and Kaiho-Ichimoto, Keiko and Harashima, Hiroko and Yamazaki, Taro and Mori, Masato and Murayama, Kei and Ohtake, Akira and Okazaki, Yasushi
PLoS Genetics, ISSN 1553-7390, 2016, Volume 12, Issue 1, pp. e1005679 - e1005679
Mitochondrial disorders have the highest incidence among congenital metabolic disorders characterized by biochemical respiratory chain complex deficiencies. It... 
RETT-SYNDROME | RNA | I DEFICIENCY | HIGH-THROUGHPUT | DNA | GENETICS & HEREDITY | DISORDERS | MUTATIONS | SEQUENCING DATA | MOLECULAR-BASIS | EXPRESSION | Mitochondrial Diseases - genetics | Mitochondrial Diseases - pathology | Humans | Child, Preschool | INDEL Mutation - genetics | Infant | Male | Mitochondria - pathology | Genetic Heterogeneity | Exome - genetics | DNA, Mitochondrial - genetics | Mitochondria - genetics | Adolescent | Chromosome Aberrations | Fibroblasts | Polymorphism, Single Nucleotide - genetics | Female | High-Throughput Nucleotide Sequencing | Child | Infant, Newborn | Mitochondrial Diseases - diagnosis | Physiological aspects | Mitochondrial diseases | Index Medicus | Medical research | Disease | Innovations | Science | Mitochondrial DNA | Genomes | Grants | Studies | Mitochondria | Insects | Deoxyribonucleic acid | Mutation | Metabolic disorders
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10. Full Text A phase II study of combination therapy with oral S-1 and cisplatin in elderly patients with advanced gastric cancer
by Sasaki, Yusuke and Iwasa, Satoru and Okazaki, Shunsuke and Goto, Masahiro and Kojima, Yasushi and Naganuma, Atsushi and Nagashima, Kengo and Nagai, Yushi and Hirano, Hidekazu and Honma, Yoshitaka and Takashima, Atsuo and Kato, Ken and Hamaguchi, Tetsuya
Gastric Cancer, ISSN 1436-3291, 5/2018, Volume 21, Issue 3, pp. 439 - 445
A combination of S-1 and cisplatin is recognized as one of the standard first-line chemotherapy regimens for patients with advanced gastric cancer. However,... 
Elderly patient | Medicine & Public Health | S-1 | Gastroenterology | Abdominal Surgery | Oncology | Cancer Research | Surgical Oncology | Gastric cancer | Cisplatin | 1ST-LINE TREATMENT | GASTROESOPHAGEAL ADENOCARCINOMA | METHOTREXATE | OXALIPLATIN | FLUOROURACIL | CHEMOTHERAPY | TRIAL | SUPPORTIVE CARE | 5-FLUOROURACIL | ONCOLOGY | GASTROENTEROLOGY & HEPATOLOGY | PLUS | Administration, Oral | Humans | Tegafur - adverse effects | Kaplan-Meier Estimate | Male | Treatment Outcome | Oxonic Acid - administration & dosage | Stomach Neoplasms - drug therapy | Adenocarcinoma - drug therapy | Oxonic Acid - adverse effects | Cisplatin - administration & dosage | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged, 80 and over | Cisplatin - adverse effects | Tegafur - administration & dosage | Female | Aged | Stomach Neoplasms - mortality | Drug Combinations | Adenocarcinoma - mortality | Antimitotic agents | Medical research | Care and treatment | Cancer patients | Chemotherapy | Analysis | Medicine, Experimental | Aged patients | Antineoplastic agents | Stomach cancer | Cancer | Creatinine | Hyponatremia | Renal function | Clinical trials | Cancer therapies | Survival | Patients | Older people | Neutropenia | Geriatrics | Index Medicus
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11. Full Text Preexisting severe cervical spinal cord compression is a significant risk factor for severe paralysis development in patients with traumatic cervical spinal cord injury without bone injury: a retrospective cohort study
by Oichi, Takeshi and Oshima, Yasushi and Okazaki, Rentaro and Azuma, Seiichi
European Spine Journal, ISSN 0940-6719, 1/2016, Volume 25, Issue 1, pp. 96 - 102
The objective of this study is to investigate whether preexisting severe cervical spinal cord compression affects the severity of paralysis once patients... 
Cervical spinal cord compression | Surgical Orthopedics | Medicine & Public Health | Soft tissue damage | Neurosurgery | Spinal cord injury | Fused vertebra | Cervical spine | CANAL COMPROMISE | STENOSIS | MRI FINDINGS | POSTERIOR LONGITUDINAL LIGAMENT | CLASSIFICATION | RELIABILITY | CLINICAL NEUROLOGY | FRACTURE | DISLOCATION | OSSIFICATION | ORTHOPEDICS | Severity of Illness Index | Spinal Cord Injuries - complications | Cervical Vertebrae - injuries | Humans | Middle Aged | Risk Factors | Male | Abbreviated Injury Scale | Young Adult | Soft Tissue Injuries - complications | Spinal Cord Compression - complications | Adolescent | Aged, 80 and over | Adult | Female | Aged | Retrospective Studies | Paralysis - etiology | Cohort Studies | Medicine, Experimental | Medical research | Paralysis | Risk factors | Spinal cord compression | Index Medicus
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12. Full Text Demeanor of rivaroxaban in activated/inactivated FXa
by Seki, Kaname and Mizuno, Yosuke and Sakashita, Toku and Nakano, Shintaro and Tanno, Jun and Okazaki, Yasushi and Muramatsu, Toshihiro and Nishimura, Shigeyuki and Senbonmatsu, Takaaki
Journal of Pharmacological Sciences, ISSN 1347-8613, 03/2017, Volume 133, Issue 3, pp. 156 - 161
Activated factor X (FXa) plays an important role in thrombin generation and inflammation. Factor X is not converted constitutively to FXa, but only after... 
Rivaroxaban | Anticoagulant | Inflammation | Activated factor X | Gene modulation | TISSUE FACTOR ACTIVITY | ANTICOAGULANTS | THROMBIN | ACTIVATED RECEPTORS | ATORVASTATIN | PHARMACOLOGY & PHARMACY | COAGULATION-FACTOR XA | GENERATION | EXPRESSION | Interleukin-8 - genetics | Human Umbilical Vein Endothelial Cells - drug effects | Factor Xa - pharmacology | Human Umbilical Vein Endothelial Cells - metabolism | Oligonucleotide Array Sequence Analysis | Humans | Intercellular Adhesion Molecule-1 - genetics | Cells, Cultured | Chemokine CCL2 - genetics | Factor Xa Inhibitors - pharmacology | Rivaroxaban - pharmacology | Receptors, Proteinase-Activated - genetics | Patient outcomes | Drug metabolism | Genotype | Genetic aspects | Blood coagulation factors | Gene expression | Health aspects | Index Medicus
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13. Full Text Characteristics of MUTYH variants in Japanese colorectal polyposis patients
by Takao, Misato and Yamaguchi, Tatsuro and Eguchi, Hidetaka and Tada, Yuhki and Kohda, Masakazu and Koizumi, Koichi and Horiguchi, Shin-ichiro and Okazaki, Yasushi and Ishida, Hideyuki
International Journal of Clinical Oncology, ISSN 1341-9625, 6/2018, Volume 23, Issue 3, pp. 497 - 503
The base excision repair gene MUTYH is the causative gene of colorectal polyposis syndrome, which is an autosomal recessive disorder associated with a high... 
Hereditary colorectal tumor | Medicine & Public Health | Multiple colorectal tumors | MUTYH gene | Oncology | Cancer Research | Surgical Oncology | PROTEIN | GERM-LINE MUTATIONS | ONCOLOGY | APC GENE | RISK | FAMILIAL ADENOMATOUS POLYPOSIS | CANCER | MYH | CARRIERS | Adenomatous Polyposis Coli - etiology | European Continental Ancestry Group - genetics | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | DNA Glycosylases - genetics | Male | Adenomatous Polyposis Coli - pathology | Genetic Variation | Adolescent | Alleles | Adult | Female | Aged | Mutation | Adenomatous Polyposis Coli - genetics | Cohort Studies | Animal genetics | Anopheles | Gastrointestinal diseases | Oncology, Experimental | Genes | Genomics | Colorectal cancer | Research | Health aspects | Genetic screening | Cancer | Index Medicus
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14. Full Text Increased Levels of Interleukin 33 in Sera and Synovial Fluid from Patients with Active Rheumatoid Arthritis
by YASUSHI MATSUYAMA and HITOAKI OKAZAKI and HIROYUKI TAMEMOTO and HIROTAKA KIMURA and YASUYUKI KAMATA and KATSUYA NAGATANI and TAKAO NAGASHIMA and MORISADA HAYAKAWA and MASAHIRO IWAMOTO and TAKU YOSHIO and SHIN-ICHI TOMINAGA and SEIJI MINOTA
The Journal of Rheumatology, ISSN 0315-162X, 01/2010, Volume 37, Issue 1, pp. 18 - 25
Objective. To determine levels of interleukin 33 (IL-33) in serum and synovial fluid (SF) and their clinical associations in patients with rheumatoid arthritis... 
Interleukin 33 | Rheumatoid arthritis | Disease activity | PROTEIN | DISEASE ACTIVITY | INTERLEUKIN 33 | MAST-CELLS | RECEPTOR | CYTOKINE | RHEUMATOLOGY | MATURATION | IL-33 | ST2 | INFLAMMATION | IN-VIVO | RHEUMATOID ARTHRITIS | DIFFERENTIATION | Interleukin-33 | Humans | Middle Aged | Cells, Cultured | Joints - pathology | Male | Interleukins - metabolism | Arthritis, Rheumatoid - pathology | Synovial Fluid - immunology | Arthritis, Rheumatoid - metabolism | Animals | Arthritis, Rheumatoid - drug therapy | Joints - immunology | Leukocytes, Mononuclear - immunology | Aged, 80 and over | Adult | Female | Leukocytes, Mononuclear - cytology | Signal Transduction - physiology | Aged | Mice | Arthritis, Rheumatoid - physiopathology | Antirheumatic Agents - therapeutic use | Index Medicus
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15. Full Text Comparison of the Japanese Orthopaedic Association (JOA) score and modified JOA (mJOA) score for the assessment of Cervical Myelopathy: A multicenter observational study
by Kato, So and Oshima, Yasushi and Oka, Hiroyuki and Chikuda, Hirotaka and Takeshita, Yujiro and Miyoshi, Kota and Kawamura, Naohiro and Masuda, Kazuhiro and Kunogi, Junichi and Okazaki, Rentaro and Azuma, Seiichi and Hara, Nobuhiro and Tanaka, Sakae and Takeshita, Katsushi
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0123022 - e0123022
Objectives The Japanese Orthopaedic Association (JOA) score is widely used to assess the severity of clinical symptoms in patients with cervical compressive... 
SPONDYLOTIC MYELOPATHY | LIGAMENT | MULTIDISCIPLINARY SCIENCES | DECOMPRESSION | RELIABILITY | AGREEMENT | VALIDITY | Disability Evaluation | Severity of Illness Index | Spinal Cord Diseases - diagnosis | Prospective Studies | Orthopedics - methods | Outcome Assessment (Health Care) | Humans | Japan | Middle Aged | Treatment Outcome | Spinal Cord Diseases - surgery | Decompression, Surgical | Cervical Vertebrae - surgery | Surveys and Questionnaires | Correlation coefficient | Spinal cord | Signs and symptoms | Correlation coefficients | Central nervous system diseases | Neurosurgery | Patients | Recovery | Validity | Hospitals | Correlation analysis | Surgery | Rheumatoid arthritis | Orthopedics | Questionnaires | Surgeons | Measurement methods | Neck | Decompression | Index Medicus
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16. Full Text Noninvasive diagnosis of TRIT1‐related mitochondrial disorder by measuring i6A37 and ms2i6A37 modifications in tRNAs from blood and urine samples
by Takenouchi, Toshiki and Wei, Fan‐Yan and Suzuki, Hisato and Uehara, Tomoko and Takahashi, Takao and Okazaki, Yasushi and Kosaki, Kenjiro and Tomizawa, Kazuhito
American Journal of Medical Genetics Part A, ISSN 1552-4825, 08/2019, Volume 179, Issue 8, pp. 1609 - 1614
Subsets of mitochondrial transfer RNA (tRNA) contain the N 6 ‐isopentenyladenosine (i 6 A) or 2‐methylthio ‐N 6 ‐isopentenyladenosine (ms 2 i 6 A) modification... 
Measurement | Analysis | Epilepsy | Physiological aspects | Diagnosis | Mass spectrometry | Transfer RNA | Urine | Energy metabolism | Phosphorylation | Biochemical analysis | tRNA | Mass spectroscopy | Ribonucleic acid--RNA | tRNA isopentenyltransferase | Mitochondria | Missense mutation | Oxidative phosphorylation | Biopsy | Peripheral blood | Mutation | Hepatotoxicity | Seizures
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