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humans (36) 36
life sciences & biomedicine (36) 36
science & technology (36) 36
cardiovascular system & cardiology (34) 34
cardiac & cardiovascular systems (33) 33
heart failure (30) 30
male (25) 25
female (23) 23
middle aged (20) 20
biological and medical sciences (19) 19
cardiology. vascular system (19) 19
medical sciences (19) 19
abridged index medicus (17) 17
cardiovascular (17) 17
heart (16) 16
aged (15) 15
chronic disease (15) 15
cardiology and cardiovascular medicine (13) 13
prognosis (13) 13
heart failure, cardiogenic pulmonary edema, cardiac enlargement (12) 12
mortality (12) 12
anemias. hemoglobinopathies (9) 9
diseases of red blood cells (9) 9
heart failure - complications (9) 9
hematologic and hematopoietic diseases (9) 9
peripheral vascular disease (9) 9
retrospective studies (8) 8
risk factors (8) 8
adult (7) 7
anemia (7) 7
cardiac patients (7) 7
heart failure - blood (7) 7
heart failure - drug therapy (7) 7
heart failure - mortality (7) 7
heart failure - physiopathology (7) 7
internal medicine (7) 7
physiological aspects (7) 7
studies (7) 7
aged, 80 and over (6) 6
exercise (6) 6
follow-up studies (6) 6
heart failure - diagnosis (6) 6
iron (6) 6
treatment outcome (6) 6
anemia - etiology (5) 5
congenital heart disease (5) 5
exercise test (5) 5
health aspects (5) 5
heart defects, congenital - physiopathology (5) 5
heart diseases (5) 5
oxygen consumption (5) 5
prospective studies (5) 5
anaemia (4) 4
cardiology (4) 4
cardiomyopathy (4) 4
cardiovascular disease (4) 4
cells, cultured (4) 4
cohort studies (4) 4
development and progression (4) 4
drug therapy (4) 4
research (4) 4
anemia, iron-deficiency - blood (3) 3
animals (3) 3
biomarkers - blood (3) 3
blood and lymphatic vessels (3) 3
cardiovascular system (3) 3
chronic heart failure (3) 3
coronary vessels (3) 3
diastolic dysfunction (3) 3
diseases of the peripheral vessels. diseases of the vena cava. miscellaneous (3) 3
double-blind method (3) 3
erythropoietin (3) 3
flow cytometry (3) 3
genetic disorders (3) 3
glycosylated hemoglobin (3) 3
heart attacks (3) 3
heart defects, congenital - mortality (3) 3
heart failure - metabolism (3) 3
iron - blood (3) 3
medical colleges (3) 3
medical research (3) 3
medicine, experimental (3) 3
metabolic diseases (3) 3
metals (3) 3
mitochondria, heart - metabolism (3) 3
other metabolic disorders (3) 3
oxidative stress (3) 3
patients (3) 3
plasma (3) 3
plasma volume (3) 3
predictive value of tests (3) 3
prevalence (3) 3
variables (3) 3
adolescent (2) 2
adrenergic beta-antagonists - therapeutic use (2) 2
adults (2) 2
age (2) 2
analysis of variance (2) 2
anemia - metabolism (2) 2
anemia - physiopathology (2) 2
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1. Disordered iron homeostasis in chronic heart failure: Prevalence, predictors, and relation to anemia, exercise capacity, and survival
by Okonko, Darlington O and Mandal, Amit K.J and Missouris, Constantinos G and Poole-Wilson, Philip A
Journal of the American College of Cardiology, ISSN 0735-1097, 09/2011, Volume 58, Issue 12, pp. 1241 - 1251
heart failure | iron | anemia | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Heart Failure - complications | Prevalence | Prognosis | Prospective Studies | Humans | Iron Metabolism Disorders - mortality | Middle Aged | Iron Metabolism Disorders - complications | Homeostasis | Male | Heart Failure - metabolism | Iron - metabolism | Anemia - metabolism | Anemia, Iron-Deficiency - mortality | Iron Metabolism Disorders - epidemiology | Exercise Tolerance - physiology | Aged, 80 and over | Iron Metabolism Disorders - metabolism | Female | Aged | Anemia, Iron-Deficiency - metabolism | Chronic Disease | Heart Failure - mortality | Heart failure | Enzymes | Anemia | Mortality | Values | Iron | Chronic illnesses
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2. Full Text Mitochondrial dysfunction and oxidative stress in CHF
by Okonko, Darlington O and Shah, Ajay M
Nature reviews cardiology, ISSN 1759-5002, 01/2015, Volume 12, Issue 1, pp. 6 - 7
Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Heart failure | Complications and side effects | Oxidative stress | Development and progression | Mitochondrial diseases | Research | Risk factors
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3. Full Text Drug treatment effects on outcomes in heart failure with preserved ejection fraction: a systematic review and meta-analysis
by Zheng, Sean Lee and Chan, Fiona T and Nabeebaccus, Adam A and Shah, Ajay M and McDonagh, Theresa and Okonko, Darlington O and Ayis, Salma
Heart (British Cardiac Society), ISSN 1355-6037, 03/2018, Volume 104, Issue 5, pp. 407 - 415
preserved ejection fraction | diastolic dysfunction | meta-analysis | heart failure | mid-range ejection fraction | systematic review | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Humans | Risk Factors | Ventricular Function, Left - drug effects | Heart Failure - physiopathology | Stroke Volume - drug effects | Treatment Outcome | Biomarkers - blood | Heart Failure - blood | Disease Progression | Recovery of Function | Heart Failure - drug therapy | Cardiovascular Agents - therapeutic use | Heart Ventricles - physiopathology | Heart Ventricles - metabolism | Cardiovascular Agents - adverse effects | Heart Failure - mortality | Heart Ventricles - drug effects | Heart failure | Mortality | Bias | Systematic review | Beta blockers | Patients | Estimates | Quality of life | Meta-analysis | Studies | Cardiology | Drug therapy | Ejection fraction | Index Medicus | Abridged Index Medicus | Heart Failure and Cardiomyopathies | 1507 | 1506
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4. Full Text Heart failure: Mitochondrial dysfunction and oxidative stress in CHF
by Okonko, Darlington O and Shah, Ajay M
Nature reviews cardiology, ISSN 1759-5002, 01/2015, Volume 12, Issue 1, pp. 6 - 8
Mitochondria, Heart - metabolism | Reactive Oxygen Species - metabolism | Humans | Oxidative Stress - physiology | Ubiquinone - analogs & derivatives | Heart Failure - physiopathology | Treatment Outcome | Heart Failure - metabolism | Mitochondria, Heart - drug effects | Heart Failure - drug therapy | Randomized Controlled Trials as Topic | Ubiquinone - therapeutic use | Oxidative Stress - drug effects | Chronic Disease | Index Medicus
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5. Full Text Mitigation of myocardial ischemia-reperfusion injury via hif-1α-frataxin signaling
by Amaral, Nelson and Okonko, Darlington O
American journal of physiology. Heart and circulatory physiology, ISSN 0363-6135, 09/2015, Volume 309, Issue 5, pp. H728 - H730
Cardiac & Cardiovascular Systems | Physiology | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Myocardial Reperfusion Injury - metabolism | Male | Animals | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Iron-Binding Proteins - metabolism | Index Medicus
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6. Full Text Metabolic abnormalities of the heart in type II diabetes
by Amaral, Nelson and Okonko, Darlington O
Diabetes & vascular disease research, ISSN 1479-1641, 7/2015, Volume 12, Issue 4, pp. 239 - 248
Metabolism | diabetes | energetics | Endocrinology & Metabolism | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Trimetazidine - therapeutic use | Diabetic Cardiomyopathies - metabolism | Mitochondria, Heart - metabolism | Diabetic Cardiomyopathies - drug therapy | Diabetic Cardiomyopathies - etiology | Oxidative Stress | Ranolazine - therapeutic use | Humans | Ubiquinone - analogs & derivatives | Organophosphorus Compounds - therapeutic use | Oxidative Phosphorylation | Diabetes Mellitus, Type 2 - metabolism | Cardiovascular Agents - therapeutic use | Antioxidants - therapeutic use | Energy Metabolism | Myocardium - metabolism | Glucose - metabolism | Ubiquinone - therapeutic use | Perhexiline - therapeutic use | Fatty Acids - metabolism | Diabetes Mellitus, Type 2 - complications | Index Medicus
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7. Full Text Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload
by Smyrnias, Ioannis and Gray, Stephen P and Okonko, Darlington O and Sawyer, Greta and Zoccarato, Anna and Catibog, Norman and López, Begoña and González, Arantxa and Ravassa, Susana and Díez, Javier and Shah, Ajay M
Journal of the American College of Cardiology, ISSN 0735-1097, 04/2019, Volume 73, Issue 14, pp. 1795 - 1806
unfolded protein response | pressure overload | mitochondria | heart | cardiomyocyte | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Mitochondria, Heart - metabolism | Signal Transduction | Humans | Myocardial Contraction - physiology | Aortic Valve Stenosis - physiopathology | Cells, Cultured | Animals | Myocytes, Cardiac - metabolism | Aortic Valve Stenosis - metabolism | Mice | Hemodynamics | Unfolded Protein Response - physiology | Cell Survival - physiology | Apoptosis | Heart | Oxidative stress | Stenosis | Homeostasis | Cell viability | Myocytes | Chaperones | Tissues | Proteins | Signal transduction | Mitochondria | Protein folding | Calcium-binding protein | Aorta | Blood pressure | Workloads | Stress response | Heart diseases | Heart failure | Stresses | Brain natriuretic peptide | Oxygen consumption | Cardiomyocytes | Histology | Patients | Variance analysis | Muscle contraction | Troponin T | Studies | NAD | Troponin | Cardiac function | Fibrosis | Biomarkers | Nicotinamide | Plasma levels
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8. Effect of Intravenous Iron Sucrose on Exercise Tolerance in Anemic and Nonanemic Patients With Symptomatic Chronic Heart Failure and Iron Deficiency. FERRIC-HF: A Randomized, Controlled, Observer-Blinded Trial
by Okonko, Darlington O and Grzeslo, Agnieszka and Witkowski, Tomasz and Mandal, Amit K.J and Slater, Robert M and Roughton, Michael and Foldes, Gabor and Thum, Thomas and Majda, Jacek and Banasiak, Waldemar and Missouris, Constantinos G and Poole-Wilson, Philip A and Anker, Stefan D and Ponikowski, Piotr
Journal of the American College of Cardiology, ISSN 0735-1097, 01/2008, Volume 51, Issue 2, pp. 103 - 112
Confidence Intervals | Anemia, Iron-Deficiency - drug therapy | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Ferric Compounds - administration & dosage | Male | Reference Values | Exercise Tolerance - drug effects | Oxygen Consumption - physiology | Dose-Response Relationship, Drug | Female | Anemia, Iron-Deficiency - complications | Heart Failure - diagnosis | Heart Failure - mortality | Heart Failure - complications | Double-Blind Method | Drug Administration Schedule | Risk Assessment | Probability | Survival Rate | Treatment Outcome | Heart Failure - drug therapy | Anemia, Iron-Deficiency - mortality | Analysis of Variance | Oxygen Consumption - drug effects | Anemia, Iron-Deficiency - diagnosis | Aged | Infusions, Intravenous | Chronic Disease | Heart rate | Heart failure | Sucrose | Anemia | Mortality | Iron | Blood pressure | Drug dosages | Chronic illnesses
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9. Full Text Effect of Intravenous Iron Sucrose on Exercise Tolerance in Anemic and Nonanemic Patients With Symptomatic Chronic Heart Failure and Iron Deficiency
by Okonko, Darlington O and Grzeslo, Agnieszka and Witkowski, Tomasz and Mandal, Amit K.J and Slater, Robert M and Roughton, Michael and Foldes, Gabor and Thum, Thomas and Majda, Jacek and Banasiak, Waldemar and Missouris, Constantinos G and Poole-Wilson, Philip A and Anker, Stefan D and Ponikowski, Piotr
Journal of the American College of Cardiology, ISSN 0735-1097, 01/2008, Volume 51, Issue 2, pp. 103 - 112
Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology
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10. Full Text Calculated plasma volume status and outcomes in patients undergoing coronary bypass graft surgery
by Maznyczka, Annette Marie and Barakat, Mohamad Fahed and Ussen, Bassey and Kaura, Amit and Abu-Own, Huda and Jouhra, Fadi and Jaumdally, Hannah and Amin-Youssef, George and Nicou, Niki and Baghai, Max and Deshpande, Ranjit and Wendler, Olaf and Kolvekar, Shyam and Okonko, Darlington O
Heart (British Cardiac Society), ISSN 1355-6037, 07/2019, Volume 105, Issue 13, pp. 1020 - 1026
heart failure | coronary artery disease surgery | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Prognosis | Humans | Middle Aged | Male | Treatment Outcome | Plasma Volume | Aged, 80 and over | Coronary Artery Bypass | Female | Aged | Retrospective Studies | Cohort Studies | Preoperative Period | Heart failure | Plasma | Edema | Intensive care | Heart surgery | Mortality | Values | Cardiovascular disease | Survival analysis | Fluids | Hospitals | Sodium | Medical prognosis | Coronary vessels | Index Medicus | Abridged Index Medicus
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11. Full Text Impaired Insulin Sensitivity as an Independent Risk Factor for Mortality in Patients With Stable Chronic Heart Failure
by Doehner, Wolfram and Rauchhaus, Mathias and Ponikowski, Piotr and Godsland, Ian F and von Haehling, Stephan and Okonko, Darlington O and Leyva, Francisco and Proudler, Anthony J and Coats, Andrew J.S and Anker, Stefan D
Journal of the American College of Cardiology, ISSN 0735-1097, 09/2005, Volume 46, Issue 6, pp. 1019 - 1026
Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Prognosis | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Risk Factors | Insulin Resistance | Male | Heart Failure - metabolism | Chronic Disease | Heart Failure - mortality | Body mass index | Insulin resistance | Weight control | Drug therapy | Insulin | Mortality
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12. Full Text Systematic review of genuine versus spurious side-effects of beta-blockers in heart failure using placebo control: Recommendations for patient information
by Barron, Anthony J and Zaman, Nabeela and Cole, Graham D and Wensel, Roland and Okonko, Darlington O and Francis, Darrel P
International journal of cardiology, ISSN 0167-5273, 2013, Volume 168, Issue 4, pp. 3572 - 3579
Cardiovascular | Heart failure | Side-effects | Beta-blockers | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Heart | Biological and medical sciences | Medical sciences | Heart failure, cardiogenic pulmonary edema, cardiac enlargement | Placebo Effect | Practice Guidelines as Topic - standards | Randomized Controlled Trials as Topic - methods | Humans | Dizziness - chemically induced | Dizziness - diagnosis | Diarrhea - chemically induced | Heart Failure - drug therapy | Diarrhea - diagnosis | Hyperglycemia - chemically induced | Hyperglycemia - diagnosis | Adrenergic beta-Antagonists - adverse effects | Heart Failure - diagnosis | Heart Failure - epidemiology | Adrenergic beta-Antagonists - therapeutic use | Complications and side effects | Patient education | Index Medicus
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