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Nature, ISSN 0028-0836, 01/2010, Volume 463, Issue 7280, pp. 501 - 506
In an effort to find new pharmacological modalities to overcome resistance to ATP-binding-site inhibitors of Bcr-Abl, we recently reported the discovery of... 
CELL LUNG-CANCER | KINASE-INHIBITOR | SELECTIVE INHIBITOR | C-ABL | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | DYNAMICS | MUTATIONS | LYMPHOBLASTIC-LEUKEMIA | IMATINIB RESISTANCE | CHRONIC MYELOID-LEUKEMIA | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Male | Transplantation, Heterologous | Piperazines - chemistry | Pyrimidines - chemistry | Pyrimidines - metabolism | Antineoplastic Agents - metabolism | Mass Spectrometry | Bone Marrow Transplantation | Inhibitory Concentration 50 | Female | Antineoplastic Agents - pharmacology | Binding Sites | Disease Models, Animal | Fusion Proteins, bcr-abl - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Protein Structure, Tertiary | Crystallization | Antineoplastic Combined Chemotherapy Protocols | Models, Molecular | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Mutation - genetics | Imatinib Mesylate | Piperazines - pharmacology | Fusion Proteins, bcr-abl - genetics | Animals | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice | Benzamides | Fusion Proteins, bcr-abl - metabolism | Drug Resistance, Neoplasm - drug effects | Nilotinib | Dasatinib | Drug resistance in microorganisms | Usage | Nuclear magnetic resonance spectroscopy | Research | Chronic myeloid leukemia | X-ray crystallography | Chromosome abnormalities | Gene mutations | Analysis | Genetic aspects | Diagnosis | Binding proteins | Drug therapy | Health aspects | Proteins | Studies | Competition | Enzymes | E coli | Kinases | Drug resistance | Crystal structure | Index Medicus
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 07/2002, Volume 67, Issue 15, pp. 5398 - 5401
A new method for beta-phenol annulation involving base-induced [4C + 2C] cycloaromatization of readily available 4-bis(methylthio)-3-buten-2-one with a variety... 
ORGANIC-SYNTHESIS | FACILE ACCESS | ANNULATION | PHENOLS | ELECTROPHILIC AROMATIC SUBSTITUTIONS | CHEMISTRY, ORGANIC | ANNELATION | CYCLOAROMATIZATION REACTION | CARBENE COMPLEXES | BENZOANNELATION | REGIOCONTROLLED SYNTHESIS | Chemistry, Organic | Ketones | Aromatic compounds | Physiological aspects | Phenols | Research | Ring formation (Chemistry) | Methylation | Cyclic compounds
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2017, Volume 8, Issue 10, pp. 1048 - 1053
NOD2 (nucleotide -binding oligomerization domain -containing protein 2) is an internal pattern recognition receptor that recognizes bacterial peptidoglycan and... 
structure-based drug design | kinase inhibitors | NOD2 | RIPK2 | ACTIVATION | DOMAIN | CHEMISTRY, MEDICINAL | KINASE | BLAU-SYNDROME | MUTATIONS | ARTHRITIS | EARLY-ONSET SARCOIDOSIS
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 1999, Volume 40, Issue 19, pp. 3797 - 3800
An efficient and versatile synthesis of substituted and annelated pyrido[2,3-b]indoles (α-carboline) involving conjugate displacement on α- oxoketene... 
ROUTE | INDOLE | ALPHA-CARBOLINES | RING | CHEMISTRY, ORGANIC | TUNICATE | AGENTS | GROSSULARINES-1 | LITHIATION | DERIVATIVES | ALKALOIDS
Journal Article
Tetrahedron, ISSN 0040-4020, 2000, Volume 56, Issue 41, pp. 8153 - 8160
An efficient regiocontrolled synthesis of highly substituted and complex polycyclic benzo[b]thiophenes has been developed via our benzoannelation strategy... 
α-oxoketene dithioacetals | aromatic annelation | benzo[ b]thiophenes | Aromatic annelation | Benzo[b]thiophenes | benzo[b]thiophenes | BENZOTHIOPHENES | CHEMISTRY, ORGANIC | THIENO<2,3-C>FURANS | PALLADIUM-CATALYZED CYCLOCARBONYLATION | CARBAZOLES | HETEROAROMATIC ANNELATION | INDOLES | CONSTRUCTION | alpha-oxoketene dithioacetals | BENZOFURANS | THIOPHENES | FACILE
Journal Article
Synthesis, ISSN 0039-7881, 1998, Volume 1998, Issue 10, pp. 1483 - 1486
An efficient regiocontrolled synthesis of substituted and annulated 1,4-dimethoxynaphthalenes as precursors for 1,4-naphthoquinone systems has been developed... 
paper | Naphthaannulation | 1,4-naphthoquinones | 1,4-dimethoxynaphthalenes | α-oxoketene dithioacetals | 2,5-dimethoxybenzylmagnesium chloride | ACID | naphthaannulation | CHEMISTRY, ORGANIC | alpha-oxoketene dithioacetals | CHROMIUM-CARBENE COMPLEXES | ANNELATION | REGIOSPECIFIC TOTAL SYNTHESIS | BETA-OXODITHIOACETALS | CYCLOAROMATIZATION
Journal Article
Nature, ISSN 0028-0836, 1/2010, Volume 463, Issue 7280, pp. 501 - 506
In an effort to find new pharmacological modalities to overcome resistance to ATP-site inhibitors of Bcr-Abl, we recently reported the discovery of GNF-2, a... 
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 11/2005, Volume 2005, Issue 22, pp. 4731 - 4731
The cover picture shows the stereoselective solid‐phase synthesis of highly substituted spiroketal molecules. Asymmetric aldol reactions on a solid phase are... 
Journal Article
09/2019
The present invention provides novel heteroaryl compounds that are linked to an aryl group via an amine linker. Such compounds are useful for the treatment of... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
Angewandte Chemie, ISSN 0044-8249, 06/2004, Volume 116, Issue 24, pp. 3258 - 3261
Journal Article
Angewandte Chemie, ISSN 0044-8249, 06/2004, Volume 116, Issue 24, pp. 3258 - 3261
Schritt für Schritt: Durch eine zwölfstufige asymmetrische Festphasensynthese mit einer Bor‐Aldolreaktion als Schlüsselschritt werden 6,6‐Spiroketale in hoher... 
Asymmetrische Synthesen | Spiroverbindungen | Chemische Biologie | Festphasensynthesen | Naturstoffe
Journal Article
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