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1. Full Text Challenges in Drug Development Targeting Anti-atherosclerotic Proteins
by Okuhira, Keiichiro
Yakugaku zasshi, ISSN 0031-6903, 02/2020, Volume 140, Issue 2, pp. 153 - 157
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology
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2. Full Text Challenges in Drug Development Targeting Anti-atherosclerotic Proteins
by Okuhira, Keiichiro
Yakugaku zasshi, ISSN 0031-6903, 02/2020, Volume 140, Issue 2, pp. 153 - 157
Index Medicus
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3. Full Text A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research
by Emam, Sherif E and Ando, Hidenori and Abu Lila, Amr Selim and Shimizu, Taro and Ukawa, Masami and Okuhira, Keiichiro and Ishima, Yu and Mahdy, Mahmoud A and Ghazy, Fakhr-eldin S and Ishida, Tatsuhiro and Tokushima University and cDepartment of Pharmaceutics and and (dDepartment of Molecular Physical Pharmaceutics and Zagazig University and bDepartment of Pharmaceutics and Industrial Pharmacy and College of Pharmacy and Faculty of Pharmacy and Hail University and aDepartment of Pharmacokinetics and Biopharmaceutics and Institute of Biomedical Sciences
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 5, pp. 733 - 742
exosome secretion | PEGylation | cationic lipid | liposome | stimulation | Liposome | Stimulation | Exosome secretion | Cationic lipid | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Exosomes - drug effects | Cell Line, Tumor | Mice | Animals | Liposomes - pharmacology | Humans | Formulations | Biological properties | Drug delivery systems | Tumor cells | Secretion | Drug delivery | Tumor cell lines | Exosomes | Vesicles | Cations | Yield | Liposomes | Physicochemical properties | Tumors | Index Medicus
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4. Full Text Doxorubicin Expands in Vivo Secretion of Circulating Exosome in Mice
by Emam, Sherif E and Ando, Hidenori and Abu Lila, Amr Selim and Kobayashi, Shinya and Shimizu, Taro and Okuhira, Keiichiro and Ishima, Yu and Ishida, Tatsuhiro and Tokushima University and cDepartment of Pharmaceutics and Zagazig University and bDepartment of Pharmaceutics and Industrial Pharmacy and College of Pharmacy and Faculty of Pharmacy and Hail University and aDepartment of Pharmacokinetics and Biopharmaceutics and Institute of Biomedical Sciences
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 7, pp. 1078 - 1083
chemotherapeutic agent | doxorubicin | exosome | splenectomy | liposomal doxorubicin | Liposomal doxorubicin | Splenectomy | Chemotherapeutic agent | Exosome | Doxorubicin | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Spleen | Size distribution | CD9 antigen | Intravenous administration | CD63 antigen | Injection | Secretions | Exosomes | Immunity | Immunosuppressive agents | Anticancer properties | Time dependence | Vesicles | Chemotherapy | Antitumor agents | Antitumor activity | Mice | In vivo methods and tests | Cancer | Tumors | Immune system | Index Medicus
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5. Full Text A Photo-Activatable Peptide Mimicking Functions of Apolipoprotein A-I
by Haruka Kawahara and Naoki Miyashita and Koki Tachibana and Yusuke Tsuda and Kyohei Morimoto and Kohei Tsuji and Akira Shigenaga and Akira Otaka and Tatsuhiro Ishida and Keiichiro Okuhira and Tokushima University Graduate School and Institute of Biomedical Sciences
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2019, Volume 42, Issue 6, pp. 1019 - 1024
Photocleavable peptide | High-density lipoprotein (HDL) | Apolipoprotein | Atherosclerosis | Cholesterol efflux | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Efflux | Light irradiation | Peptides | Therapeutic applications | Amino acids | Lipids | Mass spectroscopy | Helices | Apolipoproteins | Cholesterol | Mimicry | Apolipoprotein A | Side effects | Arteriosclerosis | Apolipoprotein A-I | Irradiation | Mass spectrometry | Lipoproteins (high density) | Index Medicus
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6. Full Text Development of hybrid small molecules that induce degradation of estrogen receptor‐alpha and necrotic cell death in breast cancer cells
by Okuhira, Keiichiro and Demizu, Yosuke and Hattori, Takayuki and Ohoka, Nobumichi and Shibata, Norihito and Nishimaki‐Mogami, Tomoko and Okuda, Haruhiro and Kurihara, Masaaki and Naito, Mikihiko
Cancer science, ISSN 1347-9032, 11/2013, Volume 104, Issue 11, pp. 1492 - 1498
Life Sciences & Biomedicine | Oncology | Science & Technology | Cell Survival - drug effects | Reactive Oxygen Species - metabolism | Antineoplastic Agents, Hormonal - pharmacology | Humans | Breast Neoplasms - drug therapy | Necrosis | Proteolysis - drug effects | MCF-7 Cells | Drug Design | Estrogen Receptor alpha - metabolism | Female | Proteasome Endopeptidase Complex - metabolism | Protein Stability | Ubiquitin | Snipers | Cell death | Estrogen | Phenols | Breast cancer | Biochemistry | Index Medicus | Original
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7. Full Text Sequence-Independent Traceless Method for Preparation of Peptide/Protein Thioesters Using CPaseY-Mediated Hydrazinolysis
by Ueda, Masahiro and Komiya, Chiaki and Arii, Sayuki and Kusumoto, Kohshi and Denda, Masaya and Okuhira, Keiichiro and Shigenaga, Akira and Otaka, Akira
Chemical & pharmaceutical bulletin, ISSN 0009-2363, 12/2020, Volume 68, Issue 12, pp. 1226 - 1232
native chemical ligation | hydrazinolysis | carboxypeptidase | protein semi-synthesis | thioesterification | protein thioester | Residues | Thioesters | Peptides | Proline | Fluorescence | Hydrazides | Leucine | Carboxypeptidase C | Hydrophobicity | Drug development | Chemical compounds | Proteins | Fluorophores | Synthetic peptides | Index Medicus
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8. Full Text A Cell Assay for Detecting Anti-PEG Immune Response against PEG-Modified Therapeutics
by Shimizu, Taro and Abu Lila, Amr S and Awata, Mizuki and Kubo, Yukiyo and Mima, Yu and Hashimoto, Yosuke and Ando, Hidenori and Okuhira, Keiichiro and Ishima, Yu and Ishida, Tatsuhiro
Pharmaceutical research, ISSN 0724-8741, 11/2018, Volume 35, Issue 11, pp. 1 - 10
Biochemistry, general | Biomedical Engineering | Biomedicine | PEGylation | enzyme-linked immunosorbent assay (ELISA) | Pharmacy | Medical Law | flow cytometry | Pharmacology/Toxicology | anti-PEG IgM | liposome | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Cell Line | B-Lymphocytes - cytology | Spleen - immunology | Ovalbumin - immunology | Humans | Male | Polyethylene Glycols - chemistry | Spleen - cytology | Polyethylene Glycols - toxicity | Particle Size | Liposomes - chemistry | Animals | B-Lymphocytes - immunology | Flow Cytometry | Immunoglobulin M - blood | Hybridomas | Antibody Formation | Plasma Cells - metabolism | Polymers - chemistry | Mice, Inbred BALB C | Glycerol - chemistry | Ovalbumin - chemistry | Liposomes - immunology | Plasma Cells - immunology | Enzymes | Therapeutics | Fluorescence | Enzyme-linked immunosorbent assay | Homeopathy | Materia medica and therapeutics | Protein binding | Spleen | Cell proliferation | Flow cytometry | Ovalbumin | Intravenous administration | Immune response | Antibodies | Immunity | MPEG encoders | Proteins | Immunogenicity | Lymphocytes B | Splenocytes | Video compression | Liposomes | Immune system | Index Medicus
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9. Full Text Development of Cell-Penetrating R7 Fragment-Conjugated Helical Peptides as Inhibitors of Estrogen Receptor-Mediated Transcription
by Nagakubo, Takaya and Demizu, Yosuke and Kanda, Yasunari and Misawa, Takashi and Shoda, Takuji and Okuhira, Keiichiro and Sekino, Yuko and Naito, Mikihiko and Kurihara, Masaaki
Bioconjugate chemistry, ISSN 1043-1802, 11/2014, Volume 25, Issue 11, pp. 1921 - 1924
Cell Line | Transcription, Genetic - drug effects | Cell-Penetrating Peptides - pharmacology | Receptors, Estrogen - metabolism | Arginine | Protein Structure, Secondary | Humans | Models, Molecular | Drug Discovery | Cell-Penetrating Peptides - chemistry | Pharmacology | Biosynthesis | Peptides | Cellular biology | Gene expression | Estrogens | Index Medicus
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10. Full Text Distribution of Polysulfide in Human Biological Fluids and Their Association with Amylase and Sperm Activities
by Ikeda, Mayumi and Ishima, Yu and Chuang, Victor T. G and Sakai, Maki and Osafune, Hiroki and Ando, Hidenori and Shimizu, Taro and Okuhira, Keiichiro and Watanabe, Hiroshi and Maruyama, Toru and Otagiri, Masaki and Akaike, Takaaki and Ishida, Tatsuhiro
Molecules (Basel, Switzerland), ISSN 1420-3049, 05/2019, Volume 24, Issue 9, p. 1689
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Index Medicus | polysulfide | aging | circadian rhythm | biological fluids
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11. Full Text Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer
by Kinoshita, Ryo and Ishima, Yu and Chuang, Victor T.G and Nakamura, Hideaki and Fang, Jun and Watanabe, Hiroshi and Shimizu, Taro and Okuhira, Keiichiro and Ishida, Tatsuhiro and Maeda, Hiroshi and Otagiri, Masaki and Maruyama, Toru
Biomaterials, ISSN 0142-9612, 09/2017, Volume 140, pp. 162 - 169
Liposome | Micelle | Human serum albumin | Nitric oxide | Enhanced permeability and retention effect | Nanoparticle albumin bound paclitaxel | Engineering | Materials Science | Technology | Engineering, Biomedical | Materials Science, Biomaterials | Science & Technology | Neoplasms - metabolism | Paclitaxel - pharmacology | Pancreatic Neoplasms - metabolism | Humans | Melanoma, Experimental - drug therapy | Protein Multimerization | Capillary Permeability - drug effects | Male | Melanoma, Experimental - metabolism | Antineoplastic Agents - therapeutic use | Paclitaxel - pharmacokinetics | Pancreatic Neoplasms - drug therapy | Albumins - therapeutic use | Nitroso Compounds - pharmacology | Albumin-Bound Paclitaxel - pharmacokinetics | Albumin-Bound Paclitaxel - therapeutic use | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Nitroso Compounds - therapeutic use | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Albumin-Bound Paclitaxel - pharmacology | Melanoma, Experimental - pathology | Serum Albumin, Human - pharmacokinetics | Paclitaxel - therapeutic use | Neoplasms - drug therapy | Drug Synergism | Serum Albumin, Human - therapeutic use | Albumins - pharmacokinetics | Albumins - pharmacology | Animals | Serum Albumin, Human - pharmacology | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Nitroso Compounds - pharmacokinetics | Neoplasms - pathology | Nitric Oxide - metabolism | Drugs | Drug delivery systems | Melanoma | Albumin | Permeability | Antineoplastic agents | Vehicles | Antimitotic agents | Chemotherapy | Colon cancer | Analysis | Pancreatic cancer | Cancer | Index Medicus
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12. Full Text Reactivity of IgM antibodies elicited by PEGylated liposomes or PEGylated lipoplexes against auto and foreign antigens
by Ando, Hidenori and Abu Lila, Amr S and Kawanishi, Munehira and Shimizu, Taro and Okuhira, Keiichiro and Ishima, Yu and Ishida, Tatsuhiro
Journal of controlled release, ISSN 0168-3659, 01/2018, Volume 270, pp. 114 - 119
Autoimmune antibody | PEGylated liposome | Polyethylene glycol (PEG) | PEGylated lipoplex, IgM | Polyreactivity | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Antigen-antibody reactions | Lupus | Dextran | Antigens | Autoantibodies | Systemic lupus erythematosus | Polyethylene glycol | Pharmacy | Drugstores | Bacteria | T cells | Polyols | Index Medicus
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13. Full Text Effect of phosphatidylserine and cholesterol on membrane-mediated fibril formation by the N-terminal amyloidogenic fragment of apolipoprotein A-I
by Mizuguchi, Chiharu and Nakamura, Mitsuki and Kurimitsu, Naoko and Ohgita, Takashi and Nishitsuji, Kazuchika and Baba, Teruhiko and Shigenaga, Akira and Shimanouchi, Toshinori and Okuhira, Keiichiro and Otaka, Akira and Saito, Hiroyuki
Scientific reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 5497 - 12
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Amyloidogenesis | Fibrils | Lipids | Cell membranes | Electrostatic properties | Cholesterol | Circular dichroism | Apolipoprotein A | Membrane fluidity | Fluidity | Apolipoprotein A-I | Calorimetry | Amyloid | Titration | Random coil | Phosphatidylserine | Conformation
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