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1. Full Text Doxorubicin Expands in Vivo Secretion of Circulating Exosome in Mice
by Emam, Sherif E and Ando, Hidenori and Abu Lila, Amr Selim and Kobayashi, Shinya and Shimizu, Taro and Okuhira, Keiichiro and Ishima, Yu and Ishida, Tatsuhiro
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 7, pp. 1078 - 1083
Modulation of tumor immunity is a known factor in the antitumor activity of many chemotherapeutic agents. Exosomes are extracellular nanometric vesicles that... 
chemotherapeutic agent | doxorubicin | exosome | splenectomy | liposomal doxorubicin | Liposomal doxorubicin | Splenectomy | Chemotherapeutic agent | Exosome | Doxorubicin | RESPONSES | SPLEEN | EXTRACELLULAR VESICLES | PHARMACOLOGY & PHARMACY | RELEASE | CELL-DERIVED EXOSOMES | CHEMOTHERAPY | Exosomes - drug effects | Injections, Intravenous | Spleen - secretion | Antibiotics, Antineoplastic - pharmacology | Male | Spleen - cytology | Spleen - drug effects | Exocytosis - drug effects | Animals | Doxorubicin - analogs & derivatives | Models, Animal | Mice | Mice, Inbred BALB C | Doxorubicin - pharmacology | Exosomes - secretion | Polyethylene Glycols - pharmacology | Spleen | Size distribution | CD9 antigen | Intravenous administration | CD63 antigen | Secretion | Injection | Secretions | Exosomes | Immunity | Immunosuppressive agents | Anticancer properties | Immune systems | Time dependence | Vesicles | Chemotherapy | Antitumor agents | Antitumor activity | In vivo methods and tests | Cancer | Tumors | Index Medicus
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2. Full Text A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research
by Emam, Sherif E and Ando, Hidenori and Abu Lila, Amr Selim and Shimizu, Taro and Ukawa, Masami and Okuhira, Keiichiro and Ishima, Yu and Mahdy, Mahmoud A and Ghazy, Fakhr-eldin S and Ishida, Tatsuhiro
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 5, pp. 733 - 742
Exosomes are tiny extracellular vesicles that are usually harvested in small quantities. Such small yield has been an obstacle for the expansion of the basic... 
exosome secretion | PEGylation | cationic lipid | liposome | stimulation | Liposome | Stimulation | Exosome secretion | Cationic lipid | DENSITY | DRUG-DELIVERY | IN-VIVO | NANOPARTICLE | MICROVESICLES | PHARMACOLOGY & PHARMACY | LIPOSOMES | Formulations | Biological properties | Drug delivery systems | Tumor cells | Secretion | Drug delivery | Tumor cell lines | Exosomes | Vesicles | Cations | Yield | Liposomes | Physicochemical properties | Tumors | Index Medicus
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3. Full Text A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research
by Sherif E.Emama and b and Hidenori Andoa and Amr Selim Abu Lilaa and c and Taro Shimizua and Masami Ukawaa and Keiichiro Okuhirad and Yu Ishimaa and Mahmoud A.Mahdyb and Fakhr-eldin S.Ghazyb and Tatsuhiro Ishidaa and Tokushima University and cDepartment of Pharmaceutics and and (dDepartment of Molecular Physical Pharmaceutics and Zagazig University and bDepartment of Pharmaceutics and Industrial Pharmacy and College of Pharmacy and Faculty of Pharmacy and Hail University and aDepartment of Pharmacokinetics and Biopharmaceutics and Institute of Biomedical Sciences
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 5, pp. 733 - 742
Exosomes are tiny extracellular vesicles that are usually harvested in small quantities. Such small yield has been an obstacle for the expansion of the basic... 
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4. Full Text A Photo-activatable peptide mimicking functions of apolipoprotein A-I
by Kawahara, Haruka and Miyashita, Naoki and Tachibana, Koki and Tsuda, Yusuke and Morimoto, Kyohei and Tsuji, Kohei and Shigenaga, Akira and Otaka, Akira and Ishida, Tatsuhiro and Okuhira, Keiichiro
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2019, Volume 42, Issue 6, pp. 1019 - 1024
Apolipoprotein A-I (apoA-I) plays a critical role in high-density lipoprotein (HDL) biogenesis, function and structural dynamics. Peptides that mimic apoA-I... 
Photocleavable peptide | High-density lipoprotein (HDL) | Apolipoprotein | Atherosclerosis | Cholesterol efflux | Efflux | Light irradiation | Peptides | Therapeutic applications | Amino acids | Lipids | Mass spectroscopy | Helices | Apolipoproteins | Cholesterol | Mimicry | Apolipoprotein A | Side effects | Arteriosclerosis | Apolipoprotein A-I | Irradiation | Mass spectrometry | Lipoproteins (high density)
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5. Full Text Development of hybrid small molecules that induce degradation of estrogen receptor‐alpha and necrotic cell death in breast cancer cells
by Okuhira, Keiichiro and Demizu, Yosuke and Hattori, Takayuki and Ohoka, Nobumichi and Shibata, Norihito and Nishimaki‐Mogami, Tomoko and Okuda, Haruhiro and Kurihara, Masaaki and Naito, Mikihiko
Cancer Science, ISSN 1347-9032, 11/2013, Volume 104, Issue 11, pp. 1492 - 1498
Manipulation of protein stability with small molecules has a great potential for both basic research and clinical therapy. Recently, we have developed a series... 
DESIGN | PROTEIN KNOCKDOWN | ANTIESTROGEN | THERAPY | ONCOLOGY | RESISTANCE | INHIBITORS | CIAP1 | Cell Survival - drug effects | Reactive Oxygen Species - metabolism | Antineoplastic Agents, Hormonal - pharmacology | Humans | Breast Neoplasms - drug therapy | Necrosis | Proteolysis - drug effects | MCF-7 Cells | Drug Design | Estrogen Receptor alpha - metabolism | Female | Proteasome Endopeptidase Complex - metabolism | Protein Stability | Ubiquitin | Snipers | Cell death | Estrogen | Phenols | Breast cancer | Biochemistry | Index Medicus
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6. Regulatory factors for ABCA1 activity of HDL generation
by Okuhira, Keiichiro
Seikagaku, ISSN 0037-1017, 2012, Volume 84, Issue 4, pp. 285 - 290
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7. Full Text A Cell Assay for Detecting Anti-PEG Immune Response against PEG-Modified Therapeutics
by Shimizu, Taro and Abu Lila, Amr S and Awata, Mizuki and Kubo, Yukiyo and Mima, Yu and Hashimoto, Yosuke and Ando, Hidenori and Okuhira, Keiichiro and Ishima, Yu and Ishida, Tatsuhiro
Pharmaceutical Research, ISSN 0724-8741, 11/2018, Volume 35, Issue 11, pp. 1 - 10
Immunogenicity of PEGylated proteins and nanomedicines represents a potential impediment against their development and use in clinical settings. The purpose of... 
Biochemistry, general | Biomedical Engineering | Biomedicine | PEGylation | enzyme-linked immunosorbent assay (ELISA) | Pharmacy | Medical Law | flow cytometry | Pharmacology/Toxicology | anti-PEG IgM | liposome | ANTIBODIES | PROTEIN | POLYETHYLENE-GLYCOL PEG | INDUCTION | REPEATED INJECTION | CHEMISTRY, MULTIDISCIPLINARY | IGM | PEPTIDE | DELIVERY | ACCELERATED BLOOD CLEARANCE | PEGYLATED LIPOSOMES | PHARMACOLOGY & PHARMACY | Enzymes | Therapeutics | Fluorescence | Enzyme-linked immunosorbent assay | Homeopathy | Materia medica and therapeutics | Protein binding | Spleen | Cell proliferation | Flow cytometry | Ovalbumin | Intravenous administration | Immune response | Antibodies | Immunity | MPEG encoders | Immune systems | Proteins | Immunogenicity | Lymphocytes B | Splenocytes | Video compression | Liposomes | Index Medicus
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8. Full Text Development of cell-penetrating r7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription
by Nagakubo, Takaya and Demizu, Yosuke and Kanda, Yasunari and Misawa, Takashi and Shoda, Takuji and Okuhira, Keiichiro and Sekino, Yuko and Naito, Mikihiko and Kurihara, Masaaki
Bioconjugate Chemistry, ISSN 1043-1802, 11/2014, Volume 25, Issue 11, pp. 1921 - 1924
The heptaarginine (R7)-conjugated peptide 5 was designed and synthesized as an inhibitor of ER-coactivator interactions and ER-mediated transcription at the... 
TAMOXIFEN | MODULATORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | ALPHA | COACTIVATOR INTERACTIONS | CHEMISTRY, MULTIDISCIPLINARY | BREAST-CANCER CELLS | THERAPY | REGULATORS | CYCLE PROGRESSION | INDUCER | BINDING | Cell Line | Transcription, Genetic - drug effects | Cell-Penetrating Peptides - pharmacology | Receptors, Estrogen - metabolism | Arginine | Protein Structure, Secondary | Humans | Models, Molecular | Drug Discovery | Cell-Penetrating Peptides - chemistry | Pharmacology | Biosynthesis | Peptides | Cellular biology | Gene expression | Estrogen | Index Medicus
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9. Full Text Effect of phosphatidylserine and cholesterol on membrane-mediated fibril formation by the N-terminal amyloidogenic fragment of apolipoprotein A-I
by Mizuguchi, Chiharu and Nakamura, Mitsuki and Kurimitsu, Naoko and Ohgita, Takashi and Nishitsuji, Kazuchika and Baba, Teruhiko and Shigenaga, Akira and Shimanouchi, Toshinori and Okuhira, Keiichiro and Otaka, Akira and Saito, Hiroyuki
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 5497 - 12
Here, we examined the effects of phosphatidylserine (PS) and cholesterol on the fibril-forming properties of the N-terminal 1-83 fragment of an amyloidogenic... 
FLUORESCENCE PROBE | DENSITY-LIPOPROTEIN PARTICLES | MODEL MEMBRANES | PROTEIN | ALPHA-SYNUCLEIN AGGREGATION | MULTIDISCIPLINARY SCIENCES | APOA-I | LIPID-MEMBRANES | HDL FORMATION | BIOLOGICAL-MEMBRANES | POLYPEPTIDE | Amyloidogenesis | Fibrils | Lipids | Cell membranes | Apolipoproteins | Electrostatic properties | Cholesterol | Circular dichroism | Apolipoprotein A | Membrane fluidity | Fluidity | Apolipoprotein A-I | Calorimetry | Amyloid | Titration | Random coil | Phosphatidylserine | Conformation
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10. Full Text Development of a peptide-based inducer of nuclear receptors degradation
by Demizu, Yosuke and Ohoka, Nobumichi and Nagakubo, Takaya and Yamashita, Hiroko and Misawa, Takashi and Okuhira, Keiichiro and Naito, Mikihiko and Kurihara, Masaaki
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2016, Volume 26, Issue 11, pp. 2655 - 2658
A peptide-based protein knockdown system for inducing nuclear receptors degradation via the ubiquitin–proteasome system was developed. Specifically, the... 
Protein knockdown | Helical peptide | Nuclear receptors | Protein–protein interaction | Protein-protein interaction | DESIGN | ACTIVATION | CHEMISTRY, MEDICINAL | SMALL MOLECULES | MODULATORS | CHEMISTRY, ORGANIC | ALPHA | ESTROGEN-RECEPTOR | CELL-DEATH | HELICAL PEPTIDES | INHIBITORS | Peptides - chemistry | Humans | Models, Molecular | Estrogen Receptor alpha - metabolism | Molecular Structure | Structure-Activity Relationship | Peptides - pharmacology | Peptides | Index Medicus
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11. Full Text Distribution of Polysulfide in Human Biological Fluids and Their Association with Amylase and Sperm Activities
by Ikeda, M and Ishima, Y and Chuang, VTG and Sakai, M and Osafune, H and Ando, H and Shimizu, T and Okuhira, K and Watanabe, H and Maruyama, T and Otagiri, M and Akaike, T and Ishida, T
MOLECULES, ISSN 1420-3049, 05/2019, Volume 24, Issue 9, p. 1689
Intracellular polysulfide could regulate the redox balance via its anti-oxidant activity. However, the existence of polysulfide in biological fluids still... 
OXIDATIVE STRESS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | polysulfide | MECHANISMS | HYDROGEN-SULFIDE | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | PLASMA | SEMEN | circadian rhythm | aging | biological fluids | Index Medicus
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12. Full Text Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways
by Emam, Sherif E and Ando, Hidenori and Lila, Amr S. Abu and Shimizu, Taro and Okuhira, Keiichiro and Ishima, Yu and Mahdy, Mahmoud A and Ghazy, Fakhr-eldin S and Sagawa, Ikuko and Ishida, Tatsuhiro
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 14493 - 11
We recently showed that in vitro incubation of cells with liposomes of varying compositions can increase exosome secretion and increase the yield of harvested... 
PHALLOIDIN | THERAPY | COATED PIT FORMATION | DENDRITIC CELLS | ACTIN | DRUG-DELIVERY | MULTIDISCIPLINARY SCIENCES | CYTOCHALASIN | ENDOCYTIC TRAFFICKING | TUMOR-DERIVED EXOSOMES | MAMMALIAN-CELLS | Proteins | Endocytosis | CD9 antigen | Vesicles | Epidermal growth factor | Tumor cells | Secretion | Liposomes | Exosomes | Cancer
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13. Full Text Molecular design, synthesis, and evaluation of sniper(ER) that induces proteasomal degradation of ERα
by Okuhira, Keiichiro and Demizu, Yosuke and Hattori, Takayuki and Ohoka, Nobumichi and Shibata, Norihito and Kurihara, Masaaki and Naito, Mikihiko
Methods in Molecular Biology, ISSN 1064-3745, 01/2016, Volume 1366, pp. 549 - 560
Manipulation of protein stability using small molecules has a great potential for both basic research and clinical therapy. Based on our protein knockdown... 
SNIPER | Proteinknockdown | Ubiquitin-proteasome system | Cell death | Estrogenreceptor | Humans | Models, Molecular | Workflow | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Blotting, Western | Breast Neoplasms - metabolism | Estrogen Receptor alpha - drug effects | Ubiquitination | MCF-7 Cells | Time Factors | Breast Neoplasms - pathology | Proteolysis | HMGB1 Protein - metabolism | Staining and Labeling | Drug Design | Estrogen Receptor alpha - metabolism | Female | Antineoplastic Agents - pharmacology | Molecular Structure | Cell Death - drug effects | Proteasome Endopeptidase Complex - metabolism | Protein Stability | Index Medicus
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14. Full Text Formation of stable nanodiscs by bihelical apolipoprotein A‐I mimetic peptide
by Kariyazono, Hirokazu and Nadai, Ryo and Miyajima, Rin and Takechi‐Haraya, Yuki and Baba, Teruhiko and Shigenaga, Akira and Okuhira, Keiichiro and Otaka, Akira and Saito, Hiroyuki
Journal of Peptide Science, ISSN 1075-2617, 02/2016, Volume 22, Issue 2, pp. 116 - 122
Nanodiscs are composed of scaffold protein or peptide such as apolipoprotein A‐I (apoA‐I) and phospholipids. Although peptide‐based nanodiscs have an advantage... 
nanodisc scaffold peptide | apoA‐I mimetic peptide | nanodisc | bihelical | apoA-I mimetic peptide | CHEMISTRY, ANALYTICAL | PHOSPHOLIPID-BILAYER NANODISCS | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEMBRANE SCAFFOLD PROTEINS | NATIVE CHEMICAL LIGATION | SOLUTION NMR | HIGH-DENSITY-LIPOPROTEIN | LIPID INTERACTION | CHOLESTEROL EFFLUX | AMPHIPATHIC HELICAL PEPTIDE | ABCA1 TRANSPORTER | Amino Acid Sequence | Protein Structure, Secondary | Cholic Acid - chemistry | Humans | Molecular Sequence Data | Phosphatidylcholines - chemistry | Particle Size | Molecular Mimicry | Peptide Fragments - chemistry | Nanostructures - chemistry | Protein Stability | Apolipoprotein A-I - chemistry | Dynamic Light Scattering | Peptides | Apolipoproteins | Index Medicus
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15. Full Text A Photo-Activatable Peptide Mimicking Functions of Apolipoprotein A-I
by Haruka Kawahara and Naoki Miyashita and Koki Tachibana and Yusuke Tsuda and Kyohei Morimoto and Kohei Tsuji and Akira Shigenaga and Akira Otaka and Tatsuhiro Ishida and Keiichiro Okuhira and Tokushima University Graduate School and Institute of Biomedical Sciences
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2019, Volume 42, Issue 6, pp. 1019 - 1024
Apolipoprotein A-I (apoA-I) plays a critical role in high-density lipoprotein (HDL) biogenesis, function and structural dynamics. Peptides that mimic apoA-I... 
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16. Full Text In vivo knockdown of pathogenic proteins via specific and nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent protein erasers (SNIPERs)
by Ohoka, Nobumichi and Okuhira, Keiichiro and Ito, Masahiro and Nagai, Katsunori and Shibata, Norihito and Hattori, Takayuki and Ujikawa, Osamu and Shimokawa, Kenichiro and Sano, Osamu and Koyama, Ryokichi and Fujita, Hisashi and Teratani, Mika and Matsumoto, Hirokazu and Imaeda, Yasuhiro and Nara, Hiroshi and Cho, Nobuo and Naito, Mikihiko
Journal of Biological Chemistry, ISSN 0021-9258, 03/2017, Volume 292, Issue 11, pp. 4556 - 4570
Many diseases, especially cancers, result from aberrant or overexpression of pathogenic proteins. Specific inhibitors against these proteins have shown... 
SMALL-MOLECULE PROTACS | TARGET | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA-DEPENDENT APOPTOSIS | ESTROGEN | DEGRADATION | CANCER | IAP PROTEINS | CIAP1 | CELL-DEATH | Index Medicus | SNIPER | proteasome | LCL161 | estrogen receptor | Protein Synthesis and Degradation | tumor therapy | ubiquitin | X-linked inhibitor of apoptosis protein (XIAP)
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17. Full Text Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer
by Kinoshita, Ryo and Ishima, Yu and Chuang, Victor T.G and Nakamura, Hideaki and Fang, Jun and Watanabe, Hiroshi and Shimizu, Taro and Okuhira, Keiichiro and Ishida, Tatsuhiro and Maeda, Hiroshi and Otagiri, Masaki and Maruyama, Toru
Biomaterials, ISSN 0142-9612, 09/2017, Volume 140, pp. 162 - 169
In the latest trend of anticancer chemotherapy research, there were many macromolecular anticancer drugs developed based on enhanced permeability and retention... 
Liposome | Micelle | Human serum albumin | Nitric oxide | Enhanced permeability and retention effect | Nanoparticle albumin bound paclitaxel | MATERIALS SCIENCE, BIOMATERIALS | NAB-PACLITAXEL | ENGINEERING, BIOMEDICAL | DOXORUBICIN | TUMOR | VASCULAR-PERMEABILITY | ANTITUMOR DRUGS | DELIVERY | THERAPEUTIC-EFFICACY | IN-VIVO | NITRIC-OXIDE | ACCUMULATION | Neoplasms - metabolism | Paclitaxel - pharmacology | Pancreatic Neoplasms - metabolism | Humans | Melanoma, Experimental - drug therapy | Protein Multimerization | Capillary Permeability - drug effects | Male | Melanoma, Experimental - metabolism | Antineoplastic Agents - therapeutic use | Paclitaxel - pharmacokinetics | Pancreatic Neoplasms - drug therapy | Albumins - therapeutic use | Nitroso Compounds - pharmacology | Albumin-Bound Paclitaxel - pharmacokinetics | Albumin-Bound Paclitaxel - therapeutic use | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Nitroso Compounds - therapeutic use | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Albumin-Bound Paclitaxel - pharmacology | Melanoma, Experimental - pathology | Serum Albumin, Human - pharmacokinetics | Paclitaxel - therapeutic use | Neoplasms - drug therapy | Drug Synergism | Serum Albumin, Human - therapeutic use | Albumins - pharmacokinetics | Albumins - pharmacology | Animals | Serum Albumin, Human - pharmacology | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Nitroso Compounds - pharmacokinetics | Neoplasms - pathology | Nitric Oxide - metabolism | Drugs | Drug delivery systems | Melanoma | Albumin | Permeability | Antineoplastic agents | Vehicles | Antimitotic agents | Chemotherapy | Colon cancer | Analysis | Pancreatic cancer | Cancer | Index Medicus
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18. Full Text Reactivity of IgM antibodies elicited by PEGylated liposomes or PEGylated lipoplexes against auto and foreign antigens
by Ando, Hidenori and Abu Lila, Amr S and Kawanishi, Munehira and Shimizu, Taro and Okuhira, Keiichiro and Ishima, Yu and Ishida, Tatsuhiro
Journal of Controlled Release, ISSN 0168-3659, 01/2018, Volume 270, pp. 114 - 119
Polyethylene glycol (PEG) is an attractive tool for the development of nanoparticle-based cancer therapy since it endows nanoparticles with... 
Autoimmune antibody | PEGylated liposome | Polyethylene glycol (PEG) | PEGylated lipoplex, IgM | Polyreactivity | IMMUNE-RESPONSE | DRUG-DELIVERY | INDEPENDENT TYPE-2 ANTIGENS | REPEATED INJECTIONS | PEG IGM | CHEMISTRY, MULTIDISCIPLINARY | B-CELLS | ACCELERATED BLOOD CLEARANCE | DISEASE | PHARMACOLOGY & PHARMACY | HEPATITIS-C | Antigen-antibody reactions | Lupus | Dextran | Antigens | Autoantibodies | Systemic lupus erythematosus | Polyethylene glycol | Pharmacy | Drugstores | Bacteria | T cells | Polyols | Index Medicus
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