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1. Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy
by Peltoniemi, Marko A and Hagelberg, Nora M and Olkkola, Klaus T and Saari, Teijo I
Clinical pharmacokinetics, ISSN 0312-5963, 09/2016, Volume 55, Issue 9, pp. 1059 - 1077
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Anesthesia - methods | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Cytochrome P-450 Enzyme System - metabolism | Biological Availability | Analgesics - pharmacokinetics | Cytochrome P-450 CYP2B6 - metabolism | Ketamine - administration & dosage | Dose-Response Relationship, Drug | Ketamine - adverse effects | Ketamine - analogs & derivatives | Pain - drug therapy | Analgesics - blood | Child | Analgesics - adverse effects | Ketamine - blood | Drug Administration Routes | Receptors, N-Methyl-D-Aspartate - drug effects | Pain - prevention & control | Analgesics - administration & dosage | Animals | Cytochrome P-450 CYP3A - metabolism | Ketamine - pharmacokinetics | Central Nervous System - drug effects
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2. Full Text Prehospital National Early Warning Score predicts early mortality
by Pirneskoski, Jussi and Kuisma, Markku and Olkkola, Klaus T and Nurmi, Jouni
Acta anaesthesiologica Scandinavica, ISSN 0001-5172, 05/2019, Volume 63, Issue 5, pp. 676 - 683
Life Sciences & Biomedicine | Anesthesiology | Science & Technology | Hospital Mortality | Humans | Middle Aged | Logistic Models | Male | Early Warning Score | Aged, 80 and over | Adult | Female | ROC Curve | Aged | Retrospective Studies | Outcome Assessment, Health Care | Emergency Medical Services | Medical records | Health aspects | Mortality | Emergency medical services | Mathematical analysis | Health services | Data processing | Death | Diagnostic systems | Patients | Trauma | Subgroups | Index Medicus
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3. Full Text Covariates of intravenous paracetamol pharmacokinetics in adults
by Allegaert, Karel and Olkkola, Klaus T and Owens, Katie H and Van de Velde, Marc and de Maat, Monique M and Anderson, Brian J and PACIA Study Grp and PACIA study group and the PACIA study group
BMC anesthesiology, ISSN 1471-2253, 09/2014, Volume 14, Issue 1, pp. 77 - 77
Life Sciences & Biomedicine | Anesthesiology | Science & Technology | Injections, Intravenous | Age Factors | Analgesics, Non-Narcotic - pharmacokinetics | Pain, Postoperative - drug therapy | Humans | Middle Aged | Acetaminophen - administration & dosage | Male | Analgesics, Non-Narcotic - administration & dosage | Analgesics, Non-Narcotic - therapeutic use | Pregnancy | Young Adult | Orthopedic Procedures | Computer Simulation | Aged, 80 and over | Adult | Female | Aged | Acetaminophen - pharmacokinetics | Acetaminophen - therapeutic use | Acetaminophen | Analysis | Plasma | Postoperative period | Intensive care | Emergency medical care | Pharmacology | Chromatography | Medicine | Studies | Confidence intervals | Birth control | Hospitals | Pain | Analgesics | Surgery | Drug therapy | Drug dosages | Age | Pharmacokinetics | Paracetamol | Intravenous administration | Index Medicus
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4. Full Text Deeper chest compression – More complications for cardiac arrest patients?
by Hellevuo, Heidi and Sainio, Marko and Nevalainen, Riikka and Huhtala, Heini and Olkkola, Klaus T and Tenhunen, Jyrki and Hoppu, Sanna
Resuscitation, ISSN 0300-9572, 2013, Volume 84, Issue 6, pp. 760 - 765
Emergency | Myocardium | Thoracic injuries | Rib fractures | Cardiopulmonary resuscitation | Cardiac arrest | Rupture | Emergency Medicine | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Cardiopulmonary Resuscitation - adverse effects | Humans | Middle Aged | Male | Pressure | Thoracic Injuries - epidemiology | Abdominal Injuries - epidemiology | Heart Massage - adverse effects | Incidence | Abdominal Injuries - etiology | Finland | Aged, 80 and over | Adult | Female | Aged | Thoracic Injuries - etiology | Heart Arrest - therapy | Complications and side effects | Medical colleges | Fractures | Analgesics | Emergency medicine | Cardiac patients | Emergency medical services | Medical imaging equipment | Index Medicus
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5. Full Text Bioavailability of dexmedetomidine after intranasal administration
by Iirola, Timo and Vilo, Sanna and Manner, Tuula and Aantaa, Riku and Lahtinen, Maria and Scheinin, Mika and Olkkola, Klaus T
European journal of clinical pharmacology, ISSN 0031-6970, 8/2011, Volume 67, Issue 8, pp. 825 - 831
Administration | Biomedicine | Intranasal | Pharmacology/Toxicology | Dexmedetomidine | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Conscious Sedation - methods | Consciousness - drug effects | Injections, Intravenous | Adrenergic alpha-2 Receptor Agonists - pharmacokinetics | Humans | Hypnotics and Sedatives - administration & dosage | Half-Life | Biological Availability | Male | Metabolic Clearance Rate | Adrenergic alpha-2 Receptor Agonists - pharmacology | Heart Rate - drug effects | Adrenergic alpha-2 Receptor Agonists - administration & dosage | Adult | Blood Pressure - drug effects | Dexmedetomidine - pharmacology | Nasal Mucosa - drug effects | Dexmedetomidine - administration & dosage | Hypnotics and Sedatives - pharmacokinetics | Dexmedetomidine - pharmacokinetics | Sleep Stages - drug effects | Administration, Intranasal | Cross-Over Studies | Norepinephrine - blood | Adrenergic alpha-2 Receptor Agonists - blood | Epinephrine - blood | Dexmedetomidine - blood | Hypnotics and Sedatives - blood | Hypnotics and Sedatives - pharmacology | Care and treatment | Pain | Heart beat | Analgesics | Emergency medicine | Noradrenaline | Central nervous system agents | Prescription drugs | Drug delivery systems | Pharmacology | Bioavailability | Index Medicus | Life Sciences | Pharmaceutical sciences
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6. Full Text Medical emergency team activation: performance of conventional dichotomised criteria versus national early warning score
by TIRKKONEN, JOONAS and OLKKOLA, KLAUS T and HUHTALA, HEINI and TENHUNEN, JYRKI and HOPPU, SANNA
Acta anaesthesiologica Scandinavica, ISSN 0001-5172, 04/2014, Volume 58, Issue 4, pp. 411 - 419
Life Sciences & Biomedicine | Anesthesiology | Science & Technology | Age Distribution | Prevalence | Prospective Studies | Vital Signs | Humans | Middle Aged | Male | Risk | Body Temperature - physiology | Patient Care Team - organization & administration | Heart Rate - physiology | Female | Blood Pressure - physiology | Odds Ratio | Reproducibility of Results | Respiratory Rate | Hospital Mortality | Comorbidity | Logistic Models | Treatment Outcome | Emergency Medical Services - statistics & numerical data | Patient Care Team - statistics & numerical data | Emergency Medical Services - organization & administration | Sex Distribution | Aged | Finland - epidemiology | Cohort Studies | Confidence intervals | Hospitals | Mortality | Index Medicus
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7. A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug-Drug Interactions
by Li, Xia and Frechen, Sebastian and Moj, Daniel and Lehr, Thorsten and Taubert, Max and Hsin, Chih-hsuan and Mikus, Gerd and Neuvonen, Pertti J and Olkkola, Klaus T and Saari, Teijo and Fuhr, Uwe
Clinical pharmacokinetics, ISSN 0312-5963, 06/2020, Volume 59, Issue 6, pp. 781 - 808
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Index Medicus
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8. Full Text Predictive equations over-estimate the resting energy expenditure in amyotrophic lateral sclerosis patients who are dependent on invasive ventilation support
by Siirala, Waltteri and Olkkola, Klaus T and Noponen, Tommi and Vuori, Arno and Aantaa, Riku
Nutrition & metabolism, ISSN 1743-7075, 2010, Volume 7, Issue 1, pp. 70 - 70
Life Sciences & Biomedicine | Nutrition & Dietetics | Science & Technology | Tracheostomy | Amyotrophic lateral sclerosis | Development and progression | Care and treatment | Diagnosis | Health aspects | Ventilators | Nutrition research
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9. Full Text Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial
by Laitio, Ruut and Hynninen, Marja and Arola, Olli and Virtanen, Sami and Parkkola, Riitta and Saunavaara, Jani and Roine, Risto O and Grönlund, Juha and Ylikoski, Emmi and Wennervirta, Johanna and Bäcklund, Minna and Silvasti, Päivi and Nukarinen, Eija and Tiainen, Marjaana and Saraste, Antti and Pietilä, Mikko and Airaksinen, Juhani and Valanne, Leena and Martola, Juha and Silvennoinen, Heli and Scheinin, Harry and Harjola, Veli-Pekka and Niiranen, Jussi and Korpi, Kirsi and Varpula, Marjut and Inkinen, Outi and Olkkola, Klaus T and Maze, Mervyn and Vahlberg, Tero and Laitio, Timo
JAMA : the journal of the American Medical Association, ISSN 0098-7484, 03/2016, Volume 315, Issue 11, pp. 1120 - 1128
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Single-Blind Method | Cardiopulmonary Resuscitation - methods | Xenon - pharmacology | Humans | Middle Aged | Male | Out-of-Hospital Cardiac Arrest - mortality | Coma - mortality | Out-of-Hospital Cardiac Arrest - therapy | Time Factors | Statistics, Nonparametric | White Matter - injuries | Adult | Female | Coma - therapy | Survivors | Administration, Inhalation | White Matter - drug effects | Treatment Outcome | White Matter - pathology | Xenon - administration & dosage | Anisotropy | Diffusion Magnetic Resonance Imaging | Finland | Survival Analysis | Hypothermia, Induced | Aged | Usage | Care and treatment | Magnetic resonance imaging | Mortality | Analysis | Xenon | Cardiac arrest | Influence | Dosage and administration | Hypothermia | Clinical trials | Scientific imaging | Heart attacks | Ischemia | Index Medicus | Abridged Index Medicus
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10. Full Text Aetiology of in-hospital cardiac arrest on general wards
by Tirkkonen, Joonas and Hellevuo, Heidi and Olkkola, Klaus T and Hoppu, Sanna
Resuscitation, ISSN 0300-9572, 2016, Volume 107, pp. 19 - 24
Emergency | In-hospital cardiac arrest | Aetiology | IHCA | Emergency Medicine | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Patients' Rooms - statistics & numerical data | Cardiopulmonary Resuscitation - statistics & numerical data | Prospective Studies | Pneumonia - epidemiology | Humans | Middle Aged | Heart Arrest - epidemiology | Patient Discharge | Hospitalization - statistics & numerical data | Male | Emergency Medical Services - statistics & numerical data | Incidence | Outcome and Process Assessment (Health Care) | Heart Diseases - epidemiology | Heart Diseases - complications | Aged, 80 and over | Heart Arrest - etiology | Pneumonia - complications | Female | Aged | Finland - epidemiology | Heart Arrest - therapy | Analgesics | Consulting services | Emergency medicine | Cardiac arrest | Index Medicus
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11. Full Text Maturation of Oxycodone Pharmacokinetics in Neonates and Infants: a Population Pharmacokinetic Model of Three Clinical Trials
by Välitalo, Pyry and Kokki, Merja and Ranta, Veli-Pekka and Olkkola, Klaus T and Hooker, Andrew C and Kokki, Hannu
Pharmaceutical research, ISSN 0724-8741, 5/2017, Volume 34, Issue 5, pp. 1125 - 1133
Biochemistry, general | Biomedical Engineering | analgesic, opioid | pain | Biomedicine | Pharmacy | oxycodone | pharmacokinetics | Medical Law | infant, extremely premature | Pharmacology/Toxicology | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Oxycodone - pharmacokinetics | Age Factors | Humans | Infant, Premature | Analgesics, Opioid - pharmacokinetics | Child, Preschool | Infant | Body Weight - physiology | Infusions, Intravenous - methods | Child | Infant, Newborn | Metabolic Clearance Rate - physiology | Infants (Newborn) | Pediatric pharmacology | Oxycodone | Central nervous system depressants | Clinical trials | Anesthesia | Models | Analgesics | Narcotics | Pain management | Pharmaceuticals | Index Medicus
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