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by Yamagami, Keitaro and Kurogi, Ryota and Kurogi, Ai and Nishimura, Kunihiro and Onozuka, Daisuke and Ren, Nice and Kada, Akiko and Nishimura, Ataru and Arimura, Koichi and Ido, Keisuke and Mizoguchi, Masahiro and Sakamoto, Tetsuya and Kayama, Takamasa and Suzuki, Michiyasu and Arai, Hajime and Hagihara, Akihito and Iihara, Koji and Masayoshi, Takigami and Kenji, Kamiyama and Kiyohiro, Houkin and Shougo, Nishi and Tetsuyuki, Yoshimoto and Sadao, Kaneko and Koji, Oka and Hiroshi, Ooyama and Kyousuke, Kamada and Kenichi, Makino and Naoki, Tokumitsu and Kazuhiro, Sako and Susumu, Suzuki and Nozomi, Suzuki and Naoto, Izumi and Kazumi, Nitta and Masahumi, Ootaki and Masanori, Isobe and Mikio, Nishiya and Takaaki, Yamazaki and Syouji, Mabuchi and Kuniaki, Ogasawara and Naohiko, Kubo and Yukihiko, Shimizu and Keiichi, Saito and Tatumi, Yamanome and Atsuo, Yoshino and Mitsuyuki, Fujitsuka and Masaaki, Takami and Hirotoshi, Ohtaka and Teruyuki, Hirano and Yosiaki, Shiokawa and Takaharu, Okada and Ichiro, Suzuki and Michihiro, Kohno and Jou, Haraoka and Yoshinori, Arai and Noriyoshi, Kawamura and Akira, Isoshima and Masaharu, Yasue and Mitsuhiko, Hokari and Takayoshi, Kobayashi and Kensuke, Kawai and Taketoshi, Maehara and Hajime, Arai and Makoto, Noguchi and Haruhiko, Hoshino and Hirofumi, Hiyama and Kensaku, Yoshida and Osamu, Utsugi and Yasuaki, Takeda and Kouichi, Tamaki and Hirohide, Karasudani and Takao, Urabe and Shiro, Kobayashi and Michio, Nakamura and Yorio, Koguchi and Junichi, Ono and Sumio, Suda and Hiromu, Hadeishi and Toshio, Fukutake and Kenji, Wakui and Hirokazu, Tanno and Naoki, Ishige and Takashi, Ohasi and Hideki, Sakai and Yasuaki, Nishimura and Takayuki, Watanabe and Takashi, Matsumoto and Naoki, Koketsu and Yuichi, Hirose and Manabu, Doyu and Toshinori, Hasegawa and Naoto, Kuwayama and Shinichi, Terao and Nobuhiko, Mizutani and Noriyuki, Suzaki and Satoshi, Okuda and Keizo, Yasui and Yukio, Seki and Yasuhiro, Hasegawa and Akira, Ikeda and Youtarou, Takeuchi and ... and J-ASPECT Study Collaborators
World Neurosurgery, ISSN 1878-8750, 2019
Background: The epidemiology of patients with traumatic brain injury (TBI) has changed dramatically over recent decades as a result of rapid advances in aging... 
Aging | Hospital mortality | Prognosis | Traumatic brain injury | Subdural hematoma | Index Medicus
Journal Article
SAE technical paper series, Volume 2012-01-0337.
This paper describes the reliability of silicon carbide (SiC) MOSFET. We clarified the relation between the lifetime of the gate oxide and the crystal defects.... 
Microscopy | Power electronics | Reliability | Hybrid electric vehicles
eJournal
Current Drug Targets, ISSN 1389-4501, 2009, Volume 10, Issue 2, pp. 131 - 139
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 29, pp. 11782 - 11787
Recombinant immunotoxins (RITs) are hybrid proteins used to treat cancer. These proteins are composed of an Fv that reacts with cancer cells joined to a... 
Bacteriophages | Immunotoxins | Reactivity | Immune response | Antibodies | B lymphocyte epitopes | Amino acids | Toxins | Epitopes | Tumors | Protein engineering | Mesothelioma | Cancer treatment | Immunotherapy | Leukemia | H-CHAIN | cancer treatment | leukemia | ANIMAL TOXICITY | MOXETUMOMAB PASUDOTOX | MULTIDISCIPLINARY SCIENCES | RFB4(DSFV)-PE38 | INFUSION | protein engineering | PHASE-I TRIAL | immunotherapy | ANTIBODY-BINDING REGIONS | ANTITOXIN ANTIBODIES | MICE | mesothelioma | HEMATOLOGIC MALIGNANCIES | Immunotherapy - methods | Protein Engineering - methods | Humans | Molecular Sequence Data | Recombinant Proteins - pharmacokinetics | Epitopes, B-Lymphocyte - immunology | Peptide Library | Statistics, Nonparametric | Immunotoxins - chemistry | Amino Acid Sequence | Immunotoxins - immunology | Enzyme-Linked Immunosorbent Assay | Antineoplastic Agents - immunology | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Neoplasms - drug therapy | Immunotoxins - genetics | Animals | Mutagenesis | Recombinant Proteins - immunology | Neoplasms - immunology | Immunotoxins - pharmacokinetics | Mice | Single-Chain Antibodies - immunology | Care and treatment | B cells | Research | Antibody-toxin conjugates | Antigenic determinants | Cancer | Proteins | Antigens | Bacteria | Mutation | Cells | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2008, Volume 105, Issue 32, pp. 11311 - 11316
Recombinant immunotoxins are hybrid proteins composed of an Fv that binds to a tumor antigen fused to a bacterial or plant toxin. Immunotoxin BL22 targets CD22... 
Immunotoxins | Immunization | Immune response | Reactivity | B lymphocytes | Antibodies | B lymphocyte epitopes | Amino acids | Epitopes | Tumors | HA22 | Antibody engineering | BL22 | Immunotherapy | Pseudomonas exotoxin A | COMPLETE REGRESSION | MULTIDISCIPLINARY SCIENCES | ANTITUMOR-ACTIVITY | CYTOTOXIC ACTIVITY | RECOMBINANT STAPHYLOKINASE VARIANTS | antibody engineering | PHASE-I TRIAL | THERAPEUTIC PROTEINS | FV FRAGMENTS | immunotherapy | ANTIBODY-BINDING REGIONS | ANTITOXIN ANTIBODIES | RFB4(DSFV)-PE38 BL22 | Recombinant Fusion Proteins - immunology | Virulence Factors - genetics | Humans | Recombinant Fusion Proteins - therapeutic use | Amino Acid Substitution - immunology | Epitopes, B-Lymphocyte - immunology | Virulence Factors - immunology | ADP Ribose Transferases - therapeutic use | Epitopes, B-Lymphocyte - genetics | Enterotoxins - immunology | Enterotoxins - therapeutic use | Antibodies - immunology | Bacterial Toxins - genetics | Leukemia, Hairy Cell - immunology | ADP Ribose Transferases - immunology | Antibodies - therapeutic use | Rabbits | Bacterial Toxins - immunology | Exotoxins - immunology | Drug Resistance, Neoplasm - immunology | Mice, SCID | Bacterial Toxins - therapeutic use | ADP Ribose Transferases - genetics | Enterotoxins - genetics | Exotoxins - therapeutic use | Animals | Exotoxins - genetics | Leukemia, Hairy Cell - drug therapy | Recombinant Fusion Proteins - genetics | Antibodies - genetics | Mutation, Missense - immunology | Mice | Mice, Inbred BALB C | Drug Resistance, Neoplasm - drug effects | Virulence Factors - therapeutic use | Physiological aspects | Chemical properties | B cells | Research | Antibody-toxin conjugates | Binding proteins | Properties | Health aspects | Proteins | Antigens | Drug resistance | Cells | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 23, pp. 8571 - 8576
Nonhuman proteins have valuable therapeutic properties, but their efficacy is limited by neutralizing antibodies. Recombinant immunotoxins (RITs) are potent... 
T lymphocytes | Immunotoxins | Hairy cell leukemia | Immune response | Cell lines | Antibodies | T lymphocyte epitopes | B lymphocyte epitopes | Epitopes | Tumors | Protein engineering | Deimmunization | IMMUNODOMINANCE | ANTIGENICITY | MOXETUMOMAB PASUDOTOX | DETERMINANTS | PROTEIN THERAPEUTICS | MULTIDISCIPLINARY SCIENCES | ELIMINATION | deimmunization | TOXICITY | protein engineering | PHASE-I TRIAL | PSEUDOMONAS-AERUGINOSA | EXOTOXIN-A | Recombinant Fusion Proteins - immunology | Epitope Mapping | Immunotherapy - methods | Virulence Factors - genetics | Humans | Recombinant Fusion Proteins - therapeutic use | Amino Acids - immunology | Peptides - genetics | Virulence Factors - immunology | Amino Acids - genetics | Lymphocyte Activation - immunology | Neoplasms - therapy | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Bacterial Toxins - genetics | Female | Epitopes, T-Lymphocyte - immunology | Protein Structure, Tertiary | ADP Ribose Transferases - immunology | Cell Survival - drug effects | Antibody Formation - immunology | Immunotoxins - immunology | Bacterial Toxins - immunology | Electrophoresis, Polyacrylamide Gel | Exotoxins - immunology | Peptides - immunology | Models, Molecular | Recombinant Fusion Proteins - chemistry | Cell Survival - immunology | Mice, SCID | Xenograft Model Antitumor Assays | ADP Ribose Transferases - genetics | Point Mutation | Immunotoxins - genetics | Animals | Immunotoxins - therapeutic use | Lymphocyte Activation - drug effects | Neoplasms - immunology | Exotoxins - genetics | Cell Line, Tumor | T-Lymphocytes - immunology | Mice | Neoplasms - pathology | Care and treatment | Oncology, Experimental | Research | T cells | Recombinant proteins | Health aspects | Cancer | Proteins | Cellular biology | Toxins | Mutation | Cancer therapies | Cells | Immune system | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2011, Volume 108, Issue 14, pp. 5742 - 5747
Many nonhuman proteins have useful pharmacological activities, but are infrequently effective in humans because of their high immunogenicity. A recombinant... 
Immunotoxins | Immune response | Reactivity | Cell lines | Antibodies | B lymphocyte epitopes | Amino acids | Toxins | Epitopes | Inhibitory concentration 50 | Protein engineering | SS1P | Passive immunotherapy | Target therapy/cancer therapeutics | ANIMAL TOXICITY | MULTIDISCIPLINARY SCIENCES | STAPHYLOKINASE VARIANTS | ANTITUMOR-ACTIVITY | passive immunotherapy | CYTOTOXIC ACTIVITY | target therapy/cancer therapeutics | protein engineering | PHASE-I TRIAL | RFB4(DSFV)-PE38 BL22 | LEUKEMIA | PSEUDOMONAS EXOTOXIN | ALTERED IMMUNOREACTIVITY | Recombinant Fusion Proteins - immunology | Virulence Factors - genetics | Protein Engineering - methods | Recombinant Fusion Proteins - therapeutic use | Molecular Sequence Data | Exotoxins - metabolism | Epitopes, B-Lymphocyte - genetics | Statistics, Nonparametric | Bacterial Toxins - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | ADP Ribose Transferases - metabolism | Recombinant Fusion Proteins - biosynthesis | Amino Acid Sequence | Immunization, Passive - methods | Enzyme-Linked Immunosorbent Assay | Models, Molecular | Antibodies, Monoclonal | ADP Ribose Transferases - genetics | Bacterial Toxins - metabolism | Animals | Mutagenesis | Exotoxins - genetics | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Virulence Factors - metabolism | Mice | Mice, Inbred BALB C | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Physiological aspects | B cells | Research | Properties | Antibody-toxin conjugates | Antigenic determinants | Proteins | Lymphocytes | Leukemia | Rodents | Bacteria | Mutation | Cells | Index Medicus | Chronic lymphatic leukemia | Intravenous administration | Amino acid composition | Cytotoxicity | Malignancy | Drug resistance | Antibody response | Antigenicity | Exotoxins | Immunogenicity | Lymphocytes B | Point mutation | Antitumor activity | Remission | exotoxin A | cancer therapeutics | Biological Sciences | target therapy
Journal Article
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, ISSN 0885-3010, 06/2015, Volume 62, Issue 6, pp. 1007 - 1015
We report piezoelectric materials composed of charge-compensated co-doped (Mg, β) x Al 1-x N (β = Zr or Hf) thin films. The effect of the dopant element into... 
Atomic measurements | Zirconium | Lattices | Crystals | Film bulk acoustic resonators | III-V semiconductor materials | Aluminum nitride | ACOUSTICS | ACOUSTIC-WAVE RESONATORS | ALUMINUM NITRIDE | ENHANCEMENT | ENGINEERING, ELECTRICAL & ELECTRONIC | Usage | Diffraction | X-rays | Research | Structure | Electric properties | Thin films | Crystal structure
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2018, Volume 115, Issue 15, pp. E3501 - E3508
Journal Article
ChemCatChem, ISSN 1867-3880, 07/2017, Volume 9, Issue 14, pp. 2638 - 2641
Green macroalgae, such as Ulva spp ., has a higher growth rate than terrestrial lingocellulosic biomass, which often leads to serious environmental issues such... 
solid acid catalysts | macroalgae | hydrolysis | oligosaccharides | ulvan | OXIDATION | ACID | OXIDE | CONVERSION | CHEMISTRY, PHYSICAL | KINETICS | GLUCOSE | ULVA-PROLIFERA | CELLULOSE | Hydrolysis | Polysaccharides | Sulfates | Sugars | Monosaccharides | Cultivation | Catalysts | Refining | Activated carbon | Algae | Catalytic activity | Raw materials | Conversion | Catalytic converters
Journal Article
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, ISSN 0885-3010, 08/2014, Volume 61, Issue 8, pp. 1322 - 1328
This paper reports the crystal structures and piezoelectric properties of Mg and Zr co-doped AlN (MgZr-doped AlN) thin films. MgZr-doped AlN thin films on Si... 
Atomic measurements | Zirconium | Lattices | Crystals | Doping | Film bulk acoustic resonators | III-V semiconductor materials | ACOUSTICS | BAND | AIN | ENHANCEMENT | ENGINEERING, ELECTRICAL & ELECTRONIC | Evaluation | Usage | Semiconductor films | Diffraction | X-rays | Piezoelectricity | Electron microscopy | Resonators | Thin films | Crystal structure | Silicon substrates | Magnesium | Aluminum nitride
Journal Article
Journal Article
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2012, Volume 907, pp. 627 - 643
Conference Proceeding
Molecular Cancer, ISSN 1476-4598, 10/2006, Volume 5, Issue 1, pp. 50 - 50
Background: The mucin MUC16 and the glycosylphosphatidylinositol anchored glycoprotein mesothelin likely facilitate the peritoneal metastasis of ovarian... 
IN-VITRO | ONCOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER ANTIGEN | SECONDARY STRUCTURE PREDICTION | MONOCLONAL-ANTIBODY | MOLECULAR-CLONING<