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Nature, ISSN 0028-0836, 08/2009, Volume 460, Issue 7257, pp. 904 - 908
Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function... 
TRANSFORMATION | PROTEIN | RETROVIRAL VECTOR GCDNSAP | NEGATIVE REGULATION | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC STEM-CELLS | V-CBL | MUTATIONS | UBIQUITIN LIGASES | MYELODYSPLASTIC SYNDROMES | P53 | NIH 3T3 Cells | Neoplasm Transplantation | ras Proteins - genetics | Phosphorylation | Proto-Oncogene Proteins c-cbl - metabolism | Humans | Leukemia, Myeloid - genetics | Molecular Sequence Data | ras Proteins - metabolism | Male | Leukemia, Myeloid - pathology | Allelic Imbalance | Ubiquitination | Base Sequence | Female | Proto-Oncogene Proteins c-cbl - deficiency | Genes, Tumor Suppressor | Proto-Oncogene Proteins c-cbl - genetics | Amino Acid Sequence | Oncogenes - genetics | Mutant Proteins - genetics | Models, Molecular | Mutant Proteins - metabolism | Chromosomes, Human, Pair 11 - genetics | Proto-Oncogene Proteins c-cbl - chemistry | Mice, Knockout | Animals | Uniparental Disomy - genetics | Leukemia, Myeloid - metabolism | Mice, Nude | Mutant Proteins - chemistry | Proto-Oncogene Proteins c-cbl - antagonists & inhibitors | Protein Conformation | Mice | Mutation | Gene mutations | Myelocytic leukemia | Physiological aspects | Tumor suppressor genes | Development and progression | Genetic aspects | Nonlymphoid leukemia | Research | Protein kinases | Proteins | Genes | Amino acids | Kinases | Cells | Clinical outcomes | Crystal structure | Index Medicus
Journal Article
Journal of Clinical Immunology, ISSN 0271-9142, 5/2015, Volume 35, Issue 4, pp. 384 - 398
We here describe treatment outcomes in two adenosine deaminase (ADA)-deficiency patients (pt) who received stem cell gene therapy (SCGT) with no cytoreductive... 
Medical Microbiology | Biomedicine | Immunology | retroviral vector(s) | Infectious Diseases | Internal Medicine | hematopoietic stem cell(s) | Gene therapy | severe combined immunodeficiency (SCID) | adenosine deaminase (ADA) | primary immunodeficiency (PID) | SEVERE COMBINED IMMUNODEFICIENCY | CHRONIC GRANULOMATOUS-DISEASE | WISKOTT-ALDRICH-SYNDROME | BONE-MARROW-CELLS | IMMUNOLOGY | RETROVIRAL VECTORS | ENZYME-REPLACEMENT THERAPY | PERIPHERAL-BLOOD LYMPHOCYTES | ADA DEFICIENCY | T-LYMPHOCYTES | HEMATOPOIETIC STEM | Genetic Therapy | Agammaglobulinemia - immunology | Agammaglobulinemia - genetics | Humans | Child, Preschool | Agammaglobulinemia - diagnosis | Infant | Immunity | Lymphocyte Subsets - immunology | Lymphocyte Subsets - metabolism | Hematopoiesis | Adenosine Deaminase - therapeutic use | Cell Differentiation | Adenosine Deaminase - deficiency | Transgenes | Infant, Newborn | Enzyme Replacement Therapy | Gene Expression | Transduction, Genetic | Adenosine Deaminase - genetics | Agammaglobulinemia - therapy | Severe Combined Immunodeficiency - diagnosis | Japan | Hematopoietic Stem Cell Transplantation | Severe Combined Immunodeficiency - therapy | Immunophenotyping | Treatment Outcome | Hematopoietic Stem Cells - metabolism | Severe Combined Immunodeficiency - immunology | Genetic Vectors - genetics | Severe Combined Immunodeficiency - genetics | Gammaretrovirus - genetics | Hematopoietic Stem Cells - cytology | Adolescent | Age of Onset | Enzyme Activation | Mutation | Adenosine Deaminase - immunology | Enzymes | Adenosine | Care and treatment | Analysis | Genes | Patient outcomes | Immunodeficiency | Stem cells | Transplantation | T cells | Hematopoietic stem cells | Index Medicus
Journal Article
Kyobu geka. The Japanese journal of thoracic surgery, ISSN 0021-5252, 07/2016, Volume 69, Issue 8, pp. 661 - 665
Journal Article
Kyobu geka. The Japanese journal of thoracic surgery, ISSN 0021-5252, 07/2016, Volume 69, Issue 8, p. 661
Single port thoracic surgery, reduced port surgery and needlescopic surgery attract attention as one of the minimally invasive surgery in thoracic surgery... 
Pneumothorax | Thoracic Surgery | Biopsy | Humans | Minimally Invasive Surgical Procedures
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2009, Volume 106, Issue 40, pp. 17163 - 17168
Controversy remains over whether the cancer stem cell (CSC) theory applies to all tumors. To determine whether cells within a highly aggressive solid tumor are... 
Hepatocytes | Neurons | Stem cells | Multipotent stem cells | Brain neoplasms | Mice | Tumor stem cells | Cells | Tumors | Cancer | Cancer stem cell | Invasion | NEURAL PROGENITORS | CANCER-CELLS | SYSTEM | PROTEIN | MULTIDISCIPLINARY SCIENCES | HEPATOCYTE GROWTH-FACTOR | GLIOBLASTOMA GROWTH | PROLIFERATION | CNS STEM-CELLS | cancer stem cell | invasion | MICE | EFFICIENT | Immunohistochemistry | Proto-Oncogene Proteins c-met - metabolism | Neurons - pathology | Brain Neoplasms - pathology | Glycoproteins - metabolism | Green Fluorescent Proteins - genetics | Promoter Regions, Genetic - genetics | Brain Neoplasms - metabolism | Antigens, CD - metabolism | Flow Cytometry | Peptides - metabolism | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Cell Differentiation | Neurons - metabolism | Nuclear Proteins - genetics | Animals, Newborn | Green Fluorescent Proteins - metabolism | Mice, Inbred C57BL | Brain Neoplasms - genetics | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Mice, Transgenic | AC133 Antigen | Clone Cells - metabolism | Mice, Knockout | Carrier Proteins - genetics | Microscopy, Confocal | Animals | Clone Cells - pathology | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Research | Identification and classification | Brain tumors | Brain | Tissue | Rodents | Cloning | Genetics | Index Medicus | Biological Sciences
Journal Article
Journal Article
Molecular Therapy - Methods & Clinical Development, ISSN 2329-0501, 09/2017, Volume 6, Issue C, pp. 8 - 16
Clinical improvement in stem cell gene therapy (SCGT) for primary immunodeficiencies depends on the engraftment levels of genetically corrected cells, and... 
gene therapy | single cell | ADA-SCID | vector integration | digital droplet PCR | MEDICINE, RESEARCH & EXPERIMENTAL | SEVERE COMBINED IMMUNODEFICIENCY | ADENOSINE-DEAMINASE-DEFICIENCY | EFFICACY | INSERTIONAL ONCOGENESIS | ENZYME REPLACEMENT THERAPY | PCR | LYMPHOCYTES
Journal Article
Pediatrics International, ISSN 1328-8067, 11/2018, Volume 60, Issue 11, pp. 1043 - 1044
Journal Article
Journal of Clinical Immunology, ISSN 0271-9142, 05/2017, Volume 37, Issue 4, p. 347
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s10875-017-0393-7 
T cells
Journal Article
Journal of Clinical Immunology, ISSN 0271-9142, 11/2017, Volume 37, Issue 8, pp. 741 - 743
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s10875-017-0441-3 
Medical Microbiology | Infectious Diseases | Internal Medicine | Biomedicine | Immunology | IMMUNOLOGY | Medical colleges | Colitis | Chronic granulomatous disease | Index Medicus
Journal Article
Arthritis Research & Therapy, ISSN 1478-6362, 12/2019, Volume 21, Issue 1, pp. 1 - 12
Background Haploinsufficiency of A20 (HA20) is caused by loss-of-function TNFAIP3 variants. Phenotypic and genetic features of HA20 remain uncertain;... 
Statistical analysis | Disease | Genomics | Genes | Families & family life | Principal components analysis | Genomes | Mutation | Patients | TNFAIP3 | Behçet’s disease | Whole exome sequencing | Autoinflammatory | Haploinsufficiency of A20
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0139274 - e0139274
Journal Article
Journal of Gastroenterology, ISSN 0944-1174, 6/2011, Volume 46, Issue 6, pp. 779 - 789
Intrahepatic cholangiocarcinoma (ICC) is rising in clinical importance due to the increasing incidence worldwide, poor prognosis, and suboptimal response to... 
Medicine & Public Health | Colorectal Surgery | Hepatology | Gastroenterology | Preclinical study | Oncology | Internal Medicine | Multi-tyrosine kinase inhibitor | Antitumor activity | Molecular targeting therapy | Surgical Oncology | Cholangiocarcinoma | SURVIVAL | BILIARY-TRACT CANCER | STAT3 | RAF/MEK/ERK PATHWAY | HEPATOCELLULAR-CARCINOMA | THERAPY | RETROVIRAL VECTOR GCDNSAP | CHOLANGIOCELLULAR CARCINOMA | TARGETS | INHIBITOR | GASTROENTEROLOGY & HEPATOLOGY | Niacinamide - analogs & derivatives | Apoptosis - drug effects | Humans | Phenylurea Compounds | Antineoplastic Agents - administration & dosage | Benzenesulfonates - administration & dosage | Bile Ducts, Intrahepatic - drug effects | Dose-Response Relationship, Drug | Benzenesulfonates - pharmacology | Female | Antineoplastic Agents - pharmacology | Bile Duct Neoplasms - drug therapy | Bile Ducts, Intrahepatic - pathology | Pyridines - administration & dosage | Survival Rate | Xenograft Model Antitumor Assays | Cholangiocarcinoma - pathology | Animals | Cholangiocarcinoma - drug therapy | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Pyridines - pharmacology | Bile Duct Neoplasms - pathology | Antimitotic agents | Medical colleges | Platelet-derived growth factor | Interleukins | Analysis | Leukemia | Dosage and administration | Antineoplastic agents | Health aspects | Vascular endothelial growth factor | Protein kinases | Endothelium | Index Medicus
Journal Article