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FEMS microbiology letters, ISSN 1574-6968, 03/2019, Volume 366, Issue 5
CRISPR-Cas systems provide adaptive immunity against mobile genetic elements, but employment of this resistance mechanism is often reported with a fitness cost... 
plasmid | CRISPR | bacteria | toxin | adaptive immunity
Journal Article
Science, ISSN 0036-8075, 2015, Volume 348, Issue 6234, pp. 581 - 585
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 2013, Volume 41, Issue 10, pp. e111 - e111
Proteins that recognize and bind specific sites in DNA are essential for regulation of numerous biological functions. Such proteins often require a negative... 
PROTEIN | REPLICATION | PADLOCK OLIGONUCLEOTIDES | HELIX FORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE | LAC REPRESSOR | BIOSENSOR | BINDING | OPERATORS | ASSOCIATION | Methods Online | replication | sequence | biosensor | operators | padlock oligonucleotides | protein | binding | association | lac repressor | helix formation
Journal Article
Journal Article
Science, ISSN 0036-8075, 2013, Volume 339, Issue 6121, pp. 768 - 770
Gene therapy is the holy grail of human medicine. Many diseases are caused by a defective gene, sometimes with a mutation as subtle as a single-nucleotide... 
Genetic Engineering - methods | Microarray Analysis - methods | Gene Targeting - methods | Animals | Humans | Clustered Regularly Interspaced Short Palindromic Repeats | Genome - genetics | RNA - chemistry | DNA Cleavage | Genome, Human - genetics | Inverted Repeat Sequences | dna cleavage | endonuclease | rna | bacteria | adaptive immunity
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2013, Volume 52, Issue 1, pp. 135 - 145
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 05/2011, Volume 18, Issue 5, pp. 529 - U141
The CRISPR (clustered regularly interspaced short palindromic repeats) immune system in prokaryotes uses small guide RNAs to neutralize invading viruses and... 
DEFENSE | BACTERIA | PROTEIN | ARCHAEOGLOBUS-FULGIDUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | R-LOOPS | MASS-SPECTROMETRY | CELL BIOLOGY | STREPTOCOCCUS-THERMOPHILUS | OF-FLIGHT INSTRUMENT | IMMUNE-SYSTEM | BIOPHYSICS | PROKARYOTES | Protein Structure, Tertiary | RNA, Guide - metabolism | Ribonucleoproteins - physiology | Escherichia coli - immunology | Escherichia coli Proteins - metabolism | Ribonucleoproteins - metabolism | Structure-Activity Relationship | Escherichia coli Proteins - physiology | DNA - chemistry | Escherichia coli - virology | RNA, Guide - physiology | RNA, Guide - chemistry | Base Sequence | RNA, Bacterial - chemistry | Escherichia coli - metabolism | RNA, Bacterial - physiology | Ribonucleoproteins - chemistry | Escherichia coli Proteins - chemistry | Nucleic Acid Conformation | Binding Sites | RNA, Bacterial - metabolism | Physiological aspects | Research | Nucleotide sequence | Structure | Plasmids | Proteins | Signal transduction | E coli | Molecular structure | Molecular biology | Deoxyribonucleic acid--DNA | Biology with specialization in Microbiology | Biological Sciences | Naturvetenskap | Biokemi och molekylärbiologi | Biologiska vetenskaper | Biochemistry and Molecular Biology | Natural Sciences | Biologi med inriktning mot mikrobiologi | mass-spectrometry | of-flight instrument | r-loops | streptococcus-thermophilus | prokaryotes | bacteria | defense | protein | archaeoglobus-fulgidus | immune-system
Journal Article
Science, ISSN 0036-8075, 8/2008, Volume 321, Issue 5891, pp. 960 - 964
Prokaryotes acquire virus resistance by integrating short fragments of viral nucleic acid into clusters of regularly interspaced short palindromic repeats... 
Bacteriophages | Proteins | Phenotypes | RNA | Microbiology | Prokaryotes | Genes | Antivirals | Viruses | Reports | Nucleotides | SYSTEM | STREPTOCOCCUS-THERMOPHILUS | ELEMENTS | EVOLUTIONARY | DNA | MULTIDISCIPLINARY SCIENCES | SEQUENCE | PROVIDES ACQUIRED-RESISTANCE | IDENTIFICATION | REPEATS | VIRUSES | DNA, Intergenic | Escherichia coli K12 - virology | Amino Acid Sequence | Genes, Bacterial | RNA, Guide - genetics | RNA, Guide - metabolism | DNA, Viral - metabolism | Molecular Sequence Data | Viral Plaque Assay | Escherichia coli Proteins - metabolism | Escherichia coli K12 - metabolism | Escherichia coli - genetics | Base Sequence | Escherichia coli - metabolism | Escherichia coli Proteins - genetics | RNA, Bacterial - genetics | Repetitive Sequences, Nucleic Acid | RNA Precursors - metabolism | Transcription, Genetic | Bacteriophage lambda - genetics | Escherichia coli K12 - genetics | Escherichia coli Proteins - chemistry | Bacteriophage lambda - growth & development | RNA, Bacterial - metabolism | Physiological aspects | Genetic aspects | Virus inhibitors | Infections | Ribonucleic acid--RNA | Genetik | CRISPR | Naturvetenskap | Biokemi | Mikrobiologi | Genetics | Biochemistry | Natural Sciences | repeats | sequence | viruses | streptococcus-thermophilus | identification | system | dna | elements | evolutionary | provides acquired-resistance
Journal Article