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Nature Communications, ISSN 2041-1723, 2019, Volume 10
Argonaute (Ago) proteins are key players in both gene regulation (eukaryotes) and host defense (prokaryotes). Acting on single-stranded nucleic-acid... 
VLAG | BacGen
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2018, Volume 14, Issue 7, pp. 642 - 651
Over the last decade, research on distinct types of CRISPR systems has revealed many structural and functional variations. Recently, several novel types of... 
Microbiologie | VLAG | Microbiology | Laboratorium voor Microbiologie | Microbiological Laboratory
Journal Article
Journal Article
Trends in Microbiology, ISSN 0966-842X, 01/2019, Volume 27, Issue 1, p. 17
Bacterial communities are known to impact human health and disease. Mixed species bioflims, mostly pathogenic in nature, have been observed in dental and... 
Pathogens | Bacterial infections | Warning systems | Digestive system | Pathogenesis | Mucosa | Colorectal cancer | Biofilms | Colon cancer | Intestine | Biomarkers | Colon | Digestive tract
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2017, Volume 66, Issue 2, pp. 221 - 233.e4
The CRISPR-associated protein Cas12a (Cpf1), which has been repurposed for genome editing, possesses two distinct nuclease activities: endoribonuclease... 
R-loop | nuclease | CRISPR RNA | target DNA cleavage | CRISPR-Cas | Cpf1 | Cas12a | Cas9 | seed sequence | crRNA processing | CRISPR-CAS SYSTEMS | IMMUNITY | COMPLEX | ENDONUCLEASE | RECOGNITION | HUMAN-CELLS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE | CLEAVAGE | CPF1 NUCLEASES | CELL BIOLOGY | RNA Precursors - chemistry | CRISPR-Associated Proteins - chemistry | Endonucleases - genetics | DNA, Bacterial - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | Bacterial Proteins - chemistry | DNA, Bacterial - chemistry | Structure-Activity Relationship | Endonucleases - metabolism | RNA, Guide - chemistry | Francisella - enzymology | Clustered Regularly Interspaced Short Palindromic Repeats | RNA, Bacterial - genetics | RNA Precursors - metabolism | Catalysis | Nucleic Acid Conformation | RNA, Bacterial - metabolism | Escherichia coli - enzymology | CRISPR-Associated Proteins - genetics | Bacterial Proteins - genetics | Models, Molecular | RNA Precursors - genetics | Endonucleases - chemistry | DNA, Bacterial - genetics | Escherichia coli - genetics | CRISPR-Associated Proteins - metabolism | RNA, Bacterial - chemistry | CRISPR-Cas Systems | Bacterial Proteins - metabolism | Protein Conformation | Gene Editing - methods | Francisella - genetics | Enzymes | Nucleases | RNA | Genomics | DNA | Crystals | Structure | Phosphates
Journal Article
Bioscience Reports, ISSN 0144-8463, 06/2018, Volume 38, Issue 3, p. 1
Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-associated genes) immune systems, astonishing progress has... 
CRISPR | Shooting | RNA-mediated interference | Genomes | Ribonucleic acid--RNA | Deoxyribonucleic acid--DNA | Immune system
Journal Article
FEMS Microbiology Letters, ISSN 0378-1097, 2019, Volume 366, Issue 5
CRISPR-Cas systems provide adaptive immunity against mobile genetic elements, but employment of this resistance mechanism is often reported with a fitness cost... 
plasmid | CRISPR | bacteria | toxin | adaptive immunity
Journal Article