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Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
Nature, ISSN 0028-0836, 11/2014, Volume 515, Issue 7527, pp. 431 - 435
Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and then restored, and underlies many disorders, notably heart attack and...
STROKE | HYPOXIA-ISCHEMIA | MECHANISM | COMPLEX-I | SUPEROXIDE-PRODUCTION | MULTIDISCIPLINARY SCIENCES | PURINE NUCLEOTIDE CYCLE | CONSEQUENCES | CARDIOPROTECTION | HYPERTENSIVE-RATS | DEHYDROGENASE | Metabolomics | Mitochondria - enzymology | Electron Transport | Reactive Oxygen Species - metabolism | Ischemia - enzymology | Male | Electron Transport Complex I - metabolism | Myocytes, Cardiac - enzymology | Myocardium - metabolism | Malates - metabolism | Reperfusion Injury - metabolism | NAD - metabolism | Disease Models, Animal | Myocardial Infarction - enzymology | Adenosine Monophosphate - metabolism | Reperfusion Injury - enzymology | Ischemia - metabolism | Mitochondria - metabolism | Myocardial Infarction - metabolism | Citric Acid Cycle | Myocardium - cytology | Stroke - enzymology | Myocardium - enzymology | Stroke - metabolism | Animals | Succinic Acid - metabolism | Fumarates - metabolism | Myocytes, Cardiac - metabolism | Aspartic Acid - metabolism | Succinate Dehydrogenase - metabolism | Mice | Reactive oxygen species | Research | Succinates | Health aspects | Analysis | Reperfusion injury | Heart | Stroke | Glucose | Metabolites | Metabolism | Carbon
STROKE | HYPOXIA-ISCHEMIA | MECHANISM | COMPLEX-I | SUPEROXIDE-PRODUCTION | MULTIDISCIPLINARY SCIENCES | PURINE NUCLEOTIDE CYCLE | CONSEQUENCES | CARDIOPROTECTION | HYPERTENSIVE-RATS | DEHYDROGENASE | Metabolomics | Mitochondria - enzymology | Electron Transport | Reactive Oxygen Species - metabolism | Ischemia - enzymology | Male | Electron Transport Complex I - metabolism | Myocytes, Cardiac - enzymology | Myocardium - metabolism | Malates - metabolism | Reperfusion Injury - metabolism | NAD - metabolism | Disease Models, Animal | Myocardial Infarction - enzymology | Adenosine Monophosphate - metabolism | Reperfusion Injury - enzymology | Ischemia - metabolism | Mitochondria - metabolism | Myocardial Infarction - metabolism | Citric Acid Cycle | Myocardium - cytology | Stroke - enzymology | Myocardium - enzymology | Stroke - metabolism | Animals | Succinic Acid - metabolism | Fumarates - metabolism | Myocytes, Cardiac - metabolism | Aspartic Acid - metabolism | Succinate Dehydrogenase - metabolism | Mice | Reactive oxygen species | Research | Succinates | Health aspects | Analysis | Reperfusion injury | Heart | Stroke | Glucose | Metabolites | Metabolism | Carbon
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2017, Volume 376, Issue 18, pp. 1713 - 1722
In this trial, 27,564 patients with cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter or higher on statin therapy were assigned to...
MODERATE | MEDICINE, GENERAL & INTERNAL | STATIN THERAPY | LDL-C | REDUCING LIPIDS | PCSK9 INHIBITION | RISK | PLACEBO-CONTROLLED TRIAL | HYPERCHOLESTEROLEMIA | CORONARY-HEART-DISEASE | EZETIMIBE | Atherosclerosis - drug therapy | Double-Blind Method | Follow-Up Studies | Cardiovascular Diseases - drug therapy | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Hypercholesterolemia - drug therapy | Anticholesteremic Agents - adverse effects | Incidence | Cardiovascular Diseases - complications | Anticholesteremic Agents - therapeutic use | Proprotein Convertase 9 - antagonists & inhibitors | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Least-Squares Analysis | Cholesterol, LDL - blood | Female | Hypercholesterolemia - complications | Aged | Drug Therapy, Combination | Prevention | Treatment outcome | Cardiovascular diseases | Drug therapy | Analysis | Stroke | Monoclonal antibodies | Cardiovascular disease | Patients | Drug dosages | Low density lipoprotein | Statins | Clinical outcomes | Cholesterol | Life Sciences | Human health and pathology
MODERATE | MEDICINE, GENERAL & INTERNAL | STATIN THERAPY | LDL-C | REDUCING LIPIDS | PCSK9 INHIBITION | RISK | PLACEBO-CONTROLLED TRIAL | HYPERCHOLESTEROLEMIA | CORONARY-HEART-DISEASE | EZETIMIBE | Atherosclerosis - drug therapy | Double-Blind Method | Follow-Up Studies | Cardiovascular Diseases - drug therapy | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Hypercholesterolemia - drug therapy | Anticholesteremic Agents - adverse effects | Incidence | Cardiovascular Diseases - complications | Anticholesteremic Agents - therapeutic use | Proprotein Convertase 9 - antagonists & inhibitors | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Least-Squares Analysis | Cholesterol, LDL - blood | Female | Hypercholesterolemia - complications | Aged | Drug Therapy, Combination | Prevention | Treatment outcome | Cardiovascular diseases | Drug therapy | Analysis | Stroke | Monoclonal antibodies | Cardiovascular disease | Patients | Drug dosages | Low density lipoprotein | Statins | Clinical outcomes | Cholesterol | Life Sciences | Human health and pathology
Journal Article
Monthly Notices of the Royal Astronomical Society, ISSN 0035-8711, 2017, Volume 464, Issue 1, pp. 1146 - 1167
Using the Murchison Widefield Array (MWA), the low-frequency Square Kilometre Array precursor located in Western Australia, we have completed the GaLactic and...
Surveys | Techniques: interferometric | Galaxies: general | RADIO IMAGING SURVEY | galaxies: general | REIONIZATION | TELESCOPE | surveys | MOLONGLO REFERENCE CATALOG | COSMOLOGY | BOOTES FIELD | FLUCTUATIONS | ASTRONOMY & ASTROPHYSICS | SOUTHERN SKY | SPECTRUM | FLUX-DENSITY SCALE | techniques: interferometric | Physics - Astrophysics of Galaxies
Surveys | Techniques: interferometric | Galaxies: general | RADIO IMAGING SURVEY | galaxies: general | REIONIZATION | TELESCOPE | surveys | MOLONGLO REFERENCE CATALOG | COSMOLOGY | BOOTES FIELD | FLUCTUATIONS | ASTRONOMY & ASTROPHYSICS | SOUTHERN SKY | SPECTRUM | FLUX-DENSITY SCALE | techniques: interferometric | Physics - Astrophysics of Galaxies
Journal Article
2005, ISBN 9783211252109, xxii, 231
Book
Monthly Notices of the Royal Astronomical Society, ISSN 0035-8711, 07/2014, Volume 444, Issue 1, pp. 606 - 619
Astronomical wide-field imaging of interferometric radio data is computationally expensive, especially for the large data volumes created by modern...
Techniques: interferometric | Methods: observational | Instrumentation: interferometers | Radio continuum: general | CALIBRATION | methods: observational | DESIGN | REPRESENTATIONS | SUBTRACTION | ALGORITHM | radio continuum: general | PROJECTION | DECONVOLUTION | POINT SOURCES | ASTRONOMY & ASTROPHYSICS | instrumentation: interferometers | techniques: interferometric | Physics - Instrumentation and Methods for Astrophysics
Techniques: interferometric | Methods: observational | Instrumentation: interferometers | Radio continuum: general | CALIBRATION | methods: observational | DESIGN | REPRESENTATIONS | SUBTRACTION | ALGORITHM | radio continuum: general | PROJECTION | DECONVOLUTION | POINT SOURCES | ASTRONOMY & ASTROPHYSICS | instrumentation: interferometers | techniques: interferometric | Physics - Instrumentation and Methods for Astrophysics
Journal Article
Astrophysical Journal, ISSN 0004-637X, 12/2016, Volume 833, Issue 1, p. 102
The Murchison Widefield Array (MWA) has collected hundreds of hours of Epoch of Reionization (EoR) data and now faces the challenge of overcoming foreground...
cosmology: reionization | cosmology: observations | RADIO OBSERVATIONS | BASE-LINE | MURCHISON WIDEFIELD ARRAY | INTERGALACTIC MEDIUM | FIELD | WEBB-SPACE-TELESCOPE | COSMOLOGY | REIONIZATION OBSERVATIONS | 21 CM EPOCH | ASTRONOMY & ASTROPHYSICS | PAPER-64 CONSTRAINTS
cosmology: reionization | cosmology: observations | RADIO OBSERVATIONS | BASE-LINE | MURCHISON WIDEFIELD ARRAY | INTERGALACTIC MEDIUM | FIELD | WEBB-SPACE-TELESCOPE | COSMOLOGY | REIONIZATION OBSERVATIONS | 21 CM EPOCH | ASTRONOMY & ASTROPHYSICS | PAPER-64 CONSTRAINTS
Journal Article
Publications of the Astronomical Society of Australia, ISSN 1323-3580, 01/2013, Volume 30, Issue 1
The Murchison Widefield Array (MWA) is one of three Square Kilometre Array Precursor telescopes and is located at the Murchison Radio-astronomy Observatory in...
radio lines: general | early Universe | techniques: image processing | techniques: interferometric-radio continuum: general | instrumentation: interferometers | CALIBRATION | WIDE-FIELD ARRAY | REIONIZATION | SUBTRACTION | SOFTWARE CORRELATOR | NONCOPLANAR ARRAYS | CHALLENGES | POINT SOURCES | IMAGES | ASTRONOMY & ASTROPHYSICS | TRANSIENTS | Physics - Instrumentation and Methods for Astrophysics
radio lines: general | early Universe | techniques: image processing | techniques: interferometric-radio continuum: general | instrumentation: interferometers | CALIBRATION | WIDE-FIELD ARRAY | REIONIZATION | SUBTRACTION | SOFTWARE CORRELATOR | NONCOPLANAR ARRAYS | CHALLENGES | POINT SOURCES | IMAGES | ASTRONOMY & ASTROPHYSICS | TRANSIENTS | Physics - Instrumentation and Methods for Astrophysics
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 12/2013, Volume 20, Issue 12, pp. 1415 - 1424
The order and timing of cell-cycle events is controlled by changing substrate specificity and different activity thresholds of cyclin-dependent kinases (CDKs)....
FISSION YEAST | BIOCHEMISTRY & MOLECULAR BIOLOGY | SACCHAROMYCES-CEREVISIAE | MUTATIONAL ANALYSIS | SUBSTRATE RECOGNITION | CELL BIOLOGY | CYCLIN-DEPENDENT KINASES | XENOPUS SUC1/CKS PROTEIN | BIOPHYSICS | RETINOBLASTOMA PROTEIN | S-PHASE | CELL-CYCLE | QUANTITATIVE MODEL | Phosphorylation | Signal Transduction | Cell Cycle Proteins - metabolism | Phosphoserine - metabolism | Phosphothreonine - metabolism | CDC2 Protein Kinase - metabolism | Saccharomyces cerevisiae - metabolism | Adaptor Proteins, Signal Transducing - physiology | Cyclins - metabolism | Phosphothreonine - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Cyclin B - metabolism | Cyclin B - physiology | Cyclins - physiology | Saccharomyces cerevisiae Proteins - physiology | Adaptor Proteins, Signal Transducing - metabolism | Cell Cycle Proteins - physiology | CDC2 Protein Kinase - physiology | Phosphoserine - chemistry | Signal transduction | Kinases | Cell cycle
FISSION YEAST | BIOCHEMISTRY & MOLECULAR BIOLOGY | SACCHAROMYCES-CEREVISIAE | MUTATIONAL ANALYSIS | SUBSTRATE RECOGNITION | CELL BIOLOGY | CYCLIN-DEPENDENT KINASES | XENOPUS SUC1/CKS PROTEIN | BIOPHYSICS | RETINOBLASTOMA PROTEIN | S-PHASE | CELL-CYCLE | QUANTITATIVE MODEL | Phosphorylation | Signal Transduction | Cell Cycle Proteins - metabolism | Phosphoserine - metabolism | Phosphothreonine - metabolism | CDC2 Protein Kinase - metabolism | Saccharomyces cerevisiae - metabolism | Adaptor Proteins, Signal Transducing - physiology | Cyclins - metabolism | Phosphothreonine - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Cyclin B - metabolism | Cyclin B - physiology | Cyclins - physiology | Saccharomyces cerevisiae Proteins - physiology | Adaptor Proteins, Signal Transducing - metabolism | Cell Cycle Proteins - physiology | CDC2 Protein Kinase - physiology | Phosphoserine - chemistry | Signal transduction | Kinases | Cell cycle
Journal Article