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1. Full Text Breast cancer: post-mastectomy radiotherapy reduces recurrence and mortality
by Orecchia, Roberto
Nature reviews. Clinical oncology, ISSN 1759-4774, 07/2014, Volume 11, Issue 7, p. 382
The recent results of the Early Breast Cancer Trialists’ Cooperative Group meta-analysis have demonstrated that post-mastectomy radiotherapy reduces breast... 
Breast Neoplasms - surgery | Breast Neoplasms - radiotherapy | Neoplasm Recurrence, Local - prevention & control | Breast Neoplasms - pathology | Humans | Mastectomy | Female | Radiotherapy, Adjuvant
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2. Full Text Carbon ion radiotherapy in Japan: an assessment of 20 years of clinical experience
by Kamada, Tadashi, MD and Tsujii, Hirohiko, MD and Blakely, Eleanor A, PhD and Debus, Jürgen, Prof and De Neve, Wilfried, Prof and Durante, Marco, Prof and Jäkel, Oliver, Prof and Mayer, Ramona, Prof and Orecchia, Roberto, Prof and Pötter, Richard, Prof and Vatnitsky, Stanislav, PhD and Chu, William T, PhD
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 2, pp. e93 - e100
Summary Charged particle therapy is generally regarded as cutting-edge technology in oncology. Many proton therapy centres are active in the USA, Europe, and... 
Hematology, Oncology and Palliative Medicine | PROTON-BEAM THERAPY | GLIOMAS | 2ND MALIGNANCIES | ONCOLOGY | LOCALIZED PROSTATE-CANCER | HEAVY CHARGED-PARTICLES | PHASE-I/II | PARTICLE RADIATION-THERAPY | PHOTON RADIATION | CERVICAL-CANCER | CHEMOTHERAPY | Neoplasms - radiotherapy | Carbon - therapeutic use | Heavy Ion Radiotherapy | Time Factors | Humans | Japan | Physicists | Sarcoma | Radiotherapy | Pancreatic cancer | X-rays | Colorectal cancer
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3. Full Text Radiation therapy for inflammatory breast cancer
by Orecchia, Roberto
European Journal of Surgical Oncology, ISSN 0748-7983, 08/2018, Volume 44, Issue 8, pp. 1148 - 1150
Inflammatory Breast Cancer (IBC) is a rare and very aggressive breast cancer, still associated with poor prognosis. Therefore, management of IBC requires... 
Inflammatory breast cancer | Radiotherapy | MASTECTOMY | SURVIVAL | SURGERY | DIAGNOSIS | CONSERVATION | ONCOLOGY | OUTCOMES | CARCINOMA | CHEMOTHERAPY | Lumpectomy | Care and treatment | Radiation | Adjuvant treatment | Breast cancer | Health aspects | Cancer
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4. Full Text Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial
by Veronesi, Umberto, Prof and Orecchia, Roberto, Prof and Maisonneuve, Patrick, DiplEng and Viale, Giuseppe, Prof and Rotmensz, Nicole, MSc and Sangalli, Claudia, MSc and Luini, Alberto, MD and Veronesi, Paolo, Prof and Galimberti, Viviana, MD and Zurrida, Stefano, Prof and Leonardi, Maria Cristina, MD and Lazzari, Roberta, MD and Cattani, Federica, MD and Gentilini, Oreste, MD and Intra, Mattia, MD and Caldarella, Pietro, MD and Ballardini, Bettina, MD
Lancet Oncology, The, ISSN 1470-2045, 2013, Volume 14, Issue 13, pp. 1269 - 1277
Summary Background Intraoperative radiotherapy with electrons allows the substitution of conventional postoperative whole breast irradiation with one session... 
Hematology, Oncology and Palliative Medicine | IRRADIATION | ONCOLOGY | RECURRENCES | CONSERVING SURGERY | CONSENSUS | WHOLE-BREAST | RADICAL-MASTECTOMY | COMPARING TOTAL MASTECTOMY | AXILLARY DISSECTION | 20-YEAR FOLLOW-UP | RADIATION-THERAPY | Breast Neoplasms - surgery | Humans | Middle Aged | Incidence | Breast Neoplasms - chemistry | Neoplasm Grading | Dose Fractionation | Female | Mastectomy, Segmental - methods | Radiotherapy Dosage | Intraoperative Period | Neoplasm Recurrence, Local - prevention & control | Biomarkers, Tumor - analysis | Kaplan-Meier Estimate | Electrons - therapeutic use | Treatment Outcome | Lymphatic Metastasis | Breast Neoplasms - radiotherapy | Carcinoma, Lobular - radiotherapy | Breast Neoplasms - pathology | Carcinoma, Ductal, Breast - radiotherapy | Radiotherapy, Adjuvant - methods | Italy | Aged | Neoplasm Recurrence, Local - epidemiology | Neoplasm Staging | Radiotherapy | Nuclear radiation | Breast cancer
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5. Full Text Tailoring radiotherapy according to cancer subtypes
by Orecchia, Roberto
The Breast, ISSN 0960-9776, 08/2017, Volume 34, pp. S91 - S94
Radiotherapy is able to improve locoregional control in breast cancer patients both after breast conserving surgery or mastectomy, with positive impact in... 
Molecular subtypes | Breast cancer | Breast radiotherapy | Adapted radiotherapy | Breast cancer biology | FOLLOW-UP | RISK | BREAST-CONSERVING SURGERY | ESTROGEN-RECEPTOR | CARCINOMA IN-SITU | OBSTETRICS & GYNECOLOGY | IRRADIATION | THERAPY | ONCOLOGY | POSTMASTECTOMY RADIOTHERAPY | PROGESTERONE-RECEPTOR | LOCOREGIONAL RECURRENCE | Breast Neoplasms - radiotherapy | Receptors, Estrogen - metabolism | Humans | Radiotherapy - methods | Receptor, ErbB-2 - metabolism | Female | Breast Neoplasms - metabolism | Receptors, Progesterone - metabolism | Lumpectomy | Radiotherapy | Cancer | Immunochemistry
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6. Full Text Post-mastectomy radiotherapy reduces recurrence and mortality
by Orecchia, Roberto
Nature Reviews Clinical Oncology, ISSN 1759-4774, 2014, Volume 11, Issue 7, pp. 382 - 384
The recent results of the Early Breast Cancer Trialists' Cooperative Group meta-analysis have demonstrated that post-mastectomy radiotherapy reduces breast... 
MASTECTOMY | ONCOLOGY | TAMOXIFEN | POSTOPERATIVE RADIOTHERAPY | BREAST-CANCER PATIENTS | PATTERNS | CHEMOTHERAPY | Prevention | Care and treatment | Relapse | Mortality | Mastectomy | Italy | Breast cancer | Research | Radiotherapy | Health aspects | Cancer
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7. Full Text Charged-particle therapy in cancer: Clinical uses and future perspectives
by Durante, Marco and Orecchia, Roberto and Loeffler, Jay S
Nature Reviews Clinical Oncology, ISSN 1759-4774, 08/2017, Volume 14, Issue 8, pp. 483 - 495
Radiotherapy with high-energy charged particles has become an attractive therapeutic option for patients with several tumour types because this approach better... 
CELL LUNG-CANCER | PROTON-BEAM THERAPY | CARBON-ION RADIOTHERAPY | ONCOLOGY | INTENSITY-MODULATED RADIOTHERAPY | HEALTH TECHNOLOGY-ASSESSMENT | PROSTATE-CANCER | ADENOID CYSTIC CARCINOMA | QUALITY-OF-LIFE | ADVANCED PANCREATIC-CANCER | RADIATION-THERAPY | Neoplasms - radiotherapy | Radiation Oncology - trends | Humans | Elementary Particles - therapeutic use | Randomized Controlled Trials as Topic | Care and treatment | Forecasts and trends | Radiotherapy | Methods | Cancer | Immune response | Clinical trials | Hypoxia | Radiation therapy | Charged particles | Tumors
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8. Full Text Breast cancer
by Veronesi, Umberto and Boyle, Peter and Goldhirsch, Aron and Orecchia, Roberto and Viale, Giuseppe
Lancet, ISSN 0140-6736, 05/2005, Volume 365, Issue 9472, pp. 1727 - 1741
Breast cancer remains a public-health issue on a global scale. We report new information about the disease from the past 5 years. Early age at first birth,... 
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9. Full Text Hodgkin's lymphoma emerging radiation treatment techniques: Trade-offs between late radio-induced toxicities and secondary malignant neoplasms
by Cella, Laura and Conson, Manuel and Pressello, Maria Cristina and Molinelli, Silvia and Schneider, Uwe and Donato, Vittorio and Orecchia, Roberto and Salvatore, Marco and Pacelli, Roberto
Radiation Oncology, ISSN 1748-717X, 01/2013, Volume 8, Issue 1, pp. 22 - 22
Background: Purpose of this study is to explore the trade-offs between radio-induced toxicities and second malignant neoplasm (SMN) induction risk of different... 
Radio-induced toxicity | Emerging radiotherapy techniques | Second malignant neoplasm | Hodgkin's lymphoma | PROTON-BEAM THERAPY | IMRT | INTENSITY-MODULATED RADIOTHERAPY | INDUCTION | BREAST-CANCER | HEART | IRRADIATION | IMPACT | ONCOLOGY | OUTCOMES | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Models, Theoretical | Radiotherapy Dosage | Hodgkin Disease - radiotherapy | Radiotherapy Planning, Computer-Assisted - methods | Humans | Neoplasms, Radiation-Induced - etiology | Female | Radiotherapy - adverse effects | Medicine, Experimental | Medical research | Radiotherapy | Hodgkin's disease | Radiation | Studies | Heart | Breasts | Optimization algorithms | Oncology | Mathematical models | Radiation therapy | Radios | Patients | Tumors | Index Medicus
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10. Full Text E3. What is Hot in breast cancer radiation oncology in 2012?
by Poortmans, Philip and Orecchia, Roberto
European Journal of Cancer, ISSN 0959-8049, 2012, Volume 48, pp. S6 - S7
Hematology, Oncology and Palliative Medicine
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11. Full Text Intraoperative radiotherapy during breast conserving surgery: A study on 1,822 cases treated with electrons
by Veronesi, Umberto and Orecchia, Roberto and Luini, Alberto and Galimberti, Viviana and Zurrida, Stefano and Intra, Mattia and Veronesi, Paolo and Arnone, Paolo and Leonardi, Maria Cristina and Ciocca, Mario and Lazzari, Roberta and Caldarella, Pietro and Rotmensz, Nicole and Sangalli, Claudia and Sances, Daniele and Maisonneuve, Patrick
Breast Cancer Research and Treatment, ISSN 0167-6806, 11/2010, Volume 124, Issue 1, pp. 141 - 151
Intraoperative radiotherapy with electrons (ELIOT) after conservative surgery for breast carcinoma was introduced at the IEO in 1999 as a research programme.... 
Conserving surgery | Breast cancer | Intraoperative radiotherapy | CONSERVATIVE TREATMENT | PROGNOSTIC-FACTORS | POSTOPERATIVE RADIOTHERAPY | RANDOMIZED-TRIAL | RADICAL-MASTECTOMY | CANCER | 20-YEAR FOLLOW-UP | RADIATION-THERAPY | IRRADIATION | ONCOLOGY | AMERICAN SOCIETY | Breast Neoplasms - surgery | Humans | Middle Aged | Carcinoma - mortality | Necrosis | Time Factors | Mastectomy, Segmental | Aged, 80 and over | Adult | Female | Carcinoma - pathology | Radiotherapy, Adjuvant | Risk Assessment | Carcinoma - surgery | Risk Factors | Kaplan-Meier Estimate | Neoplasm Recurrence, Local | Proportional Hazards Models | Treatment Outcome | Carcinoma - radiotherapy | Radiation Dosage | Radiation Injuries - etiology | Breast Neoplasms - radiotherapy | Breast Neoplasms - pathology | Intraoperative Care | Fibrosis | Breast Neoplasms - mortality | Italy | Aged | Neoplasm Staging | Lumpectomy | Radiotherapy | Nuclear radiation | Electrons
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12. Full Text Robotic Image-Guided Stereotactic Radiotherapy, for Isolated Recurrent Primary, Lymph Node or Metastatic Prostate Cancer
by Jereczek-Fossa, Barbara Alicja, M.D., Ph.D and Beltramo, Giancarlo, M.D and Fariselli, Laura, M.D and Fodor, Cristiana, M.Sc and Santoro, Luigi, M.Sc and Vavassori, Andrea, M.D and Zerini, Dario, M.D and Gherardi, Federica, M.D and Ascione, Carmen, M.D and Bossi-Zanetti, Isa, M.D and Mauro, Roberta, M.D and Bregantin, Achille, M.Sc and Bianchi, Livia Corinna, M.D and De Cobelli, Ottavio, M.D and Orecchia, Roberto, M.D
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2012, Volume 82, Issue 2, pp. 889 - 897
Purpose To evaluate the outcome of robotic CyberKnife (Accuray, Sunnyvale, CA)–based stereotactic radiotherapy (CBK-SRT) for isolated recurrent primary, lymph... 
Radiology | Hematology, Oncology and Palliative Medicine | Robotic stereotactic radiotherapy | Lymph node recurrence | Recurrent prostate cancer | Stereotactic radiotherapy | CRITERIA | MANAGEMENT | BODY RADIOTHERAPY | RADIOSURGERY | TOXICITY | RADIATION-THERAPY | ONCOLOGY | EXTERNAL-BEAM IRRADIATION | BRACHYTHERAPY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Organs at Risk - radiation effects | Fiducial Markers | Lymph Nodes - surgery | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Femur Head - radiation effects | Positron-Emission Tomography | Neoplasm Recurrence, Local - surgery | Radiosurgery - adverse effects | Urinary Bladder - radiation effects | Feasibility Studies | Neoplasm Recurrence, Local - diagnostic imaging | Multimodal Imaging - methods | Aged, 80 and over | Prostatic Neoplasms - blood | Prostatic Neoplasms - diagnostic imaging | Radiosurgery - methods | Neoplasm Recurrence, Local - blood | Urethra - radiation effects | Prostatic Neoplasms - drug therapy | Radiotherapy Dosage | Prostatic Neoplasms - pathology | Prostatic Neoplasms - surgery | Lymphatic Metastasis | Rectum - radiation effects | Tumor Burden | Prostate-Specific Antigen - blood | Disease-Free Survival | Radiotherapy, Image-Guided - methods | Choline | Androgen Antagonists - therapeutic use | Robotics - methods | Aged | Retreatment - methods | Carbon Radioisotopes | Radiotherapy | Prostate cancer | Metastasis | Index Medicus | PROSTATE | PATIENTS | NEOPLASMS | CHOLINE | LYMPH NODES | RECTUM | STABILIZATION | METASTASES | ANTIGENS | RADIATION DOSES | POSITRON COMPUTED TOMOGRAPHY | RADIOLOGY AND NUCLEAR MEDICINE | RADIOTHERAPY | ANDROGENS
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13. Full Text How Do the ASTRO Consensus Statement Guidelines for the Application of Accelerated Partial Breast Irradiation Fit Intraoperative Radiotherapy? A Retrospective Analysis of Patients Treated at the European Institute of Oncology
by Leonardi, Maria Cristina, M.D and Maisonneuve, Patrick, Ing and Mastropasqua, Mauro Giuseppe, M.D and Morra, Anna, M.D and Lazzari, Roberta, M.D and Rotmensz, Nicole, M.Sc and Sangalli, Claudia, D.M and Luini, Alberto, M.D and Veronesi, Umberto, M.D and Orecchia, Roberto, M.D
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2012, Volume 83, Issue 3, pp. 806 - 813
Purpose To verify how the classification according to the American Society for Therapeutic Radiation Oncology (ASTRO) consensus statement (CS) for the... 
Radiology | Hematology, Oncology and Palliative Medicine | Partial breast irradiation | Breast cancer | ASTRO | Consensus statement | Intraoperative electrons | ONCOLOGY | CONSERVING SURGERY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | MARGIN STATUS | Breast Neoplasms - surgery | United States | Humans | Middle Aged | Neoplasms, Second Primary - mortality | Carcinoma, Intraductal, Noninfiltrating - mortality | Mastectomy, Segmental | Aged, 80 and over | Adult | Female | Retrospective Studies | Carcinoma, Intraductal, Noninfiltrating - surgery | Societies, Medical - standards | Breast Neoplasms - epidemiology | Databases, Factual | Carcinoma, Intraductal, Noninfiltrating - radiotherapy | Europe | Electrons - therapeutic use | Tumor Burden | Cancer Care Facilities | Consensus | Intraoperative Care - standards | Neoplasms, Second Primary - epidemiology | Disease-Free Survival | Breast Neoplasms - radiotherapy | Carcinoma, Intraductal, Noninfiltrating - pathology | Breast Neoplasms - pathology | Breast Neoplasms - mortality | Aged | Carcinoma, Intraductal, Noninfiltrating - epidemiology | Practice Guidelines as Topic | Radiation Oncology - standards | Radioisotope brachytherapy | Radiotherapy | Health aspects | Radiation | SURGERY | IRRADIATION | PATIENTS | MAMMARY GLANDS | NEOPLASMS | CLINICAL TRIALS | ELECTRONS | RECOMMENDATIONS | METASTASES | RADIOLOGY AND NUCLEAR MEDICINE | CLASSIFICATION | RADIOTHERAPY
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14. Correlation of dose with toxicity and tumour response to 90Y- and 177Lu-PRRT provides the basis for optimization through individualized treatment planning
by Cremonesi, Marta and Ferrari, Mahila Esmeralda and Bodei, Lisa and Chiesa, Carlo and Sarnelli, Anna and Garibaldi, Cristina and Pacilio, Massimiliano and Strigari, Lidia and Summers, Paul Eugene and Orecchia, Roberto and Grana, Chiara Maria and Botta, Francesca
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 12/2018, Volume 45, Issue 13, pp. 2426 - 2441
PurposePeptide receptor radionuclide therapy (PRRT) with 90Y-labelled and 177Lu-labelled peptides is an effective strategy for the treatment of... 
Peptide receptor radionuclide therapy (PRRT) | Dose–toxicity | Dosimetry | Dose–effect | Absorbed dose correlations | Dosimeters | English language | Peptides | Toxicity | Clinical trials | Radioisotopes | Radiation therapy | Patients | Optimization | Yttrium isotopes | Metastases | Lutetium isotopes | Correlation analysis | Tumors | Neuroendocrine tumors | Index Medicus
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15. Full Text Oncoplastic Breast-Conserving Surgery for Tumors Larger than 2 Centimeters: Is it Oncologically Safe? A Matched-Cohort Analysis
by De Lorenzi, Francesca and Loschi, Pietro and Bagnardi, Vincenzo and Rotmensz, Nicole and Hubner, Gabriel and Mazzarol, Giovanni and Orecchia, Roberto and Galimberti, Viviana and Veronesi, Paolo and Colleoni, Marco Angelo and Toesca, Antonio and Peradze, Nickolas and Mario, Rietjens
Annals of Surgical Oncology, ISSN 1068-9265, 6/2016, Volume 23, Issue 6, pp. 1852 - 1859
Oncoplastic surgery is a well-established approach that combines conserving treatment for breast cancer and plastic surgery techniques. Although this approach... 
Oncology | Medicine & Public Health | Surgical Oncology | Surgery | SURGERY | IRRADIATION | CONSERVATIVE TREATMENT | THERAPY | ONCOLOGY | MAMMAPLASTY | RECONSTRUCTION | LUMPECTOMY | PARTIAL MASTECTOMY | QUADRANTECTOMY | AXILLARY DISSECTION | CANCER | Breast Neoplasms - surgery | Carcinoma, Ductal, Breast - surgery | Carcinoma, Lobular - pathology | Carcinoma, Lobular - surgery | Prognosis | Follow-Up Studies | Neoplasm Invasiveness | Humans | Middle Aged | Survival Rate | Neoplasm Recurrence, Local - mortality | Neoplasm Recurrence, Local - surgery | Case-Control Studies | Neoplasm Recurrence, Local - pathology | Breast Neoplasms - pathology | Matched-Pair Analysis | Adult | Carcinoma, Ductal, Breast - pathology | Female | Aged | Mastectomy, Segmental - mortality | Lumpectomy | Surgery, Plastic | Analysis | Tumors
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16. Full Text Carbon ion radiotherapy and completion pancreatectomy. A feasible model to explore a new integrated approach?
by Lorenzo, Cobianchi and Piero, Fossati and Andrea, Peloso and Silvia, Brugnatelli and Alessandro, Vanoli and Francesca, Valvo and Roberto, Orecchia and Paolo, Dionigi
Pancreatology, ISSN 1424-3903, 2016, Volume 17, Issue 1, pp. 19 - 21
  By treating our two patients we could directly evaluate the macroscopic biologic effect of CIRT on the surgical field and tissues, and we performed... 
Endocrinology & Metabolism | Gastroenterology and Hepatology | CHEMORADIATION | PANCREATIC DUCTAL ADENOCARCINOMA | GASTROENTEROLOGY & HEPATOLOGY | CANCER | GEMCITABINE | Heavy Ion Radiotherapy | Humans | Pancreatectomy | Carcinoma, Pancreatic Ductal - therapy | Pancreaticoduodenectomy | Radiotherapy, Adjuvant | Pancreatic Neoplasms - therapy | Care and treatment | Pancreatic diseases | Radiotherapy | Methods | Chemotherapy | Rodents | Surgery | Pancreatic cancer | Conflicts of interest | Radiation therapy | Metastasis | Carbon | Cancer therapies | Patients
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17. Full Text Morphological analysis of amoeboid-mesenchymal transition plasticity after low and high LET radiation on migrating and invading pancreatic cancer cells
by Facoetti, Angelica and Di Gioia, Carmela and Pasi, Francesca and Di Liberto, Riccardo and Corbella, Franco and Nano, Rosanna and Ciocca, Mario and Valvo, Francesca and Orecchia, Roberto
Anticancer Research, ISSN 0250-7005, 08/2018, Volume 38, Issue 8, pp. 4585 - 4591
Background/Aim: Cell migration and invasion are fundamental components of tumor cell metastasis that represent the biggest threat to the survival and quality... 
Amoeboid | Invasiveness | Carbon ions | Migration | Pancreatic cancer | Irradiation | Transition | Normal fibroblasts | Mesenchymal | ENHANCE MOTILITY | amoeboid | MECHANISMS | transition | irradiation | carbon ions | invasiveness | pancreatic cancer | IN-VITRO | INVASION | ONCOLOGY | mesenchymal | normal fibroblasts | TUMOR-STROMAL INTERACTIONS | Cell survival | Mesenchyme | Tumor cells | Radiation dosage | Metastases | Cell adhesion & migration | Quality of life | Ionizing radiation | Linear energy transfer (LET) | Morphology | Cell lines | Fibroblasts | Energy transfer | Background radiation | Cell migration | Cancer | Tumors
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