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1. Full Text Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
by Koeth, Robert A and Wang, Zeneng and Levison, Bruce S and Buffa, Jennifer A and Org, Elin and Sheehy, Brendan T and Britt, Earl B and Fu, Xiaoming and Wu, Yuping and Li, Lin and Smith, Jonathan D and Didonato, Joseph A and Chen, Jun and Li, Hongzhe and Wu, Gary D and Lewis, James D and Warrier, Manya and Brown, J Mark and Krauss, Ronald M and Tang, W.H. Wilson and Bushman, Frederic D and Lusis, Aldons J and Hazen, Stanley L
Nature Medicine, ISSN 1078-8956, 05/2013, Volume 19, Issue 5, pp. 576 - 585
Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (MA), which is further metabolized to a proatherogenic species,... 
MEDICINE, RESEARCH & EXPERIMENTAL | BILE-ACID | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | DIET | REVERSE CHOLESTEROL TRANSPORT | GUT MICROBIOME | CARDIOVASCULAR-DISEASE | MICE | CORONARY-HEART-DISEASE | RECEPTORS | EXPRESSION | Atherosclerosis - physiopathology | Humans | Methylamines - blood | Carnitine - chemistry | Carnitine - metabolism | Cholesterol - metabolism | Choline - chemistry | Desmosterol - metabolism | Meat | Mice, Knockout | Atherosclerosis - etiology | Macrophages - metabolism | Animals | Intestines - microbiology | Time Factors | Mass Spectrometry | Female | Atherosclerosis - microbiology | Mice | Metagenome | Methylamines - metabolism | RNA - metabolism | Physiological aspects | Levocarnitine | Genetic aspects | Research | Microbiota (Symbiotic organisms) | Microbial metabolism | Biomedical research | Diet | Risk factors | Atherosclerosis | Index Medicus
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2. Full Text Individual diet has sex-dependent effects on vertebrate gut microbiota
by Bolnick, Daniel I and Snowberg, Lisa K and Hirsch, Philipp E and Lauber, Christian L and Org, Elin and Parks, Brian and Lusis, Aldons J and Knight, Rob and Caporaso, J. Gregory and Svanbäck, Richard and Teknisk-naturvetenskapliga vetenskapsområdet and Biologiska sektionen and Uppsala universitet and Institutionen för ekologi och genetik and Limnologi
Nature Communications, ISSN 2041-1723, 07/2014, Volume 5, Issue 1, pp. 4500 - 4500
Vertebrates harbour diverse communities of symbiotic gut microbes. Host diet is known to alter microbiota composition, implying that dietary treatments might... 
STABLE-ISOTOPES | POPULATION | TROPHIC POSITION | MULTIDISCIPLINARY SCIENCES | HABITAT | ECOLOGY | DIVERSITY | THREESPINE STICKLEBACK | COMMUNITIES | SPECIALIZATION | EURASIAN PERCH | Mice - microbiology | Dysbiosis - drug therapy | Species Specificity | Humans | Gastrointestinal Tract - microbiology | Molecular Sequence Data | Male | DNA Primers - genetics | Dysbiosis - microbiology | Sequence Analysis, DNA | Smegmamorpha - microbiology | Microbiota | Phenotype | Animals | Analysis of Variance | Diet | Base Sequence | Sex Factors | RNA, Ribosomal, 16S - genetics | Female | Perches - microbiology | Index Medicus | Biological Sciences | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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3. Full Text ALOX5AP gene and the PDE4D gene in a central European population of stroke patients
by Lõhmussaar, Elin and Gschwendtner, Andreas and Mueller, Jakob C and Org, Tõnis and Wichmann, Erich and Hamann, Gerhard and Meitinger, Thomas and Dichgans, Martin
Stroke, ISSN 0039-2499, 04/2005, Volume 36, Issue 4, pp. 731 - 736
Background and Purpose - Recent evidence has implicated the genes for 5-lipoxygenase activating protein (ALOX5AP) and phosphodiesterase 4D (PDE4D) as... 
Genetics | Stroke | ACTIVATION | PROTEIN-KINASE | SUSCEPTIBILITY | IDENTIFICATION | stroke | CONFERS RISK | CLINICAL NEUROLOGY | genetics | PERIPHERAL VASCULAR DISEASE | PHOSPHODIESTERASE | 5-LIPOXYGENASE | ISCHEMIC-STROKE | EXPRESSION | COMPLEX DISEASE | Haplotypes | Europe, Eastern | Cyclic Nucleotide Phosphodiesterases, Type 4 | Humans | Middle Aged | Cyclic Nucleotide Phosphodiesterases, Type 3 | Male | Risk | Case-Control Studies | Iceland | Stroke - genetics | Ischemia | Female | Odds Ratio | Microsatellite Repeats | Membrane Proteins - genetics | Gene Frequency | Risk Factors | Genotype | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | Genetic Markers | Linkage Disequilibrium | Carrier Proteins - genetics | Magnetic Resonance Imaging | Regression Analysis | Edetic Acid - chemistry | 5-Lipoxygenase-Activating Proteins | Alleles | Sex Factors | Aged | Polymorphism, Single Nucleotide | Index Medicus
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4. Full Text Genetic studies of body mass index yield new insights for obesity biology
by Locke, Adam E and Kahali, Bratati and Berndt, Sonja I and Justice, Anne E and Pers, Tune H and Day, Felix R and Powell, Corey and Vedantam, Sailaja and Buchkovich, Martin L and Yang, Jian and Croteau-Chonka, Damien C and Esko, Tonu and Fall, Tove and Ferreira, Teresa and Gustafsson, Stefan and Kutalik, Zoltán and Luan, Jian'an and Mägi, Reedik and Randall, Joshua C and Winkler, Thomas W and Wood, Anew R and Workalemahu, Tsegaselassie and Faul, Jessica D and Smith, Jennifer A and Hua Zhao, Jing and Zhao, Wei and Chen, Jin and Fehrmann, Rudolf and Hedman, Åsa K and Karjalainen, Juha and Schmidt, Ellen M and Absher, Devin and Amin, Najaf and Anderson, Denise and Beekman, Marian and Bolton, Jennifer L and Bragg-Gresham, Jennifer L and Buyske, Steven and Demirkan, Ayse and Deng, Guohong and Ehret, Georg B and Feenstra, Bjarke and Feitosa, Mary F and Fischer, Krista and Goel, Anuj and Gong, Jian and Jackson, Anne U and Kanoni, Stavroula and Kleber, Marcus E and Kristiansson, Kati and Lim, Unhee and Lotay, Vaneet and Mangino, Massimo and Mateo Leach, Irene and Medina-Gomez, Carolina and Medland, Sarah E and Nalls, Michael A and Palmer, Cameron D and Pasko, Dorota and Pechlivanis, Sonali and Peters, Marjolein J and Prokopenko, Inga and Shungin, Dmitry and Stančáková, Alena and Strawbridge, Rona J and Ju Sung, Yun and Tanaka, Toshiko and Teumer, Alexander and Trompet, Stella and van der Laan, Sander W and van Setten, Jessica and van Vliet-Ostaptchouk, Jana V and Wang, Zhaoming and Yengo, Loïc and Zhang, Weihua and Isaacs, Aaron and Albrecht, Eva and Ärnlöv, Johan and Arscott, Gillian M and Attwood, Antony P and Bandinelli, Stefania and Barrett, Amy and Bas, Isabelita N and Bellis, Claire and Bennett, Amanda J and Berne, Christian and Blagieva, Roza and Blüher, Matthias and Böhringer, Stefan and Bonnycastle, Lori L and Böttcher, Yvonne and Boyd, Heather A and Bruinenberg, Marcel and Caspersen, Ida H and Ida Chen, Yii-Der and Clarke, Robert and Daw, E. Warwick and de Craen, Anton J. M and Delgado, Graciela and Dimitriou, Maria and ... and ADIPOGen Consortium and PAGE Consortium and LifeLines Cohort Study and MIGen Consortium and CARDIOGRAMplusC4D Consortium and MuTHER Consortium and ICBP and CKDGen Consortium and Int Endogene Consortium and GENIE Consortium and MAGIC Investigators and ReproGen Consortium and AGEN-BMI Working Grp and GLGC and International Endogene Consortium and AGEN-BMI Working Group and The PAGE Consortium and The International Endogene Consortium and The MAGIC Investigators and The ReproGen Consortium and The CKDGen Consortium and The ADIPOGen Consortium and The ICBP and The CARDIOGRAMplusC4D Consortium and The GLGC and The GENIE Consortium and The AGEN-BMI Working Group and The MIGen Consortium and The MuTHER Consortium and The LifeLines Cohort Study and Medicinska fakulteten and Umeå universitet and Medicin and Institutionen för folkhälsa och klinisk medicin and Institutionen för odontologi and Enheten för biobanksforskning and Näringsforskning
Nature, ISSN 0028-0836, 2015, Volume 518, Issue 7538, pp. 197 - U401
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and... 
INDIVIDUALS | PROVIDES INSIGHTS | METAANALYSIS | VARIANTS | MULTIDISCIPLINARY SCIENCES | HIPPOCAMPAL | GLYCEMIC TRAITS | ARCHITECTURE | TOPIRAMATE | LOCI | GENOME-WIDE ASSOCIATION | Body Mass Index | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Age Factors | Humans | Male | Continental Population Groups - genetics | Adiposity - genetics | Obesity - genetics | Europe - ethnology | Obesity - metabolism | Insulin - metabolism | Synapses - metabolism | Polymorphism, Single Nucleotide - genetics | Female | Glutamic Acid - metabolism | Energy Metabolism - genetics | Adipogenesis - genetics | Insulin Secretion | Quantitative Trait Loci - genetics | Body mass index | Obesity | Genetic research | Genetic aspects | Research | Diabetes | Gene expression | Health aspects | Studies | Genomics | Genetics | Biology | Genomes | Metabolic disorders | Meta-analysis | Index Medicus | Hälsovetenskaper | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Medical and Health Sciences | Medicin och hälsovetenskap | Public Health, Global Health, Social Medicine and Epidemiology | Health Sciences
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5. Full Text Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort
by Org, Elin and Blum, Yuna and Kasela, Silva and Mehrabian, Margarete and Kuusisto, Johanna and Kangas, Antti J and Soininen, Pasi and Wang, Zeneng and Ala-Korpela, Mika and Hazen, Stanley L and Laakso, Markku and Lusis, Aldons J
Genome Biology, ISSN 1474-7596, 04/2017, Volume 18, Issue 1, pp. 70 - 70
Background: The gut microbiome is a complex and metabolically active community that directly influences host phenotypes. In this study, we profile gut... 
TMAO | Type 2 diabetes | Host-microbiota interactions | Serum metabolites | Metabolic traits | HIGH-FAT | POPULATION | ENTEROTYPES | RISK | INSULIN SENSITIVITY | L-CARNITINE | DIET | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | DIVERSITY | PHOSPHATIDYLCHOLINE | REVEALS | Body Mass Index | Amino Acids - blood | Bacteria - metabolism | Glucose Tolerance Test | Microbiota - physiology | Diabetes Mellitus, Type 2 - microbiology | Humans | Middle Aged | Gastrointestinal Microbiome | Male | Metabolic Syndrome - blood | Diabetes Mellitus, Type 2 - blood | Phenotype | Metabolic Syndrome - microbiology | Lipids - blood | Bacteria - classification | Aged | Methylamines | Fatty Acids - blood | Blood Glucose - metabolism | Cohort Studies | rRNA 16S | Taxonomy | Microbiomes | Glucose | Metabolic syndrome | Body mass index | Microbiota | Metabolites | Population | Physiology | Blood pressure | Lipid metabolism | Bioinformatics | Heart diseases | Community structure | Phenotypes | Fasting | Diabetes mellitus | Coronary artery | Fatty acids | Multiculturalism & pluralism | Serum levels | Studies | Glucose tolerance | Trimethylamine | Insulin resistance | Metabolic disorders | Index Medicus
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6. Full Text New genetic loci link adipose and insulin biology to body fat distribution
by Shungin, Dmitry and Winkler, Thomas W and Croteau-Chonka, Damien C and Ferreira, Teresa and Locke, Adam E and Mägi, Reedik and Strawbridge, Rona J and Pers, Tune H and Fischer, Krista and Justice, Anne E and Workalemahu, Tsegaselassie and Wu, Joseph M. W and Buchkovich, Martin L and Heard-Costa, Nancy L and Roman, Tamara S and ng, Alexander W and Song, Ci and Gustafsson, Stefan and Day, Felix R and Esko, Tonu and Fall, Tove and Kutalik, Zoltán and Luan, Jian'an and Randall, Joshua C and Scherag, Ané and Vedantam, Sailaja and Wood, Anew R and Chen, Jin and Fehrmann, Rudolf and Karjalainen, Juha and Kahali, Bratati and Liu, Ching-Ti and Schmidt, Ellen M and Absher, Devin and Amin, Najaf and Anderson, Denise and Beekman, Marian and Bragg-Gresham, Jennifer L and Buyske, Steven and Demirkan, Ayse and Ehret, Georg B and Feitosa, Mary F and Goel, Anuj and Jackson, Anne U and Johnson, Toby and Kleber, Marcus E and Kristiansson, Kati and Mangino, Massimo and Mateo Leach, Irene and Medina-Gomez, Carolina and Palmer, Cameron D and Pasko, Dorota and Pechlivanis, Sonali and Peters, Marjolein J and Prokopenko, Inga and Stančáková, Alena and Ju Sung, Yun and Tanaka, Toshiko and Teumer, Alexander and van Vliet-Ostaptchouk, Jana V and Yengo, Loïc and Zhang, Weihua and Albrecht, Eva and Ärnlöv, Johan and Arscott, Gillian M and Bandinelli, Stefania and Barrett, Amy and Bellis, Claire and Bennett, Amanda J and Berne, Christian and Blüher, Matthias and Böhringer, Stefan and Bonnet, Fabrice and Böttcher, Yvonne and Bruinenberg, Marcel and Carba, Delia B and Caspersen, Ida H and Clarke, Robert and Daw, E. Warwick and Deelen, Joris and Deelman, Ewa and Delgado, Graciela and Doney, Alex S. F and Eklund, Niina and Erdos, Michael R and Estrada, Karol and Eury, Elodie and Frieich, Nele and Garcia, Melissa E and Gieaitis, Vilmantas and Gigante, Bruna and Go, Alan S and Golay, Alain and Grallert, Harald and Grammer, Tanja B and Gräßler, Jürgen and Grewal, Jagvir and Groves, Christopher J and Haller, Toomas and Hallmans, Goran and ... and PAGE Consortium and LifeLines Cohort Study and CARDIOGRAMplusC4D Consortium and MuTHER Consortium and ICBP and ADIPOGEN Consortium and CKDGen Consortium and GEFOS Consortium and Int Endogene Consortium and GENIE Consortium and MAGIC Investigators and ReproGen Consortium and GLGC and ADIPOGen Consortium and International Endogene Consortium and The PAGE Consortium and The International Endogene Consortium and The MAGIC Investigators and The ReproGen Consortium and The CKDGen Consortium and The ADIPOGen Consortium and The ICBP and The CARDIOGRAMplusC4D Consortium and The GENIE Consortium and The GLGC and The GEFOS Consortium and The MuTHER Consortium and The LifeLines Cohort Study and Högskolan Dalarna and Akademin Utbildning, hälsa och samhälle and Medicinsk vetenskap
Nature, ISSN 0028-0836, 2015, Volume 518, Issue 7538, pp. 187 - U378
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our... 
HUMAN HEIGHT | ABDOMINAL ADIPOSITY | MULTIDISCIPLINARY SCIENCES | COMMON SNPS | SUSCEPTIBILITY LOCI | GLYCEMIC TRAITS | FALSE DISCOVERY | MESENCHYMAL STEM-CELLS | GENOME-WIDE ASSOCIATION | ADIPOGENIC DIFFERENTIATION | SEXUAL-DIMORPHISM | Body Mass Index | Genome-Wide Association Study | Age Factors | Neovascularization, Physiologic - genetics | Epigenesis, Genetic | Humans | Male | Continental Population Groups - genetics | Sex Characteristics | Obesity - genetics | Europe - ethnology | Genome, Human - genetics | Adipose Tissue - metabolism | Insulin - metabolism | Models, Biological | Adipocytes - metabolism | Insulin Resistance - genetics | Polymorphism, Single Nucleotide - genetics | Female | Body Fat Distribution | Transcription, Genetic - genetics | Adipogenesis - genetics | Waist-Hip Ratio | Quantitative Trait Loci - genetics | Adipose tissues | Quantitative trait loci | Genetic research | Genetic aspects | Research | Metabolism | Health aspects | Studies | Body mass index | Genealogy | Body fat | Insulin resistance | Genetics | Genomes | Abdomen | Meta-analysis | Index Medicus | Life Sciences | Adipocytes/metabolism Adipogenesis/genetics Adipose Tissue/metabolism Age Factors Body Fat Distribution Body Mass Index Continental Population Groups/genetics Epigenesis, Genetic Europe/ethnology Female Genome, Human/genetics Genome-Wide Association Study Humans Insulin/metabolism Insulin Resistance/genetics Male Models, Biological Neovascularization, Physiologic/genetics Obesity/genetics Polymorphism, Single Nucleotide/genetics Quantitative Trait Loci/genetics Sex Characteristics Transcription, Genetic/genetics Waist-Hip Ratio | Clinical Medicine | Hälsa och välfärd | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Health and Welfare
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