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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 04/2016, Volume 24, Issue 7, pp. 1573 - 1581
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2018, Volume 61, Issue 9, pp. 3870 - 3888
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2012, Volume 55, Issue 20, pp. 8745 - 8756
Journal Article
Journal Article
Journal of Biomolecular Screening, ISSN 1087-0571, 01/2015, Volume 20, Issue 1, pp. 131 - 140
Methods to discover biologically active small molecules include target-based and phenotypic screening approaches. One of the main difficulties in drug... 
Enzyme Inhibitors | Parasitic Sensitivity Tests | Cyclic Nucleotide Phosphodiesterases, Type 4 | Humans | Neglected Diseases | 3',5'-Cyclic-AMP Phosphodiesterases | Protozoan Proteins | Drug Discovery | Journal Article | Trypanosoma cruzi | Chagas Disease | Research Support, Non-U.S. Gov't | Inhibitory Concentration 50 | Drug Evaluation, Preclinical | Antiparasitic Agents | neglected tropical diseases (NTDs) | cell-based screening | phosphodiesterase (PDE) inhibitors | antiparasitic activity | fragment-based drug discovery (FBDD) | phenotypic screening | phenotypic drug discovery (PDD) | PARASITES | CHEMISTRY, ANALYTICAL | TRYPANOSOMA-BRUCEI | ASSAY | DRUG DISCOVERY | BIOCHEMICAL RESEARCH METHODS | SENSITIVITY | TBRPDEB1 | PHOSPHODIESTERASE B1 | IN-VITRO | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PLASMODIUM-FALCIPARUM | INHIBITORS | Drug Evaluation, Preclinical - methods | Protozoan Proteins - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Drug Discovery - methods | Neglected Diseases - drug therapy | Trypanosoma cruzi - enzymology | Parasitic Sensitivity Tests - methods | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Antiparasitic Agents - pharmacology | Chagas Disease - drug therapy | Trypanosoma cruzi - drug effects | Antiparasitic Agents - chemistry | Antiparasitic agents | Phenotype | Research | Analysis | Index Medicus
Journal Article
Chemical Communications, ISSN 1359-7345, 04/2004, Volume 10, Issue 7, pp. 790 - 791
This communication describes the development of a controlled microwave methodology for rapid milliliter-scale PCR. 
ORGANIC-CHEMISTRY | SITE | SELECTION | PROTEINS | CHEMISTRY, MULTIDISCIPLINARY | DNA
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 08/2009, Volume 17, Issue 16, p. 5933
Inhibitors have been synthesized and evaluated for inhibitory efficiency on the plasmepsin orthologues (PM.sub.4) which are present in the digestive vacuole of... 
Malaria | Proteases
Journal Article
ACS Omega, ISSN 2470-1343, 04/2019, Volume 4, Issue 4, pp. 6585 - 6596
As over 6 million people are infected with Chagas disease and only limited therapeutic options are available, there is an urgent need for novel drugs. The... 
Chemistry(all) | Chemical Engineering(all) | IN-VITRO | ETIOLOGIC AGENT | STEROL 14-ALPHA-DEMETHYLASE | CHAGAS-DISEASE | RANDOMIZED-TRIAL | BRUCEI | PHOSPHODIESTERASE C | INHIBITORS | CHEMISTRY, MULTIDISCIPLINARY | CYP51 | BENZNIDAZOLE
Journal Article
ChemInform, ISSN 0931-7597, 03/2009, Volume 40, Issue 12, pp. no - no
ChemInform is a weekly ing Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform of an... 
pyridine derivatives | multi‐membered N‐heterocycles | pyrrole derivatives
Journal Article
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