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1. Full Text Role of Phosphoinositide 3-Kinase in Innate Immunity
by Hazeki, Kaoru and Nigorikawa, Kiyomi and Hazeki, Osamu
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2007, Volume 30, Issue 9, pp. 1617 - 1623
Recent advances in our understanding of the molecular basis of mammalian host immune responses to microbial invasion suggest that the first line of defense... 
glycogen synthase kinase-3β | NF-κB | Akt | Toll-like receptor | phosphoinositide 3-kinase | Phosphoinositide 3-kinase | Glycogen synthase kinase-3β | glycogen synthase kinase-3 beta | INDUCED NO PRODUCTION | NITRIC-OXIDE SYNTHASE | PHOSPHATIDYLINOSITOL 3-KINASE | PROTEIN-KINASE | MEDIATED SIGNAL-TRANSDUCTION | ADAPTER MOLECULE | phosphomositide 3-kinase | NF-kappa B | RECEPTOR-ASSOCIATED KINASE | NEGATIVE REGULATION | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | toll-like receptor | NF-KAPPA-B | Glycogen Synthase Kinase 3 - physiology | Animals | Immunity, Innate - physiology | Humans | Phosphatidylinositol 3-Kinases - physiology | Toll-Like Receptors - physiology | Signal Transduction - physiology | Phosphatidylinositol 3-Kinases - metabolism | Cytokines - biosynthesis | Isoenzymes - physiology
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2. Full Text Involvement of Class II Phosphoinositide 3-Kinase alpha-Isoform in Antigen-Induced Degranulation in RBL-2H3 Cells
by Nigorikawa, K and Hazeki, K and Guo, Y and Hazeki, O
PLOS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, p. e111698
In this study, we present findings that suggest that PI3K-C2 alpha, a member of the class II phosphoinositide 3-kinase (PI3K) subfamily, regulates the process... 
GRANULE EXOCYTOSIS | ACTIVATION | PHOSPHATIDYLINOSITOL 3-PHOSPHATE | C2-BETA | MEMBRANE | MULTIDISCIPLINARY SCIENCES | MAST-CELLS | C2 DOMAIN | C2-ALPHA | SECRETION | MAMMALIAN-CELLS | Calcium - pharmacology | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Isoenzymes - genetics | beta-N-Acetylhexosaminidases - metabolism | Humans | RNA, Messenger - genetics | Rats | RNA, Messenger - metabolism | Gene Knockdown Techniques | Neuropeptide Y - metabolism | Animals | Transfection | Receptors, IgE - metabolism | Isoenzymes - metabolism | Cell Line, Tumor | Class II Phosphatidylinositol 3-Kinases - genetics | RAW 264.7 Cells | Mice | Antigens - pharmacology | Cell Degranulation - drug effects | RNA, Small Interfering - metabolism | Health sciences | Antigens | Enzymes | Calcium mobilization | Calcium (intracellular) | CD63 antigen | Leukemia | siRNA | Exocytosis | Mammals | Kinases | 1-Phosphatidylinositol 3-kinase | Proteins | Vesicles | Secretory vesicles | Degranulation | Protein expression | Localization | Calcium ions
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3. Full Text A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling
by Masayuki Ii and Naoko Matsunaga and Kaoru Hazeki and Kazuyo Nakamura and Katsunori Takashima and Tsukasa Seya and Osamu Hazeki and Tomoyuki Kitazaki and Yuji Iizawa
Molecular Pharmacology, ISSN 0026-895X, 04/2006, Volume 69, Issue 4, pp. 1288 - 1295
Proinflammatory mediators such as cytokines and NO play pivotal roles in various inflammatory diseases. To combat inflammatory diseases successfully,... 
RHEUMATOID-ARTHRITIS | INFLAMMATORY-BOWEL-DISEASE | ENDOTOXIN ANTAGONIST | NITRIC-OXIDE | SEPTIC SHOCK | PHARMACOLOGY & PHARMACY | INTERLEUKIN-1 RECEPTOR | INTERFERON-BETA | NF-KAPPA-B | TLR4 | ADAPTER MOLECULE | Cell Line | Nitric Oxide - biosynthesis | Sulfonamides - pharmacology | Blotting, Western | MAP Kinase Signaling System | Toll-Like Receptor 4 - physiology | Animals | Signal Transduction - drug effects | Polymerase Chain Reaction | Mice | Enzyme Activation | Toll-Like Receptor 4 - antagonists & inhibitors | Cytokines - biosynthesis
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4. Full Text PIKfyve Regulates the Endosomal Localization of CpG Oligodeoxynucleotides to Elicit TLR9-Dependent Cellular Responses
by Hazeki, Kaoru and Uehara, Masami and Nigorikawa, Kiyomi and Hazeki, Osamu
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e73894
TLR9 is a receptor for oligodeoxynucleotides that contain unmethylated CpG motifs (CpG). Because TLR9 resides in the endoplasmic reticulum during the... 
PATHWAYS | TOLL-LIKE-RECEPTOR-4 | ACTIVATION | TRANSPORT | DENDRITIC CELLS | NUCLEIC-ACID | TOLL-LIKE RECEPTOR-9 | DNA | MULTIDISCIPLINARY SCIENCES | INDUCTION | INHIBITOR | Cell Line | Cytokines - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | RNA, Messenger - genetics | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | RNA, Messenger - metabolism | Endosomes - metabolism | Gene Knockdown Techniques | Gene Expression Regulation - drug effects | Phosphatidylinositol 3-Kinases - genetics | Animals | Signal Transduction - drug effects | Aminopyridines - pharmacology | Protein Binding | Female | Biological Transport - drug effects | Mice | Macrophages, Peritoneal - metabolism | Toll-Like Receptor 9 - metabolism | Cytokines - genetics | Macrophages, Peritoneal - drug effects | Oligodeoxyribonucleotides - metabolism | Oligodeoxynucleotides | Phosphates | Salmonella | Phosphorylation | Oligonucleotides | mRNA | Phosphatidylinositol 3-phosphate | Kinases | Experiments | Lipopolysaccharides | Proteins | Signal transduction | Toll-like receptors | Life sciences | Localization | Stains | Deoxyribonucleic acid--DNA | CpG islands | Cytokines | Dendritic cells | Cloning | Rheumatology | Stat3 protein | MAP kinase | JNK protein | Gene expression | TLR9 protein | Signaling | Ligands | Membrane trafficking | Laboratory animals | Endoplasmic reticulum | Deoxyribonucleic acid
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5. Full Text Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice
by Akao, Yuusuke and Ebihara, Takashi and Masuda, Hisayo and Saeki, Yoshiko and Akazawa, Takashi and Hazeki, Kaoru and Hazeki, Osamu and Matsumoto, Misako and Seya, Tsukasa
Cancer Science, ISSN 1347-9032, 08/2009, Volume 100, Issue 8, pp. 1494 - 1501
Oral administration of hot-water extract of Spirulina, cyanobacterium Spirulina platensis, leads to augmentation of NK cytotoxicity in humans. Here, we applied... 
BACILLUS-CALMETTE-GUERIN | HUMAN DENDRITIC CELLS | CYTOKINE PRODUCTION | NK CELLS | ONCOLOGY | WALL SKELETON | TOLL-LIKE RECEPTORS | BLUE-GREEN-ALGA | PLATENSIS | CALCIUM SPIRULAN | CANCER | Cell Wall - immunology | Spirulina - immunology | Dendritic Cells - immunology | NK Cell Lectin-Like Receptor Subfamily K - immunology | Melanoma, Experimental - immunology | Bone Marrow Cells - immunology | Adjuvants, Immunologic - metabolism | Myeloid Differentiation Factor 88 - immunology | Killer Cells, Natural - immunology | Female | Powders | Specific Pathogen-Free Organisms | Administration, Oral | Bone Marrow Cells - cytology | Lymphocyte Activation | Mice, Inbred C57BL | Spleen - cytology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Drug Synergism | Animals | BCG Vaccine - immunology | Mice | Interferon-gamma - biosynthesis | Cell research | Killer cells | Dendritic cells | Immunotherapy | Melanoma | Universities and colleges | Tumors | Index Medicus
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6. Full Text Class-IA Phosphoinositide 3-Kinase p110β Triggers GPCR-Induced Superoxide Production in p110γ-Deficient Murine Neutrophils
by Nigorikawa, Kiyomi and Hazeki, Osamu and Hazeki, Kaoru and Kumazawa, Takashi and Itoh, Yuhta and Hoshi, Megumi
Journal of Pharmacological Sciences, ISSN 1347-8613, 2012, Volume 120, Issue 4, pp. 270 - 279
Studies with knockout mice have indicated that the only isoform of phosphoinositide 3-kinase (PI3K) functioning in the oxidative burst of mouse neutrophils in... 
guanine nucleotide-binding protein–coupled receptor (GPCR) | isoform-specific inhibitor | phosphoinositide 3-kinase (PI3K) | neutrophil | knockout mouse | guanine nucleotide-binding protein-coupled receptor (GPCR) | Phosphoinositide 3-kinase (PI3K) | Neutrophil | Guanine nucleotide-binding protein-coupled receptor (GPCR) | Isoform-specific inhibitor | Knockout mouse | GAMMA | REGULATORY SUBUNIT | INDUCED ACTIVATION | NADPH-OXIDASE | P110-ALPHA | PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE | PEPTIDE | BETA | SIGNAL-TRANSDUCTION | PHARMACOLOGY & PHARMACY | PI3K-GAMMA | Class Ia Phosphatidylinositol 3-Kinase - physiology | Animals | Mice, Inbred C57BL | Cells, Cultured | Superoxides - metabolism | Class Ib Phosphatidylinositol 3-Kinase - deficiency | Mice | Receptors, G-Protein-Coupled - agonists | Neutrophils - metabolism | Isoenzymes - physiology | Mice, Knockout | Receptors, G-Protein-Coupled - physiology
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7. Full Text Phosphoinositide phosphatase Sac3 regulates the cell surface expression of scavenger receptor A and formation of lipid droplets in macrophages
by Morioka, Shin and Nigorikawa, Kiyomi and Hazeki, Osamu and Hazeki, Kaoru and Ohmura, Michiko and Sakamoto, Hiromi and Matsumura, Takuma and Takasuga, Shunsuke
Experimental Cell Research, ISSN 0014-4827, 08/2017, Volume 357, Issue 2, pp. 252 - 259
The findings of this study suggest that the phosphoinositide phosphatase Sac3 maintains the protein level of scavenger receptor A (SR-A) and regulates foam... 
ArPIKfyve | PIKfyve | Sac3 | Foam cell formation | SR-A | COMPLEX | TURNOVER | ATHEROSCLEROSIS | NEURODEGENERATION | PROLIFERATION | ABUNDANCE | CELL BIOLOGY | TRANSPORT | ONCOLOGY | MUTATION | PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE | Phosphoinositide Phosphatases - genetics | Phosphoric Monoester Hydrolases - genetics | Flavoproteins - metabolism | Flavoproteins - genetics | Humans | Gene Knockdown Techniques - methods | Macrophages - metabolism | Animals | Phosphoinositide Phosphatases - metabolism | RAW 264.7 Cells | Cell Membrane - metabolism | Mice | Lipid Droplets - metabolism | Phosphoric Monoester Hydrolases - metabolism | Scavenger Receptors, Class A - metabolism | Receptors, Scavenger - metabolism | Macrophages | Medical colleges | Phosphatases
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8. Full Text C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase
by Okazaki, Natsumi and Hazeki, Kaoru and Izumi, Tatsuhiro and Nigorikawa, Kiyomi and Hazeki, Osamu
Journal of Biochemistry, ISSN 0021-924X, 03/2011, Volume 149, Issue 3, pp. 265 - 274
The complement system is a classic central player in innate immunity. Most pathogens activate both complement and the toll-like receptor (TLR) pathway.... 
IL-12 | C5a | IL-10 | phosphoinositide 3-kinase | ERK | GAMMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-COUPLED RECEPTORS | P85-ALPHA SUBUNIT | ADAPTIVE IMMUNITY | INNATE RESISTANCE | INTERLEUKIN-12 PRODUCTION | PATHWAY | ROLES | NEGATIVE REGULATION | CELL-ACTIVATION | Cells, Cultured | Serine Endopeptidases - pharmacology | Interleukin-12 - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Animals | Androstadienes - pharmacology | Lipopolysaccharides - pharmacology | Interleukin-10 - metabolism | Female | Electrophoretic Mobility Shift Assay | Flavonoids - pharmacology | Mice | Toll-Like Receptors - metabolism | Pertussis Toxin - pharmacology
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9. Full Text Inositol polyphosphate-4-phosphatase type i negatively regulates phagocytosis via dephosphorylation of phagosomal ptdins (3,4)P2
by Nigorikawa, Kiyomi and Hazeki, Kaoru and Sasaki, Junko and Omori, Yumio and Miyake, Mikiko and Morioka, Shin and Guo, Ying and Sasaki, Takehiko and Hazeki, Osamu
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, p. e0142091
Phagocytosis is a highly conserved process whereby phagocytic cells engulf pathogens and apoptotic bodies. The present study focused on the role of inositol... 
Phosphorylation | Humans | Phagosomes - metabolism | Cells, Cultured | Male | Mice, Transgenic | Macrophages - cytology | Phosphoric Monoester Hydrolases - physiology | Blotting, Western | Mice, Knockout | Macrophages - metabolism | Animals | Female | Phosphatidylinositols - metabolism | Cell Membrane - metabolism | Mice | Phagocytosis | Health sciences | Phagocytes | Endocytosis | Immunology | Inositol polyphosphate | Dephosphorylation | Phosphatase | Macrophages | Localization | Laboratory animals | Apoptosis
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10. Full Text Involvement of class II phosphoinositide 3-kinase a-isoform in antigen-induced degranulation in RBL-2H3 cells
by Nigorikawa, Kiyomi and Hazeki, Kaoru and Guo, Ying and Hazeki, Osamu
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10
Antigens | Enzymes
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11. Full Text Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model
by Morioka, Shin and Nigorikawa, Kiyomi and Sasaki, Junko and Hazeki, Kaoru and Kasuu, Yoshihiro and Sasaki, Takehiko and Hazeki, Osamu
Innate Immunity, ISSN 1753-4259, 8/2016, Volume 22, Issue 6, pp. 444 - 451
Phosphatidylinositol 3-kinase (PI3K)/Akt signaling has been implicated in the anti-inflammatory response in a mouse model of endotoxemia and sepsis. The... 
macrophage | Akt | Inpp4a | phosphoinositides | sepsis | MEDICINE, RESEARCH & EXPERIMENTAL | GRAM-NEGATIVE SEPSIS | ACTIVATION | PHAGOCYTOSIS | INFLAMMATORY RESPONSES | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MICROBIOLOGY | KAPPA-B | IMMUNOLOGY | PHOSPHOINOSITIDE 3-KINASE | SIGNALING PATHWAY | LIPOPOLYSACCHARIDE | INFECTION | Lung - microbiology | Phosphoric Monoester Hydrolases - genetics | Phosphatidylinositol Phosphates - metabolism | Cytokines - metabolism | Signal Transduction | Humans | Macrophages, Peritoneal - physiology | Mice, Inbred C57BL | Cells, Cultured | Peritonitis - immunology | Shock, Septic - immunology | Mice, Knockout | Animals | Macrophages, Peritoneal - microbiology | Peritonitis - genetics | Escherichia coli Infections - immunology | Mice | Phosphoric Monoester Hydrolases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Escherichia coli - physiology | Lung - immunology | Disease Models, Animal | Shock, Septic - genetics
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12. Full Text Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics
by Hazeki, Osamu and Hazeki, Kaoru and Nigorikawa, Kiyomi and Takaba, Yuki and Segawa, Tomohiro and Nukuda, Akiko and Masuda, Ayaka and Ishikawa, Yuki and Kubota, Koji and Takasuga, Shunsuke
FEBS Letters, ISSN 0014-5793, 11/2012, Volume 586, Issue 22, pp. 4010 - 4015
► In macrophages lacking PIKfyve, PtdIns(3)P elimination from phagosome was delayed. ► In macrophages lacking PTEN, PtdIns(3)P elimination from phagosome was... 
PTEN | PIKfyve | IgG-opsonized red blood cell | RAW264.7 macrophage | Phosphoinositide 3′-phosphatase | Phagosome maturation | ACTIVATION | MYOTUBULARIN | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MATURATION | PHOSPHOINOSITIDE 3-KINASE | Phosphoinositide 3 '-phosphatase | CELL BIOLOGY | RECEPTOR-MEDIATED PHAGOCYTOSIS | BIOPHYSICS | CLASS-III | BIOGENESIS | CLASS-I | PHOSPHATASES | Cell Line | PTEN Phosphohydrolase - genetics | Phosphatidylinositol Phosphates - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Phagosomes - metabolism | PTEN Phosphohydrolase - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Macrophages - cytology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - genetics | Macrophages - metabolism | Animals | RNA Interference | Aminopyridines - pharmacology | Female | Macrophages - drug effects | Mice | Microscopy, Fluorescence | Enzymes | Phospholipids | Phosphatases | Universities and colleges | Macrophages
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13. Full Text Critical roles of the p110β subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells
by Tsukamoto, Ken and Hazeki, Kaoru and Hoshi, Megumi and Nigorikawa, Kiyomi and Inoue, Norimitsu and Sasaki, Takehiko and Hazeki, Osamu
Journal of Immunology, ISSN 0022-1767, 02/2008, Volume 180, Issue 4, pp. 2054 - 2061
It has been suggested that PI3K participates in TLR signaling. However, identifying, specific roles for individual PI3K subtypes in signaling has remained... 
GAMMA | SIGNALING PATHWAY | PROTEIN-KINASE | PHOSPHATIDYLINOSITOL 3-KINASE | CLASS-I | IMMUNOLOGY | NF-KAPPA-B | ADAPTER MOLECULE | PERTUSSIS TOXIN | INNATE IMMUNITY | BETA | Nitric Oxide Synthase Type II - biosynthesis | Nitrites - metabolism | Enzyme Activation - immunology | Signal Transduction - immunology | Phosphatidylinositol 3-Kinases - deficiency | Toll-Like Receptors - physiology | Female | Proto-Oncogene Proteins c-akt - metabolism | Macrophages - immunology | Isoenzymes - physiology | Cell Line | Gene Expression Regulation - immunology | Isoenzymes - genetics | Mice, Inbred C57BL | Macrophages, Peritoneal - immunology | Isoenzymes - deficiency | Down-Regulation - genetics | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | Macrophages - metabolism | Animals | Class I Phosphatidylinositol 3-Kinases | Nitric Oxide Synthase Type II - genetics | Down-Regulation - immunology | Lipopolysaccharides - pharmacology | Phosphatidylinositol 3-Kinases - physiology | Mice | Enzyme Activation - genetics | Macrophages, Peritoneal - metabolism | Nitrites - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors
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14. Full Text Specific role for p85/p110β in GTP-binding-protein-mediated activation of Akt
by Kubo, Hiroshi and Hazeki, Kaoru and Takasuga, Shunsuke and Hazeki, Osamu
Biochemical Journal, ISSN 0264-6021, 12/2005, Volume 392, Issue 3, pp. 607 - 614
We prepared CHO (Chinese hamster ovary) cells expressing both IR (insulin receptor) and A, R (A, adenosine receptor). Treatment of the cells with insulin or... 
Gβγ subunit | Phosphoinositide 3-kinase | Adenosine | p110β | Short-hairpin RNA (shRNA) | Akt | GTP-binding-protein-coupled receptor (GPCR) | RAS ACTIVATION | RNA INTERFERENCE | G beta gamma subunit | p110 beta | INSULIN-INDUCED ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE BETA | adenosine | GROWTH-FACTOR RECEPTOR | short-hairpin RNA (shRNA) | G-BETA-GAMMA | LYSOPHOSPHATIDIC ACID | SIGNALING PATHWAY | COUPLED RECEPTORS | phosphoinositide 3-kinase | CHO, Chinese hamster ovary | EGF, epithelial growth factor | PI3K, phosphoinositide 3-kinase | βARK-CT, β-adrenergic receptor kinase-C-terminal peptide | PtdIns(3,4,5)P3, phosphatidylinositol 3,4,5-trisphosphate | IGF-1, insulin growth factor-1 | DTT, dithiothreitol | PP, pyrazolopyrimidine | IR, insulin receptor | GFP, green fluorescent protein | PIA, N6-(2-phenylisopropyl)adenosine | p110β-middle, middle part of p110β | Gβγ, βγ subunits of GTP-binding protein | LPA, lysophosphatidic acid | siRNA, small interfering RNA | RTK, receptor tyrosine kinase | GPCR, GTP-binding-protein-coupled receptor | FBS, foetal bovine serum | shRNA, short hairpin RNA | RT-PCR, reverse transcription-PCR | A1R, A1 adenosine receptor | PDGF, platelet-derived growth factor
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15. Full Text Specific role of phosphoinositide 3-kinase p110α in the regulation of phagocytosis and pinocytosis in macrophages
by Tamura, Namiko and Hazeki, Kaoru and Okazaki, Natsumi and Kametani, Yukiko and Murakami, Hiroki and Takaba, Yuki and Ishikawa, Yuki and Nigorikawa, Kiyomi and Hazeki, Osamu
Biochemical Journal, ISSN 0264-6021, 10/2009, Volume 423, Issue 1, pp. 99 - 108
PI3K (phosphoinositide 3-kinase) alpha has been implicated in phagocytosis and fluid-phase pinocytosis in macrophages. The subtype-specific role of PI3K in... 
Zymosan | Pinocytosis | Phosphoinositide 3-kinase α (PI3Kα) | Fcγ receptor (FcγR) | Phagocytosis | Macrophage | phagocytosis | ACTIVATION | pinocytosis | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | macrophage | DISTINCT ROLES | RECEPTOR-MEDIATED PHAGOCYTOSIS | P110-BETA | phosphoinositide 3-kinase alpha (PI3K alpha) | CYTOKINE PRODUCTION | NEGATIVE REGULATION | zymosan | IA PI3K ISOFORMS | CELL | Fc gamma receptor (Fc gamma R)
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