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1. Full Text Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands
by Laksono, Brigitta M and de Vries, Rory D and Verburgh, R Joyce and Verburgh, R. Joyce and Visser, Eline G and de Jong, Alwin and Fraaij, Pieter L A and Fraaij, Pieter L. A and Ruijs, Wilhemina L M and Ruijs, Wilhemina L. M and Nieuwenhuijse, David F and van den Ham, Henk-Jan and van den Ham, Henk-Jan and Koopmans, Marion P. G and Koopmans, Marion P G and van Zelm, Menno C and van Zelm, Menno C and Osterhaus, Albert D M E and Osterhaus, Albert D. M. E and de Swart, Rik L and de Swart, Rik L
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4944 - 10
Measles causes a transient immune suppression, leading to increased susceptibility to opportunistic infections. In experimentally infected non-human primates... 
APOPTOSIS | PROTEIN | VIRUS INFECTION | MULTIDISCIPLINARY SCIENCES | EXPANSION | ADULTS | RECEPTOR | T-CELLS | IMMUNODEFICIENCY | LYMPHOCYTES | CHILDREN | Measles - virology | Humans | Netherlands - epidemiology | Child, Preschool | Male | Leukocytes, Mononuclear - virology | Measles - immunology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Disease Outbreaks | Leukocytes, Mononuclear - immunology | Amnesia - virology | B-Lymphocytes - virology | Female | CD4-Positive T-Lymphocytes - virology | Child | Measles - epidemiology | Immune Tolerance | B-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - virology | Adolescent | Immunologic Memory | Amnesia - immunology | CD8-Positive T-Lymphocytes - immunology | Measles virus - physiology | T-Lymphocytes, Regulatory - virology | Immunological memory | Memory cells | Immunoregulation | Pathogenesis | CD8 antigen | Vaccination | Viruses | Outbreaks | Leukocytes (mononuclear) | Lymphocytes T | Vaccines | CD4 antigen | Lymphocytes B | Lymphocytes | Measles | Peripheral blood mononuclear cells | Primates | Amnesia | Children | Long-term effects
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2. Full Text Network meta-analysis correlates with analysis of merged independent transcriptome expression data
by Winter, Christine and Kosch, Robin and Ludlow, Martin and Osterhaus, Albert D. M. E and Jung, Klaus
BMC Bioinformatics, ISSN 1471-2105, 03/2019, Volume 20, Issue 1, pp. 144 - 10
BackgroundUsing meta-analysis, high-dimensional transcriptome expression data from public repositories can be merged to make group comparisons that have not... 
Research synthesis | Network meta-analysis | Fold change | Gene expression | Meta-analysis | PROTEIN | BIOCHEMICAL RESEARCH METHODS | MICROARRAY ANALYSIS | CELL-DEATH | LYMPHOTOXIN-BETA | MESSENGER-RNA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CXCR3 | ENCEPHALITIS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | GENE-EXPRESSION | INFECTION | ZIKA VIRUS | Computer Simulation | Humans | Gene Expression Regulation | Gene Expression Profiling | Transcriptome - genetics | Network Meta-Analysis | Gene Regulatory Networks | Genetic research | RNA | Analysis | Repositories | Data analysis | Merging | Independent study | Data processing | Infections | Zika virus | Ribonucleic acid--RNA | Datasets | Studies | Proteins | DNA microarrays | Correlation analysis | West Nile virus | Dimensional analysis | Data sets | Cancer | Apoptosis
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3. Full Text Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets
by Sander Herfst and Eefje J. A. Schrauwen and Martin Linster and Salin Chutinimitkul and Emmie de Wit and Vincent J. Munster and Erin M. Sorrell and Theo M. Bestebroer and David F. Burke and Derek J. Smith and Guus F. Rimmelzwaan and Albert D. M. E. Osterhaus and Ron A. M. Fouchier
Science, ISSN 0036-8075, 6/2012, Volume 336, Issue 6088, pp. 1534 - 1541
Highly pathogenic avian influenza A/H5N1 virus can cause morbidity and mortality in humans but thus far has not acquired the ability to be transmitted by... 
Receptors | Inoculation | Experimental infection | Disease transmission | Pandemics | REPORTS | Viruses | Orthomyxoviridae | Ferrets | Genetic mutation | Amino acid substitution | A VIRUS | TO-PERSON TRANSMISSION | MEDIATED SELECTION | H5N1 VIRUS | HEMAGGLUTININ | MULTIDISCIPLINARY SCIENCES | HOST | INFECTION | MODEL | RECEPTOR SPECIFICITY | PATHOGENIC AVIAN INFLUENZA | Immune Sera | Reassortant Viruses - pathogenicity | Influenza A Virus, H5N1 Subtype - physiology | Poultry | Receptors, Virus - metabolism | Air Microbiology | Humans | Virulence | Molecular Sequence Data | Influenza A Virus, H5N1 Subtype - genetics | Virus Shedding | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Respiratory System - virology | Female | Influenza, Human - virology | Oseltamivir - pharmacology | Disease Models, Animal | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Reverse Genetics | Antiviral Agents - pharmacology | Mutagenesis, Site-Directed | RNA Replicase - genetics | Viral Proteins - chemistry | Sialic Acids - metabolism | Viral Proteins - genetics | Influenza, Human - epidemiology | Containment of Biohazards | Influenza A Virus, H5N1 Subtype - drug effects | Influenza in Birds - epidemiology | Influenza, Human - transmission | Hemagglutinin Glycoproteins, Influenza Virus - metabolism | Animals | Orthomyxoviridae Infections - transmission | Virus Replication | RNA Replicase - chemistry | Influenza in Birds - virology | Influenza A Virus, H5N1 Subtype - pathogenicity | Mutation | Serial Passage | Orthomyxoviridae Infections - virology | Amino Acid Substitution | Avian influenza | Diseases and pests | Physiological aspects | Development and progression | Research | Animal diseases | Amino acids | Avian flu | Small mammals | Index Medicus | Polymerase | Human | Proteins | Influenza | Droplets | Genetic modification
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4. Full Text Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
by Zaki, Ali M and van Boheemen, Sander and Bestebroer, Theo M and Osterhaus, Albert D.M.E and Fouchier, Ron A.M
The New England Journal of Medicine, ISSN 0028-4793, 11/2012, Volume 367, Issue 19, pp. 1814 - 1820
On June 24, 2012, a 60-year-old man died of progressive respiratory infection in Saudi Arabia. A novel coronavirus was identified as a potential cause of this... 
MEDICINE, GENERAL & INTERNAL | GENOMES | DISEASE | INFLUENZA | PCR ASSAYS | IDENTIFICATION | ACUTE RESPIRATORY SYNDROME | Genome, Viral | Coronavirus - classification | Blood Urea Nitrogen | Humans | Middle Aged | DNA, Viral - analysis | Male | Sputum - virology | Lung - diagnostic imaging | Phylogeny | Reverse Transcriptase Polymerase Chain Reaction | Renal Insufficiency - etiology | Blood Cell Count | Radiography | Pneumonia, Viral - diagnostic imaging | Pneumonia, Viral - complications | Fatal Outcome | Coronavirus - genetics | Creatinine - blood | Pneumonia, Viral - virology | Virus Replication - physiology | Coronavirus - physiology | Coronavirus - isolation & purification | Case studies | Pneumonia | Care and treatment | Bacterial pneumonia | Severe acute respiratory syndrome | Causes of | Coronaviruses | Diagnosis | Health aspects | Cell culture | Enzymes | Disease | Diagnostic tests | Viruses | Outbreaks | Infections | Genomes | RNA polymerase | Patients | Hospitals | Surveillance | Influenza | Sputum | Renal failure
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5. Full Text Dengue Virus Pathogenesis: an Integrated View
by Byron E. E. Martina and Penelope Koraka and Albert D. M. E. Osterhaus
Clinical Microbiology Reviews, ISSN 0893-8512, 10/2009, Volume 22, Issue 4, pp. 564 - 581
Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
ANTIBODY-DEPENDENT ENHANCEMENT | INFECTED RHESUS-MONKEYS | HUMAN DENDRITIC CELLS | MACROPHAGE ACTIVATION SYNDROME | ARGENTINE HEMORRHAGIC-FEVER | HETEROLOGOUS ANTIVIRAL IMMUNITY | MICROBIOLOGY | NECROSIS-FACTOR-ALPHA | CROSS-REACTIVE ANTIBODIES | BLOOD MONONUCLEAR-CELLS | ENDOTHELIAL GROWTH-FACTOR | Dengue Virus - physiology | Dengue - virology | Dengue - pathology | Humans | Dengue Virus - pathogenicity | Reviews
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6. Full Text Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution
by Björn F. Koel and David F. Burke and Theo M. Bestebroer and Stefan van der Vliet and Gerben C. M. Zondag and Gaby Vervaet and Eugene Skepner and Nicola S. Lewis and Monique I. J. Spronken and Colin A. Russell and Mikhail Y. Eropkin and Aeron C. Hurt and Ian G. Barr and Jan C. de Jong and Guus F. Rimmelzwaan and Albert D. M. E. Osterhaus and Ron A. M. Fouchier and Derek J. Smith
Science, ISSN 0036-8075, 11/2013, Volume 342, Issue 6161, pp. 976 - 979
The molecular basis of antigenic drift was determined for the hemagglutinin (HA) of human influenza A/H3N2 virus. From 1968 to 2003, antigenic change was... 
Phenotypes | Receptors | Reactivity | Influenza | REPORTS | Antibodies | Viruses | Amino acids | Orthomyxoviridae | Ferrets | Amino acid substitution | ANTIBODY | HEMAGGLUTININ | RECOGNITION | A VIRUSES | MULTIDISCIPLINARY SCIENCES | Antigens, Viral - immunology | Humans | Amino Acid Substitution - immunology | Amino Acid Substitution - genetics | Antigens, Viral - genetics | Binding Sites - genetics | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Influenza A Virus, H3N2 Subtype - genetics | Mutation | Influenza A Virus, H3N2 Subtype - immunology | Evolution, Molecular | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Influenza viruses | Physiological aspects | Host-parasite relationships | Research | Health aspects | Binding sites (Biochemistry) | Antigens | Evolutionary biology | Neurons | Binding sites | Immune systems | Evolution | Drift
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7. Full Text The Potential for Respiratory Droplet-Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host
by Colin A. Russell and Judith M. Fonville and André E. X. Brown and David F. Burke and David L. Smith and Sarah L. James and Sander Herfst and Sander van Boheemen and Martin Linster and Eefje J. Schrauwen and Leah Katzelnick and Ana Mosterín and Thijs Kuiken and Eileen Maher and Gabriele Neumann and Albert D. M. E. Osterhaus and Yoshihiro Kawaoka and Ron A. M. Fouchier and Derek J. Smith
Science, ISSN 0036-8075, 6/2012, Volume 336, Issue 6088, pp. 1541 - 1547
Avian A/H5N1 influenza viruses pose a pandemic threat. As few as five amino acid substitutions, or four with reassortaient, might be sufficient for... 
Disease transmission | Surveillance | Virions | REPORTS | Viruses | Orthomyxoviridae | Infections | Nucleotides | Genetic mutation | Sequencing | Amino acid substitution | DYNAMICS | H5N1 | REPLICATION | MODEL | A VIRUSES | MULTIDISCIPLINARY SCIENCES | Adaptation, Physiological | Receptors, Virus - metabolism | Air Microbiology | Humans | Influenza A Virus, H5N1 Subtype - genetics | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Respiratory System - virology | Influenza, Human - virology | RNA Replicase - genetics | Selection, Genetic | Sialic Acids - metabolism | Probability | Viral Proteins - genetics | Birds | Glycosylation | Influenza, Human - transmission | Mammals | Hemagglutinin Glycoproteins, Influenza Virus - metabolism | Animals | Genetic Fitness | Orthomyxoviridae Infections - transmission | Models, Biological | Influenza in Birds - virology | Influenza A Virus, H5N1 Subtype - pathogenicity | High-Throughput Nucleotide Sequencing | Mutation | Orthomyxoviridae Infections - virology | Amino Acid Substitution | Evolution, Molecular | Influenza, Human - immunology | Avian influenza | Physiological aspects | Development and progression | Research | Epidemiology | Amino acids | Evolution | Avian flu | Influenza | Circulating | Mathematical models | Droplets
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8. Full Text Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation
by Haagmans, Bart L, PhD and Al Dhahiry, Said H S, PhD and Reusken, Chantal B E M, PhD and Raj, V Stalin, PhD and Galiano, Monica, PhD and Myers, Richard, PhD and Godeke, Gert-Jan, BSc and Jonges, Marcel, MSc and Farag, Elmoubasher, MPH and Diab, Ayman, MPH and Ghobashy, Hazem, PhD and Alhajri, Farhoud, BSc and Al-Thani, Mohamed, ABCM and Al-Marri, Salih A, ABFM and Al Romaihi, Hamad E, ABCM and Al Khal, Abdullatif, PhD and Bermingham, Alison, PhD and Osterhaus, Albert D M E, Prof and AlHajri, Mohd M, Dr and Koopmans, Marion P G, Prof
The Lancet Infectious Diseases, ISSN 1473-3099, 2014, Volume 14, Issue 2, pp. 140 - 145
Summary Background Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe lower respiratory tract infection in people. Previous studies... 
Infectious Disease | INFECTIOUS DISEASES | BAT | PROTEIN | Coronavirus Infections - diagnosis | Disease Reservoirs - virology | Humans | Middle Aged | Molecular Sequence Data | RNA, Viral - analysis | Male | Phylogeny | Reverse Transcriptase Polymerase Chain Reaction | Zoonoses - virology | Camelus - virology | Animals | Coronavirus Infections - veterinary | Sequence Analysis, RNA | Coronavirus Infections - epidemiology | Coronavirus Infections - virology | Qatar - epidemiology | Base Sequence | Zoonoses - epidemiology | Coronavirus - genetics | Disease Outbreaks - veterinary | Adult | Zoonoses - diagnosis | Coronavirus - isolation & purification | Health aspects | Public health | Investigations | Respiratory distress syndrome | Patients | Shipments | Contracts
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9. Full Text Pathogenesis and Transmission of Swine-Origin 2009 A(H1N1) Influenza Virus in Ferrets
by Vincent J. Munster and Emmie de Wit and Judith M. A. van den Brand and Sander Herfst and Eefje J. A. Schrauwen and Theo M. Bestebroer and David van de Vijver and Charles A. Boucher and Marion Koopmans and Guus F. Rimmelzwaan and Thijs Kuiken and Albert D. M. E. Osterhaus and Ron A. M. Fouchier
Science, ISSN 0036-8075, 7/2009, Volume 325, Issue 5939, pp. 481 - 483
The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments. In a ferret pathogenesis and... 
Inoculation | Throat | Disease transmission | Lungs | Aerosols | Viruses | Orthomyxoviridae | Reports | Infections | Ferrets | Trachea | A VIRUS | H5N1 VIRUSES | HUMANS | VIRULENCE | MULTIDISCIPLINARY SCIENCES | MAMMALS | Bronchi - virology | Influenza, Human - pathology | Humans | Orthomyxoviridae Infections - pathology | Child, Preschool | Influenza A Virus, H1N1 Subtype - pathogenicity | Virus Shedding | Influenza, Human - transmission | Trachea - virology | Respiratory System - virology | Animals | Orthomyxoviridae Infections - transmission | Virus Replication | Female | Influenza, Human - virology | Seasons | Orthomyxoviridae Infections - virology | Swine - virology | Disease Models, Animal | Development and progression | Genetic aspects | Swine influenza | Animal diseases | Pathology | Mammals | Swine flu
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10. Full Text Newly Identified Viruses in Human Gastroenteritis Pathogens or Not?
by Smits, SL and Osterhaus, ADME and Koopmans, MP
PEDIATRIC INFECTIOUS DISEASE JOURNAL, ISSN 0891-3668, 01/2016, Volume 35, Issue 1, pp. 104 - 107
INFECTIONS | PREVALENCE | IMMUNOLOGY | virus | HUMAN FECES | HUMAN BOCAVIRUS | PEDIATRICS | human | picobirnavirus | picornavirus | INFECTIOUS DISEASES | disease | astrovirus | case-control | VIRAL COMMUNITY | CARDIOVIRUSES | parvovirus | diarrhea | CHILDREN | polyomavirus | gastroenteritis | COSAVIRUS | pathogen | SAFFOLD VIRUS | viral metagenomics | age | Viruses - classification | Gastroenteritis - epidemiology | Metagenomics | Viruses - genetics | Humans | Communicable Diseases, Emerging - epidemiology | Gastroenteritis - virology | Communicable Diseases, Emerging - virology | Metagenome
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11. Full Text Novel hepatitis E virus in ferrets, the Netherlands
by Stalin Raj, V and Smits, Saskia L and Pas, Suzan D and Provacia, Lisette B.V and Moorman-Roest, Hanneke and Osterhaus, Albert D. M. E and Haagmans, Bart L
Emerging Infectious Diseases, ISSN 1080-6040, 08/2012, Volume 18, Issue 8, pp. 1369 - 1370
INFECTIOUS DISEASES | IMMUNOLOGY | Humans | Netherlands - epidemiology | Molecular Sequence Data | Hepatitis E - virology | Hepatitis E virus - genetics | Phylogeny | Sequence Analysis, DNA | Ferrets - virology | Feces - virology | Animals | Hepatitis E virus - classification | Hepatitis E - veterinary | Hepatitis E virus - isolation & purification | Causes of | Reports | Genetic aspects | Diagnosis | Identification and classification | Hepatitis E virus | Zoonoses | Letter | hepatitis E virus | viruses | ferrets | pyrosequencing | Letters to the Editor | PCR | the Netherlands
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12. Full Text Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
by Raj, V. Stalin and Mou, Huihui and Smits, Saskia L and Dekkers, Dick H. W and Müller, Marcel A and Dijkman, Ronald and Muth, Doreen and Demmers, Jeroen A. A and Zaki, Ali and Fouchier, Ron A. M and Thiel, Volker and Drosten, Christian and Rottier, Peter J. M and Osterhaus, Albert D. M. E and Bosch, Berend Jan and Haagmans, Bart L
Nature, ISSN 0028-0836, 03/2013, Volume 495, Issue 7440, pp. 251 - 254
Most human coronaviruses cause mild upper respiratory tract disease but may be associated with more severe pulmonary disease in immunocompromised individuals'.... 
ANGIOTENSIN-CONVERTING ENZYME-2 | PATHOGENESIS | BATS | ACUTE-RESPIRATORY-SYNDROME | RESERVOIRS | MULTIDISCIPLINARY SCIENCES | SARS CORONAVIRUS | AMINOPEPTIDASE-N | MECHANISMS | Coronavirus - classification | Dipeptidyl Peptidase 4 - metabolism | Receptors, Virus - metabolism | Humans | Cercopithecus aethiops | Coronavirus Infections - genetics | Molecular Sequence Data | Dipeptidyl Peptidase 4 - genetics | Host Specificity | Receptors, Virus - genetics | Animals | Coronavirus Infections - metabolism | Coronavirus - metabolism | Coronavirus Infections - epidemiology | Coronavirus Infections - virology | Epithelial Cells - virology | Bronchioles - cytology | COS Cells | Chiroptera | Complications and side effects | Medical research | Coronavirus infections | Proteases | Physiological aspects | Causes of | Medicine, Experimental | Coronaviruses | Diagnosis | Research | Ubiquitin-proteasome system | Proteins | Studies | Infections | Pathogenesis | Epidemiology
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