X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (52) 52
humans (33) 33
biochemistry & molecular biology (30) 30
drug discovery (27) 27
biotechnology & applied microbiology (20) 20
animals (18) 18
biochemical research methods (17) 17
proteins (17) 17
ligands (15) 15
prediction (15) 15
mathematical & computational biology (14) 14
molecular sequence data (14) 14
amino acid sequence (13) 13
chemistry, medicinal (13) 13
databases, factual (12) 12
pharmacology & pharmacy (12) 12
research (12) 12
bioinformatics (11) 11
discovery (11) 11
binding sites (10) 10
databases, chemical (10) 10
genomics (10) 10
internet (10) 10
protein conformation (10) 10
proteins - chemistry (10) 10
computer science, interdisciplinary applications (9) 9
design (9) 9
drug design (9) 9
identification (9) 9
software (9) 9
models, molecular (8) 8
research article (8) 8
biology (7) 7
chemistry (7) 7
chemistry, multidisciplinary (7) 7
classification (7) 7
computational biology - methods (7) 7
drug discovery - methods (7) 7
drugs (7) 7
genomes (7) 7
homologous proteins (7) 7
multidisciplinary sciences (7) 7
3-dimensional structure (6) 6
computer science, information systems (6) 6
data mining (6) 6
drug resistance (6) 6
drug therapy (6) 6
pharmaceutical preparations - chemistry (6) 6
pharmacology (6) 6
protein (6) 6
protein structure, secondary (6) 6
protein structure, tertiary (6) 6
secondary structure (6) 6
sequence alignment (6) 6
structure-activity relationship (6) 6
applications notes (5) 5
binding (5) 5
biochemistry (5) 5
biological assay (5) 5
biophysics (5) 5
cancer (5) 5
chemogenomics (5) 5
computer science applications (5) 5
computer simulation (5) 5
crystal-structure (5) 5
data-bank (5) 5
databases, protein (5) 5
genes (5) 5
genome (5) 5
hydrogen bonding (5) 5
information (5) 5
kinases (5) 5
pharmaceutical sciences (5) 5
physical and theoretical chemistry (5) 5
physiological aspects (5) 5
receptors (5) 5
sequence homology, amino acid (5) 5
target (5) 5
templates (5) 5
tuberculosis (5) 5
activation (4) 4
algorithms (4) 4
amino acids (4) 4
cell biology (4) 4
computer graphics and computer-aided design (4) 4
databases and ontologies (4) 4
library and information sciences (4) 4
ligand efficiency (4) 4
medicine (4) 4
methods (4) 4
molecular biology (4) 4
molecular targeted therapy (4) 4
molecular weight (4) 4
ontology (4) 4
polypharmacology (4) 4
proteins - metabolism (4) 4
rats (4) 4
reproducibility of results (4) 4
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


by Bansal, Mukesh and Yang, Jichen and Karan, Charles and Menden, Michael P and Costello, James C and Tang, Hao and Xiao, Guanghua and Li, Yajuan and Allen, Jeffrey and Zhong, Rui and Chen, Beibei and Kim, Minsoo and Wang, Tao and Heiser, Laura M and Realubit, Ronald and Mattioli, Michela and Alvarez, Mariano J and Shen, Yao and Gallahan, Daniel and Singer, Dinah and Saez-Rodriguez, Julio and Xie, Yang and Stolovitzky, Gustavo and Califano, Andrea and Abbuehl, Jean-Paul and Altman, Russ B and Balcome, Shawn and Bell, Ana and Bender, Andreas and Berger, Bonnie and Bernard, Jonathan and Bieberich, Andrew A and Borboudakis, Giorgos and Chan, Christina and Chen, Ting-Huei and Choi, Jaejoon and Coelho, Luis Pedro and Creighton, Chad J and Dampier, Will and Davisson, V. Jo and Deshpande, Raamesh and Diao, Lixia and Di Camillo, Barbara and Dundar, Murat and Ertel, Adam and Goswami, Chirayu P and Gottlieb, Assaf and Gould, Michael N and Goya, Jonathan and Grau, Michael and Gray, Joe W and Hejase, Hussein A and Hoffmann, Michael F and Homicsko, Krisztian and Homilius, Max and Hwang, Woochang and Ijzerman, Adriaan P and Kallioniemi, Olli and Karacali, Bilge and Kaski, Samuel and Kim, Junho and Krishnan, Arjun and Lee, Junehawk and Lee, Young-Suk and Lenselink, Eelke B and Lenz, Peter and Li, Lang and Li, Jun and Liang, Han and Mpindi, John-Patrick and Myers, Chad L and Newton, Michael A and Overington, John P and Parkkinen, Juuso and Prill, Robert J and Peng, Jian and Pestell, Richard and Qiu, Peng and Rajwa, Bartek and Sadanandam, Anguraj and Sambo, Francesco and Sridhar, Arvind and Sun, Wei and Toffolo, Gianna M and Tozeren, Aydin and Troyanskaya, Olga G and Tsamardinos, Ioannis and Van Vlijmen, Herman W. T and Wang, Wen and Wegner, Joerg K and Wennerberg, Krister and Van Westen, Gerard J. P and Xia, Tian and Yang, Yang and Yao, Victoria and Yuan, Yuan and Zeng, Haoyang and Zhang, Shihua and Zhao, Junfei and Zhou, Jian and NCI-DREAM Community and Cellworks Group
Nature Biotechnology, ISSN 1087-0156, 12/2014, Volume 32, Issue 12, pp. 1213 - 1222
Recent therapeutic successes have renewed interest in drug combinations, but experimental screening approaches are costly and often identify only small numbers... 
DRUG-COMBINATIONS | NETWORK | THERAPY | INHIBITION | MODELS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | RESISTANCE | CANCER | EXPRESSION | CHEMOTHERAPY | SYSTEMS BIOLOGY | Drug Synergism | B-Lymphocytes - drug effects | Algorithms | Computer Simulation | Humans | Drug Combinations | Pharmaceutical research | Drug therapy, Combination | Research | Computers | Drug therapy | Predictions
Journal Article
Cochrane Database of Systematic Reviews, ISSN 1469-493X, 04/2017, Volume 2017, Issue 4, p. CD011748
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 1/2012, Volume 40, Issue D1, pp. D1100 - D1107
ChEMBL is an Open Data database containing binding, functional and ADMET information for a large number of drug-like bioactive compounds. These data are... 
ACCESSIBLE DATABASE | RECEPTORS | INFORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PREDICTION | User-Computer Interface | Proteins - metabolism | Databases, Protein | Humans | Pharmaceutical Preparations - chemistry | Proteins - chemistry | Drug Discovery | Databases, Factual
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 01/2014, Volume 42, Issue 1, pp. D1083 - D1090
ChEMBL is an open large-scale bioactivity database (https://www.ebi.ac.uk/chembl), previously described in the 2012 Nucleic Acids Research Database Issue.... 
DESIGN | LIGAND EFFICIENCY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | RECEPTOR | TARGETS | IDENTIFICATION | AGONISTS | RESOURCE | Databases, Chemical | Humans | Pharmaceutical Preparations - chemistry | Proteins - drug effects | Ligands | Internet | Proteins - chemistry | Binding Sites | Drug Discovery | VI. Genomic variation, diseases and drugs
Journal Article
Nucleic acids research, ISSN 0305-1048, 2015, Volume 43, Issue 1, pp. W612 - W620
ChEMBL is now a well-established resource in the fields of drug discovery and medicinal chemistry research. The ChEMBL database curates and stores standardized... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | INFORMATION-SYSTEM | User-Computer Interface | Internet | Databases, Chemical | Drug Discovery | Systems Integration | Web Server issue
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1 - 25
Lack of efficacy in the intended disease indication is the major cause of clinical phase drug development failure. Explanations could include the poor external... 
TRIAL | CLINICAL DEVELOPMENT | MULTIDISCIPLINARY SCIENCES | PRODUCTIVITY | MENDELIAN RANDOMIZATION | ATTRITION | LESSONS | CORONARY-HEART-DISEASE | THRESHOLDS | DECLINE | Proteins | Genomes | Disease | Drug development | Genomics | Success
Journal Article
12.