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Nature, ISSN 0028-0836, 2015, Volume 521, Issue 7550, pp. 43 - 37
Journal Article
Molecular Cell, ISSN 1097-2765, 2010, Volume 37, Issue 5, pp. 714 - 727
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 12/2009, Volume 38, Issue 6, pp. 1922 - 1931
Hypoxia-inducible factors (HIFs) are critical transcription factors that mediate cell survival during reduced oxygen conditions (hypoxia). At regular oxygen... 
HIF | UBIQUITIN LIGASE | PATHWAY | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEAR-PORE COMPLEX | TRANSCRIPTIONAL REPRESSION | ALPHA | HIF-1-ALPHA | TARGET PROTEINS | SUMOYLATION | Molecular Biology
Journal Article
Journal Article
eLife, ISSN 2050-084X, 11/2016, Volume 5
Colorectal cancer (CRC) organoids can be derived from almost all CRC patients and therefore capture the genetic diversity of this disease. We assembled a panel... 
Journal Article
Nature, ISSN 0028-0836, 05/2015, Volume 521, Issue 7550, pp. 43 - 7
Crypt stem cells represent the cells of origin for intestinal neoplasia. Both mouse and human intestinal stem cells can be cultured in medium containing the... 
Journal Article
Methods in Cell Biology, ISSN 0091-679X, 01/2018, Volume 145, pp. 91 - 106
Examining cell behavior in its correct tissue context is a major challenge in cell biology. The recent development of mammalian stem cell-based organoid... 
Aneuploidy | Chromosome | Organoid | Tumor | Mitosis | Stem cell | HUMAN COLON | PREIMPLANTATION EMBRYOS | COMPONENT | CHROMOSOMAL INSTABILITY | CYCLE | CELL BIOLOGY | Cell Division - physiology | Microscopy - methods | Organoids - physiology | Animals | Humans | Stem Cells - physiology | Cell Culture Techniques - methods | Index Medicus
Conference Proceeding
Molecular and Cellular Biology, ISSN 0270-7306, 10/2010, Volume 30, Issue 20, pp. 4828 - 4839
Nucleotide excision repair (NER) operates through coordinated assembly of repair factors into pre- and postincision complexes. The postincision step of NER... 
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 04/2010, Volume 38, Issue 6, pp. 1922 - 1931
Hypoxia-inducible factors (HIFs) are critical transcription factors that mediate cell survival during reduced oxygen conditions (hypoxia). At regular oxygen... 
Journal Article
Journal Article
Nature, ISSN 0028-0836, 05/2015, Volume 521, Issue 7550, p. 43
Crypt stem cells represent the cells of origin for intestinal neoplasia. Both mouse and human intestinal stem cells can be cultured in medium containing the... 
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 10/2010, Volume 30, Issue 20, pp. 4828 - 4839
Nucleotide excision repair (NER) operates through coordinated assembly of repair factors into pre- and postincision complexes. The postincision step of NER... 
Life Sciences | Molecular biology | Biochemistry, Molecular Biology
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2017, Volume 23, Issue 1, pp. 60 - 68
Forward genetic screens with CRISPR-Cas9 genome editing enable high-resolution detection of genetic vulnerabilities in cancer cells. We conducted genome-wide... 
MEDICINE, RESEARCH & EXPERIMENTAL | RNF43 | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | CANCER | CELL BIOLOGY | ESSENTIAL GENES | INHIBITION | GROWTH | MUTATIONAL LANDSCAPE | WNT | RECEPTORS | Frizzled Receptors - antagonists & inhibitors | Neoplasm Transplantation | Oncogene Proteins - genetics | Pancreatic Neoplasms - metabolism | Colorectal Neoplasms - genetics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Molecular Targeted Therapy | RNA, Messenger - metabolism | Carcinoma, Pancreatic Ductal - genetics | Adenocarcinoma - metabolism | Flow Cytometry | Organoids - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats | Adenocarcinoma - genetics | Real-Time Polymerase Chain Reaction | Colorectal Neoplasms - metabolism | Frizzled Receptors - metabolism | Pancreatic Neoplasms - genetics | DNA-Binding Proteins - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Antibodies - pharmacology | Animals | Wnt Signaling Pathway - drug effects | Wnt Signaling Pathway - genetics | Cell Cycle Checkpoints - drug effects | Fluorescent Antibody Technique | Organoids - drug effects | Cell Line, Tumor | Mice | Care and treatment | Pancreatic cancer | Innovations | Development and progression | Genotype | Genetic engineering | Cellular signal transduction | Genetic aspects | Health aspects | Cell proliferation | Adenocarcinoma | Therapy | Wnt protein | Frizzled protein | Xenotransplantation | Colorectal carcinoma | Antibodies | Genomes | Cell surface | Genetic screening | Proteins | Receptors | Organoids | Xenografts | Inhibition | Pancreas | Recombinant | CRISPR | Immunoglobulins | Screens | Signaling | Mutation | Cancer | Tumors | Index Medicus
Journal Article