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PLOS Genetics, ISSN 1553-7390, 2011, Volume 7, Issue 3, pp. e1001324 - e1001324
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2017, Volume 23, Issue 1, pp. 69 - 78
In acute myeloid leukemia (AML), therapy resistance frequently occurs, leading to high mortality among patients. However, the mechanisms that render leukemic... 
TRANSFORMATION | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | SOMATIC MUTATIONS | CELL BIOLOGY | THERAPY | GENE EZH2 | DIFFERENTIATION | INHIBITOR | EXPRESSION | Immunohistochemistry | CDC2 Protein Kinase | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | Neoplasm Transplantation | Cyclin-Dependent Kinases - metabolism | Cytarabine - pharmacology | Immunoprecipitation | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Bortezomib - pharmacology | Gene Knockdown Techniques | Young Adult | Flow Cytometry | Mass Spectrometry | Aged, 80 and over | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Enhancer of Zeste Homolog 2 Protein - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Blotting, Western | Homeodomain Proteins - genetics | Drug Resistance, Neoplasm - genetics | Protein Kinase Inhibitors | Animals | Proteomics | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Aged | Mice | Protein Processing, Post-Translational | Histones - metabolism | Proteasome Endopeptidase Complex - metabolism | Pyridones - pharmacology | Leukemia, Myeloid, Acute - genetics | Genetic aspects | Methyltransferases | Drug resistance | Health aspects | Drugs | Therapy | Hsp90 protein | Phosphorylation | Leukemia | Chemoresistance | Cytotoxicity | Kinases | Degradation | Proteins | Cytarabine | Restoration | Histone methyltransferase | HOX gene | Protein-tyrosine kinase | Tyrosine | Bortezomib | Myeloid leukemia | Heat shock proteins | Gene expression | Patients | Sensitivity | Inhibitors | Derepression | Cell lines | Proteasomes | Blast resistance | Methylation | Acute myeloid leukemia | Heat shock | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2007, Volume 13, Issue 10, pp. 2916 - 2922
Purpose: Recently, high numbers of regulatory T cells within the stem cell graft were described to be associated with less graft-versus-host disease (GVHD)... 
foxp3 | γδTCR | unrelated | allogeneic | PBSC | transplantation | graft composition
Journal Article
Nature Cell Biology, ISSN 1465-7392, 07/2017, Volume 19, Issue 7, pp. 844 - 855
Leukaemogenesis requires enhanced self-renewal, which is induced by oncogenes. The underlying molecular mechanisms remain incompletely understood. Here, we... 
RIBOSOMAL-RNA METHYLATION | BREAST-CANCER | BIOGENESIS | HEMATOPOIETIC STEM-CELLS | TRANSCRIPTION | GRANULOCYTIC DIFFERENTIATION | ACUTE MYELOID-LEUKEMIA | PROTEIN-SYNTHESIS | POLYMERASE-I | TRANSLATIONAL CONTROL | CELL BIOLOGY | Myeloid-Lymphoid Leukemia Protein - metabolism | Oncogene Proteins, Fusion - metabolism | Cell Proliferation | Leukemia - pathology | Humans | Leukemia - metabolism | RNA, Ribosomal - genetics | Protein Interaction Maps | Cell Self Renewal | RNA, Small Nucleolar - metabolism | Time Factors | Cell Transformation, Neoplastic - genetics | U937 Cells | HEK293 Cells | Ribonucleoproteins - genetics | DEAD-box RNA Helicases - metabolism | Leukemia - genetics | Repressor Proteins - metabolism | Genetic Predisposition to Disease | Core Binding Factor Alpha 2 Subunit - metabolism | Signal Transduction | Mice, Inbred C57BL | RNA, Ribosomal - metabolism | Repressor Proteins - genetics | Ribonucleoproteins - metabolism | Gene Expression Regulation, Leukemic | Transcription Factors - genetics | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins c-myc - metabolism | RNA, Small Nucleolar - genetics | Mice, Knockout | RUNX1 Translocation Partner 1 Protein | Transcription Factors - metabolism | DEAD-box RNA Helicases - genetics | Phenotype | Animals | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | K562 Cells | HL-60 Cells | Proto-Oncogene Proteins c-myc - genetics | Cell Transformation, Neoplastic - pathology | Methylation | Core Binding Factor Alpha 2 Subunit - genetics | Enhancer-of-split protein | Leukemia | rRNA | Myc protein | snoRNA | DNA helicase | AML1 protein | Molecular modelling | Clonal deletion | Ribonucleic acids | Stem cells | Deletion | In vitro methods and tests | RNA helicase | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 2126 - 14
Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative disorder of early childhood characterized by mutations activating RAS signaling.... 
ISLAND METHYLATOR PHENOTYPE | MOLECULAR CLASSIFICATION | DNA METHYLATION | EPITHELIAL-CELLS | CIS-REGULATORY ELEMENTS | MULTIDISCIPLINARY SCIENCES | CHRONIC LYMPHOCYTIC-LEUKEMIA | STEM-CELL TRANSPLANTATION | NERVE SHEATH TUMORS | MYELODYSPLASTIC SYNDROMES | SOMATIC MUTATIONS | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Chromatin - metabolism | Up-Regulation | Prognosis | Prospective Studies | Leukemia, Myelomonocytic, Juvenile - therapy | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Child, Preschool | Infant | Male | Antineoplastic Agents - therapeutic use | DNA (Cytosine-5-)-Methyltransferase 1 - metabolism | DNA (Cytosine-5-)-Methyltransferases - metabolism | Noonan Syndrome - pathology | DNA Methylation | DNA Mutational Analysis | Proto-Oncogene Proteins c-cbl | Female | Leukemia, Myelomonocytic, Juvenile - genetics | Child | Proto-Oncogene Proteins p21(ras) - metabolism | Epigenomics | Leukemia, Myelomonocytic, Juvenile - pathology | Hematopoietic Stem Cell Transplantation | Signal Transduction - genetics | Gene Expression Regulation, Leukemic | Noonan Syndrome - genetics | Leukemia, Myelomonocytic, Juvenile - mortality | Biopsy | Mutation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Chromatin - genetics | Myelomonocytic leukemia | Chromatin | Leukemia | DNMT1 protein | Subgroups | Myeloproliferative diseases | K-Ras protein | Signal transduction | Signaling | Genetic markers | DNA methylation | Children | Methylation | Monosomy | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Journal Article
Mucosal Immunology, ISSN 1933-0219, 2019, Volume 12, Issue 3, pp. 733 - 745
The gene encoding for Epstein-Barr virus-induced G-protein-coupled receptor 2 (EBI2) is a risk gene for inflammatory bowel disease (IBD). Together with its... 
ACTIVATION | INFLAMMATORY-BOWEL-DISEASE | IMMUNE-RESPONSES | ULCERATIVE-COLITIS | TISSUE | IMMUNOLOGY | B-CELL MIGRATION | IDENTIFICATION | EXPRESSION | GRADIENT | 25-HYDROXYCHOLESTEROL | Inflammatory bowel disease | Inflammation | Colon | Immune system
Journal Article