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1. Full Text Methods for the directed evolution of proteins
by Packer, Michael S and Liu, David R
Nature Reviews Genetics, ISSN 1471-0056, 07/2015, Volume 16, Issue 7, pp. 379 - 394
Directed evolution has proved to be an effective strategy for improving or altering the activity of biomolecules for industrial, research and therapeutic... 
RANDOM MUTAGENESIS | GREEN FLUORESCENT PROTEIN | TRANSFER-RNA SYNTHETASE | CHEMICAL COMPLEMENTATION | COMPUTATIONAL DESIGN | ESCHERICHIA-COLI | MOLECULAR EVOLUTION | GENETICS & HEREDITY | ANTIBIOTIC-RESISTANCE | IN-VITRO COMPARTMENTALIZATION | YEAST SURFACE DISPLAY | Proteins - genetics | Animals | Proteins - metabolism | Protein Engineering - methods | Humans | Substrate Specificity | Directed Molecular Evolution | Genetic Techniques | Genetic research | Cellular proteins | Research | Properties | Genetic regulation
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2. Full Text Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
by Komor, Alexis C and Kim, Yongjoo B and Packer, Michael S and Zuris, John A and Liu, David R
Nature, ISSN 0028-0836, 04/2016, Volume 533, Issue 7603, pp. 420 - 424
Current genome-editing technologies introduce double-stranded (ds) DNA breaks at a target locus as the first step to gene correction1,2. Although most genetic... 
ENZYME APOBEC1 | ENDONUCLEASE | PROTEINS | CRISPR-CAS9 NUCLEASES | MULTIDISCIPLINARY SCIENCES | Apolipoprotein E4 - genetics | RNA, Guide - genetics | Humans | Genome - genetics | Templates, Genetic | INDEL Mutation - genetics | Uridine - genetics | Point Mutation - genetics | APOBEC-1 Deaminase | Base Sequence | Cytidine - genetics | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Genetic Engineering - methods | Cell Line | DNA - metabolism | Genes, p53 - genetics | Uracil-DNA Glycosidase - antagonists & inhibitors | DNA - genetics | Deoxyribonuclease I - metabolism | Animals | CRISPR-Associated Proteins - metabolism | Cytidine Deaminase - metabolism | DNA Repair | CRISPR-Cas Systems | Mice | DNA Cleavage | Genetic research | Genetic engineering | Research | Genomics | Methods | Proteins | Enzymes | Genetic disorders | Amino acids | Genomes | Mutation | DNA repair | Deoxyribonucleic acid--DNA
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3. Full Text Programmable base editing of T to G C in genomic DNA without DNA cleavage
by Gaudelli, Nicole M and Komor, Alexis C and Rees, Holly A and Packer, Michael S and Badran, Ahmed H and Bryson, David I and Liu, David R
Nature, ISSN 0028-0836, 11/2017, Volume 551, Issue 7681, pp. 464 - 471
The spontaneous deamination of cytosine is a major source of transitions from C·G to T·A base pairs, which account for half of known pathogenic point mutations... 
Directed evolution | Fracture mechanics | Disease | Biological evolution | Genomes | Drug resistance | Experiments | Guanine | Efficiency | Bacteria | Cleavage | Evolution | Cytosine | Nuclease | Deoxyribonucleic acid--DNA | Transfer RNA | CRISPR | Protein engineering | Enzymes | Adenosine | Base pairs | Adenine | Ductile-brittle transition | Adenosine deaminase | Ribonucleic acid--RNA | Studies | Antibiotics | Deamination | Mutation
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4. Full Text Programmable base editing of A.T to G.C in genomic DNA without DNA cleavage
by Gaudelli, NM and Komor, AC and Rees, HA and Packer, MS and Badran, AH and Bryson, DI and Liu, DR
NATURE, ISSN 0028-0836, 11/2017, Volume 551, Issue 7681, pp. 464 - 464
The spontaneous deamination of cytosine is a major source of transitions from C.G to T.A base pairs, which account for half of known pathogenic point mutations... 
PRECISE | ADENOSINE-DEAMINASE | CYTOSINE DEAMINATION | TARGET BASE | MULTIDISCIPLINARY SCIENCES | MUTATION | DIRECTED EVOLUTION | TADA | RICE | Methods | Nucleotide sequencing | DNA sequencing
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5. Full Text Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions
by Kim, Y Bill and Komor, Alexis C and Levy, Jonathan M and Packer, Michael S and Zhao, Kevin T and Liu, David R
Nature Biotechnology, ISSN 1087-0156, 04/2017, Volume 35, Issue 4, pp. 371 - 376
Base editing induces single-nucleotide changes in the DNA of living cells using a fusion protein containing a catalytically defective Streptococcus pyogenes... 
STAPHYLOCOCCUS-AUREUS CAS9 | DOMAIN | DNA CLEAVAGE | APOBEC3G | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CRYSTAL-STRUCTURE | CRISPR-CAS9 | MAMMALIAN-CELLS | Endonucleases - genetics | Cytidine Deaminase - genetics | Bacterial Proteins - genetics | Genome - genetics | Recombinant Fusion Proteins - genetics | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Gene Editing - methods | Base Composition - genetics | Methods | Nucleotide sequencing | DNA sequencing | genome editing | CRISPR | protein engineering | Base editing | Cas9 | single-nucleotide polymorphism | genetic disease
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6. Full Text Phage-assisted continuous evolution of proteases with altered substrate specificity
by Packer, Michael S and Rees, Holly A and Liu, David R
Nature communications, 10/2017, Volume 8, Issue 1, p. 956
Here we perform phage-assisted continuous evolution (PACE) of TEV protease, which canonically cleaves ENLYFQS, to cleave a very different target sequence,... 
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7. Full Text Phage-assisted continuous evolution of proteases with altered substrate specificity
by Packer, Michael S and Rees, Holly A and Liu, David R
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1 - 11
Here we perform phage-assisted continuous evolution (PACE) of TEV protease, which canonically cleaves ENLYFQS, to cleave a very different target sequence,... 
CONTINUOUS DIRECTED EVOLUTION | CHYMOTRYPSIN | FACTOR VIIA | TEV PROTEASE | CONVERTING TRYPSIN | STRUCTURAL BASIS | VIRUS PROTEASE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | ESCHERICHIA-COLI CYTOPLASM | SUBTILISIN E | Therapeutic applications | Phages | Proteinase | Amino acid sequence | Cultures | Interleukin 23 | Substrates | Proteins | Signaling | Protease | Splenocytes | Substrate specificity | Hemophilia | Evolution | Mutation | Dissection
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8. Full Text Impact of facial conformation on canine health: Brachycephalic obstructive airway syndrome
by Packer, Rowena M.A and Hendricks, Anke and Tivers, Michael S and Burn, Charlotte C
PLoS ONE, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, p. e0137496
The domestic dog may be the most morphologically diverse terrestrial mammalian species known to man; pedigree dogs are artificially selected for extreme... 
WELFARE | OBESITY | MULTIDISCIPLINARY SCIENCES | SLEEP-APNEA SYNDROME | DISORDERS | PREVALENCE | DOG BREEDS | Breeding | Face - pathology | Risk Factors | Probability | Male | Dog Diseases - pathology | Syndrome | Animals | Airway Obstruction - pathology | Dogs | Female | Airway Obstruction - veterinary | Craniosynostoses - pathology | Obesity | Veterinary colleges | Risk groups | Terrestrial environments | Sleep apnea | Veterinary medicine | Standards | Risk factors | Respiratory tract | Sleep disorders | Weight control | Sleep | Apnea | Pedigree | Registration | Larynx | Neck | Respiration | Conformation
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9. Full Text A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations
by Dickinson, Bryan C and Packer, Michael S and Badran, Ahmed H and Liu, David R
Nature Communications, ISSN 2041-1723, 2015, Volume 5, Issue 1, p. 5352
The laboratory evolution of protease enzymes has the potential to generate proteases with therapeutically relevant specificities and to assess the... 
MUTAGENESIS | VARIANTS | PROTEIN EVOLUTION | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | INHIBITOR | SELECTION | CLEAVAGE | HEPATITIS-C | STRINGENCY | DISCOVERY | Amino Acid Sequence | Gene Expression | Isoquinolines | Peptide Hydrolases - genetics | Humans | Protease Inhibitors | Molecular Sequence Data | Viral Proteins - genetics | Lactams | Genetic Techniques | Drug Resistance, Viral - genetics | Hepacivirus - enzymology | Sulfonamides | Bacteriophage M13 | Mutation | Evolution, Molecular
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10. Full Text The Cleptoparasitic Bee Genus Chiasmognathus (Hymenoptera: Apidae) in Kenya, with the Description of Two New Species
by Engel, Michael S and Packer, Laurence and Martins, Dino J
Journal of East African Natural History, ISSN 1026-1613, 09/2019, Volume 108, Issue 1, p. 17
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11. Full Text The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy
by Bharamgoudar, Reshma and Sonsale, Aniket and Hodson, James and Griffiths, Ewen and CholeS Study Grp and West Midlands Res Collaborative and CholeS Study Group, West Midlands Research Collaborative and on behalf of the CholeS Study Group, West Midlands Research Collaborative
Surgical Endoscopy, ISSN 0930-2794, 7/2018, Volume 32, Issue 7, pp. 3149 - 3157
The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff... 
Theatre utilisation | Gynecology | Prediction | Scoring tool | Operative duration | Medicine & Public Health | Laparoscopic cholecystectomy | Surgery | Hepatology | Gastroenterology | Abdominal Surgery | Patient factors | Proctology | SURGERY | IMPACT | TIME | Medicine, Experimental | Medical research | Laparoscopic surgery | Laparoscopy | Patient satisfaction | Resveratrol | Cholecystectomy
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12. Full Text Publisher Correction: Programmable base editing of AT to GC in genomic DNA without DNA cleavage
by Gaudelli, Nicole M and Komor, Alexis C and Rees, Holly A and Packer, Michael S and Badran, Ahmed H and Bryson, David I and Liu, David R
Nature, ISSN 0028-0836, 07/2018, Volume 559, Issue 7714, p. E8
Journal Article