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Journal Article
Cell Reports, ISSN 2211-1247, 12/2015, Volume 13, Issue 11, pp. 2425 - 2439
To identify therapeutic targets for glioblastoma (GBM), we performed genome-wide CRISPR-Cas9 knockout (KO) screens in patient-derived GBM stem-like cells... 
WEE1 | CRISPR-Cas9 | Glioblastoma | cancer therapeutics | functional genomics | PKMYT1 | gene editing | Myt1 | Cancer therapeutics | Gene editing | Functional genomics | ACTIVATION | PROTEIN | GENE-EXPRESSION | GOLGI | PHOSPHORYLATES CDC2 | HUMAN MYT1 | INHIBITORY KINASE | BRAIN | RNAI SCREEN | REQUIREMENT | CELL BIOLOGY | Neoplastic Stem Cells - cytology | Phosphorylation | Mitosis | Protein-Tyrosine Kinases - metabolism | Humans | Microscopy, Video | Time-Lapse Imaging | Tumor Suppressor Protein p53 - genetics | CDC2 Protein Kinase - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | Receptor, Epidermal Growth Factor - metabolism | Neoplastic Stem Cells - metabolism | RNA Interference | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Glioblastoma - metabolism | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Cell Survival - drug effects | Gene Library | CDC2 Protein Kinase - antagonists & inhibitors | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Pyrimidines - pharmacology | CRISPR-Cas Systems - genetics | Membrane Proteins - antagonists & inhibitors | Glioblastoma - pathology | Nuclear Proteins - antagonists & inhibitors | Cyclin B - metabolism | Genome, Human | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1 - 17
Many of the regulatory features governing erythrocyte specification, maturation, and associated disorders remain enigmatic. To identify new regulators of... 
Osteoprogenitor cells | Erythropoiesis | Translation | Regulators | Transcription | rRNA | Genes | Methyltransferase | Erythrocytes | Biosynthesis | Gene expression | RNA-binding protein | Red blood cells | Specifications | Heme | Bone marrow
Journal Article
2008, 1. Aufl., Current topics in microbiology and immunology, ISBN 3540751572, Volume 320., viii, 273
In the last few years the major effect that RNAi has had in invertebrate systems like C.elegans and drosophila is beginning to take hold in mammalian systems... 
RNA | Gene silencing | Immunology | Human Genetics | Biomedicine
Book
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, p. e0172884
Ion channels and transporters have increasingly recognized roles in cancer progression through the regulation of cell proliferation, migration, and death.... 
MODELS | TRANSPORTERS | CLONING | GLIOMA | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | BIOLOGY | GENES | IDENTIFICATION | CANCER | TUMORS | Gap Junctions - metabolism | Prognosis | Neoplastic Stem Cells - drug effects | Humans | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Transcriptome | Cell Survival - genetics | Ion Channels - genetics | Antineoplastic Agents - therapeutic use | Gap Junctions - genetics | Gene Expression Profiling | Brain Neoplasms - metabolism | Gene Knockdown Techniques | Glioblastoma - genetics | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | Signal Transduction | Brain Neoplasms - genetics | Treatment Outcome | Glioblastoma - therapy | Ion Channels - metabolism | Glioblastoma - pathology | Brain Neoplasms - therapy | Survival Analysis | Cell Line, Tumor | Cluster Analysis | RNA sequencing | Usage | Care and treatment | Gene mutations | Stem cells | Genetic aspects | Ion channels | Research | Glioblastoma multiforme | Cell proliferation | Enrichment | Brain | Brain cancer | Genomics | Glioblastoma | Genomes | Biology | Malignancy | Neurosurgery | Gene sequencing | Cell cycle | Bioinformatics | Medical research | Pharmacology | Gene expression | Ribonucleic acid--RNA | Survival | Children & youth | Medicine | Brain research | Cell death | Medical prognosis | Point mutation | Neural stem cells | Mutation | Cell migration | Cancer | Tumors | RNA | Ribonucleic acid
Journal Article
Nature Cell Biology, ISSN 1465-7392, 04/2010, Volume 12, Issue 4, pp. 372 - 379
Journal Article
Nature, ISSN 0028-0836, 07/2017, Volume 547, Issue 7663, pp. 355 - 359
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 10, p. e77053
Glioblastoma multiforme (GBM) is the most common primary brain cancer in adults and there are few effective treatments. GBMs contain cells with molecular and... 
CANCER-CELLS | SOLID TUMORS | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | HUMAN GLIOMAS | IMAGE-BASED SCREENS | CENTRAL-NERVOUS-SYSTEM | BRAIN-BARRIER MODEL | ADHERENT CULTURE | PHASE-I | TUMOR-INITIATING CELLS | Small Molecule Libraries - pharmacology | Glioblastoma - enzymology | Neoplastic Stem Cells - drug effects | Humans | Brain Neoplasms - pathology | Brain Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Cell Cycle Proteins - antagonists & inhibitors | Glioblastoma - genetics | Swine | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Neoplastic Stem Cells - pathology | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | Drug Screening Assays, Antitumor - methods | Cell Cycle Proteins - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Protein-Serine-Threonine Kinases - genetics | Brain Neoplasms - genetics | Thiophenes - pharmacology | Proto-Oncogene Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Tumor Suppressor Protein p53 - deficiency | Blood-Brain Barrier - drug effects | Neural Stem Cells - enzymology | Neural Stem Cells - pathology | Blotting, Western | Blood-Brain Barrier - metabolism | Mice, Knockout | Animals | Cell Cycle Checkpoints - drug effects | Glioblastoma - pathology | Cell Line, Tumor | Benzimidazoles - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Neoplastic Stem Cells - enzymology | Indans - pharmacology | Viral antibodies | Polo | Brain tumors | Stem cells | Antibodies | Tumor proteins | Glioblastoma multiforme | Neuroimaging | Image processing | Polo-like kinase 1 | Laboratories | p53 Protein | Brain cancer | Glioblastoma | Childrens health | Membrane permeability | Stem cell transplantation | Kinases | Cancer therapies | Defects | Allografts | Blood-brain barrier | Clonal deletion | DNA methylation | Deletion | Polo-like kinase | Cyclin-dependent kinase inhibitors | Pharmaceutical industry | Bioinformatics | Pharmaceutical sciences | Medical research | Antibody microarrays | INK4 protein | Permeability | Gene expression | Medical screening | Endothelial cells | Image analysis | Sensitivity | Brain research | Inhibitors | Neural stem cells | Adults | Mutation | Molecular biology | Human behavior | Tumors | Cancer
Journal Article
Cancer Research, ISSN 0008-5472, 12/2015, Volume 75, Issue 23 Supplement, pp. A02 - A02
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2019, Volume 21, Issue Supplement_6, pp. vi39 - vi39
Abstract Nicotinamide adenine dinucleotide (NAD) metabolic pathways have been shown to be critical targets in many cancers, including brain tumors. However,... 
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2019, Volume 21, Issue Supplement_6, pp. vi41 - vi41
Abstract Chemical or genetic perturbation of the spliceosome function may represent a therapeutic opportunity for Glioblastoma multiforme (GBM) and other... 
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2019, Volume 21, Issue Supplement_6, pp. vi42 - vi42
Abstract Current standard of care therapy for glioblastoma (GBM) includes cytoreduction followed by ablative therapies that target rapidly dividing cell types.... 
Journal Article