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Nature Structural and Molecular Biology, ISSN 1545-9993, 08/2014, Volume 21, Issue 9, pp. 803 - 809
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, pp. e103638 - e103638
Journal Article
NATURE, ISSN 0028-0836, 07/2016, Volume 535, Issue 7611, pp. 252 - 252
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, pp. e0145705 - e0145705
Autoantibodies and the immunoreceptors to which they bind can contribute to the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA). Spleen... 
RHEUMATOID-ARTHRITIS | SELECTIVE-INHIBITION | PRECLINICAL CHARACTERIZATION | ACTIVATES SYK | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | RECEPTOR | NEUTROPHILS | SYK INHIBITORS | EXPRESSION | T-CELLS | Neutrophils - cytology | Arthritis, Experimental - drug therapy | Pyridines - chemistry | Triazoles - chemistry | Humans | Rats, Inbred Lew | Collagen - chemistry | Crystallography, X-Ray | Hypertension - drug therapy | Male | Dose-Response Relationship, Drug | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Inflammation - drug therapy | HEK293 Cells | Inhibitory Concentration 50 | Female | Syk Kinase | Janus Kinase 2 - antagonists & inhibitors | Skin - pathology | Cell Line | Receptors, Fc - chemistry | Indazoles - chemistry | Arthritis, Experimental - physiopathology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Rats | Rats, Sprague-Dawley | Neutropenia - drug therapy | Basophils - cytology | Animals | Eosinophils - cytology | Edema - pathology | Inflammation - physiopathology | Protein-Tyrosine Kinases - antagonists & inhibitors | Inflammation | Enzyme inhibitors | Drug therapy | Joints | Testing | Animal models | Disease | Pathogenesis | RANTES | Clinical trials | Activation | Biochemistry | Arthritis | Kinases | Signal transduction | Receptors | Cell activation | Anaphylaxis | Immunology | Janus kinase 2 | Protein-tyrosine kinase receptors | Inhibition | Pharmaceutical industry | Protein-tyrosine kinase | Neutropenia | Lupus | Hypertension | Spleen | Tyrosine | Edema | Medical research | Autoantibodies | Cytokines | Pharmacology | Bioavailability | Immune systems | Fc receptors | Signaling | Chemistry | Inhibitors | Rheumatoid arthritis | Collagen | Syk protein | Passive cutaneous anaphylaxis | Skin | Autoimmune diseases | Adapter proteins | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 2, pp. 535 - 542
The drugs lenalidomide and pomalidomide bind to the protein cereblon, directing the CRL4-CRBN E3 ligase toward the transcription factors Ikaros and Aiolos to... 
SYSTEMIC-LUPUS-ERYTHEMATOSUS | COMPLEX | CHEMISTRY, MEDICINAL | SUSCEPTIBILITY LOCI | LENALIDOMIDE | CHINESE HAN POPULATION | THALIDOMIDE | IDENTIFICATION | MULTIPLE-MYELOMA CELLS | POMALIDOMIDE | CRL4(CRBN) UBIQUITIN LIGASE | Index Medicus
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 9, pp. 4401 - 4410
Triple negative breast cancer (TNBC) is an aggressive disease with high relapse rates and few treatment options. Outlined in previous publications, we... 
CFI-402257 | POTENT | CHEMISTRY, MEDICINAL | CHECKPOINT | MPS1 | DISCOVERY
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2017, Volume 60, Issue 21, pp. 8989 - 9002
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7611, p. 252
Immunomodulatory drugs bind to cereblon (CRBN) to confer differentiated substrate specificity on the CRL4CRBN E3 ubiquitin ligase. Here we report the... 
Drugs | Proteins | Enzymes | Ligands | Mutation | Cancer therapies | Cancer
Journal Article
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, ISSN 2053-2733, 2014, Volume 70, Issue a1, pp. C1640 - C1640
Conference Proceeding
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