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1. Full Text DNA methylation-based classification of central nervous system tumours
by Capper, David and Jones, David T. W and Sill, Martin and Hovestadt, Volker and Schrimpf, Daniel and Sturm, Dominik and Koelsche, Christian and Sahm, Felix and Chavez, Lukas and Reuss, David E and Kratz, Annekathrin and Wefers, Annika K and Huang, Kristin and Pajtler, Kristian W and Schweizer, Leonille and Stichel, Damian and Olar, Aiana and Engel, Nils W and Lindenberg, Kerstin and Harter, Patrick N and Braczynski, Anne K and Plate, Karl H and Dohmen, Hildegard and Garvalov, Boyan K and Coras, Roland and Hölsken, Annett and Hewer, Ekkehard and Bewerunge-Hudler, Melanie and Schick, Matthias and Fischer, Roger and Beschorner, Rudi and Schittenhelm, Jens and Staszewski, Ori and Wani, Khalida and Varlet, Pascale and Pages, Melanie and Temming, Petra and Lohmann, Dietmar and Selt, Florian and Witt, Henik and Milde, Till and Witt, Olaf and Aronica, Eleonora and Giangaspero, Felice and Rushing, Elisabeth and Scheurlen, Wolfram and Geisenberger, Christoph and Roiguez, Fausto J and Becker, Albert and Preusser, Matthias and Haberler, Christine and Bjerkvig, Rolf and Cryan, Jane and Farrell, Michael and Deckert, Martina and Hench, J. rgen and Frank, Stephan and Serrano, Jonathan and Kannan, Kasthuri and Tsirigos, Aristotelis and Brück, Wolfgang and Hofer, Silvia and Brehmer, Stefanie and Seiz-Rosenhagen, Marcel and Hänggi, Daniel and Hans, Volkmar and Rozsnoki, Stephanie and Hansford, Jordan R and Kohlhof, Patricia and Kristensen, Bjarne W and Lechner, Matt and Lopes, Beatriz and Mawrin, Christian and Ketter, Ralf and Kulozik, Aneas and Khatib, Ziad and Heppner, Frank and Koch, Arend and Jouvet, Anne and Keohane, Catherine and Mühleisen, Helmut and Mueller, Wolf and Pohl, Ute and Prinz, Marco and Benner, Axel and Zapatka, Marc and Gottardo, Nicholas G and ever, Pablo Hernáiz and Kramm, Christof M and Müller, Hermann L and Rutkowski, Stefan and von Hoff, Katja and Frühwald, Michael C and Gnekow, Astrid and Fleischhack, Guun and Tippelt, Stephan and Calaminus, Gabriele and Monoranu, Camelia-Maria and Perry, Arie and Jones, Chris and ...
Nature (London), ISSN 0028-0836, 2018, Volume 555, Issue 7697, pp. 469 - 474
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Central Nervous System Neoplasms - classification | Reproducibility of Results | Central Nervous System Neoplasms - genetics | Humans | Middle Aged | Child, Preschool | Infant | Male | Unsupervised Machine Learning | Young Adult | Central Nervous System Neoplasms - pathology | DNA Methylation | Adolescent | Aged, 80 and over | Adult | Female | Aged | Central Nervous System Neoplasms - diagnosis | Child | Cohort Studies | Genetic aspects | Nucleotide sequencing | Diagnosis | Methylation | Observations | Methods | DNA sequencing | Tumors | Cancer | Analysis | DNA | Machine learning | Central nervous system | Classifiers | Brain cancer | Standardization | Clinical trials | Probability | Data processing | Nervous system | Genomes | Gene expression | Generalized linear models | Learning algorithms | Classification | Diagnostic software | DNA methylation | Diagnostic systems | Bioinformatics | Deoxyribonucleic acid--DNA | Index Medicus
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2. Full Text MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism
by Bandopadhayay, Pratiti and Ramkissoon, Lori A and Jain, Payal and Bergthold, Guillaume and Wala, Jeremiah and Zeid, Rhamy and Schumacher, Steven E and Urbanski, Laura and O'Rourke, Ryan and Gibson, William J and Pelton, Kristine and Ramkissoon, Shakti H and Han, Harry J and Zhu, Yuankun and Choudhari, Namrata and Silva, Amanda and Boucher, Katie and Henn, Rosemary E and Kang, Yun Jee and Knoff, David and Paolella, Brenton R and Gladden-Young, Adrianne and Varlet, Pascale and Pages, Melanie and Horowitz, Peleg M and Federation, Alexander and Malkin, Hayley and Tracy, Adam A and Seepo, Sara and Ducar, Matthew and Van Hummelen, Paul and Santi, Mariarita and Buccoliero, Anna Maria and Scagnet, Mirko and Bowers, Daniel C and Giannini, Caterina and Puget, Stephanie and Hawkins, Cynthia and Tabori, Uri and Klekner, Almos and Bognar, Laszlo and Burger, Peter C and Eberhart, Charles and Rodriguez, Fausto J and Hill, D. Ashley and Mueller, Sabine and Haas-Kogan, Daphne A and Phillips, Joanna J and Santagata, Sandro and Stiles, Charles D and Bradner, James E and Jabado, Nada and Goren, Alon and Grill, Jacques and Ligon, Azra H and Goumnerova, Liliana and Waanders, Angela J and Storm, Phillip B and Kieran, Mark W and Ligon, Keith L and Beroukhim, Rameen and Resnick, Adam C
Nature genetics, ISSN 1061-4036, 03/2016, Volume 48, Issue 3, pp. 273 - 282
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | RNA-Binding Proteins - genetics | Humans | Oncogene Proteins, Fusion - biosynthesis | Carcinogenesis - genetics | Gene Expression Regulation, Neoplastic | Glioma - genetics | RNA-Binding Proteins - biosynthesis | Exome - genetics | Comparative Genomic Hybridization | Oncogene Proteins, Fusion - genetics | Gene Rearrangement | Glioma - pathology | Oncogene Proteins v-myb - biosynthesis | Cell Line, Tumor | Oncogene Proteins v-myb - genetics | High-Throughput Nucleotide Sequencing | Mutation | Child | Epigenetic inheritance | Gliomas | Genetic research | Development and progression | Tumor suppressor genes | Genetic aspects | Research | Gene expression | Health aspects | Proteins | Pediatrics | Medical research | Transcription factors | Brain research | Brain cancer | Genomes | Kinases | Tumors | Cancer | Index Medicus
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3. Full Text Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma
by Bandopadhayay, Pratiti and Piccioni, Federica and O'Rourke, Ryan and Ho, Patricia and Gonzalez, Elizabeth M and Buchan, Graham and Qian, Kenin and Gionet, Gabrielle and Girard, Emily and Coxon, Margo and Rees, Matthew G and Brenan, Lisa and Dubois, Frank and Shapira, Ofer and Greenwald, Noah F and Pages, Melanie and Iniguez, Amanda Balboni and Paolella, Brenton R and Meng, Alice and Sinai, Claire and Roti, Giovanni and Dharia, Neekesh V and Creech, Amanda and Tanenbaum, Benjamin and Khadka, Prasidda and Tracy, Adam and Tiv, Hong L and Hong, Andrew L and Coy, Shannon and Rashid, Rumana and Lin, Jia-Ren and Cowley, Glenn S and Lam, Fred C and Goodale, Amy and Lee, Yenarae and Schoolcraft, Kathleen and Vazquez, Francisca and Hahn, William C and Tsherniak, Aviad and Bradner, James E and Yaffe, Michael B and Milde, Till and Pfister, Stefan M and Qi, Jun and Schenone, Monica and Carr, Steven A and Ligon, Keith L and Kieran, Mark W and Santagata, Sandro and Olson, James M and Gokhale, Prafulla C and Jaffe, Jacob D and Root, David E and Stegmaier, Kimberly and Johannessen, Cory M and Beroukhim, Rameen
Nature communications, ISSN 2041-1723, 06/2019, Volume 10, Issue 1, pp. 2400 - 2400
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Cycle Proteins - drug effects | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Cyclin D2 - metabolism | Humans | Drug Resistance, Neoplasm | Gene Expression Profiling | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neurogenesis - drug effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Medulloblastoma - genetics | Basic Helix-Loop-Helix Transcription Factors - drug effects | Cerebellar Neoplasms - drug therapy | Cell Cycle Proteins - metabolism | Neural Stem Cells - drug effects | Cerebellar Neoplasms - genetics | Azepines - pharmacology | Triazoles - pharmacology | Cell Lineage | Animals | Cyclin D2 - drug effects | CRISPR-Cas Systems | Cell Line, Tumor | Mice | Proto-Oncogene Proteins c-myc - genetics | S Phase - drug effects | Cell Cycle - drug effects | Medulloblastoma - drug therapy | Neural Stem Cells - metabolism | Proteins - antagonists & inhibitors | CRISPR | Cell culture | Regulators | Transcription factors | Profiling | Genomes | Myc protein | Gene expression | Kinases | Cyclin-dependent kinase 4 | Homeobox | Amplification | Drug tolerance | Medulloblastoma | Open reading frames | Inhibition | Index Medicus
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4. Full Text Comprehensive analysis of the MLH1 promoter region in 480 patients with colorectal cancer and 1150 controls reveals new variants including one with a heritable constitutional MLH1 epimutation
by Morak, Monika and Ibisler, Ayseguel and Keller, Gisela and Jessen, Ellen and Laner, Andreas and Gonzales-Fassrainer, Daniela and Locher, Melanie and Massdorf, Trisari and Nissen, Anke M and Benet-Pagès, Anna and Holinski-Feder, Elke
Journal of medical genetics, ISSN 0022-2593, 04/2018, Volume 55, Issue 4, pp. 240 - 248
genetic screening/counselling | cancer: colon | genetics | epigenetics | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Phenotypes | MLH1 protein | Colorectal carcinoma | MSH2 protein | Colorectal cancer | Gene expression | Proteins | Gene silencing | MSH6 protein | Classification | Alleles | DNA methylation | Mutation | Deoxyribonucleic acid--DNA | CpG islands | Tumors
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5. Full Text Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes
by Castel, David and Philippe, Cathy and Calmon, Raphaël and Le Dret, Ludivine and Truffaux, Nathalène and Boddaert, Nathalie and Pagès, Mélanie and Taylor, Kathryn R and Saulnier, Patrick and Lacroix, Ludovic and Mackay, Alan and Jones, Chris and Sainte-Rose, Christian and Blauwblomme, Thomas and Andreiuolo, Felipe and Puget, Stephanie and Grill, Jacques and Varlet, Pascale and Debily, Marie-Anne
Acta neuropathologica, ISSN 0001-6322, 12/2015, Volume 130, Issue 6, pp. 815 - 827
Medicine & Public Health | Pathology | Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Brain Stem Neoplasms - radiotherapy | Neurons - pathology | Oligodendroglia - metabolism | Prognosis | Glioma - diagnosis | Brain Stem Neoplasms - pathology | Humans | Astrocytes - pathology | Pons - radiation effects | Child, Preschool | Male | Glioma - radiotherapy | Glioma - genetics | Astrocytes - radiation effects | Pons - surgery | Brain Stem Neoplasms - diagnosis | Glioma - pathology | Female | Neurons - metabolism | Oligodendroglia - radiation effects | Child | Pons - pathology | Oligodendroglia - pathology | Phenotype | Brain Stem Neoplasms - genetics | Histones - genetics | Pons - metabolism | HeLa Cells | Mutation | Neurons - radiation effects | Astrocytes - metabolism | Cohort Studies | Index Medicus | Original Paper
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6. Full Text Prevalence of CNV-neutral structural genomic rearrangements in MLH1, MSH2, and PMS2 not detectable in routine NGS diagnostics
by Morak, Monika and Steinke-Lange, Verena and Massdorf, Trisari and Benet-Pages, Anna and Locher, Melanie and Laner, Andreas and Kayser, Katrin and Aretz, Stefan and Holinski-Feder, Elke
Familial cancer, ISSN 1389-9600, 01/2020, Volume 19, Issue 2, pp. 161 - 167
Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Breakpoints | Phenotypes | MLH1 protein | Mismatch repair | Colorectal carcinoma | MSH2 protein | DNA repair | DNA sequencing | Tumors | Index Medicus
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7. Full Text Primary Leptomeningeal Gliomatosis in Children and Adults: A Morphological and Molecular Comparative Study With Literature Review
by Tauziede-Espariat, Arnault and Maues de Paula, Andre and Pages, Melanie and Laquerriere, Annie and Caietta, Emilie and Delpont, Benoit and Viennet, Gabriel and Medeiros de Bustos, Elisabeth and Moulin, Thierry and Barnerias, Christine and Vauleon, Elodie and Grill, Jacques and Chiforeanu, Dan and Vasiljevic, Alexandre and Varlet, Pascale
Neurosurgery, ISSN 0148-396X, 03/2016, Volume 78, Issue 3, pp. 343 - 352
Histones | Isocitrate dehydrogenase | Primary leptomeningeal gliomatosis | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Surgery | Science & Technology | Neuroimaging | Meningeal Carcinomatosis - diagnosis | Prognosis | Biomarkers, Tumor - analysis | Humans | Meningeal Carcinomatosis - mortality | Child, Preschool | Male | Neoplasms, Neuroepithelial - diagnosis | Neoplasms, Neuroepithelial - mortality | Adult | Female | Retrospective Studies | Child | Neurosurgery | Biopsy | Medical prognosis | Brain cancer | Index Medicus
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8. Full Text Biomolecular Network Reconstruction Identifies T-Cell Homing Factors Associated With Survival in Colorectal Cancer
by Mlecnik, Bernhard and Tosolini, Marie and Charoentong, Pornpimol and Kirilovsky, Amos and Bindea, Gabriela and Berger, Anne and Camus, Matthieu and Gillard, Mélanie and Bruneval, Patrick and Fridman, Wolf–Herman and Pagès, Franck and Trajanoski, Zlatko and Galon, Jérôme
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2010, Volume 138, Issue 4, pp. 1429 - 1440
Gastroenterology and Hepatology | Colorectal Cancer | Immune Reaction | Chemokines | Integrative Biology | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Colorectal Neoplasms - mortality | T-Lymphocytes - physiology | Cell Adhesion Molecules - genetics | Cell Adhesion Molecules - physiology | Prognosis | Tissue Array Analysis | Colorectal Neoplasms - genetics | Humans | Chemokines - physiology | Gene Expression Profiling | Chemokines - genetics | Receptors, Antigen, T-Cell - physiology | Disease-Free Survival | Phenotype | Colorectal Neoplasms - immunology | Oncology, Experimental | Colorectal cancer | Research | Universities and colleges | T cells | Cancer | Tumors | Index Medicus | Abridged Index Medicus
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