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by Coulter, Tanya I., MRCPI and Chandra, Anita, PhD, FRCPath and Bacon, Chris M., PhD, FRCPath and Babar, Judith, MRCP, FRCR and Curtis, James, PhD and Screaton, Nick, FRCP, FRCR and Goodlad, John R., MD, FRCPath and Farmer, George, MD and Steele, Cathal Laurence, MB and Leahy, Timothy Ronan, MRCPI and Doffinger, Rainer, PhD, FRCPath and Baxendale, Helen, PhD, FRCPath and Bernatoniene, Jolanta, PhD and Edgar, J. David M., FRCP, FRCPath and Longhurst, Hilary J., PhD, FRCPath and Ehl, Stephan, MD, PhD and Speckmann, Carsten, MD and Grimbacher, Bodo, MD, PhD and Sediva, Anna, MD, PhD and Milota, Tomas, MD and Faust, Saul N., PhD, FRCPCH and Williams, Anthony P., PhD, FRCPath and Hayman, Grant, FRCP, FRCPath and Kucuk, Zeynep Yesim, MD and Hague, Rosie, MRCP, FRCPH and French, Paul, MD, MRCS, DipFMS, FRCPath and Brooker, Richard, FRCPCH and Forsyth, Peter, FRCPath and Herriot, Richard, FRCP, FRCPath and Cancrini, Caterina, MD, PhD and Palma, Paolo, MD, PhD and Ariganello, Paola, MD and Conlon, Niall, PhD, FRCPath and Feighery, Conleth, PhD, FRCPath and Gavin, Patrick J., MD and Jones, Alison, PhD, FRCPCH and Imai, Kohsuke, MD, PhD and Ibrahim, Mohammad A.A., PhD, FRCP, FRCPath and Markelj, Gašper, MD and Abinun, Mario, MD, PhD and Rieux-Laucat, Frédéric, PhD and Latour, Sylvain, PhD and Pellier, Isabelle, MD, PhD and Fischer, Alain, MD, PhD and Touzot, Fabien, MD, PhD and Casanova, Jean-Laurent, MD, PhD and Durandy, Anne, MD, PhD and Burns, Siobhan O., MD, PhD and Savic, Sinisa, PhD, FRCPath and Kumararatne, D.S., FRCPath, DPhil (Oxon) and Moshous, Despina, MD, PhD and Kracker, Sven, PhD and Vanhaesebroeck, Bart, PhD, FMedSci and Okkenhaug, Klaus, PhD and Picard, Capucine, MD, PhD and Nejentsev, Sergey, MD, PhD and Condliffe, Alison M., PhD, FRCP and Cant, Andrew James, MD, FRCP, FRCPH
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in... 
Allergy and Immunology | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Activated phosphoinositide 3-kinase delta syndrome | IMMUNOLOGICAL FEATURES | HYPER-IGM SYNDROME | p110 delta-activating mutation causing senescent T cells | hematopoietic stem cell | COMMON VARIABLE IMMUNODEFICIENCY | PIK3CD | IMMUNOLOGY | lymphadenopathy | REFERENCE VALUES | P110-DELTA | phosphoinositide 3-kinase delta | P110 DELTA | B-CELL | ALLERGY | transplantation | MUTATIONS | Recurrence | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Young Adult | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Adult | Female | Surveys and Questionnaires | Herpesviridae Infections - genetics | Child | Immunologic Deficiency Syndromes - therapy | Hematopoietic Stem Cell Transplantation | International Cooperation | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Animals | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Survival Analysis | Immunologic Deficiency Syndromes - genetics | Mice | Cohort Studies | Index Medicus | Abridged Index Medicus | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2013, Volume 133, Issue 4, pp. 1099 - 1108.e12
Journal Article
Lancet Infectious Diseases, The, ISSN 1473-3099, 2015, Volume 15, Issue 9, pp. 1108 - 1114
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 135, Issue 3, pp. 753 - 761.e2
Background Chronic granulomatous disease (CGD) is a primary immune deficiency characterized by a defect in reactive oxygen species production. Although the... 
Allergy and Immunology | B cell | reactive oxygen species deficiency | Chronic granulomatous disease | proliferation | memory B-cell compartment | long-term memory | measles | NADPH OXIDASE | ACTIVATION | IMMUNOLOGICAL MEMORY | MECHANISMS | STRENGTH | IMMUNOLOGY | IDENTIFICATION | RESPONSES | ALLERGY | GENERATION | DURATION | LYMPHOCYTES | Antigens, CD - immunology | Reactive Oxygen Species - metabolism | Humans | Vaccination | Granulomatous Disease, Chronic - genetics | Toll-Like Receptor 9 - genetics | Child, Preschool | NADPH Oxidases - immunology | Infant | Male | Granulomatous Disease, Chronic - immunology | Immunologic Memory - drug effects | Antigens, CD - genetics | Measles - immunology | Case-Control Studies | Toll-Like Receptor 9 - immunology | Young Adult | Reactive Oxygen Species - immunology | NADPH Oxidases - genetics | Female | Measles - prevention & control | B-Lymphocytes - pathology | Membrane Glycoproteins - immunology | Granulomatous Disease, Chronic - pathology | Gene Expression | Pokeweed Mitogens - pharmacology | Immunophenotyping | NADPH Oxidase 2 | Receptors, Antigen, B-Cell - immunology | Membrane Glycoproteins - genetics | Viral Vaccines - administration & dosage | B-Lymphocytes - drug effects | Phenotype | B-Lymphocytes - immunology | Adolescent | Receptors, Antigen, B-Cell - genetics | Cell Proliferation - drug effects | Primary Cell Culture | Care and treatment | Immunodeficiency | Proteins | Flow cytometry | Cell growth | Data analysis | Disease | Measles | Software | Age | Immune system | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2013, Volume 133, Issue 2, pp. 592 - 594.e1
Journal Article
American Journal of Cardiology, The, ISSN 0002-9149, 2012, Volume 109, Issue 10, pp. 1411 - 1417
Journal Article
American Journal of Cardiology, The, ISSN 0002-9149, 2013, Volume 112, Issue 6, pp. 792 - 798
High residual platelet reactivity (RPR) on clopidogrel treatment has been associated with increased risk for ischemic events during follow-up in patients with... 
Cardiovascular | CLOPIDOGREL THERAPY | OF-CARE ASSAY | IMPACT | REVASCULARIZATION | RESPONSIVENESS | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | MULTICENTER REGISTRY | PROTON PUMP INHIBITORS | DRUG-ELUTING STENTS | CLINICAL-OUTCOMES | Myocardial Infarction - chemically induced | Myocardial Infarction - epidemiology | Prognosis | Prospective Studies | Follow-Up Studies | Ticlopidine - therapeutic use | Death, Sudden, Cardiac - epidemiology | Humans | Male | Death, Sudden, Cardiac - etiology | Incidence | Purinergic P2Y Receptor Antagonists - adverse effects | Stroke - chemically induced | Ticlopidine - adverse effects | Electrocardiography | Female | Stroke - epidemiology | Purinergic P2Y Receptor Antagonists - therapeutic use | Hemorrhage - epidemiology | Ticlopidine - analogs & derivatives | Acute Coronary Syndrome - drug therapy | Coronary Angiography | Acute Coronary Syndrome - diagnosis | Acute Coronary Syndrome - surgery | Italy | Aged | Platelet Activation - drug effects | Hemorrhage - chemically induced | Transluminal angioplasty | Medicine, Experimental | Medical research | Care and treatment | Coronary heart disease | Patient outcomes | Cardiovascular disease | Heart attacks | Acute coronary syndromes | Angina pectoris | Cardiology | Coronary vessels | Index Medicus | Abridged Index Medicus
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