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Annals of the Rheumatic Diseases, ISSN 0003-4967, 05/2016, Volume 75, Issue 5, pp. 883 - 890
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 03/2015, Volume 74, Issue 3, pp. e20 - e20
Journal Article
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2015, Volume 74, Issue Suppl 2, pp. 956 - 956
BackgroundType 2 innate lymphoid cells (ILC2), a recently identified population of cells with lymphoid morphology lacking re-arranged antigen-specific... 
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2015, Volume 74, Issue Suppl 2, pp. 584 - 585
BackgroundInterleukin-35 (IL-35) is the most recent addition to the IL-12 family, which also includes IL-12, IL-23 and IL-27. IL-35 consists of p35/IL-12a and... 
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 02/2015, Volume 21, Issue 2, pp. 150 - 158
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 07/2015, Volume 74, Issue 7, pp. 1408 - 1416
ObjectivesWe have previously described the antifibrotic role of the soluble guanylate cyclase (sGC). The mode of action, however, remained elusive. In the... 
GROWTH-FACTOR-BETA | TRANS-DIFFERENTIATION | FIBROTIC DISORDERS | DISEASE | KINASE | EXPERIMENTAL DERMAL FIBROSIS | RHEUMATOLOGY | SYSTEMIC-SCLEROSIS | HYPERTENSION | INDUCED FIBROBLAST ACTIVATION | MAP Kinase Signaling System - physiology | Receptors, Cytoplasmic and Nuclear - deficiency | Skin - metabolism | Humans | Scleroderma, Systemic - pathology | Fibrosis - metabolism | Case-Control Studies | Scleroderma, Systemic - physiopathology | Transforming Growth Factor beta - antagonists & inhibitors | Fibrosis - prevention & control | Skin - pathology | Disease Models, Animal | Fibroblasts - metabolism | Pyrazoles - pharmacology | Scleroderma, Systemic - metabolism | Cells, Cultured | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Receptors, Cytoplasmic and Nuclear - agonists | Fibroblasts - pathology | Mice, Knockout | Collagen - metabolism | Guanylate Cyclase - deficiency | Animals | MAP Kinase Signaling System - drug effects | Cyclic GMP - metabolism | Receptors, Transforming Growth Factor beta - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Signal Transduction - physiology | Mice | Pyridines - pharmacology | In Vitro Techniques | Smad Proteins - metabolism | Transforming Growth Factor beta - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 04/2013, Volume 72, Issue 4, pp. 614 - 620
Objectives Epigenetic modifications such as DNA methylation and histone acetylation have been implicated in the pathogenesis of systemic sclerosis. However,... 
SCLERODERMA FIBROBLASTS | METHYLATION | EPIGENETICS | COLLAGEN EXPRESSION | DISEASE | EXTRACELLULAR-MATRIX | MECHANISMS | RHEUMATOLOGY | SYSTEMIC-SCLEROSIS | PREVENTS | T-CELLS | Scleroderma, Diffuse - metabolism | Fibroblasts - enzymology | Antibiotics, Antineoplastic - pharmacology | Humans | Middle Aged | Male | Fibrosis - metabolism | Epigenesis, Genetic - physiology | Young Adult | Scleroderma, Diffuse - pathology | Fos-Related Antigen-2 - metabolism | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Scleroderma, Diffuse - chemically induced | Adult | Mice, Inbred DBA | Epigenesis, Genetic - drug effects | DNA Methylation - physiology | Disease Models, Animal | Fibrosis - chemically induced | Cells, Cultured | Enzyme Inhibitors - pharmacology | Fibroblasts - pathology | Collagen - metabolism | Animals | Bleomycin - pharmacology | Dermis - pathology | Mice | Fibrosis - pathology | Histones - metabolism | DNA Methylation - drug effects | Jumonji Domain-Containing Histone Demethylases - metabolism | Care and treatment | Fibrosis | Histones | Influence | Genetic aspects | Research | Methylation | Chromatin | Immunoglobulins | Disease | Pathogenesis | Gene expression | Experiments | Proteins | Studies | Biopsy | Collagen | DNA methylation | Epigenetics | Fibroblasts | Extracellular matrix | Deoxyribonucleic acid--DNA | Cancer | Index Medicus
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2014, Volume 73, Issue 6, pp. 1232 - 1239
Objectives Activated Wnt signalling with decreased expression of endogenous inhibitors has recently been characterised as a central pathomechanism in systemic... 
TARGETED DISRUPTION | DNA METHYLATION | EPIGENETIC INACTIVATION | MOUSE MODEL | EXPERIMENTAL DERMAL FIBROSIS | TYROSINE KINASE INHIBITOR | SKIN FIBROSIS | FRIZZLED-RELATED PROTEIN-1 | EXTRACELLULAR-MATRIX | RHEUMATOLOGY | IDIOPATHIC PULMONARY-FIBROSIS | Leukocytes, Mononuclear - metabolism | Epigenesis, Genetic | Humans | Middle Aged | Male | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Promoter Regions, Genetic - genetics | Case-Control Studies | Young Adult | Adult | Female | Fibroblasts - metabolism | DNA (Cytosine-5-)-Methyltransferase 1 | Membrane Proteins - genetics | Enzyme Inhibitors - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Scleroderma, Systemic - genetics | Azacitidine - analogs & derivatives | DNA Methylation - genetics | Down-Regulation - drug effects | Down-Regulation - genetics | Azacitidine - pharmacology | Animals | Wnt Signaling Pathway - drug effects | Wnt Signaling Pathway - genetics | Fibroblasts - drug effects | Aged | Mice | DNA Methylation - drug effects | Polymerase chain reaction | Epigenetic inheritance | Usage | Systemic scleroderma | Methyltransferases | Scleroderma (Disease) | Research | Risk factors | Proteins | Enzymes | Immunoglobulins | DNA methylation | Epigenetics | Clinical trials | Fibroblasts | Extracellular matrix | Kinases | Gene expression | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2016, Volume 75, Issue Suppl 2, pp. 735 - 736
BackgroundSystemic sclerosis (SSc) is a chronic fibrotic connective disease of unknown etiology that affects the skin and internal organs. Transforming growth... 
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2015, Volume 74, p. 960
  Background Hedgehog signalling plays a key-role in the pathogenesis of fibrosis in SSc. Besides the canonical hedgehog pathway with activation of Gli... 
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2015, Volume 74, Issue Suppl 2, pp. 960 - 961
BackgroundHedgehog signalling plays a key-role in the pathogenesis of fibrosis in SSc. Besides the canonical hedgehog pathway with activation of Gli... 
Journal Article
Journal Article