Journal of Cellular Physiology, ISSN 0021-9541, 09/2009, Volume 220, Issue 3, pp. 565 - 568
Journal Article
STEM CELLS, ISSN 1066-5099, 03/2016, Volume 34, Issue 3, pp. 523 - 536
In facing the daunting challenge of using human embryonic and induced pluripotent stem cells to study complex neural circuit disorders such as schizophrenia,...
Autism spectrum disorders | Induced pluripotent stem cells | Schizophrenia | Bipolar disorder | Genetics | Drug discovery | Induced neuronal cells | PROGENITOR CELLS | DIRECTED DIFFERENTIATION | IPSC-DERIVED NEURONS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | IN-VITRO | INNERVATING MOTOR-NEURONS | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MOUSE MODEL | FRAGILE-X-SYNDROME | HUMAN FIBROBLASTS | HEMATOLOGY | Autism Spectrum Disorder - genetics | Human Embryonic Stem Cells - transplantation | Mood Disorders - therapy | Schizophrenia - therapy | Schizophrenia - genetics | Mood Disorders - genetics | Humans | Induced Pluripotent Stem Cells - transplantation | Autism Spectrum Disorder - therapy | Gene Regulatory Networks | Stem Cell Research | Autism | Nervous system diseases | Stem cells
Autism spectrum disorders | Induced pluripotent stem cells | Schizophrenia | Bipolar disorder | Genetics | Drug discovery | Induced neuronal cells | PROGENITOR CELLS | DIRECTED DIFFERENTIATION | IPSC-DERIVED NEURONS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | IN-VITRO | INNERVATING MOTOR-NEURONS | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MOUSE MODEL | FRAGILE-X-SYNDROME | HUMAN FIBROBLASTS | HEMATOLOGY | Autism Spectrum Disorder - genetics | Human Embryonic Stem Cells - transplantation | Mood Disorders - therapy | Schizophrenia - therapy | Schizophrenia - genetics | Mood Disorders - genetics | Humans | Induced Pluripotent Stem Cells - transplantation | Autism Spectrum Disorder - therapy | Gene Regulatory Networks | Stem Cell Research | Autism | Nervous system diseases | Stem cells
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 09/2009, Volume 220, Issue 3, pp. 562 - 568
Oxygen (O2) is a substrate for energy production in the cell and is a rapid regulator of cellular metabolism. Recent studies have also implicated O2 and its...
PROGENITOR CELLS | GROWTH-FACTOR RECEPTOR | IN-VITRO | PHYSIOLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | BONE MORPHOGENETIC PROTEINS | NITRIC-OXIDE | SUBCORTICAL WHITE-MATTER | CENTRAL-NERVOUS-SYSTEM | HIGH-GRADE GLIOMA | TUMOR-INITIATING CELLS | CELL BIOLOGY | Brain Diseases - metabolism | Neurons - pathology | Cell Proliferation | Signal Transduction | Humans | Nerve Regeneration | Stem Cells - metabolism | Brain Neoplasms - metabolism | Oxygen - metabolism | Cell Hypoxia | Stem Cell Transplantation | Cell Lineage | Neurons - transplantation | Stroke - metabolism | Animals | Brain Diseases - pathology | Neoplastic Stem Cells - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Stem Cells - pathology | Cell Differentiation | Neurons - metabolism | Brain Diseases - surgery | Apoptosis
PROGENITOR CELLS | GROWTH-FACTOR RECEPTOR | IN-VITRO | PHYSIOLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | BONE MORPHOGENETIC PROTEINS | NITRIC-OXIDE | SUBCORTICAL WHITE-MATTER | CENTRAL-NERVOUS-SYSTEM | HIGH-GRADE GLIOMA | TUMOR-INITIATING CELLS | CELL BIOLOGY | Brain Diseases - metabolism | Neurons - pathology | Cell Proliferation | Signal Transduction | Humans | Nerve Regeneration | Stem Cells - metabolism | Brain Neoplasms - metabolism | Oxygen - metabolism | Cell Hypoxia | Stem Cell Transplantation | Cell Lineage | Neurons - transplantation | Stroke - metabolism | Animals | Brain Diseases - pathology | Neoplastic Stem Cells - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Stem Cells - pathology | Cell Differentiation | Neurons - metabolism | Brain Diseases - surgery | Apoptosis
Journal Article
Nature Neuroscience, ISSN 1097-6256, 11/2015, Volume 18, Issue 12, pp. 1707 - 1712
Recent research on disparate psychiatric disorders has implicated rare variants in genes involved in global gene regulation and chromatin modification, as well...
HUMAN BRAIN | DE-NOVO MUTATIONS | DNA METHYLATION | NONCODING GENETIC-VARIATION | EXPRESSION VARIATION | REGULATORY NETWORKS | PSYCHIATRIC-DISORDERS | BIPOLAR DISORDER | TRANSCRIPTIONAL REGULATION | DISEASE MECHANISMS | NEUROSCIENCES | Mental Disorders - genetics | Animals | Chromosome Mapping - trends | Epigenesis, Genetic - genetics | Chromosome Mapping - methods | Humans | Brain - pathology | Genetic Code - genetics | Transcriptome - genetics | Mental Disorders - diagnosis | Brain - physiology | Technology application | Usage | Journalism, Medical | Databases | Genetic variation | Development and progression | Genetic aspects | Identification and classification | Mental illness
HUMAN BRAIN | DE-NOVO MUTATIONS | DNA METHYLATION | NONCODING GENETIC-VARIATION | EXPRESSION VARIATION | REGULATORY NETWORKS | PSYCHIATRIC-DISORDERS | BIPOLAR DISORDER | TRANSCRIPTIONAL REGULATION | DISEASE MECHANISMS | NEUROSCIENCES | Mental Disorders - genetics | Animals | Chromosome Mapping - trends | Epigenesis, Genetic - genetics | Chromosome Mapping - methods | Humans | Brain - pathology | Genetic Code - genetics | Transcriptome - genetics | Mental Disorders - diagnosis | Brain - physiology | Technology application | Usage | Journalism, Medical | Databases | Genetic variation | Development and progression | Genetic aspects | Identification and classification | Mental illness
Journal Article
STEM CELLS, ISSN 1066-5099, 03/2016, Volume 34, Issue 3, pp. 523 - 536
Journal Article
Stem cells (Dayton, Ohio), ISSN 1066-5099, 3/2016, Volume 34, Issue 3, pp. 523 - 536
In facing the daunting challenge of using human embryonic and induced pluripotent stem cells (hESCs, hiPSCs) to study complex neural circuit disorders such as...
bipolar disorder | genetics | induced neuronal cells | drug discovery | induced pluripotent stem cells | autism spectrum disorders | schizophrenia
bipolar disorder | genetics | induced neuronal cells | drug discovery | induced pluripotent stem cells | autism spectrum disorders | schizophrenia
Journal Article
Stem Cell Reports, ISSN 2213-6711, 12/2015, Volume 5, Issue 6, pp. 933 - 945
As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the...
PLURIPOTENT STEM-CELLS | GROUND-STATE | DYSREGULATION | TISSUE | NEURONS | MODEL | INDUCTION | DIFFERENTIATION | SELF-ORGANIZATION | REVEALS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Induced Pluripotent Stem Cells - pathology | Brain - physiopathology | Humans | Brain Diseases - genetics | Drug Discovery - methods | Neurogenesis | Brain Diseases - physiopathology | Brain - drug effects | Brain - metabolism | Brain Diseases - drug therapy | Brain Diseases - pathology | Brain - pathology | Mosaicism | Induced Pluripotent Stem Cells - cytology | Precision Medicine - methods | Induced Pluripotent Stem Cells - metabolism
PLURIPOTENT STEM-CELLS | GROUND-STATE | DYSREGULATION | TISSUE | NEURONS | MODEL | INDUCTION | DIFFERENTIATION | SELF-ORGANIZATION | REVEALS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Induced Pluripotent Stem Cells - pathology | Brain - physiopathology | Humans | Brain Diseases - genetics | Drug Discovery - methods | Neurogenesis | Brain Diseases - physiopathology | Brain - drug effects | Brain - metabolism | Brain Diseases - drug therapy | Brain Diseases - pathology | Brain - pathology | Mosaicism | Induced Pluripotent Stem Cells - cytology | Precision Medicine - methods | Induced Pluripotent Stem Cells - metabolism
Journal Article
Cell Stem Cell, ISSN 1934-5909, 12/2008, Volume 3, Issue 6, pp. 670 - 680
To realize the promise of stem cell biology, it is important to identify the precise time in the history of the cell when developmental potential is...
STEMCELL | PROGENITOR CELLS | DIVISIONS | NEURONS | NEUROGENESIS | CENTRAL-NERVOUS-SYSTEM | PROLIFERATION | DIFFERENTIATION | GLIOGENESIS | LINEAGES | REVEALS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Glial Fibrillary Acidic Protein - genetics | Oligodendroglia - metabolism | Central Nervous System - metabolism | Image Cytometry - methods | Multipotent Stem Cells - metabolism | Fibroblast Growth Factor 2 - pharmacology | Neurons - cytology | Central Nervous System - embryology | Cell Movement - physiology | Multipotent Stem Cells - drug effects | Transfection - methods | Fibroblast Growth Factor 2 - metabolism | Neurons - metabolism | Oligodendroglia - cytology | Cell Differentiation - physiology | Ciliary Neurotrophic Factor - pharmacology | Astrocytes - cytology | Microscopy, Video - methods | Cells, Cultured | Rats | Genes, Reporter - genetics | Rats, Sprague-Dawley | Cell Lineage - physiology | Cell Movement - drug effects | Ciliary Neurotrophic Factor - metabolism | Animals | Central Nervous System - cytology | Multipotent Stem Cells - cytology | Neurogenesis - physiology | Tissue Culture Techniques - methods | Astrocytes - metabolism
STEMCELL | PROGENITOR CELLS | DIVISIONS | NEURONS | NEUROGENESIS | CENTRAL-NERVOUS-SYSTEM | PROLIFERATION | DIFFERENTIATION | GLIOGENESIS | LINEAGES | REVEALS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Glial Fibrillary Acidic Protein - genetics | Oligodendroglia - metabolism | Central Nervous System - metabolism | Image Cytometry - methods | Multipotent Stem Cells - metabolism | Fibroblast Growth Factor 2 - pharmacology | Neurons - cytology | Central Nervous System - embryology | Cell Movement - physiology | Multipotent Stem Cells - drug effects | Transfection - methods | Fibroblast Growth Factor 2 - metabolism | Neurons - metabolism | Oligodendroglia - cytology | Cell Differentiation - physiology | Ciliary Neurotrophic Factor - pharmacology | Astrocytes - cytology | Microscopy, Video - methods | Cells, Cultured | Rats | Genes, Reporter - genetics | Rats, Sprague-Dawley | Cell Lineage - physiology | Cell Movement - drug effects | Ciliary Neurotrophic Factor - metabolism | Animals | Central Nervous System - cytology | Multipotent Stem Cells - cytology | Neurogenesis - physiology | Tissue Culture Techniques - methods | Astrocytes - metabolism
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 2019, Volume 24, Issue 11, pp. 1576 - 1582
The Genomics Workgroup of the National Advisory Mental Health Council (NAMHC) recently issued a set of recommendations for advancing the NIMH psychiatric...
INDIVIDUALS | COMPLEX | VARIANTS | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARCHITECTURE | RISK | DISORDERS | COMMON | NEUROSCIENCES | Mental health | Genetic research | Genetics | Genetic aspects | Research | Mental illness | Psychiatric research | Genetic variance | Mental disorders | Nucleotide sequence | Genomics | Statistics | Deoxyribonucleic acid--DNA
INDIVIDUALS | COMPLEX | VARIANTS | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARCHITECTURE | RISK | DISORDERS | COMMON | NEUROSCIENCES | Mental health | Genetic research | Genetics | Genetic aspects | Research | Mental illness | Psychiatric research | Genetic variance | Mental disorders | Nucleotide sequence | Genomics | Statistics | Deoxyribonucleic acid--DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2009, Volume 4, Issue 7, p. e6206
Background: Glioblastoma multiforme (GBM) is one of most common and still poorly treated primary brain tumors. In search for new therapeutic approaches, Bone...
BIOLOGY | Cytochrome | TOR protein | Brain | Pediatrics | Phosphorylation | Transcription | Laboratories | Brain tumors | Brain cancer | Central nervous system | Glioblastoma | Proline | AKT protein | Oncology | Nervous system | Bone tumors | Biology | Neurosurgery | Kinases | Proteins | Signal transduction | Cell growth | Rodents | Cell cycle | Tension | Procollagen-proline dioxygenase | Oxygen | Bone morphogenetic protein 2 | Hydroxylase | Glioblastoma multiforme | Signaling | Molecular modelling | Stem cells | Hypoxia | Control stability | Mutation | Oxygen tension | Differentiation | Stimuli | Tumors
BIOLOGY | Cytochrome | TOR protein | Brain | Pediatrics | Phosphorylation | Transcription | Laboratories | Brain tumors | Brain cancer | Central nervous system | Glioblastoma | Proline | AKT protein | Oncology | Nervous system | Bone tumors | Biology | Neurosurgery | Kinases | Proteins | Signal transduction | Cell growth | Rodents | Cell cycle | Tension | Procollagen-proline dioxygenase | Oxygen | Bone morphogenetic protein 2 | Hydroxylase | Glioblastoma multiforme | Signaling | Molecular modelling | Stem cells | Hypoxia | Control stability | Mutation | Oxygen tension | Differentiation | Stimuli | Tumors
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 6/2003, Volume 161, Issue 5, pp. 911 - 921
The ability of stem cells to generate distinct fates is critical for the generation of cellular diversity during development. Central nervous system (CNS) stem...
Receptors | Neurons | Neuroglia | Stem cells | Central nervous system | Antibodies | Smooth muscle | Cultured cells | Neural stem cells | Cells | STAT | Bone morphogenetic protein | SMAD | Mammalian FRAP | Stem cell | PROGENITOR CELLS | ASTROCYTIC DIFFERENTIATION | SERINE PHOSPHORYLATION | bone morphogenetic protein | CELL BIOLOGY | LINEAGE COMMITMENT | stem cell | IN-VIVO | CENTRAL-NERVOUS-SYSTEM | GROWTH-FACTOR | NEURAL CREST | RECEPTORS | mammalian FRAP | Central Nervous System - metabolism | Stem Cells - cytology | Peripheral Nervous System - embryology | Stem Cells - metabolism | Cell Lineage - drug effects | Central Nervous System - embryology | Muscle, Smooth - embryology | Peripheral Nervous System - cytology | Neural Crest - metabolism | DNA-Binding Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Neuroglia - cytology | Trans-Activators - genetics | Fetus | Bone Morphogenetic Proteins - pharmacology | Cell Differentiation - physiology | Ciliary Neurotrophic Factor - pharmacology | Neural Crest - cytology | Bone Morphogenetic Protein 4 | Cells, Cultured | Rats | Muscle, Smooth - metabolism | DNA-Binding Proteins - genetics | Sirolimus - pharmacology | Cell Lineage - physiology | Ciliary Neurotrophic Factor - metabolism | Animals | Carrier Proteins - metabolism | Central Nervous System - cytology | Phosphotransferases (Alcohol Group Acceptor) | Signal Transduction - drug effects | Cell Differentiation - drug effects | Neural Crest - embryology | Smad1 Protein | Peripheral Nervous System - metabolism | Smad Proteins | STAT1 Transcription Factor | Stem Cells - drug effects | Neuroglia - metabolism | Signal Transduction - physiology | Trans-Activators - metabolism | Mice | STAT3 Transcription Factor | TOR Serine-Threonine Kinases | Muscle, Smooth - cytology | Bone morphogenetic proteins | Research | bone morphogenetic protein; stem cell; SMAD; STAT; mammalian FRAP
Receptors | Neurons | Neuroglia | Stem cells | Central nervous system | Antibodies | Smooth muscle | Cultured cells | Neural stem cells | Cells | STAT | Bone morphogenetic protein | SMAD | Mammalian FRAP | Stem cell | PROGENITOR CELLS | ASTROCYTIC DIFFERENTIATION | SERINE PHOSPHORYLATION | bone morphogenetic protein | CELL BIOLOGY | LINEAGE COMMITMENT | stem cell | IN-VIVO | CENTRAL-NERVOUS-SYSTEM | GROWTH-FACTOR | NEURAL CREST | RECEPTORS | mammalian FRAP | Central Nervous System - metabolism | Stem Cells - cytology | Peripheral Nervous System - embryology | Stem Cells - metabolism | Cell Lineage - drug effects | Central Nervous System - embryology | Muscle, Smooth - embryology | Peripheral Nervous System - cytology | Neural Crest - metabolism | DNA-Binding Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Neuroglia - cytology | Trans-Activators - genetics | Fetus | Bone Morphogenetic Proteins - pharmacology | Cell Differentiation - physiology | Ciliary Neurotrophic Factor - pharmacology | Neural Crest - cytology | Bone Morphogenetic Protein 4 | Cells, Cultured | Rats | Muscle, Smooth - metabolism | DNA-Binding Proteins - genetics | Sirolimus - pharmacology | Cell Lineage - physiology | Ciliary Neurotrophic Factor - metabolism | Animals | Carrier Proteins - metabolism | Central Nervous System - cytology | Phosphotransferases (Alcohol Group Acceptor) | Signal Transduction - drug effects | Cell Differentiation - drug effects | Neural Crest - embryology | Smad1 Protein | Peripheral Nervous System - metabolism | Smad Proteins | STAT1 Transcription Factor | Stem Cells - drug effects | Neuroglia - metabolism | Signal Transduction - physiology | Trans-Activators - metabolism | Mice | STAT3 Transcription Factor | TOR Serine-Threonine Kinases | Muscle, Smooth - cytology | Bone morphogenetic proteins | Research | bone morphogenetic protein; stem cell; SMAD; STAT; mammalian FRAP
Journal Article
Regenerative Medicine, ISSN 1746-0751, 01/2012, Volume 7, Issue 1, pp. 33 - 36
The nervous system is consistently viewed as a target of high interest for stem cell-based therapeutics. In the USA, the National Institute of Neurological...
National Institute of Mental Health (U.S.) - economics | National Institute of Neurological Disorders and Stroke (U.S.) - economics | Neurosciences - economics | Animals | United States | Humans | Neurosciences - organization & administration | Stem Cell Research - economics
National Institute of Mental Health (U.S.) - economics | National Institute of Neurological Disorders and Stroke (U.S.) - economics | Neurosciences - economics | Animals | United States | Humans | Neurosciences - organization & administration | Stem Cell Research - economics
Journal Article
STEM CELLS, ISSN 1066-5099, 01/2007, Volume 25, Issue 1, pp. 63 - 68
Bone morphogenetic proteins (BMPs) are a class of morphogens that are critical regulators of the central nervous system (CNS), peripheral nervous system, and...
Growth factor Bone morphogenetic protein | TGF‐β receptor | Neural differentiation | Pleiotropic effects | Neural stem cell | Bone morphogenetic protein receptor | Smad proteins | Proliferation | Mammalian target of rapamycin p38 mitogen‐activated protein kinase | Neural crest | Apoptosis | TGF-β receptor | Bone morphogenetic protein | Growth factor | pleiotropic effects | neural stem cell | TGF-BETA | neural crest | apoptosis | CELL BIOLOGY | ROOF PLATE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HEMATOLOGY | PROGENITOR CELLS | bone morphogenetic protein receptor | DENDRITIC GROWTH | proliferation | NEURONS IN-VITRO | SONIC HEDGEHOG | SYMPATHETIC NEURONS | Mammalian target of rapamycin p38 mitogen-activated protein kinase | TGF-beta receptor | ONCOLOGY | DEVELOPMENTAL-CHANGES | growth factor bone morphogenetic protein | neural differentiation | IBMP RECEPTOR BMPRIB | DORSAL SPINAL-CORD | Bone Morphogenetic Proteins - physiology | Humans | Neurons - cytology | Stem Cells - cytology | Embryonic Development | Morphogenesis | Animals | Models, Biological | Cell Division | Neurons - physiology | Signal Transduction - physiology | Stem Cells - physiology | Cell Differentiation
Growth factor Bone morphogenetic protein | TGF‐β receptor | Neural differentiation | Pleiotropic effects | Neural stem cell | Bone morphogenetic protein receptor | Smad proteins | Proliferation | Mammalian target of rapamycin p38 mitogen‐activated protein kinase | Neural crest | Apoptosis | TGF-β receptor | Bone morphogenetic protein | Growth factor | pleiotropic effects | neural stem cell | TGF-BETA | neural crest | apoptosis | CELL BIOLOGY | ROOF PLATE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HEMATOLOGY | PROGENITOR CELLS | bone morphogenetic protein receptor | DENDRITIC GROWTH | proliferation | NEURONS IN-VITRO | SONIC HEDGEHOG | SYMPATHETIC NEURONS | Mammalian target of rapamycin p38 mitogen-activated protein kinase | TGF-beta receptor | ONCOLOGY | DEVELOPMENTAL-CHANGES | growth factor bone morphogenetic protein | neural differentiation | IBMP RECEPTOR BMPRIB | DORSAL SPINAL-CORD | Bone Morphogenetic Proteins - physiology | Humans | Neurons - cytology | Stem Cells - cytology | Embryonic Development | Morphogenesis | Animals | Models, Biological | Cell Division | Neurons - physiology | Signal Transduction - physiology | Stem Cells - physiology | Cell Differentiation
Journal Article