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1. Full Text P53 at the endoplasmic reticulum regulates apoptosis in a Ca 2+ -dependent manner
by Giorgi, Carlotta and Bonora, Massimo and Sorrentino, Giovanni and Missiroli, Sonia and Poletti, Federica and Suski, Jan M and Ramirez, Fabian Galindo and Rizzuto, Rosario and Virgilio, Francesco Di and Zito, Ester and Pandolfi, Pier Paolo and Wieckowski, Mariusz R and Mammano, Fabio and Sal, Giannino Del and Pinton, Paolo
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2015, Volume 112, Issue 6, pp. 1779 - 1784
Mitochondria-associated membranes | Calcium | Endoplasmic reticulum | Apoptosis | P53
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2. Full Text Abstract IA15: New insights on the role of tumor suppressor phosphatases
by Pandolfi, Pier Paolo
Molecular Cancer Therapeutics, ISSN 1535-7163, 07/2015, Volume 14, Issue 7 Supplement, pp. IA15 - IA15
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3. Full Text Abstract IA3: The Co-Clinical Trial Project
by Pandolfi, Pier Paolo
Molecular Cancer Research, ISSN 1541-7786, 11/2014, Volume 12, Issue 11 Supplement, pp. IA3 - IA3
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4. Full Text Abstract IA12: The noncoding RNA revolution in cancer research
by Pandolfi, Pier Paolo
Cancer Research, ISSN 0008-5472, 10/2013, Volume 73, Issue 19 Supplement, pp. IA12 - IA12
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5. Full Text An Integrated Genome Wide CRISPRa Approach to Functionalize IncRNAs in Drug Resistance
by Bester, Assaf C and Lee, Jonathan D and Chavez, Alejandro and Lee, Yu-Ru and Nachmani, Daphna and Vora, Su and Victor, Joshua and Sauvageau, Martin and Rinn, John L and Provero, Paolo and Church, George M and Clohessy, John G and Pandolfi, Pier Paolo
Cell, ISSN 0092-8674, 4/2018, Volume 173, Issue 3, pp. 649 - 664.e20
Resistance to chemotherapy plays a significant role in cancer mortality. To identify genetic units affecting sensitivity to cytarabine, the mainstay of... 
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6. Full Text Immunology: Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF
by Maeda, Takahiro and Merghoyb, Taha and Hobbs, Robin M and Dong, Lin and Maeda, Manami and Zakrzewski, Johannes and Van Den Brink, Marcel R.M and Zelent, Arthur and Shigematsu, Hirokazu and Akashi, Koichi and Teruya-Feldstein, Julie and Cattoretti, Giorgio and Pandolfi, Pier Paolo
Science, ISSN 0036-8075, 05/2007, Volume 316, Issue 5826, pp. 860 - 866
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7. Full Text A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
by Salmena, Leonardo and Poliseno, Laura and Tay, Yvonne and Kats, Lev and Pandolfi, Pier Paolo
Cell, ISSN 0092-8674, 2011, Volume 146, Issue 3, pp. 353 - 358
Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs “talk” to each other using microRNA response... 
MESSENGER-RNAS | GENE | NONCODING RNAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | EXPRESSION | PSEUDOGENES | UNTRANSLATED REGION | GENOME | MICRORNA SPONGES | REVEALS | CELL BIOLOGY | Neoplasms - metabolism | Animals | Pseudogenes | Neoplasms - genetics | Humans | RNA, Messenger - genetics | Gene Expression Regulation | Gene Expression Profiling | MicroRNAs - genetics | RNA, Untranslated - genetics | RNA - genetics | RNA - metabolism | RNA | Index Medicus
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8. Full Text The Mouse Hospital and its integration in ultra-precision approaches to cancer care
by Clohessy, John G and Pandolfi, Pier Paolo
Frontiers in Oncology, ISSN 2234-943X, 08/2018, Volume 8, pp. 340 - 340
Precision medicine holds real promise for the treatment of cancer. Adapting therapeutic strategies so patients receive individualized treatment protocols, will... 
Co-Clinical Trial | Precision medicine | Mouse models | PDX | Mouse Hospital | Cancer | mouse models | STEM-CELLS | CLINICAL TRIAL PROJECT | TUMOR ORGANOIDS | ORGANOID TRANSPLANTATION | DRUG-RESISTANCE | HETEROGENEITY | MODELS | ONCOLOGY | PROSTATE-CANCER | precision medicine | cancer | MICE | PATIENT-DERIVED XENOGRAFTS | Care and treatment | Research | Patient outcomes | Oncology, Experimental | Methods
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9. Full Text Corrigendum: Loss of LDAH associated with prostate cancer and hearing loss
by Currall, Benjamin B and Chen, Ming and Sallari, Richard C and Cotter, Maura and Wong, Kristen E and Robertson, Nahid G and Penney, Kathryn L and Lunardi, Andrea and Reschke, Markus and Hickox, Ann E and Yin, Yanbo and Wong, Garrett T and Fung, Jacqueline and Brown, Kerry K and Williamson, Robin E and Sinnott-Armstrong, Nicholas A and Kammin, Tammy and Ivanov, Andrew and Zepeda-Mendoza, Cinthya J and Shen, Jun and Quade, Bradley J and Signoretti, Sabina and Arnos, Kathleen S and Banks, Alexander S and Patsopoulos, Nikolaos and Liberman, M Charles and Kellis, Manolis and Pandolfi, Pier Paolo and Morton, Cynthia C
Human Molecular Genetics, ISSN 0964-6906, 05/2019, Volume 28, Issue 10, pp. 1753 - 1754
Corrigendum
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10. Full Text PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage
by Zhang, Jinfang and Lee, Yu-Ru and Dang, Fabin and Gan, Wenjian and Menon, Archita Venugopal and Katon, Jesse M and Hsu, Chih-Hung and Asara, John M and Tibarewal, Priyanka and Leslie, Nicholas R and Shi, Yang and Pandolfi, Pier Paolo and Wei, Wenyi
Cancer discovery, ISSN 2159-8274, 06/2019, Volume 9, Issue 9, pp. CD-18-0083 - 1323
The function of PTEN in the cytoplasm largely depends on its lipid-phosphatase activity, though which it antagonizes the PI3K-AKT oncogenic pathway. However,... 
Index Medicus
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11. Full Text Loss of LDAH associated with prostate cancer and hearing loss
by Currall, Benjamin B and Chen, Ming and Sallari, Richard C and Cotter, Maura and Wong, Kristen E and Robertson, Nahid G and Penney, Kathryn L and Lunardi, Andrea and Reschke, Markus and Hickox, Ann E and Yin, Yanbo and Wong, Garrett T and Fung, Jacqueline and Brown, Kerry K and Williamson, Robin E and Sinnott-Armstrong, Nicholas A and Kammin, Tammy and Ivanov, Andrew and Zepeda-Mendoza, Cinthya J and Shen, Jun and Quade, Bradley J and Signoretti, Sabina and Arnos, Kathleen S and Banks, Alexander S and Patsopoulos, Nikolaos and Liberman, M Charles and Kellis, Manolis and Pandolfi, Pier Paolo and Morton, Cynthia C
Human Molecular Genetics, ISSN 0964-6906, 12/2018, Volume 27, Issue 24, pp. 4194 - 4203
Abstract Great strides in gene discovery have been made using a multitude of methods to associate phenotypes with genetic variants, but there still remains a... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | GENE-EXPRESSION | PATHOLOGY | RISK VARIANTS | LIPID DROPLETS | MOUSE MODELS | HYDROLASE | GENOME-WIDE ASSOCIATION | FUNCTIONAL GENOMICS | CONSENSUS REPORT | Index Medicus
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12. Full Text Abstract 601: Essential role of LRF in mesenchymal stem cell differentiation and tumorigenesis through Dlk1 and Sox9 repression
by Guarnerio, Jlenia and Lunardi, Andrea and Pandolfi, Pier Paolo
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 601 - 601
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13. Full Text "Snorkeling" for missing players in cancer
by Taulli, Riccardo and Pandolfi, Pier Paolo
Journal of Clinical Investigation, ISSN 0021-9738, 08/2012, Volume 122, Issue 8, pp. 2765 - 2768
Small nucleolar RNAs (snoRNAs) are emerging as an important new class of genes deregulated in cancer. Orphans snoRNAs are encoded outside of ribosomal protein... 
NONCODING RNA | MULTIPLE-MYELOMA | MEDICINE, RESEARCH & EXPERIMENTAL | MMSET | SMALL NUCLEOLAR RNAS | GROWTH | PTEN | SNORNA HOST GENES | GAS5 | MICRORNA | Genetic aspects | Genetic engineering | MicroRNA | Genes | Multiple myeloma | Cancer
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14. Full Text Guest Editor
by Pandolfi, Pier Paolo
Oncogene, ISSN 0950-9232, 09/2008, Volume 27, Issue 41, pp. 5385 - 5385
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15. Full Text The Multiple Roles of PTEN in Tumor Suppression
by Di Cristofano, Antonio and Pandolfi, Pier Paolo
Cell, ISSN 0092-8674, 2000, Volume 100, Issue 4, pp. 387 - 390
In his celebrated monolog, the Shakespearean hero Hamlet clearly identified two extreme remedies: “To die: to sleep; no more” against “the heartache and the... 
Phosphatases | Tumors
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16. Full Text The Epitranscriptome of Non-coding RNAs in Cancer
by Esteller, Manel and Pandolfi, Pier Paolo
Cancer discovery, ISSN 2159-8274, 4/2017, Volume 7, Issue 4, pp. 359 - 368
The activity of RNA is controlled by different types of post-transcriptional modifications, such as the addition of methyl groups and other chemical and... 
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17. Full Text Aberrant mRNA translation in cancer pathogenesis: An old concept revisited comes finally of age
by Pandolfi, Pier Paolo and Pandolfi, Pier Paolo
Oncogene, ISSN 0950-9232, 04/2004, Volume 23, Issue 18, pp. 3134 - 3137
mRNA translation | Ribosome | Dkc1 | Cell size | Nucleolus | Tumor suppressor
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18. Full Text Posttranscriptional regulation of PTEN by competing endogenous RNAs
by Tay, Yvonne and Pandolfi, Pier Paolo
Methods in Molecular Biology, ISSN 1064-3745, 2016, Volume 1388, pp. 139 - 154
PTEN expression can be dysregulated in cancers via multiple mechanisms including genomic loss, epigenetic silencing, transcriptional repression, and... 
PTEN | ceRNA | miRNA | MicroRNA | Competing endogenous RNA | PTEN Phosphohydrolase - genetics | Computational Biology - methods | Animals | HCT116 Cells | Humans | Gene Expression Regulation | Mice | MicroRNAs - genetics | RNA - genetics | Index Medicus
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19. Full Text Modeling cancer-associated mutations of PTEN in mice
by Papa, Antonella and Pandolfi, Pier Paolo
Methods in Molecular Biology, ISSN 1064-3745, 2016, Volume 1388, pp. 289 - 306
Manipulation of mammalian genome and generation of genetically engineered mouse models (GEMMs) has revolutionized the scientific approach to address biological... 
Knock-in mice | PTEN | Southern blot analysis | Embryonic stem cells | Point mutations | DNA sequencing | PTEN Phosphohydrolase - genetics | Animals | Neoplasms - genetics | Mice | Mutation | Gene Knock-In Techniques - methods | Disease Models, Animal | Index Medicus
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20. Full Text Activation of Akt/protein kinase B overcomes a G(2)/M cell cycle checkpoint induced by DNA damage
by Kandel, ES and Skeen, J and Majewski, N and Di Cristofano, A and Pandolfi, PP and Feliciano, CS and Gartel, A and Hay, N
MOLECULAR AND CELLULAR BIOLOGY, ISSN 0270-7306, 11/2002, Volume 22, Issue 22, pp. 7831 - 7841
Activation of Akt, or protein kinase B, is frequently observed in human cancers. Here we report that Akt activation via overexpression of a constitutively... 
PHOSPHATIDYLINOSITOL 3-KINASE/AKT | GENETIC INSTABILITY | CANCER CELLS | SIGNALING PATHWAY | TUMOR SUPPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYC-MEDIATED APOPTOSIS | MISMATCH REPAIR | UP-REGULATION | EXPRESSION | P53 | CELL BIOLOGY | Gamma Rays | Humans | Protein-Serine-Threonine Kinases | Phosphatidylinositol 3-Kinases - metabolism | Recombinant Fusion Proteins - metabolism | CDC2 Protein Kinase - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | PTEN Phosphohydrolase | Tumor Suppressor Proteins - genetics | Genes, Tumor Suppressor | Proto-Oncogene Proteins - metabolism | Cell Line | Phosphoric Monoester Hydrolases - genetics | Tumor Suppressor Proteins - metabolism | Stem Cells - radiation effects | Tumor Suppressor Protein p53 - metabolism | Rats | Proto-Oncogene Proteins - genetics | Proto-Oncogene Proteins c-myc - metabolism | Proto-Oncogene Proteins c-akt | Animals | DNA Repair | Cell Cycle - physiology | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Stem Cells - physiology | Mice | DNA Damage | Enzyme Activation | Phosphoric Monoester Hydrolases - metabolism | Genes, cdc | Index Medicus
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