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41. Full Text Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance
by Kats, Lev M and Reschke, Markus and Taulli, Riccardo and Pozdnyakova, Olga and Burgess, Kerri and Bhargava, Parul and Straley, Kimberly and Karnik, Rahul and Meissner, Alexander and Small, Donald and Su, Shinsan M and Yen, Katharine and Zhang, Jiangwen and Pandolfi, Pier Paolo
Cell stem cell, ISSN 1934-5909, 03/2014, Volume 14, Issue 3, pp. 329 - 341
Cell & Tissue Engineering | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Proliferation | Homeodomain Proteins - metabolism | Hematopoietic Stem Cells - pathology | Neoplasm Proteins - metabolism | Hematopoiesis | Transcription, Genetic | Cell Differentiation | Spleen - pathology | Oncogenes | Disease Models, Animal | Leukemia, Myeloid, Acute - pathology | Mice, Inbred C57BL | Carcinogenesis - genetics | Erythroid Cells - metabolism | Isocitrate Dehydrogenase - genetics | Mice, Transgenic | Mutation - genetics | fms-Like Tyrosine Kinase 3 - metabolism | Carcinogenesis - pathology | Animals | Bone Marrow - pathology | Erythroid Cells - pathology | Isocitrate Dehydrogenase - metabolism | Mice | Myeloid Ecotropic Viral Integration Site 1 Protein | Cell Transformation, Neoplastic - pathology | Leukemia, Myeloid, Acute - genetics | Index Medicus
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42. Full Text Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors
by Carracedo, Arkaitz and Baselga, Jose and Paolo Pandolfi, Pier
Cell cycle (Georgetown, Tex.), ISSN 1538-4101, 12/2008, Volume 7, Issue 24, pp. 3805 - 3809
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Therapy | MAPK | Feedback | mTORC1 | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Signal Transduction | Humans | Multiprotein Complexes | Enzyme Inhibitors - pharmacology | Transcription Factors - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Sirolimus - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | MAP Kinase Signaling System | Mechanistic Target of Rapamycin Complex 1 | Neoplasms - drug therapy | Transcription Factors - metabolism | Feedback, Physiological | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice | TOR Serine-Threonine Kinases | Index Medicus
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43. Full Text The PTEN-PI3K Axis in Cancer
by Papa, Antonella and Pandolfi, Pier Paolo
Biomolecules (Basel, Switzerland), ISSN 2218-273X, 04/2019, Volume 9, Issue 4, p. 153
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Neoplasms - metabolism | Phosphatidylinositol 3-Kinases - genetics | PTEN Phosphohydrolase - genetics | Animals | Signal Transduction | Humans | PTEN Phosphohydrolase - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Index Medicus | PTEN | Review | PI3K | targeted therapies | cancer predisposition syndromes | mouse models of human cancer
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44. Full Text Breast Cancer — Loss of PTEN Predicts Resistance to Treatment
by Pandolfi, Pier Paolo
The New England journal of medicine, ISSN 0028-4793, 11/2004, Volume 351, Issue 22, pp. 2337 - 2338
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Gynecology. Andrology. Obstetrics | Mammary gland diseases | Biological and medical sciences | General aspects | Medical sciences | Tumors | Tumor Suppressor Proteins - metabolism | Signal Transduction | Humans | Receptor, ErbB-2 - metabolism | Antibodies, Monoclonal - therapeutic use | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Breast Neoplasms - drug therapy | Breast Neoplasms - metabolism | Antibodies, Monoclonal, Humanized | PTEN Phosphohydrolase | Female | Enzyme Activation | Mutation | Phosphoric Monoester Hydrolases - metabolism | Trastuzumab | Medicine, Experimental | Medical research | Care and treatment | Breast cancer | Research | Tumor antigens | Proteins | Kinases | Index Medicus | Abridged Index Medicus
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45. Full Text SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
by Finley, Lydia W.S and Carracedo, Arkaitz and Lee, Jaewon and Souza, Amanda and Egia, Ainara and Zhang, Jiangwen and Teruya-Feldstein, Julie and Moreira, Paula I and Cardoso, Sandra M and Clish, Clary B and Pandolfi, Pier Paolo and Haigis, Marcia C
Cancer cell, ISSN 1535-6108, 2011, Volume 19, Issue 3, pp. 416 - 428
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Sirtuin 3 - metabolism | Humans | Immunoblotting | Male | Transplantation, Heterologous | Mice, 129 Strain | Cell Hypoxia | Neoplasms - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | HEK293 Cells | Protein Stability | Fibroblasts - metabolism | Gene Expression | Sirtuin 3 - genetics | Cells, Cultured | Reverse Transcriptase Polymerase Chain Reaction | Metabolomics - methods | Mice, Knockout | Animals | Mice, Nude | Cell Line, Tumor | Glucose - metabolism | Glycolysis | Fibroblasts - cytology | Mice | Neoplasms - pathology | Index Medicus
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46. Full Text Haplo‐insufficiency: a driving force in cancer
by Berger, Alice H and Pandolfi, Pier Paolo
The Journal of pathology, ISSN 0022-3417, 01/2011, Volume 223, Issue 2, pp. 138 - 147
tumour suppressor gene | DOK2 | cancer | haplo‐insufficiency | gene | haplo-insufficiency | Pathology | Oncology | Life Sciences & Biomedicine | Science & Technology | Haploinsufficiency - genetics | PTEN Phosphohydrolase - genetics | Genes, p53 | Animals | Neoplasms - genetics | Humans | Adaptor Proteins, Signal Transducing - genetics | Neoplasms, Experimental - genetics | Mice | Phosphoproteins - genetics | Genes, Tumor Suppressor | Index Medicus
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47. Full Text The Oncogenic MicroRNA miR-22 Targets the TET2 Tumor Suppressor to Promote Hematopoietic Stem Cell Self-Renewal and Transformation
by Song, Su Jung and Ito, Keisuke and Ala, Ugo and Kats, Lev and Webster, Kaitlyn and Sun, Su Ming and Jongen-Lavrencic, Mojca and Manova-Todorova, Katia and Teruya-Feldstein, Julie and Avigan, David E and Delwel, Ruud and Pandolfi, Pier Paolo
Cell stem cell, ISSN 1934-5909, 07/2013, Volume 13, Issue 1, pp. 87 - 101
Cell & Tissue Engineering | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Proliferation | Luciferases - metabolism | Hematologic Neoplasms - mortality | Humans | Gene Expression Regulation, Neoplastic | Hematologic Neoplasms - pathology | Immunoenzyme Techniques | DNA-Binding Proteins - metabolism | Flow Cytometry | Cell Transformation, Neoplastic - genetics | Cell Differentiation | Real-Time Polymerase Chain Reaction | Proto-Oncogene Proteins - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Survival Rate | Hematopoietic Stem Cells - metabolism | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Cell Transformation, Neoplastic - metabolism | Blotting, Western | Animals | Hematopoietic Stem Cells - cytology | Fluorescent Antibody Technique | Myelodysplastic Syndromes - mortality | Hematologic Neoplasms - genetics | Mice | Myelodysplastic Syndromes - genetics | MicroRNAs - physiology | Cell Transformation, Neoplastic - pathology | Myelodysplastic Syndromes - pathology | Index Medicus
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48. Full Text Acute Promyelocytic Leukemia: A Paradigm for Oncoprotein-Targeted Cure
by de Thé, Hugues and Pandolfi, Pier Paolo and Chen, Zhu
Cancer cell, ISSN 1535-6108, 11/2017, Volume 32, Issue 5, pp. 552 - 560
mouse models | targeted therapy | retinoic acid | differentiation | SUMO | RARA | precision medicine | arsenic | PML | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Oncogene Proteins - genetics | Oncogene Proteins, Fusion - metabolism | Tretinoin - administration & dosage | Tumor Suppressor Proteins - metabolism | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Oncogene Proteins - metabolism | Oncogene Proteins - antagonists & inhibitors | Arsenicals - administration & dosage | Leukemia, Promyelocytic, Acute - metabolism | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Oncogene Proteins, Fusion - genetics | Tumor Suppressor Proteins - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Leukemia, Promyelocytic, Acute - genetics | Leukemia, Promyelocytic, Acute - drug therapy | Medical colleges | Arsenic | Analysis | Tretinoin | Index Medicus
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