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Circulation Research, ISSN 0009-7330, 09/2012
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 11/2018, Volume 198, Issue 10, pp. 1345 - 1348
For the SU-5416/hypoxia rat models, male Sprague-Dawley rats (200-250 g) were injected subcutaneously with SU-5416 (Sigma; 20 mg/kg body weight). Overall, our... 
MEF2 | REGULATOR | INHIBITION | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | CRITICAL CARE MEDICINE | Angiogenesis | Lungs | Pathogenesis | Pulmonary arteries | Rodents | Homeostasis | Hypoxia | Smooth muscle | Evacuations & rescues | Pulmonary hypertension | Cancer | Veins & arteries
Journal Article
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A16855 - A16855
Heart failure (HF) is the most frequent cause of hospitalization in people over 65 years. Endothelial dysfunction correlates with worse outcomes in HF, and... 
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, p. 21228
Myocardial hypertrophy is an adaptive response to hemodynamic demands. Although angiogenesis is critical to support the increase in heart mass with matching... 
SKELETAL-MUSCLE | PRESSURE-OVERLOAD | PROTEIN-TURNOVER | MULTIDISCIPLINARY SCIENCES | CARDIAC-HYPERTROPHY | GENE-EXPRESSION | GROWTH-FACTOR | TRANSCRIPTION FACTOR | UP-REGULATION | FAILURE | CORONARY-ARTERY-DISEASE | RGS Proteins - genetics | Up-Regulation | TOR Serine-Threonine Kinases - metabolism | Cardiomegaly - pathology | Multiprotein Complexes - genetics | Proto-Oncogene Proteins c-akt - genetics | Mechanistic Target of Rapamycin Complex 1 | Neovascularization, Pathologic - pathology | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | RGS Proteins - metabolism | Nitric Oxide Synthase Type III - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Endothelium - pathology | MicroRNAs - biosynthesis | Nitric Oxide Synthase Type III - genetics | Mice, Knockout | Proteins - genetics | Myocytes, Cardiac - pathology | Animals | Proteins - metabolism | Endothelium - metabolism | Nitric Oxide - genetics | Myocytes, Cardiac - metabolism | Neovascularization, Pathologic - genetics | Mice | MicroRNAs - genetics | Neovascularization, Pathologic - metabolism | Cardiomegaly - genetics | Nitric Oxide - metabolism | Cardiomegaly - metabolism | Angiogenesis | Phosphorylation | Placenta | Paracrine signalling | AKT protein | Cardiomyocytes | Heart diseases | Hypertrophy | Endothelium | FOXO3 protein
Journal Article
Trends in Endocrinology & Metabolism, ISSN 1043-2760, 11/2017, Volume 28, Issue 11, pp. 759 - 760
Elabela (ELA), the second peptide ligand for the apelin receptor, APLNR, was previously found in lower vertebrates to be crucial for endoderm and cardiac... 
embryo development | GPCR | preeclampsia | APLNR signaling | ENDOCRINOLOGY & METABOLISM | Pregnancy | Animals | Apelin Receptors | Humans | Pre-Eclampsia | Female | Penetrance | Mice | Peptide Hormones - genetics | Mice, Knockout
Journal Article
Seminars in Perinatology, ISSN 0146-0005, 12/2018, Volume 42, Issue 8, pp. 487 - 500
Gene therapy carries the potential to treat more than 10,000 human monogenic diseases and benefit an even greater number of complex polygenic conditions. The... 
DYSTROPHIN EXPRESSION | HUMAN-CELLS | DNA | PEDIATRICS | CYNOMOLGUS MONKEY | HUMAN EMBRYO | CAS9 | SELF-ORGANIZATION | GENOME | ONE-STEP GENERATION | CHROMOSOMAL REARRANGEMENTS | OBSTETRICS & GYNECOLOGY | Medical colleges | Developmental biology | Genes | Technology and civilization | Genetic research | Ethical aspects | Cardiovascular agents
Journal Article
Circulation Research, ISSN 0009-7330, 01/2013, Volume 112, Issue 1, pp. 90 - 102
Journal Article
Development, ISSN 0950-1991, 09/2009, Volume 136, Issue 18, pp. 3173 - 3183
Journal Article
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A14803 - A14803
The considerable atheroprotection afforded by statins (HMG-CoA reductase inhibitors) is thought to be above and beyond that expected from their cholesterol... 
Journal Article
Circulation, ISSN 0009-7322, 2015, Volume 131, Issue 2, pp. 190 - 199
Background-Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary arterioles, characterized by increased pulmonary arterial pressure... 
Transcriptional activation | Endothelial cells | Pulmonary hypertension | HDAC INHIBITORS | CELLS | endothelial cells | HISTONE DEACETYLASE 4 | CARDIAC & CARDIOVASCULAR SYSTEMS | pulmonary hypertension | MOUSE | VALPROIC ACID | transcriptional activation | MICE LACKING | GROWTH | ACTIVATED-RECEPTOR-GAMMA | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | TRANSCRIPTION FACTOR | MEF2 Transcription Factors - genetics | Monocrotaline | Hypertension, Pulmonary | Male | Hypertrophy, Right Ventricular - etiology | RNA Interference | Transcription, Genetic | Drug Evaluation, Preclinical | Pyrroles - therapeutic use | Hydroxamic Acids - pharmacology | Apelin | Disease Models, Animal | RNA, Small Interfering - pharmacology | Cells, Cultured | Fibroblast Growth Factor 2 - biosynthesis | Rats | MicroRNAs - biosynthesis | Hypoxia - complications | MEF2 Transcription Factors - physiology | Rats, Sprague-Dawley | Arterioles - pathology | Pyrroles - pharmacology | Animals | Fibroblast Growth Factor 2 - genetics | Intercellular Signaling Peptides and Proteins - pharmacology | Hypertrophy, Right Ventricular - prevention & control | Histone Deacetylase Inhibitors - pharmacology | Hydroxamic Acids - therapeutic use | Histone Deacetylase Inhibitors - therapeutic use | Hemodynamics | Endothelial Cells - pathology | Pulmonary Artery - pathology | Endothelial Cells - drug effects | Care and treatment | Research | Gene expression | Genetic regulation | Health aspects
Journal Article
Journal of Visualized Experiments, ISSN 1940-087X, 09/2018, Volume 2018, Issue 139
micro-RNAs (miRNAs) are single-stranded RNA transcripts that bind to messenger RNAs (mRNAs) and inhibit their translation or promote their degradation. To... 
Expression profiling | LNA probe | Cardiac hypertrophy | Micro-RNA | Genetics | In situ hybridization | Issue 139 | Immunostaining | expression profiling | MULTIDISCIPLINARY SCIENCES | SCHIZOPHRENIA | immunostaining | BIOGENESIS | DYSREGULATION | cardiac hypertrophy | micro-RNA | in situ hybridization | MICRORNA
Journal Article
Circulation, ISSN 0009-7322, 11/2015, Volume 132, Issue Suppl_3 Suppl 3, pp. A12518 - A12518
RationaleSprouting angiogenesis is governed by the concept of tip/stalk cells that guides our understanding of the transition from vascular sprouting to... 
Journal Article