Human Molecular Genetics, ISSN 0964-6906, 06/2007, Volume 16, Issue 12, pp. 1469 - 1477
Little is known about the genes and proteins involved in the process of human memory. To identify genetic factors related to human episodic memory performance,...
COMPLEX HUMAN-DISEASES | HIPPOCAMPUS | MILD MENTAL IMPAIRMENT | DELETED REGION | ALZHEIMERS-DISEASE | POOLED DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEDIAL TEMPORAL-LOBE | GENETICS & HEREDITY | NEUROBLASTOMA | IDENTIFICATION | ASSOCIATION | Calcium-Binding Proteins - metabolism | Brain - anatomy & histology | Humans | Memory | Middle Aged | Genotype | Male | Brain - metabolism | Magnetic Resonance Imaging | Animals | Adolescent | Alleles | Mental Recall - physiology | Trans-Activators - genetics | Adult | Female | Trans-Activators - metabolism | Mice | Polymorphism, Single Nucleotide | Genome | Calcium-Binding Proteins - genetics | Cohort Studies
COMPLEX HUMAN-DISEASES | HIPPOCAMPUS | MILD MENTAL IMPAIRMENT | DELETED REGION | ALZHEIMERS-DISEASE | POOLED DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEDIAL TEMPORAL-LOBE | GENETICS & HEREDITY | NEUROBLASTOMA | IDENTIFICATION | ASSOCIATION | Calcium-Binding Proteins - metabolism | Brain - anatomy & histology | Humans | Memory | Middle Aged | Genotype | Male | Brain - metabolism | Magnetic Resonance Imaging | Animals | Adolescent | Alleles | Mental Recall - physiology | Trans-Activators - genetics | Adult | Female | Trans-Activators - metabolism | Mice | Polymorphism, Single Nucleotide | Genome | Calcium-Binding Proteins - genetics | Cohort Studies
Journal Article
Science, ISSN 0036-8075, 10/2006, Volume 314, Issue 5798, pp. 475 - 478
Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA...
Haplotypes | Temporal lobe | Magnetic resonance imaging | Memory | Coordinate systems | Reports | Memory recall | Population genetics | Hippocampus | Genotypes | Human genetics | HIPPOCAMPUS | PROTEIN-KINASE-C | ACTIVATION | POPULATION STRATIFICATION | MULTIDISCIPLINARY SCIENCES | POLYMORPHISM | COGNITION | Hippocampus - chemistry | United States | Humans | Middle Aged | Male | Proteins - analysis | Brain - physiology | Phosphoproteins | Adult | Female | Proteins - physiology | Gene Expression | Membrane Proteins - genetics | Attention | Intracellular Signaling Peptides and Proteins | Genotype | Reverse Transcriptase Polymerase Chain Reaction | Switzerland | Proteins - genetics | Magnetic Resonance Imaging | Animals | Adolescent | Alleles | Brain Chemistry | Mice | Polymorphism, Single Nucleotide | Hippocampus - physiology | Calcium-Binding Proteins - genetics | Cohort Studies | Allelomorphism | Research | Complementation (Genetics) | Analysis
Haplotypes | Temporal lobe | Magnetic resonance imaging | Memory | Coordinate systems | Reports | Memory recall | Population genetics | Hippocampus | Genotypes | Human genetics | HIPPOCAMPUS | PROTEIN-KINASE-C | ACTIVATION | POPULATION STRATIFICATION | MULTIDISCIPLINARY SCIENCES | POLYMORPHISM | COGNITION | Hippocampus - chemistry | United States | Humans | Middle Aged | Male | Proteins - analysis | Brain - physiology | Phosphoproteins | Adult | Female | Proteins - physiology | Gene Expression | Membrane Proteins - genetics | Attention | Intracellular Signaling Peptides and Proteins | Genotype | Reverse Transcriptase Polymerase Chain Reaction | Switzerland | Proteins - genetics | Magnetic Resonance Imaging | Animals | Adolescent | Alleles | Brain Chemistry | Mice | Polymorphism, Single Nucleotide | Hippocampus - physiology | Calcium-Binding Proteins - genetics | Cohort Studies | Allelomorphism | Research | Complementation (Genetics) | Analysis
Journal Article
Nature neuroscience, ISSN 1097-6256, 2019, Volume 22, Issue 10, pp. 1617 - 1623
Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of...
MULTIPLE-SCLEROSIS | MRI | SCHIZOPHRENIA | LOCI | NEUROSCIENCES | ALZHEIMERS | AGE | Medical colleges | Brain | Medical imaging equipment | Neurophysiology | Pleiotropy | Functional anatomy | Magnetic resonance imaging | Disorders | Aging | Neurodevelopmental disorders | Risk analysis | Risk factors | Structure-function relationships | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
MULTIPLE-SCLEROSIS | MRI | SCHIZOPHRENIA | LOCI | NEUROSCIENCES | ALZHEIMERS | AGE | Medical colleges | Brain | Medical imaging equipment | Neurophysiology | Pleiotropy | Functional anatomy | Magnetic resonance imaging | Disorders | Aging | Neurodevelopmental disorders | Risk analysis | Risk factors | Structure-function relationships | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
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Full Text
DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART)
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, p. e39135
Twin-studies suggest that a significant portion of individual differences in the propensity to take risks resides in people's genetic make-up and there is...
IMAGING GENETICS | AVAILABILITY | GENOTYPE | VARIABLE NUMBER | MULTIDISCIPLINARY SCIENCES | VNTR POLYMORPHISM | PROPENSITY | PERSONALITY-TRAIT | DOPAMINE TRANSPORTER GENE | IMPULSIVITY | BRAIN | Humans | Middle Aged | Genotype | Male | Tandem Repeat Sequences | Dopamine Plasma Membrane Transport Proteins - genetics | Polymorphism, Genetic | Young Adult | Risk-Taking | Adolescent | Adult | Female | 3' Untranslated Regions | Genetic aspects | Genetic polymorphisms | Behavior | Brain | Neurosciences | Genes | Risk | Family medical history | Gene polymorphism | Neostriatum | Reinforcement | Dopamine transporter | Food | Dopamine receptors | Impulsivity | Sensitivity analysis | Dopamine | Analogue | Decision making | Alcoholism | Risk taking | Carriers | Studies | 3' Untranslated regions | Alleles | Transporter | Polymorphism
IMAGING GENETICS | AVAILABILITY | GENOTYPE | VARIABLE NUMBER | MULTIDISCIPLINARY SCIENCES | VNTR POLYMORPHISM | PROPENSITY | PERSONALITY-TRAIT | DOPAMINE TRANSPORTER GENE | IMPULSIVITY | BRAIN | Humans | Middle Aged | Genotype | Male | Tandem Repeat Sequences | Dopamine Plasma Membrane Transport Proteins - genetics | Polymorphism, Genetic | Young Adult | Risk-Taking | Adolescent | Adult | Female | 3' Untranslated Regions | Genetic aspects | Genetic polymorphisms | Behavior | Brain | Neurosciences | Genes | Risk | Family medical history | Gene polymorphism | Neostriatum | Reinforcement | Dopamine transporter | Food | Dopamine receptors | Impulsivity | Sensitivity analysis | Dopamine | Analogue | Decision making | Alcoholism | Risk taking | Carriers | Studies | 3' Untranslated regions | Alleles | Transporter | Polymorphism
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2013, Volume 110, Issue 46, pp. E4369 - E4374
In the last decade there has been an exponential increase in knowledge about the genetic basis of complex human traits, including neuropsychiatric disorders....
PTSD | Emotional memory | Pharmacology | POSTTRAUMATIC-STRESS-DISORDER | MULTIDISCIPLINARY SCIENCES | DIPHENHYDRAMINE | RISK | GENE SET ANALYSIS | RECONSOLIDATION BLOCKADE | PSYCHOMOTOR PERFORMANCE | emotional memory | pharmacology | SEDATION | PSYCHIATRIC-DISORDERS | WIDE ASSOCIATION | GSA-SNP | Diphenhydramine - pharmacology | Memory - drug effects | Oligonucleotides - genetics | Humans | Drug Discovery - methods | Genotype | Logistic Models | Male | Fluorometry | Switzerland | Genome, Human - genetics | Cross-Over Studies | Young Adult | Stress Disorders, Post-Traumatic - drug therapy | Polymerase Chain Reaction | Polymorphism, Single Nucleotide - genetics | Adult | Female | Interviews as Topic | Survivors - psychology | Stress Disorders, Post-Traumatic - genetics | Data Mining - methods | Memory - physiology | Biological Sciences | PNAS Plus
PTSD | Emotional memory | Pharmacology | POSTTRAUMATIC-STRESS-DISORDER | MULTIDISCIPLINARY SCIENCES | DIPHENHYDRAMINE | RISK | GENE SET ANALYSIS | RECONSOLIDATION BLOCKADE | PSYCHOMOTOR PERFORMANCE | emotional memory | pharmacology | SEDATION | PSYCHIATRIC-DISORDERS | WIDE ASSOCIATION | GSA-SNP | Diphenhydramine - pharmacology | Memory - drug effects | Oligonucleotides - genetics | Humans | Drug Discovery - methods | Genotype | Logistic Models | Male | Fluorometry | Switzerland | Genome, Human - genetics | Cross-Over Studies | Young Adult | Stress Disorders, Post-Traumatic - drug therapy | Polymerase Chain Reaction | Polymorphism, Single Nucleotide - genetics | Adult | Female | Interviews as Topic | Survivors - psychology | Stress Disorders, Post-Traumatic - genetics | Data Mining - methods | Memory - physiology | Biological Sciences | PNAS Plus
Journal Article
Development and Psychopathology, ISSN 0954-5794, 11/2016, Volume 28, Issue 4, pp. 1401 - 1412
Child abuse is associated with a number of emotional and behavioral problems. Nevertheless, it has been argued that these adverse consequences may not hold for...
PHYSICAL ABUSE | GLUCOCORTICOID-RECEPTOR | DNA METHYLATION | CORPORAL PUNISHMENT | PSYCHOLOGY, DEVELOPMENTAL | PSYCHIATRIC-DISORDERS | STRESS | PROMOTER | BETA-ENDORPHIN | DIFFICULTIES QUESTIONNAIRE | MALTREATMENT | Epigenetics | Child abuse & neglect | Mental health
PHYSICAL ABUSE | GLUCOCORTICOID-RECEPTOR | DNA METHYLATION | CORPORAL PUNISHMENT | PSYCHOLOGY, DEVELOPMENTAL | PSYCHIATRIC-DISORDERS | STRESS | PROMOTER | BETA-ENDORPHIN | DIFFICULTIES QUESTIONNAIRE | MALTREATMENT | Epigenetics | Child abuse & neglect | Mental health
Journal Article
Translational Psychiatry, ISSN 2158-3188, 2019, Volume 9, Issue 1, pp. 12 - 13
Schizophrenia is a severe mental disorder characterized by numerous subtle changes in brain structure and function. Machine learning allows exploring the...
MRI SCANS | METAANALYSIS | PSYCHIATRY | VOLUME | LIKELIHOOD ESTIMATION | SEGMENTATION | RISK | CLASSIFICATION | 1ST-EPISODE | DEFICITS | Attention Deficit Disorder with Hyperactivity - physiopathology | Humans | Middle Aged | Bipolar Disorder - physiopathology | Male | Schizophrenia - diagnostic imaging | Machine Learning | Case-Control Studies | Gray Matter - diagnostic imaging | Young Adult | Magnetic Resonance Imaging | Attention Deficit Disorder with Hyperactivity - diagnostic imaging | Bipolar Disorder - diagnostic imaging | Schizophrenia - physiopathology | Gray Matter - physiopathology | Adolescent | Adult | Female | Schizophrenia | Bipolar disorder | Nuclear magnetic resonance--NMR | Artificial intelligence
MRI SCANS | METAANALYSIS | PSYCHIATRY | VOLUME | LIKELIHOOD ESTIMATION | SEGMENTATION | RISK | CLASSIFICATION | 1ST-EPISODE | DEFICITS | Attention Deficit Disorder with Hyperactivity - physiopathology | Humans | Middle Aged | Bipolar Disorder - physiopathology | Male | Schizophrenia - diagnostic imaging | Machine Learning | Case-Control Studies | Gray Matter - diagnostic imaging | Young Adult | Magnetic Resonance Imaging | Attention Deficit Disorder with Hyperactivity - diagnostic imaging | Bipolar Disorder - diagnostic imaging | Schizophrenia - physiopathology | Gray Matter - physiopathology | Adolescent | Adult | Female | Schizophrenia | Bipolar disorder | Nuclear magnetic resonance--NMR | Artificial intelligence
Journal Article
Cerebral Cortex, ISSN 1047-3211, 08/2007, Volume 17, Issue 8, pp. 1934 - 1947
Journal Article
NeuroImage, ISSN 1053-8119, 04/2019, Volume 189, pp. 459 - 467
Encoding and retrieval of emotionally arousing stimuli depend on the activation of multiple interconnected brain regions, with people showing differences in...
Pictures | fMRI | Encoding | MVPA | Recognition | ANXIETY | DISORDERS | NEUROSCIENCES | NEUROIMAGING | RETRIEVAL | MODELS | CORTEX | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | AMYGDALA-HIPPOCAMPAL CONNECTIVITY | VALENCE | Neurosciences | Mental illness | Memory | Analysis | Brain | Young adults | Amygdala | Mental disorders | Scanners | Brain mapping | Perceptions | Emotions | Post traumatic stress disorder | Ratings & rankings | Arousal | Functional magnetic resonance imaging | Parietal lobe | Behavior
Pictures | fMRI | Encoding | MVPA | Recognition | ANXIETY | DISORDERS | NEUROSCIENCES | NEUROIMAGING | RETRIEVAL | MODELS | CORTEX | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | AMYGDALA-HIPPOCAMPAL CONNECTIVITY | VALENCE | Neurosciences | Mental illness | Memory | Analysis | Brain | Young adults | Amygdala | Mental disorders | Scanners | Brain mapping | Perceptions | Emotions | Post traumatic stress disorder | Ratings & rankings | Arousal | Functional magnetic resonance imaging | Parietal lobe | Behavior
Journal Article
BIOLOGICAL PSYCHIATRY, ISSN 0006-3223, 02/2010, Volume 67, Issue 4, pp. 304 - 308
Background: The risk for posttraumatic stress disorder (PTSD) depends on the number of traumatic event types experienced in a dose-response relationship, but...
post-traumatic stress disorder | FUNCTIONAL POLYMORPHISM | ENVIRONMENT INTERACTION | COMT GENE | refugees | GENOTYPE | ANXIETY | PSYCHIATRY | NEUROSCIENCE | SCHIZOPHRENIA | genetic polymorphisms | NEUROSCIENCES | FEAR | risk | PHARMACOGENETICS | COMT polymorphism | AMYGDALA | Genetic Predisposition to Disease | Humans | Life Change Events | Middle Aged | Risk Factors | Africa | Probability | Male | Catechol O-Methyltransferase - genetics | Chi-Square Distribution | Young Adult | Adolescent | Adult | Female | Valine - genetics | Aged | Polymorphism, Single Nucleotide | Stress Disorders, Post-Traumatic - genetics | Methionine - genetics | Multiple Traumatic Events | Etiology | Neuroanatomy | Survivors | Genetic Markers | Refugees | PTSD (DSM-IV) | Rwandans | Genocide | Biologic Markers | Neurophysiology
post-traumatic stress disorder | FUNCTIONAL POLYMORPHISM | ENVIRONMENT INTERACTION | COMT GENE | refugees | GENOTYPE | ANXIETY | PSYCHIATRY | NEUROSCIENCE | SCHIZOPHRENIA | genetic polymorphisms | NEUROSCIENCES | FEAR | risk | PHARMACOGENETICS | COMT polymorphism | AMYGDALA | Genetic Predisposition to Disease | Humans | Life Change Events | Middle Aged | Risk Factors | Africa | Probability | Male | Catechol O-Methyltransferase - genetics | Chi-Square Distribution | Young Adult | Adolescent | Adult | Female | Valine - genetics | Aged | Polymorphism, Single Nucleotide | Stress Disorders, Post-Traumatic - genetics | Methionine - genetics | Multiple Traumatic Events | Etiology | Neuroanatomy | Survivors | Genetic Markers | Refugees | PTSD (DSM-IV) | Rwandans | Genocide | Biologic Markers | Neurophysiology
Journal Article
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, ISSN 1552-4841, 12/2012, Volume 159B, Issue 8, pp. 958 - 969
WWC1 was first implicated in human cognition through a genome wide association study in 2006 that reported an association of the intronic single nucleotide...
rs17070145 | common variant | single nucleotide polymorphism | human | WWC1 | Human | Common variant | Rs17070145 | Single nucleotide polymorphism | VARIANTS | PSYCHIATRY | ALZHEIMERS-DISEASE | PERFORMANCE | SCHIZOPHRENIA | POLYMORPHISM | HEIGHT | HERITABILITY | MESSENGER-RNA | FAMILIES | GENETICS & HEREDITY | GENETIC INFLUENCES | Genome-Wide Association Study | Humans | Middle Aged | Memory, Episodic | Male | Cognition | Phosphoproteins - genetics | Learning | Neuropsychological Tests | Young Adult | Adolescent | Alleles | Aged, 80 and over | Adult | Female | Aged | Polymorphism, Single Nucleotide | Memory, Short-Term | Intracellular Signaling Peptides and Proteins - genetics | Nervous system diseases | Neurosciences | Analysis | Short-term memory | Universities and colleges | Societies | Associations, institutions, etc | Psychiatric services
rs17070145 | common variant | single nucleotide polymorphism | human | WWC1 | Human | Common variant | Rs17070145 | Single nucleotide polymorphism | VARIANTS | PSYCHIATRY | ALZHEIMERS-DISEASE | PERFORMANCE | SCHIZOPHRENIA | POLYMORPHISM | HEIGHT | HERITABILITY | MESSENGER-RNA | FAMILIES | GENETICS & HEREDITY | GENETIC INFLUENCES | Genome-Wide Association Study | Humans | Middle Aged | Memory, Episodic | Male | Cognition | Phosphoproteins - genetics | Learning | Neuropsychological Tests | Young Adult | Adolescent | Alleles | Aged, 80 and over | Adult | Female | Aged | Polymorphism, Single Nucleotide | Memory, Short-Term | Intracellular Signaling Peptides and Proteins - genetics | Nervous system diseases | Neurosciences | Analysis | Short-term memory | Universities and colleges | Societies | Associations, institutions, etc | Psychiatric services
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 12, p. e15246
The genetic basis of phenotypic variation can be partially explained by the presence of copy-number variations (CNVs). Currently available methods for CNV...
HUMAN GENOME | GENE | ARRAY-CGH | DISEASE | SUSCEPTIBILITY | BIOLOGY | SEGMENTAL DUPLICATIONS | HAPLOTYPE | EVOLUTIONARY HISTORY | STRUCTURAL VARIATION | European Continental Ancestry Group - genetics | Oligonucleotide Array Sequence Analysis | Humans | Rwanda | Genotype | Gene Dosage | Switzerland | Genetic Variation | Algorithms | Sensitivity and Specificity | Models, Genetic | Polymorphism, Single Nucleotide | African Continental Ancestry Group - genetics | Genome, Human | Cluster Analysis | Genetic aspects | Single nucleotide polymorphisms | Genes | Genomics | Populations | Laboratories | Phenotypic variations | Feasibility studies | Mental health | Genomes | Genetic diversity | Single-nucleotide polymorphism | Population genetics | Medicine | Studies | Hospitals | Maps | Spiders | Population | Gene mapping | Localization | Polymorphism
HUMAN GENOME | GENE | ARRAY-CGH | DISEASE | SUSCEPTIBILITY | BIOLOGY | SEGMENTAL DUPLICATIONS | HAPLOTYPE | EVOLUTIONARY HISTORY | STRUCTURAL VARIATION | European Continental Ancestry Group - genetics | Oligonucleotide Array Sequence Analysis | Humans | Rwanda | Genotype | Gene Dosage | Switzerland | Genetic Variation | Algorithms | Sensitivity and Specificity | Models, Genetic | Polymorphism, Single Nucleotide | African Continental Ancestry Group - genetics | Genome, Human | Cluster Analysis | Genetic aspects | Single nucleotide polymorphisms | Genes | Genomics | Populations | Laboratories | Phenotypic variations | Feasibility studies | Mental health | Genomes | Genetic diversity | Single-nucleotide polymorphism | Population genetics | Medicine | Studies | Hospitals | Maps | Spiders | Population | Gene mapping | Localization | Polymorphism
Journal Article
Psychoneuroendocrinology, ISSN 0306-4530, 09/2019, Volume 107, pp. 72 - 72
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2008, Volume 4, Issue 4, pp. T105 - T106
Journal Article
Biological Psychiatry, ISSN 0006-3223, 02/2010, Volume 67, Issue 4, pp. 304 - 308
Background: The risk for posttraumatic stress disorder (PTSD) depends on the number of traumatic event types experienced in a dose-response relationship, but...
post-traumatic stress disorder | risk | refugees | genetic polymorphisms | COMT polymorphism
post-traumatic stress disorder | risk | refugees | genetic polymorphisms | COMT polymorphism
Journal Article
Neuron, ISSN 0896-6273, 03/2014, Volume 81, Issue 5, pp. 1203 - 1213
Working memory, the capacity of actively maintaining task-relevant information during a cognitive task, is a heritable trait. Working memory deficits are...
SYSTEM | RISK LOCI | CIRCUITRY | SET ANALYSIS | CEREBELLUM | SCHIZOPHRENIA | REGISTRATION | BIPOLAR DISORDER | COGNITION | NEUROSCIENCES | GENOME-WIDE ASSOCIATION | Humans | Magnetic Resonance Imaging - methods | Male | Memory, Short-Term - physiology | Cerebellum - physiology | Healthy Volunteers | Brain - physiology | Case-Control Studies | Young Adult | Calcium Channels - physiology | Algorithms | Schizophrenia - genetics | Schizophrenia - physiopathology | Cognition - physiology | Adult | Female | Parietal Lobe - physiology | Aged | Genome-Wide Association Study - methods | Calcium Channels - genetics | Prefrontal Cortex - physiology | Brain | Neurosciences | Neurons | Genes | Genomics | Short-term memory | Schizophrenia | Genetic research | Disease susceptibility | Genetic aspects | Attention deficit disorder | Proteins | Studies | Neural networks | Bipolar disorder | Genomes | Kinases | Gene expression | Binding sites | Data bases
SYSTEM | RISK LOCI | CIRCUITRY | SET ANALYSIS | CEREBELLUM | SCHIZOPHRENIA | REGISTRATION | BIPOLAR DISORDER | COGNITION | NEUROSCIENCES | GENOME-WIDE ASSOCIATION | Humans | Magnetic Resonance Imaging - methods | Male | Memory, Short-Term - physiology | Cerebellum - physiology | Healthy Volunteers | Brain - physiology | Case-Control Studies | Young Adult | Calcium Channels - physiology | Algorithms | Schizophrenia - genetics | Schizophrenia - physiopathology | Cognition - physiology | Adult | Female | Parietal Lobe - physiology | Aged | Genome-Wide Association Study - methods | Calcium Channels - genetics | Prefrontal Cortex - physiology | Brain | Neurosciences | Neurons | Genes | Genomics | Short-term memory | Schizophrenia | Genetic research | Disease susceptibility | Genetic aspects | Attention deficit disorder | Proteins | Studies | Neural networks | Bipolar disorder | Genomes | Kinases | Gene expression | Binding sites | Data bases
Journal Article