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Genome Research, ISSN 1088-9051, 12/2017, Volume 27, Issue 12, pp. 2050 - 2060
The identification of genomic rearrangements with high sensitivity and specificity using massively parallel sequencing remains a major challenge, particularly... 
VARIANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESOLUTION | STRUCTURAL-VARIATION | IDENTIFICATION | VARIATION DISCOVERY | CANCER GENOMES | INSERTIONS | INDELS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | PAIRED-END | READS | Genome-wide association studies | Usage | Research | Gene mutations | Genetic variation | Genomics | Method
Journal Article
Cell, ISSN 0092-8674, 02/2012, Volume 148, Issue 4, pp. 780 - 791
Journal Article
BMC Genomics, ISSN 1471-2164, 06/2012, Volume 13, Issue 1, pp. 261 - 261
Journal Article
by Adema, Coen M and Hillier, LaDeana W and Jones, Catherine S and Loker, Eric S and Knight, Matty and Minx, Patrick and Oliveira, Guilherme and Raghavan, Nithya and Shedlock, Anew and do Amaral, Laurence Roigues and Arican-Goktas, Halime D and Assis, Juliana G and Baba, Elio Hideo and Baron, Olga L and Bayne, Christopher J and Bickham-Wright, Utibe and Biggar, Kyle K and Blouin, Michael and Bonning, Bryony C and Botka, Chris and Bridger, Joanna M and Buckley, Katherine M and Buddenborg, Sarah K and Lima Caldeira, Roberta and Carleton, Julia and Carvalho, Omar S and Castillo, Maria G and Chalmers, Iain W and Christensens, Mikkel and Clifton, Sana and Cosseau, Celine and Coustau, Christine and Cripps, Richard M and Cuesta-Astroz, Yesid and Cummins, Scott F and di Stephano, Leon and Dinguirard, Nathalie and Duval, David and Emrich, Scott and Feschotte, Céic and Feyereisen, Rene and FitzGerald, Peter and Fronick, Catrina and Fulton, Lucinda and Galinier, Richard and Gava, Sana G and Geusz, Michael and Geyer, Kathrin K and Giraldo-Calderón, Gloria I and de Souza Gomes, Matheus and Gordy, Michelle A and Gourbal, Benjamin and Grunau, Christoph and Hanington, Patrick C and Hoffmann, Karl F and Hughes, Daniel and Humphries, Judith and Jackson, Daniel J and Jannotti-Passos, Liana K and de Jesus Jeremias, Wander and Jobling, Susan and Kamel, Bishoy and Kapusta, Aurélie and Kaur, Satwant and Koene, Joris M and Kohn, Anea B and Lawson, Dan and Lawton, Scott P and Liang, D.C and Limpanont, Yanin and Liu, Sijun and Lockyer, Anne E and Lovato, TyAnna L and Ludolf, Fernanda and Magrini, Vince and McManus, Donald P and Medina, Monica and Misra, Milind and Mitta, Guillaume and Mkoji, Gerald M and Montague, Michael J and Montelongo, Cesar and Moroz, Leonid L and Munoz-Torres, Monica C and Niazi, Umar and Noble, Leslie R and Oliveira, Francislon S and Pais, Fabiano S and Papenfuss, Anthony T and Peace, Rob and Pena, Janeth J and Pila, Emmanuel A and Quelais, Titouan and Raney, Brian J and Rast, Jonathan P and Rollinson, David and Rosse, Izinara C and Rotgans, Bronwyn and Routledge, Edwin J and Ryan, Kathryn M and ...
Nature Communications, ISSN 2041-1723, 05/2017, Volume 8, Issue 1, p. 15451
Journal Article
Genome Biology, ISSN 1474-7596, 08/2017, Volume 18, Issue 1, pp. 150 - 15
Deep mutational scanning is a widely used method for multiplex measurement of functional consequences of protein variants. We developed a new deep mutational... 
DESIGN | DOMAIN | AFFINITY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SEQUENCE | GENETICS & HEREDITY | PROTEINS | BINDING | PARALLEL | Design | Hypothesis testing | Proteins | Scanning | Libraries | Mathematical models | Bioinformatics | Methods
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1985 - 15
STING is an innate immune cytosolic adaptor for DNA sensors that engage malaria parasite (Plasmodium falciparum) or other pathogen DNA. As P. falciparum... 
RESPONSES | SIGNALING PATHWAYS | EXTRACELLULAR VESICLES | PLASMODIUM-FALCIPARUM | HOST MORTALITY | MULTIDISCIPLINARY SCIENCES | EXOSOMES | RECEPTOR | RED-BLOOD-CELLS | INFECTION | MEDIATED TRANSFER | DNA, Protozoan - immunology | Phosphorylation | Extracellular Vesicles - ultrastructure | Cytosol - immunology | Humans | Erythrocytes | Plasmodium falciparum - immunology | Extracellular Vesicles - metabolism | Cell Nucleus - metabolism | Extracellular Vesicles - immunology | Extracellular Vesicles - genetics | Plasmodium falciparum - genetics | Membrane Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Interferon Regulatory Factor-3 - immunology | Cell Line | RNA, Protozoan - immunology | Signal Transduction | Membrane Proteins - immunology | Immunity, Innate | Cryoelectron Microscopy | Malaria, Falciparum - parasitology | RNA, Protozoan - metabolism | Monocytes | DNA, Protozoan - metabolism | Malaria, Falciparum - immunology | Interferon Regulatory Factor-3 - metabolism | Plasmodium falciparum - pathogenicity | Cytosol - metabolism | Primary Cell Culture | Vector-borne diseases | Malaria | Blood cells | Virulence | Parasites | Leukocytes | Gene expression | Ribonucleic acid--RNA | Cytosol | Nuclei | Blood | White blood cells | Receptors | Vesicles | Red blood cells | Interferon regulatory factor 3 | Parasitic diseases | Internalization | Sensors | Deoxyribonucleic acid--DNA | Immune system
Journal Article
Structure, ISSN 0969-2126, 02/2016, Volume 24, Issue 2, pp. 293 - 299
Certain peptide folds, owing to a combination of intrinsic stability and resilience to amino acid substitutions, are particularly effective for the display of... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | SHEET | MOTIF | POLYPEPTIDES | DISCOVERY | CELL BIOLOGY | MIN-23 | BIOPHYSICS | SERVER | SECONDARY STRUCTURE ANALYSES | CYSTINE KNOT | PROTEINS | SCAFFOLD | Cysteine | Animals | Peptides - chemistry | Protein Structure, Secondary | Mass Spectrometry | Models, Molecular | Mollusk Venoms - chemistry | Protein Folding | Snails - chemistry | Neuropeptides - chemistry
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2017, Volume 114, Issue 24, pp. 6406 - 6411
Tumors of distinct tissues of origin and genetic makeup display common hallmark cellular phenotypes, including sustained proliferation, suppression of cell... 
Evolution | Systems biology | Transcriptomics | Atavism | Cancer | systems biology | SURVIVAL | EVOLUTIONARY | MULTIDISCIPLINARY SCIENCES | atavism | transcriptomics | RESISTANCE | cancer | evolution | EXPRESSION | HISTORY | Genetic aspects | Genetic transformation | Comparative analysis | Health aspects | Tumors | Biological Sciences
Journal Article