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Journal of General Internal Medicine, ISSN 0884-8734, 10/2019
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 12/2019, Volume 25, Issue 23, pp. 7089 - 7097
Purpose: While mutations in BRAF in metastatic colorectal cancer (mCRC) most commonly occur at the V600 amino acid, with the advent of next-generation... 
COLON-CANCER | CETUXIMAB | GENOMIC LANDSCAPE | ACTIVATION | INHIBITION | PREDICTIVE BIOMARKER | ONCOLOGY | SENSITIVITY | KRAS WILD-TYPE | MUTATIONS | CHEMOTHERAPY
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 2019, Volume 25, Issue 10, pp. 2988 - 2995
MAVERICC compared the efficacy and safety of modified leucovorin/5-fluorouracil/oxaliplatin plus bevacizumab (mFOLFOX6-BV) with... 
Journal Article
The Oncologist, ISSN 1083-7159, 02/2019, Volume 24, Issue 2, pp. 193 - 201
Background In nongastric gastrointestinal (GI) cancers, HER2‐positive (HER2+) disease is not common. In breast cancer, HER2 status is associated with increased... 
Biomarker | Brain metastases | HER2 | Gastrointestinal cancer | GASTROESOPHAGEAL ADENOCARCINOMA | PROGNOSTIC-FACTORS | ESOPHAGEAL | LAPATINIB | OVEREXPRESSION | THERAPY | ONCOLOGY | BREAST-CANCER PATIENTS | GENOMIC CHARACTERIZATION | CARCINOMA
Journal Article
Cancer Discovery, ISSN 2159-8274, 09/2017, Volume 7, Issue 9, pp. 934 - 936
Drug development for rare molecular targets in oncology presents unique challenges. In this issue of Cancer Discovery, Drilon and colleagues report the... 
ACQUIRED-RESISTANCE | TRIALS | MUTATIONS | ONCOLOGY | CANCER | INHIBITOR ENTRECTINIB
Journal Article
The Oncologist, ISSN 1083-7159, 12/2019, Volume 24, Issue 12, pp. 1557 - 1561
Background Sub‐Saharan Africa is simultaneously facing a rising incidence of cancer and a dearth of medical professionals because of insufficient training... 
Medical education | Global oncology | Capacity building
Journal Article
Cancer Discovery, ISSN 2159-8274, 02/2018, Volume 8, Issue 2, pp. 164 - 173
"Liquid biopsy" approaches analyzing cell-free DNA (cfDNA) from the blood of patients with cancer are increasingly utilized in clinical practice. However, it... 
TARGETED THERAPY | KRAS MUTATIONS | HETEROGENEITY | EGFR MONOCLONAL-ANTIBODIES | EVOLUTION | ONCOLOGY | CLONAL HEMATOPOIESIS | ACQUIRED-RESISTANCE | EXTRACELLULAR DOMAIN | BLOCKADE | CETUXIMAB RESISTANCE | Cell-free DNA | colorectal cancer | circulating tumor DNA
Journal Article
Journal Article
JOURNAL FOR IMMUNOTHERAPY OF CANCER, ISSN 2051-1426, 08/2019, Volume 7, Issue 1, pp. 226 - 11
Background Immune checkpoint inhibitors (ICI) have demonstrated remarkable efficacy as cancer therapeutics, however, their use remains limited due to the... 
Checkpoint inhibitor | ANTIBODIES | TNF alpha | CANCER-IMMUNOTHERAPY | IMMUNOLOGY | MELANOMA | Infliximab | ANTI-CTLA-4 | COLITIS | ONCOLOGY | Immune related enterocolitis | Immune related adverse events | CTLA-4 | PD-1 | Patients | Endoscopy | Cancer | TNFα
Journal Article
The Oncologist, ISSN 1083-7159, 10/2019, Volume 24, Issue 10, pp. 1340 - 1347
Background Alterations in the DNA damage response (DDR) pathway confer sensitivity to certain chemotherapies, radiation, and other DNA damage repair targeted... 
Tumor mutational burden | Poly (ADP‐ribose) polymerase | Gastrointestinal cancers | DNA damage response | Immunotherapy
Journal Article
Journal for ImmunoTherapy of Cancer, ISSN 2051-1426, 08/2019, Volume 7, Issue 1
Immune checkpoint inhibitors (ICI) have demonstrated remarkable efficacy as cancer therapeutics, however, their use remains limited due to the development of... 
Journal Article
Journal of Gastrointestinal Surgery, ISSN 1091-255X, 11/2017, Volume 21, Issue 11, pp. 1831 - 1840
Journal Article
Cancer Discovery, ISSN 2159-8274, 04/2018, Volume 8, Issue 4, pp. 417 - 427
Clonal heterogeneity associated with acquired resistance presents a critical therapeutic challenge. Whole-exome sequencing of paired tumor biopsies and... 
Journal Article