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Gastroenterology, ISSN 0016-5085, 05/2013, Volume 144, Issue 5, p. 1042
Transforming growth factor (TGF)-[beta]-activated kinase 1 (TAK1) is activated in different cytokine signaling pathways. Deletion of Tak1 from hepatocytes... 
Liver cancer | Analysis | Fibrosis | Fluorescence | Vascular endothelial growth factor | Carcinogenesis | Growth factors
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2013, Volume 123, Issue 5, p. 2231
  Chronic pancreatitis is an inflammatory disease that causes progressive destruction of pancreatic acinar cells and, ultimately, loss of pancreatic function.... 
Rodents | Pancreas | Kinases | Chronic illnesses
Journal Article
Cell, ISSN 0092-8674, 01/2010, Volume 140, Issue 2, pp. 197 - 208
Journal Article
Science, ISSN 0036-8075, 3/2010, Volume 327, Issue 5970, pp. 1223 - 1228
Sestrin s are conserved proteins that accumulate in cells exposed to stress, potentiate adenosine monophosphate-activated protein kinase (AMPK), and inhibit... 
Pathology | Reactive oxygen species | Cell growth | Phenotypes | Drosophila | Genes | Muscles | Lipids | Research Articles | Skeletal muscle | Cells | TARGET | MULTIDISCIPLINARY SCIENCES | GROWTH | MITOCHONDRIA | EXTENDS LIFE-SPAN | AUTOPHAGY | RESTRICTION | STRESS | CONTRIBUTES | DROSOPHILA | MTOR | Protein Kinases - metabolism | Wings, Animal - cytology | AMP-Activated Protein Kinases - metabolism | Drosophila melanogaster - physiology | Reactive Oxygen Species - metabolism | Oxidative Stress | Heart - physiology | Molecular Sequence Data | JNK Mitogen-Activated Protein Kinases - metabolism | Drosophila Proteins - metabolism | Autophagy | Drosophila melanogaster - metabolism | Heat-Shock Proteins - genetics | Drosophila Proteins - physiology | Wings, Animal - growth & development | Forkhead Transcription Factors - metabolism | Aging | Mitochondria, Muscle - physiology | Models, Animal | Transcription, Genetic | Drosophila Proteins - antagonists & inhibitors | Fat Body - metabolism | Amino Acid Sequence | Signal Transduction | Muscles - physiology | Drosophila melanogaster - cytology | Gene Expression Regulation | Cell Size | Drosophila Proteins - chemistry | Triglycerides - metabolism | Wings, Animal - metabolism | Feedback, Physiological | Animals | Drosophila melanogaster - growth & development | Mitochondria, Muscle - ultrastructure | TOR Serine-Threonine Kinases | Drosophila Proteins - genetics | Heat-Shock Proteins - physiology | Heat-Shock Proteins - chemistry | Physiological aspects | Cellular proteins | Rapamycin | Properties | Proteins | Cellular biology | Insects | Kinases
Journal Article
Cell Metabolism, ISSN 1550-4131, 07/2014, Volume 20, Issue 1, pp. 133 - 144
Obesity can result in insulin resistance, hepatosteatosis, and nonalcoholic steatohepatitis (NASH) and increases liver cancer risk. Obesity-induced insulin... 
RAPAMYCIN | LIFE-SPAN | HEPATOCELLULAR-CARCINOMA | ACTIVATION | SIGNALING PATHWAY | ENDOCRINOLOGY & METABOLISM | COMPLEX 1 | PROLIFERATION | CANCER | PROGRESSION | TRANSPLANTATION | CELL BIOLOGY | Diethylnitrosamine - toxicity | Inflammation - pathology | Cell Proliferation | Reactive Oxygen Species - metabolism | TOR Serine-Threonine Kinases - metabolism | Fatty Liver - pathology | Mitosis | Humans | Male | Hepatocytes - metabolism | Sirolimus - toxicity | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Liver - injuries | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Hepatocytes - cytology | Liver - drug effects | Diet, High-Fat | Liver Neoplasms - pathology | Regulatory-Associated Protein of mTOR | Interleukin-6 - metabolism | STAT3 Transcription Factor - metabolism | DNA Damage - drug effects | Glucose Tolerance Test | Fatty Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Animals | Cell Transformation, Neoplastic | Adaptor Proteins, Signal Transducing - deficiency | Adaptor Proteins, Signal Transducing - genetics | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Mice, Obese | Mice | Adaptor Proteins, Signal Transducing - metabolism | Carcinoma, Hepatocellular - metabolism | Liver cancer | Ablation (Surgery) | Liver | Analysis | Physiological aspects | Insulin resistance | Cellular signal transduction | Inflammation | Tumors | Medical colleges | Interleukins
Journal Article
Immunity, ISSN 1074-7613, 2011, Volume 35, Issue 1, pp. 34 - 44
Detection of microbial constituents by membrane associated and cytoplasmic pattern recognition receptors is the essence of innate immunity, leading to... 
CELLS | CONNEXIN-43 | PHOSPHORYLATION | LETHAL FACTOR | IN-VIVO | BACILLUS-ANTHRACIS | STAPHYLOCOCCUS-AUREUS | RELEASE | IMMUNOLOGY | CASPASE-1 ACTIVATION | NEUTROPHIL RECRUITMENT | Inflammasomes - metabolism | Bacillus anthracis - pathogenicity | Apoptosis - drug effects | Oncogene Protein v-akt - antagonists & inhibitors | Adenosine Triphosphate - secretion | Antigens, Bacterial - immunology | Immunity, Innate - genetics | Macrophages, Peritoneal - pathology | Antigens, Bacterial - genetics | Virulence - genetics | Interleukin-1beta - metabolism | Bacterial Toxins - genetics | Bacillus anthracis - genetics | Anthrax - immunology | Connexin 43 - metabolism | Bacterial Toxins - immunology | Mice, Inbred C57BL | Cells, Cultured | Interleukin-1beta - immunology | Macrophages, Peritoneal - immunology | Mutation - genetics | Anthrax - microbiology | Apoptosis Regulatory Proteins - metabolism | Bacterial Toxins - metabolism | Animals | Macrophages, Peritoneal - microbiology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Bacillus anthracis - immunology | Receptors, Purinergic P2X7 - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | Antigens, Bacterial - metabolism | Oligomers | Disease susceptibility | Macrophages | Protein kinases | Proteins | Kinases | Infections
Journal Article
Cell, ISSN 0092-8674, 2011, Volume 147, Issue 1, pp. 173 - 184
Journal Article
Gastroenterology, ISSN 0016-5085, 2013, Volume 144, Issue 5, pp. 1042 - 1054.e4
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2014, Volume 124, Issue 8, pp. 3566 - 3578
The MAP kinase kinase kinase TGF beta-activated kinase 1 (TAK1) is activated by TLRs, IL-1, TNF, and TGF beta and in turn activates IKK-NF-kappa beta and JNK,... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | HEPATOCELLULAR-CARCINOMA | ACTIVATED PROTEIN-KINASE | LIPID-METABOLISM | TAK1 | INSULIN-RESISTANCE | IN-VIVO | NF-KAPPA-B | CANCER | HEPATOCYTE-SPECIFIC DELETION | AMP-Activated Protein Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Autophagy - physiology | Hepatocytes - metabolism | Liver Neoplasms, Experimental - prevention & control | Autophagy - drug effects | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Liver Neoplasms, Experimental - metabolism | Multiprotein Complexes - metabolism | Hepatocytes - cytology | MAP Kinase Kinase Kinases - deficiency | Liver Neoplasms, Experimental - genetics | Fatty Acids - metabolism | Hepatocytes - drug effects | Fatty Liver - genetics | Fatty Liver - metabolism | Oxidation-Reduction | MAP Kinase Kinase Kinases - genetics | Mice, Inbred C57BL | Fatty Liver - prevention & control | Mice, Transgenic | MAP Kinase Kinase Kinases - metabolism | Sirolimus - pharmacology | Mice, Knockout | Animals | Mice | PPAR alpha - metabolism | Prevention | Autophagy (Cytology) | Liver diseases | Physiological aspects | Biological oxidation (Metabolism) | Research | Protein kinases | Studies | Phosphorylation | Rodents | Liver | Lipids | Biosynthesis | Tumorigenesis | Kinases | Laboratory animals | Gene expression | Autophagy
Journal Article
Cell Metabolism, ISSN 1550-4131, 09/2012, Volume 16, Issue 3, pp. 311 - 321
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2013, Volume 60, Issue 4, pp. 782 - 791
Background & Aims Neutrophils are important immune effectors required for sterile and non-sterile inflammatory responses. However, neutrophils are associated... 
Gastroenterology and Hepatology | Toll like receptor | Inflammation | Liver fibrosis | Neutrophil | S100A9 | FIBROSIS | STERILE INFLAMMATION | CHEMOKINES | RECEPTOR | ACETAMINOPHEN HEPATOTOXICITY | MICE | ALCOHOLIC HEPATITIS | GASTROENTEROLOGY & HEPATOLOGY | TLR4 | EXPRESSION | CELL | Toll-Like Receptor 2 - genetics | Humans | Male | Leukocyte L1 Antigen Complex - immunology | Signal Transduction - immunology | Toll-Like Receptor 2 - deficiency | Toll-Like Receptor 4 - deficiency | Calgranulin B - immunology | Calgranulin B - genetics | Calgranulin A - immunology | Chemical and Drug Induced Liver Injury, Chronic - immunology | Chemical and Drug Induced Liver Injury - pathology | Disease Models, Animal | Neutrophil Infiltration - immunology | Mice, Inbred C57BL | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Carbon Tetrachloride - toxicity | Wound Healing - immunology | Chemical and Drug Induced Liver Injury, Chronic - pathology | Chemical and Drug Induced Liver Injury - immunology | Mice, Knockout | Chemokine CXCL2 - immunology | Animals | Toll-Like Receptor 2 - immunology | Chemokine CXCL2 - biosynthesis | Mice | Liver cirrhosis | Liver | CXCL-1, chemokine (C-X-C motif) ligand 1 | IL6, interleukin-6 | PCNA, proliferating cell nuclear antigen | CCL-5, chemokine (C-C motif) ligand 5 | IHC, immunohistochemistry | CXCL-2, chemokine (C-X-C motif) ligand 2 | ROS, reactive oxygen species | CCL-2, chemokine (C-C motif) ligand 2 | NASH, non-alcoholic steatohepatitis | APAP ALF, acetaminophen acute liver failure | LTA, lipoteichoic acid | α-SMA, α-smooth muscle actin | ALD, alcoholic liver disease | PBC, primary biliary cirrhosis | ALT, alanine transaminase | TNF-α, tumor necrosis factor-α | CCl4, carbon tetrachloride | PSC, primary sclerosing cholangitis | TLR, toll like receptor | AHH, acute alcoholic hepatitis | S100A9, S100 calcium binding protein A9 | S100A8, S100 calcium binding protein A8
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2014, Volume 124, Issue 8, pp. 3566 - 3566
The MAP kinase kinase kinase TGF beta -activated kinase 1 (TAK1) is activated by TLRs, IL-1, TNF, and TGF beta and in turn activates IKK-NF- Kappa B and JNK,... 
Journal Article