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Cell Reports, ISSN 2211-1247, 10/2018, Volume 25, Issue 4, pp. 1018 - 1026.e4
Neomorphic mutations in NADP-dependent isocitrate dehydrogenases ( IDH1 and IDH2 ) contribute to tumorigenesis in several cancers. Although significant... 
Journal Article
Cell Reports, ISSN 2211-1247, 10/2018, Volume 25, Issue 4, pp. 1018 - 1026.e4
Neomorphic mutations in NADP-dependent isocitrate dehydrogenases ( and ) contribute to tumorigenesis in several cancers. Although significant research has... 
NADPH | metabolic flux analysis | deuterium | IDH1 | IDH2 | redox metabolism | 2-hydroxyglutrate (2HG) | metabolism | cancer | SUPPORT | STEM-CELLS | PENTOSE-PHOSPHATE PATHWAY | ACID | METABOLISM | MUTANT IDH1 | ALPHA-KETOGLUTARATE | INHIBITOR | TUMOR-GROWTH | CANCER | CELL BIOLOGY
Journal Article
Molecular cell, ISSN 1097-2765, 11/2014, Volume 56, Issue 3, pp. 425 - 435
Pyruvate lies at a central biochemical node connecting carbohydrate, amino acid, and fatty acid metabolism, and the regulation of pyruvate flux into... 
Journal Article
The Plant Cell, ISSN 1040-4651, 6/2012, Volume 24, Issue 6, pp. 2470 - 2482
Journal Article
Nature, ISSN 0028-0836, 04/2016, Volume 532, Issue 7598, pp. 255 - 258
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2016, Volume 22, Issue 10, pp. 1108 - 1119
Continuous de novo fatty acid synthesis is a common feature of cancer that is required to meet the biosynthetic demands of a growing tumor. This process is... 
PROSTATE | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | PHOSPHORYLATION SITES | CELL BIOLOGY | SYNTHASE | METABOLISM | LIPOGENESIS | AMPK | HEPATIC STEATOSIS | Lung Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - genetics | Allosteric Regulation | Humans | Lung Neoplasms - metabolism | Molecular Targeted Therapy | Tumor Suppressor Protein p53 - genetics | Acetyltransferases - antagonists & inhibitors | Lipid Metabolism - genetics | Pyrimidinones - pharmacology | Acetyl-CoA Carboxylase - antagonists & inhibitors | Lung Neoplasms - genetics | Cell Proliferation - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Thiophenes - pharmacology | Mice, Knockout | Xenograft Model Antitumor Assays | Animals | Lipid Metabolism - drug effects | Cell Proliferation - drug effects | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Fatty Acids - biosynthesis | Synthesis | Growth | Cancer cells | Genetic aspects | Models | Research | Lung cancer, Non-small cell | Fatty acids | Carboxylases | Animal models | p53 Protein | Xenotransplantation | Lung | Lung cancer | Pharmacology | LKB1 protein | Allosteric properties | Liability | Acetyl-CoA carboxylase | Xenografts | Carboplatin | Genetic engineering | Inhibition | Dimerization | Viability | Cancer | Tumors | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2016, Volume 61, Issue 2, pp. 185 - 186
In this issue of , use stable isotope tracing, mass spectrometry, and nutrient modulation in cancer cells to highlight the role of serine in supporting... 
FLUX | METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Neoplasms - metabolism | DNA Methylation | Adenosine Triphosphate - biosynthesis | Methionine - metabolism | Serine - metabolism | Humans | Methylation | Epigenetic inheritance | Serine | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 07/2012, Volume 72, Issue 14 Supplement, pp. PR5 - PR5
Journal Article
Nature Communications, ISSN 2041-1723, 11/2015, Volume 6, Issue 1, pp. 8784 - 8784
Journal Article
by Ghinda, Diana and Chen, Suzan and Bedaiwy, Mahmoud and Jabri, Hussam and Alshardan, Mohammad and Taccone, Michael S and Lai, Carolyn and Rabski, Jessica and Tsai, Eve and Dedek, Annemarie and Xu, Jian and Tsai, Eve and Lombroso, Paul and Hildebrand, Mike and Mothe, Andrea and Tator, Charles H and Siladi, Andrew and Nally, Jaqueline and Stirling, David and Keller, Anastasia and Buckley, Christian and Shum-Siu, Alice and Magnuson, David and Rosenbaum, Benjamin P and Kelly, Michael L and Ahuja, Christopher and Ahuja, Christopher and Nori, Satoshi and Khazaei, Mohamad and Ahlfors, Jan-Eric and Liu, Yang and Wang, Jian and Fuehrmann, Tobias and Pakulska, Malgosia and Hettiaratchi, Marian H and Poon, Peter and Shoichet, Molly S and Fehlings, Michael G and Fehlings, Michael G and Fehlings, Michael G and Hazrati, Lili-Naz and Cherian, Leela and Nilewski, Lizanne and Tour, James M and Kent, Thomas A and Robertson, Claudia S and Wilde, Elisabeth and Newsome, Mary and Scheibel, Randall and Troyanskaya, Maya and Velez, Carmen and Wade, Benjamin and Drennon, Ann Marie and York, Gerald and Bigler, Erin and Abildskov, Tracy and Taylor, Brian and Jaramillo, Carlos and Eapen, Blessen and Belanger, Heather and Morey, Rajendra and Haswell, Courtney and Levin, Harvey and Hinds, Sidney and Walker, William and Walker, William and Kochunov, Peter and Jahanshad, Neda and Thompson, Paul and Tate, David and Statz, Jonathan and Goodrich, Jessica and Goforth, Cdr Carl and Tschiffely, Anna E and Arena, John D and Smith, Douglas H and Wolf, John A and Johnson, Victoria E and Rhodes, James and Friess, Stuart and Lee, Taylor and Lycke, Roy J and Jang, Ikbeom and Vike, Nicole L and Nauman, Eric A and Talavage, Thomas M and Rispoli, Joseph V and Alonso-Escalante, Jose and Fulton, William and Sodhi, Chhinder and Hackam, David J and Nasr, Isam W and Hubbard, W B and Joseph, Binoy and Spry, Malinda L and Vekaria, Hemendra J and Saatman, Kathryn and Sullivan, Patrick G and Sullivan, Patrick G and Vascak, Michal and ...
Journal of Neurotrauma, ISSN 0897-7151, 08/2018, Volume 35, Issue 16, pp. A-1 - A-285
[...]the vast majority of basic science pain research ends at target identification and validation in rodent models of chronic pain without confirmation in... 
Abstracts | Neurosciences | Keywords | Traumatic brain injury | Cytokines | Central nervous system | Inflammation | Gene expression | Trauma | Studies | Brain research | Hospitals | Pain | Rodents | Stem cells | DNA methylation | Biomarkers | Spinal cord injuries | Growth factors | Research centers | Proteins
Journal Article