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The FEBS Journal, ISSN 1742-464X, 04/2018, Volume 285, Issue 8, pp. 1456 - 1476
Journal Article
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 10/2017, Volume 56, Issue 41, pp. 12586 - 12589
A 24‐step synthesis of (±)‐forskolin is presented, which delivered hundred milligram quantities of this complex diterpene in one pass. Transformations key to... 
adenylyl cyclases | structural analogues | forskolin | natural product synthesis | ACTIVATION | ADENYLYL-CYCLASE ISOFORMS | KEY INTERMEDIATE | DIHYDROPYRAN-4-ONE | (+/-)-FORSKOLIN | CHEMISTRY, MULTIDISCIPLINARY | TRANSPOSITION | INHIBITION | ALLYLIC ALCOHOLS | ENANTIOSELECTIVE ROUTE | DERIVATIVES | Citric acid | Transposition | Synthesis | Semisynthesis | Forskolin
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 12/2018, Volume 83, Issue 24, pp. 15380 - 15405
3,4-Substituted-5-aminopyrazoles and 4-substituted-2-aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We... 
ARYL BROMIDES | POTENT | DICARBONYL-COMPOUNDS | COUPLING REACTIONS | COMPLEXES | CHEMISTRY, ORGANIC | CATALYZED ALPHA-ARYLATION | RECEPTOR | HALOGEN DANCE | INHIBITORS | IDENTIFICATION
Journal Article
Journal Article
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2019, Volume 58, Issue 4, pp. 1062 - 1066
Reported is the identification of the furo[3,2‐b]pyridine core as a novel scaffold for potent and highly selective inhibitors of cdc‐like kinases (CLKs) and... 
inhibitors | biological activity | kinases | chemical probes | heterocycles | PURINE | SMALL-MOLECULE | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | Couplings | Pyridines | Signal transduction | Inhibitors | Lymphocytes B | Hedgehog protein | Kinases | Scaffolds | Optimization | Modulators
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2010, Volume 9, Issue 8, pp. 2344 - 2353
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2017, Volume 16, Issue 9, pp. 1831 - 1842
Journal Article
Tetrahedron, ISSN 0040-4020, 10/2015, Volume 71, Issue 40, p. 7575
Syntheses of carbocyclic analogs of dehydroaltenusin tautomers are reported. Both target compounds, cDHA... 
Isoenzymes | Cattle | DNA
Journal Article
Neoplasia, ISSN 1522-8002, 10/2017, Volume 19, Issue 10, p. 830
Although Chk1 kinase inhibitors are currently under clinical investigation as effective cancer cell sensitizers to the cytotoxic effects of numerous... 
Senescence | Phenotypes | Mitosis | p53 Protein | CHK1 protein | Colorectal cancer | Cytotoxicity | Cisplatin | Cyclin-dependent kinase inhibitor p21 | Colon cancer | Cell death | Platinum | S phase | Cell cycle | Colon | PTEN protein | Apoptosis
Journal Article
Tetrahedron, ISSN 0040-4020, 10/2015, Volume 71, Issue 40, pp. 7575 - 7582
Syntheses of carbocyclic analogs of dehydroaltenusin tautomers are reported. Both target compounds,... 
DNA damage repair | DNA polymerase | Dehydroaltenusin | Regioselective aldol condensation | Spirocyclic compounds | REAGENT | REPLICATION | ENONES | CHEMISTRY, ORGANIC | FATTY-ACIDS | CANCER | BETA
Journal Article
Haematologica, ISSN 0390-6078, 04/2019, p. haematol.2018.203430
Introduction of small-molecule inhibitors of B-cell receptor signaling and BCL2 protein significantly improves therapeutic options in chronic lymphocytic... 
Journal Article