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Alzheimer's Research and Therapy, ISSN 1758-9193, 03/2017, Volume 9, Issue 1, pp. 1 - 9
Background 18F-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired helical filaments (PHF). However, high levels of 18F-THK5351... 
Selegiline | Alzheimer's disease | Positron emission tomography | Monoamine oxidase-B | F-THK5351 tau tracer | Hypotheses | Medical imaging | Nuclear magnetic resonance--NMR | Brain research | Disease | Binding sites | 18F-THK5351 tau tracer | Alzheimer’s disease
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1 - 13
The link between brain amyloid-β (Aβ), metabolism, and dementia symptoms remains a pressing question in Alzheimer’s disease. Here, using positron emission... 
Glucose metabolism | Brain | Signs and symptoms | Neurofibrillary tangles | Cognitive ability | Positron emission | Dementia disorders | Agglomeration | Metabolism | Positron emission tomography | Hypometabolism | Dementia
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 06/2018, Volume 64, Issue s1, pp. S23 - S31
Cautious optimism is appropriate for a near future (five years) time frame for a number of drugs acting on the different pathophysiological components of... 
Phosphorylation | Tau protein | Medical treatment | Biomarkers | Amyloid | Inflammation | Diagnosis | Medical diagnosis
Journal Article
Alzheimer's Research and Therapy, ISSN 1758-9193, 07/2018, Volume 10, Issue 1, pp. 74 - 14
Journal Article
Alzheimer's Research & Therapy, ISSN 1758-9193, 12/2018, Volume 10, Issue 1, pp. 1 - 11
Background: There is accumulating evidence that synaptic loss precedes neuronal loss and correlates best with impaired memory formation in Alzheimer’s disease... 
Medical imaging | Nuclear magnetic resonance--NMR | Memory | Cognitive ability | Clinical trials | Proteins | Body fluids | Hypotheses | Brain research | Cognition & reasoning | Biomarkers | Alzheimers disease | Dementia | Amyloid-β | Synaptic loss | Alzheimer’s disease | Synaptosomal-associated protein 25
Journal Article
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 06/2018, Volume 45, Issue 6, pp. 1021 - 1030
Purpose We aimed to determine the amyloid (Aβ) and tau biomarker levels associated with imminent Alzheimer’s disease (AD) - related metabolic decline in... 
Amyloid-PET | F]FDG PET | Phosphorylated tau | Preclinical Alzheimer’s disease | Elderly people | Brain | Thresholds | Neurodegenerative diseases | Positron emission | Clinical trials | Cerebrospinal fluid | Metabolism | Glucose metabolism | Tau protein | Neurodegeneration | Biomarkers | Tomography | Elderly | Alzheimer's disease | Positron emission tomography | Geriatrics
Journal Article
IEEE Transactions on Medical Imaging, ISSN 0278-0062, 08/2017, Volume 36, Issue 8, pp. 1758 - 1768
Segmentation and volumetric quantification of white matter hyperintensities (WMHs) is essential in assessment and monitoring of the vascular burden in aging... 
Elderly people | Automation | Segmentation | Image processing | Neurodegenerative diseases | Scanners | Cognition | Substantia alba | Datasets | Image segmentation | Magnetic resonance imaging | Aging | Robustness | Alzheimers disease | Alzheimer's disease | Elderly | Geriatrics
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2016, Volume 12, Issue 7, pp. P381 - P381
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2019, Volume 15, Issue 7, pp. P899 - P899
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 12/2019, Volume 56, Issue 12, pp. 8336 - 8344
Beginning in the early stages of Alzheimer’s disease (AD), the hippocampus reduces its functional connections to other cortical regions due to synaptic... 
Functional connectivity | Neurology | Neurosciences | Biomedicine | Alzheimer’s disease | Mild cognitive impairment | Neurobiology | Brain network | Hippocampus | Cell Biology | Atrophy | Neuroimaging | Neural networks | Cortex | Brain mapping | Functional magnetic resonance imaging | Alzheimer's disease | Convergence
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 07/2019, Volume 56, Issue 7, p. 4916
We investigated the association between amyloid-[beta] deposition and white matter (WM) integrity as a determinant of brain glucose hypometabolism across the... 
Brain | Medical research | PET imaging | Anisotropy | Medicine, Experimental | Research institutes | Glucose | Alzheimer's disease | Dextrose
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2016, Volume 12, Issue 7, pp. P925 - P926
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2016, Volume 12, Issue 7, pp. P68 - P69
(4) McGill Centre for Studies in Aging, Montreal, QC, Canada 
Neurology | Alzheimer's disease
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2016, Volume 12, Issue 7, pp. P527 - P527
(4) McGill Centre for Studies in Aging, Montreal, QC, Canada 
Neurology | Alzheimer's disease | Diagnostic imaging
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2016, Volume 12, Issue 7, pp. P66 - P67
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2016, Volume 12, Issue 7, pp. P1152 - P1152
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2016, Volume 12, Issue 7, pp. P627 - P628
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2016, Volume 12, Issue 7, pp. P916 - P917
(4) McGill Centre for Studies in Aging, Montreal, QC, Canada 
Neurology
Journal Article
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