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Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 02/2020, Volume 30, Issue 4, p. 126928
One of the most commonly used strategies to reduce hERG (human ether-a-go-go) activity in the drug candidates is introduction of a carboxylic acid group.... 
Journal Article
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7674, pp. 128 - 132
The dynamic and reversible acetylation of proteins, catalysed by histone acetyltransferases (HATs) and histone deacetylases (HDACs), is a major epigenetic... 
ANDROGEN RECEPTOR | ACETYLTRANSFERASES P300 | MULTIDISCIPLINARY SCIENCES | SMALL-MOLECULE INHIBITOR | HISTONE | Catalytic Domain - drug effects | p300-CBP Transcription Factors - antagonists & inhibitors | Prostatic Neoplasms, Castration-Resistant - enzymology | Histone Acetyltransferases - chemistry | Humans | Receptors, Androgen - metabolism | Crystallography, X-Ray | Male | Antineoplastic Agents - therapeutic use | Hematologic Neoplasms - enzymology | Hematologic Neoplasms - pathology | Cell Lineage - drug effects | Heterocyclic Compounds, 4 or More Rings - pharmacology | Prostatic Neoplasms, Castration-Resistant - pathology | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Biocatalysis - drug effects | Histone Acetyltransferases - metabolism | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | p300-CBP Transcription Factors - chemistry | Binding, Competitive | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 4 or More Rings - chemistry | Models, Molecular | Neoplasms - enzymology | Prostatic Neoplasms, Castration-Resistant - drug therapy | Antineoplastic Agents - chemistry | Mice, SCID | Enzyme Inhibitors - therapeutic use | Acetyl Coenzyme A - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | p300-CBP Transcription Factors - metabolism | Animals | Histone Acetyltransferases - antagonists & inhibitors | Cell Line, Tumor | Hematologic Neoplasms - drug therapy | Protein Conformation | Cell Proliferation - drug effects | Mice | Neoplasms - pathology | Care and treatment | Chemical inhibitors | Usage | Transferases | Binding proteins | Health aspects | Tumors | Histone deacetylase | Transcription factors | Molecular structure | Transcription | Peptides | Androgen receptors | Amino acids | Event-related potentials | Selectivity | Catalytic activity | Kinases | Experiments | Crystallography | Proteins | CREB-binding protein | Castration | Xenografts | Coenzyme A | Acetylation | Catalysis | Inhibition | Crystal structure | Hematology | Feasibility studies | Cyclic AMP response element-binding protein | Histone acetyltransferase | Inhibitors | Microscopy | Natural products | Regulatory mechanisms (biology) | Epigenetics | Ligands | Prostate cancer | Prostate | Cancer | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Journal Article
Journal of Neuroinflammation, ISSN 1742-2094, 05/2014, Volume 11, Issue 1, p. 95
Complement activation at the C3 convertase level has been associated with acute neuroinflammation and secondary brain injury after severe head trauma. The... 
Cr2-/-mice | Complement receptor | Neuroinflammation | Secondary brain injury | Closed head injury | SYSTEM | AUTOANTIBODIES | TISSUE-INJURY | IMMUNITY | ACTIVATION | NATURAL ANTIBODIES | IMMUNOLOGY | NEUROSCIENCES | NEUROPROTECTION | COMPLEMENT-RECEPTOR-2 | Cr2(-/-) mice | ACCUMULATION | Microglia - metabolism | Neurons - pathology | Craniocerebral Trauma - blood | Homeodomain Proteins - metabolism | Receptors, Complement 3d - immunology | Male | fas Receptor - metabolism | Brain - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Phosphopyruvate Hydratase - blood | Receptors, Complement 3d - genetics | Female | Neurons - metabolism | Disease Models, Animal | Complement C3 - metabolism | Mice, Inbred C57BL | Receptors, Complement 3b - deficiency | Receptors, Complement 3d - deficiency | Homeodomain Proteins - genetics | Mice, Knockout | Immunoglobulin M - therapeutic use | Animals | Craniocerebral Trauma - drug therapy | Brain - pathology | Mice | Craniocerebral Trauma - pathology | Astrocytes - metabolism | Immunoglobulin M | B cells | Neurons | Cell death | Cytokines | Neuropathology | Colleges & universities | Nervous system | Experiments | Bone surgery | Polymerase chain reaction | Signal transduction | Scholarships & fellowships | Head injuries | Brain research | Blood-brain barrier | Rodents | Brain damage | Laboratory animals
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 5, pp. 2376 - 2387
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2018, Volume 28, Issue 3, p. 533
Compound 1 regulates significantly fewer genes than the PPAR[delta] modulator, GW501516. Both compounds are efficacious in a thermal injury model of muscle... 
Genes | Comparative analysis | Gene expression
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2017, Volume 27, Issue 23, p. 5230
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.bmcl.2017.10.037... 
Plasma physics | Furans
Journal Article
Nature, ISSN 0028-0836, 06/2018, Volume 558, Issue 7710, pp. E1 - E1
In the originally published version of this Letter, the authors Arthur F. Kluge, Michael A. Patane and Ce Wang were inadvertently omitted from the author list.... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2012, Volume 55, Issue 15, pp. 6934 - 6941
Journal Article
ACS medicinal chemistry letters, ISSN 1948-5875, 06/2019, Volume 10, Issue 6, pp. 1013 - 1013
[This corrects the article DOI: 10.1021/acsmedchemlett.8b00287.]. 
Journal Article
Tetrahedron, ISSN 0040-4020, 1992, Volume 48, Issue 28, pp. 5757 - 5821
Journal Article
Clinical Ophthalmology, ISSN 1177-5467, 2011, Volume 5, Issue 1, pp. 633 - 643
To assess safety and efficacy of EGP-437 (dexamethasone phosphate 40 mg/mL [DP]) in dry eye patients. The study employed a prospective, single-center,... 
Iontophoresis | Ocular protection index (OPI) | Controlled adverse environment (CAE) | Dry eye | Clinical trials | Ophthalmology | dry eye | iontophoresis | Controlled Adverse Environment (CAE) | ocular protection index (OPI) | Original Research
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 2010, Volume 147, Issue 2, pp. 225 - 231
Journal Article
Journal Article