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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2012, Volume 109, Issue 2, p. 553
Protein-trafficking pathways are targeted here in human melanoma cells using methods independent of oncogene mutational status, and the ability to up-regulate... 
Proteins | Medical treatment | Mutation | Cells | Apoptosis | Cancer
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 06/2011, Volume 660, Issue 1, pp. 103 - 110
The melanocortin MC sub(1) receptor is a G-protein coupled receptor expressed in the melanocytes of the skin and hair and is known for its key role in the... 
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2011, Volume 660, Issue 1, pp. 103 - 110
The melanocortin MC receptor is a G-protein coupled receptor expressed in the melanocytes of the skin and hair and is known for its key role in the regulation... 
MC1R | Tanning | Melanoma | Melanocyte | Pigmentation | Red hair colour
Journal Article
Pigment Cell & Melanoma Research, ISSN 1755-1471, 05/2012, Volume 25, Issue 3, pp. 370 - 374
Journal Article
British Journal of Haematology, ISSN 0007-1048, 10/2016, Volume 175, Issue 1, pp. 141 - 153
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 09/2019
Abstract Susceptibility of influenza A viruses to baloxavir can be affected by changes at amino acid residue 38 in the polymerase acidic (PA) protein.... 
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2017, Volume 8, Issue 3, pp. 321 - 326
We report the discovery of a new potent allosteric effector of sickle cell hemoglobin, GBT440 (36), that increases the affinity of hemoglobin for oxygen and... 
sickle cell hemoglobin | oxygen affinity | red blood cell partitioning | Schiff-base formation | aldehyde | Sickle cell disease | allosteric modulator | CHEMISTRY, MEDICINAL | PYRIDYL DERIVATIVES | ANTISICKLING AGENT | POTENT | STRUCTURAL BASIS | DISEASE | ANEMIA | BINDING
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2012, Volume 109, Issue 2, pp. 553 - 558
Protein-trafficking pathways are targeted here in human melanoma cells using methods independent of oncogene mutational status, and the ability to up-regulate... 
Molecules | Melanosomes | Cell lines | Melanoma | Melanocytes | Protein transport | Genetic mutation | Organelles | Cells | Apoptosis | Agouti-signaling peptide | Chemotherapy | Treatment resistance | Targeted therapy | targeted therapy | CELLS | MULTIDISCIPLINARY SCIENCES | agouti-signaling peptide | AGOUTI SIGNALING PROTEIN | MELANOGENESIS | chemotherapy | HERMANSKY-PUDLAK-SYNDROME | HUMAN KERATINOCYTES | NUCLEOTIDE EXCISION-REPAIR | EARLY ENDOSOMES | LYSOSOME-RELATED ORGANELLES | MULTIDRUG-RESISTANCE | treatment resistance | MELANOCYTES | Humans | Molecular Sequence Data | Immunoblotting | Receptor, Melanocortin, Type 1 - metabolism | RNA Interference | Dacarbazine - pharmacology | Dacarbazine - analogs & derivatives | Antineoplastic Agents - pharmacology | Intracellular Signaling Peptides and Proteins - genetics | Melanosomes - drug effects | Amino Acid Sequence | Vesicular Transport Proteins - genetics | Cisplatin - pharmacology | Down-Regulation - drug effects | Microscopy, Electron | Mutation - genetics | Protein Transport - genetics | Up-Regulation - drug effects | Vesicular Transport Proteins - deficiency | DNA Repair | Melanoma - drug therapy | Cell Line, Tumor | Temozolomide | Carboplatin - pharmacology | Drug Resistance, Neoplasm - physiology | Microscopy, Fluorescence | Drug Resistance, Neoplasm - drug effects | Care and treatment | Development and progression | Cellular signal transduction | Genetic aspects | Research | Drug therapy | Methods | Cancer | Protein binding | Biological Sciences
Journal Article
Physiological Reports, ISSN 2051-817X, 09/2016, Volume 4, Issue 17, pp. e12965 - n/a
Although exertional dyspnea and worsening hypoxia are hallmark clinical features of idiopathic pulmonary fibrosis (IPF), no drug currently available could... 
hypoxia | Dyspnea | idiopathic pulmonary fibrosis | quality of life | Niacinamide - analogs & derivatives | Hypoxia - drug therapy | Male | Dyspnea - etiology | Idiopathic Pulmonary Fibrosis - chemically induced | Idiopathic Pulmonary Fibrosis - metabolism | Oxygen - metabolism | Bleomycin - metabolism | Collagen - drug effects | Niacinamide - pharmacokinetics | Models, Animal | Benzaldehydes - pharmacokinetics | Bronchoalveolar Lavage Fluid - cytology | Oxyhemoglobins - metabolism | Dyspnea - diagnosis | Niacinamide - metabolism | Administration, Oral | Mice, Inbred C57BL | Benzaldehydes - pharmacology | Hypoxia - complications | Bleomycin - administration & dosage | Bleomycin - adverse effects | Random Allocation | Oxyhemoglobins - drug effects | Oxygen - blood | Niacinamide - administration & dosage | Benzaldehydes - metabolism | Collagen - metabolism | Animals | Benzaldehydes - administration & dosage | Idiopathic Pulmonary Fibrosis - pathology | Leukocytes - drug effects | Mice | Hypoxia - chemically induced | Niacinamide - pharmacology | Leukocytes - metabolism | Idiopathic Pulmonary Fibrosis - drug therapy | Oxygen | Laboratories | Body weight | Lung diseases | Bronchus | Body weight loss | Bleomycin | Hypoxemia | Pulmonary fibrosis | Lungs | Collagen | Fibrosis | Hemoglobin | Hypoxia | Affinity | Respiration | Sickle cell disease | Alveoli | Drug dosages | Chronic illnesses
Journal Article
Journal Article
01/2010, ISBN 9781109708950
The range of skin colors seen across the world are a result of the skin attempting to maximize vitamin D production while minimizing UV radiation related... 
Biochemistry
Dissertation